• Journal of Preventive Medicine and Public Health
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• v.47 no.3
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• pp.136-143
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• 2014

The Global Burden of Disease (GBD) study has been instrumental in guiding global health policy development since the early 1990s. The GBD 2010 project provided rich information about the key causes of mortality, disability-adjusted life years, and their associated risk factors in Japan and provided a unique opportunity to incorporate these data into health planning. As part of the latest update of this project, GBD 2013, the Japanese GBD collaborators plan to update and refine the available burden of disease data by incorporating sub-national estimates of the burden of disease at the prefectural level. These estimates will provide health planners and policy makers at both the national and prefectural level with new, more refined tools to adapt local public health initiatives to meet the health needs of local populations. Moreover, they will enable the Japanese health system to better respond to the unique challenges in their rapidly aging population and as a complex combination of non-communicable disease risk factors begin to dominate the policy agenda. Regional collaborations will enable nations to learn from the experiences of other nations that may be at different stages of the epidemiological transition and have different exposure profiles and associated health effects. Such analyses and improvements in the data collection systems will further improve the health of the Japanese, maintain Japan's excellent record of health equity, and provide a better understanding of the direction of health policy in the region.

• Molecular & Cellular Toxicology
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• v.3 no.3
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• pp.208-213
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• 2007

With the help of a development and popularization of microarray technology that enable to us to simultaneously investigate the expression pattern of thousands of genes, the toxicogenomics experimenters can interpret the genome-scale interaction between genes exposed in toxicant or toxicant-related environment. The ultimate and primary goal of toxicogenomics identifies functional context among the group of genes that are differentially or similarly coexpressed under the specific toxic substance. On the other side, public reference databases with transcriptom, proteom, and biological pathway information are needed for the analysis of these complex omics data. However, due to the heterogeneous and independent nature of these databases, it is hard to individually analyze a large omics annotations and their pathway information. Fortunately, several web sites of the public database provide information linked to other. Nevertheless it involves not only approriate information but also unnecessary information to users. Therefore, the systematically integrated database that is suitable to a demand of experimenters is needed. For these reasons, we propose SOP (Search of Omics Pathway) database system which is constructed as the integrated biological database converting heterogeneous feature of public databases into combined feature. In addition, SOP offers user-friendly web interfaces which enable users to submit gene queries for biological interpretation of gene lists derived from omics experiments. Outputs of SOP web interface are supported as the omics annotation table and the visualized pathway maps of KEGG PATHWAY database. We believe that SOP will appear as a helpful tool to perform biological interpretation of genes or proteins traced to omics experiments, lead to new discoveries from their pathway analysis, and design new hypothesis for a next toxicogenomics experiments.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.43 no.1 s.343
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• pp.121-126
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• 2006

This paper report on the design and implementation of a 9.6kbps DSSS CDMA modem for a medium speed wireless link. The proposed modem provides a general purpose I/O interface with a microprocessor. The I/O interface consists of 8-bit data bus, chip enable, read/write, and interrupt pins. In transmit block, the 8-bit data delivered from the I/O interface buffer is converted to 9.6kbps serial data, which are spreaded into 76.8kcps with 8-bit PN code generated inside the modem by direct sequence method. An 8-bit training sequence is preceded in the data frame for data synchronization in receiver. In receiver block the PN code is synchronized from the received data spreaded to 76.8kcps and find the data timing from the 8-bit training sequence. We have used the Early-and-Late integration method. The modem has been implemented and verified using a Xilix FPGA board and has been fabricated as an ASIC CHIP through Hynir $0.25{\mu}m$ CMOS. The multiple accessing method is DSSS CDMA.

• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.9
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• pp.28-35
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• 2015

In this paper, we propose to identify redundant power states of high-level power model based on clock gating enable signals(CGENs) using dependencies of Boolean functions and structural dependencies of clock gating cells. Three functional dependencies between two CGENs, namely equvalence, inversion, and inclusion, are used. Functions of CGENs in a circuit are represented by binary decision diagrams (BDDs) and the functional relations are used to reduce the number of power states. The structural dependency appears when a clock gating cell drives another clock gating cells in a circuit. Automatic dependency checking algorithm has been proposed. The experimental results show the average number of power state is reduced by 59%.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.10
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• pp.51-57
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• 2016

In this paper, we propose an optimal energy management system using the data inference scheme and the cloud hosting technique in order to improve the efficiency of the energy management. We have been interested in the issue that the energy-saving and efficient management techniques are very useful for reducing the production and supply of energy. The energy management system refers to the control and management system in order to enable the efficient use of energy and also to maintain a comfortable and functional working environment effectively with the help of a computer. The proposed system controls a variety of equipment for energy management, and also gets the data for the inference from the changes in energy consumption environment, which is implemented to enable efficient energy management by adapting and controlling the changes optimally in the working environment. In order to evaluate the performance of the implemented system, some experiments have been performed under consideration of the monthly electric power consumption on the server that the inference engine is operating for the target facilities. Finally, the results show that the proposed system has a good performance.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.11B
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• pp.1245-1253
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• 2009

Since 2000, the demand for multimedia content consumption has been continuously increasing. The research and standardization for the mobile broadcast service has been done to deliver multimedia contents to the huge number of users with the minimum cost. A few commercial services started after the related standards were released. We call this mobile broadcast service the 1st generation service. Now, many experts are researching and developing the technologies for 3Screens(TV, PC, and Mobile) Services that an user can enjoy multimedia contents at every place with the various networks and devices. To enable this service, two main technical areas exist. The first is a core network technology that can support the various access network and the second is a common application layer technology. To resolve these technical areas, we propose IMS(IP Multimedia Subsystem) based OMA BCAST(Open Mobile Alliance Mobile Broadcast Service Enabler Suite) as the technical solution for 3 Screen Services in the paper. In addition, we propose application layer multicast that is enable to implement IMS based OMA BCAST to the existing network with the minimum cost. Finally, we show how we can save the implementation cost of IMS based OMA BCAST with the simulation results.

