• Bulletin of the Korean Chemical Society
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• 제26권12호
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• pp.1923-1924
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• 2005

• Journal of Applied Biological Chemistry
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• 제56권3호
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• pp.187-189
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• 2013

The antimicrobial activities of emodin and its derivatives (anthraquinone, alizarin, and alizarin-3-methyliminodiacetic acid) were evaluated using a paper disc diffusion method against foodborne bacteria (Bacillus cereus, Listeria monocytogenes, Staphylococcus intermedius, Salmonella typhimurium and Shigella sonnei). Emodin isolated from C. tora seeds has an antimicrobial activity against Bacillus cereus, followed by alizarin-3-methyliminodiacetic acid ($13.0{\pm}2.5mm$) and alizarin ($11.5{\pm}1.2mm$). Furthermore, emodin showed the antimicrobial activity against S. sonnei and S. typhimurium. In conclusion, C. tora seed and its active component derivatives are useful for the development of natural products on food supplemental agents and pharmaceuticals.

• 약학회지
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• 제27권1호
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• pp.37-43
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• 1983

The rhizome of Polygonum sachalinense Fr. Schm. (=Reynoutria sachalinensis Nakai, Polygonaceae) has been used as "Polygoni Rhizoma" (Hu Zhang) in the Orient as laxatives, diuretics and for treatment of suppurative dermatitis, gonorrhoea, favus and athlete's foot. From the methanolic extract of the dried rhizome physcion, emodin, emodin-8-O-$\beta$-D-glucoside as anthraquinone derivatives and .betha.-sitosterol glucoside were isolated and identified. Stilbene derivatives which have antibacterial and antifungal activities were also isolated.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3887-3891
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• 2015

Aloe-emodin (1, 8-dihydroxy-3-hydroxyl-methylanthraquinone; AE) and emodin (1,3,8-trihydroxy-6-methylanthraquinone; EM) are anthraquinone derivatives that have been detected in some medical plants and share similar anthraquinone structures. AE and EM have been shown to exhibit anticancer activities in various cancer cell lines; however, the inhibitory effects of these derivatives on the growth of cancer cells were previously reported to be different. Gastric cancer is the second most common cause of cancer cell death worldwide. In the present study, we examined the inhibitory effects of 0.05 mM AE and 0.05 mM EM on the proliferation of the MKN45 human gastric cancer cell line. The proliferation of MKN45 cells was significantly inhibited in AE- and EM-treated groups 24 h and 48 h after treatment. Furthermore, the inhibitory effects of EM were stronger than those of AE. The cell cycle of MKN45 cells were arrested in G0/G1 phase or G0/G1 and G2/M phases by AE and EM, respectively. However, an analysis of intracellular polyamine levels and DNA fragmentation revealed that the mechanisms underlying cell death following cell arrest induced by AE and EM differed.

• 생약학회지
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• 제17권1호
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• pp.73-77
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• 1986

Anthraquinones, physcion (I), mp $204{\sim}205^{\circ}$ and emodin (II), mp $254{\sim}255^{\circ}$, and $emodin-8-O-{\beta}-{_D}-glucoside$ (IV), mp $191{\sim}192^{\circ}$ together with ${\beta}-sitosterol$ glucoside (III), mp $280{\sim}282^{\circ}$ were isolated from the roots of Polygonum ellipticum Migo and P. sachalinense Fr. Schm. (Polygonaccae). Stilbene derivatives, 3,5,4'-trihydroxystibene (V), mp $258{\sim}260^{\circ}$ and $3,5,4'-trihydroxystilbene-3-O-{\beta}-{_D}-glucoside$ (VI), mp $142{\sim}144^{\circ}$ were also isolated.

• 약학회지
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• 제38권4호
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• pp.410-417
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• 1994

As one of the studies for Korean cultivated Rhubarb, which has been used stomachic bitter, laxative and purgative, etc, MeOH extract of the leaves was fractionated with ether, ethylacetate. From the ether fraction of MeOH extract, two anthraquinone derivatives, 1,6,8-trihydroxy-3-methyl anthraquinone(emodin, $C_{15}H_{10}O_5$), 1,6,8-trihydroxy-3-hydroxymethyl anthraquinone (citrerosein, $C_{15}H_{10}O_6$) and from the ethyl acetate fraction of MeOH extract, one anthraquinone derivative, emodin-8-${\beta}$-D-glucopyranoside$(C_{21}H_{20}O_{10})$ were isolated and identified through the physico-chemical properties and spectroscopic evidences(UV, IR, NMR, Mass), respectively.

• 생약학회지
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• 제12권4호
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• pp.221-226
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• 1981

Besides the emodin, three anthraquinone derivatives were isolated from the roots of Polygonum ciliinerve (Nakai) Owi which is indigenous exclusively to Korea. Two of them were identified as physcion and emodin-8-O-${\beta}$-D-glucoside by mp, uv, ir and nmr spectra. And the third was converted to physcion and sugar by hydrolysis. The quantitative analysis of free and combined form of emodin and physcion was done by the spectrophotometry.

• Archives of Pharmacal Research
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• 제18권4호
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• pp.282-288
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• 1995

The sutdies were carried out to evaluate the consituents in the rihzomes of the cultivated Korean Rhubarb (Polygonaceae). From the acetone fraction ofl methanol extract Compound I (1, 8-dihydroxy-3-methyl anthraquinone, chrysophanic acid), Compound II($chrysophanol-8-O-{\beta}-D-glucopyranoside$), Compound III ($emodin-8-O-{\beta}-D-glucopyranoside$) and Compound IV ($aloe-emodin-8-O-{\beta}-D-glucopyranoside$), and from the ether fraction Compound V(1, 8-dihydorxy-3-emthyl-6-methoxy anthraquinone, physcion) and Compound VI (1, 6, 8-thitydroxy-3-emthyl anthrauinone, emodin), and also from the n-buthanol fraction Compound VII ($rhapontigenin-3-O-{\beta}-D-glucopyranoside, rhaponticin$) and Compound VIII ($piceatannol-3'-O-{\beta}-D-glucopyranoside$), were isolated and identified on the basis of their physico-chemical and spectroscopic evidences (UV, IR, H-NMR, C-NMR, EI-MS), respectively.

• 한국한의학연구원논문집
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• 제13권3호
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• pp.157-163
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• 2007

Objective: Polygonum multiflorum Thunberg (Polygonaceae) has been traditionally used as a tonic and the purgative in China and Korea. The genus Polygonum is a source of a wide range of phenolic compound, flavanoids, anthraquinones, stilbenes and tannins. In this study, three anthraquinones were isolated and quantitative determination of anthraquinones from P multiflorum has been developed for quality standardization. Methods : Three anthraquinone derivatives were isolated from a methanol extract of the radix of P. multiflorum by the chromatographic separation. Their structures were identified as emodin, physcion and ${\omega}$-hydroxyemodin on the basis of spectral data (MS, lH-NMR, 13C-NMR) and chemical analysis. HPLC analysis was performed to determine the contents of emodin, physcion, chrysophanol, rhein and ${\omega}$-hydroxyemodin in P. multiflorum from different specimens were collected from twenty Korean markets. Results: According to the results, the contents of emodin, physcion, chrysophanol, rhein and ${\omega}$-hydroxyemodin were 0.145%, 0.434%, 0.016%, 0.026%, 0.030% by HPLC, respectively. Conclusions : In these results, we have determined the contents of emodin, physcion, chrysophanol, rhein and ${\omega}$-hydroxyemodin in P. multiflorum, respectively. We hope that this study will contribute to