• Journal of Biomedical Engineering Research
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• v.39 no.1
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• pp.22-29
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• 2018

Intervertebral disc(IVD) mainly consists of Annulus fibrosus(AF) and Nucleus pulposus(NP), playing a role of distributing a mechanical load on vertebral body. IVD tissue engineering has been developed the methods to achieve anatomic morphology and restoration of biological function. The goal of present study is to identify the possibilities for creating a substitute of IVD the morphology and biological functions are the same as undamaged complete IVD. To fabricate the AF and NP combine biphasic IVD tissue, AF tissue scaffolds have been printed by 3D bio-printing system with natural biomaterials and NP tissues have been prepared by scaffold-free culture system. We evaluated whether the combined structure of 3D printed AF scaffold and scaffold-free NP tissue construct could support the architecture and cell functions as IVD tissue. 3D printed AF scaffolds were printed with 60 degree angle stripe patterned lamella structure(the inner-diameter is 5mm, outer-diameter is 10 mm and height is 3 mm). In the cytotoxicity test, the 3D printed AF scaffold showed good cell compatibility. The results of histological and immunohistochemical staining also showed the newly synthesized collagens and glycosaminoglycans, which are specific makers of AF tissue. And scaffold-free NP tissue actively synthesized glycosaminoglycans and type 2 collagen, which are the major components of NP tissue. When we combined two engineered tissues to realize the IVD, combined biphasic tissues showed a good integration between the two tissues. In conclusion, this study describes the fabrication of Engineered biphasic IVD tissue by using enable techniques of tissue engineering. This fabricated biphasic tissue would be used as a model system for the study of the native IVD tissue. In the future, it may have the potential to replace the damaged IVD in the future.

• Journal of Astronomy and Space Sciences
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• v.32 no.3
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• pp.209-219
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• 2015

The Accurate Ranging System for Geodetic Observation - Mobile (ARGO-M) was successfully developed as the first Korean mobile Satellite Laser Ranging (SLR) system in 2012, and has joined in the International Laser Ranging Service (ILRS) tracking network, DAEdeoK (DAEK) station. The DAEK SLR station was approved as a validated station in April 2014, through the ILRS station "data validation" process. The ARGO-M system is designed to enable 2 kHz laser ranging with millimeter-level precision for geodetic, remote sensing, navigation, and experimental satellites equipped with Laser Retro-reflector Arrays (LRAs). In this paper, we present the design and development of a next generation high-repetition-rate SLR system for ARGO-M. The laser ranging rate up to 10 kHz is becoming an important issue in the SLR community to improve ranging precision. To implement high-repetition-rate SLR system, the High-repetition-rate SLR operation system (HSLR-10) was designed and developed using ARGO-M Range Gate Generator (A-RGG), so as to enable laser ranging from 50 Hz to 10 kHz. HSLR-10 includes both hardware controlling software and data post-processing software. This paper shows the design and development of key technologies of high-repetition-rate SLR system. The developed system was tested successfully at DAEK station and then moved to Sejong station, a new Korean SLR station, on July 1, 2015. HSLR-10 will begin normal operations at Sejong station in the near future.

• Journal of Sensor Science and Technology
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• v.1 no.2
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• pp.147-154
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• 1992

This paper describes the design of implantable 8-channel telemetering system to get physiological signals. The internal circuits of this system are designed not only to achieve as small size and low power dissipation as possible, but also to enable continuous measurement of physiological signals. Its main functions are to enable continuous measurement of physiological signals and to accomplish on-off power switching of an implantable battery by receiving appropriate command signals from an external circuit. To integrate implantable biotelemetry system, we performed layout of internal system using Lambda based $2{\mu}m$ n-well design rules. This system, used together with appropriate sensors, is expected to be capable of measuring and transmitting such significant parameters as pressure, pH, and temperature.

• Journal of Sensor Science and Technology
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• v.5 no.1
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• pp.43-50
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• 1996

This paper presents a manufacture of the multiple subjects biotelemetry system using custom CMOS IC fabricated $1.5{\mu}m$ n-well process technology. The implantable circuits of the system except sensor interface circuits including FM transmitter are fabricated on a single chip with the sire of $4{\times}4mm^{2}$. It is possible to assemble the implantable system in a hybrid package as small as $3{\times}3{\times}2.5cm$ by using this chip, It's main function is to enable continuous measurement simultaneously up to 7-channel physiological signals from the selected one among 8 subjects. Another features of this system are to enable continuous measurement of physiological signals, and to accomplish ON/OFF switching of an implanted battery by subject selection signal with command signal from the external circuit. If this system is coupled with another appropriate sensors in medical field, various physiological parameters such as pressure, pH and temperature are to be measured effectively in the near future.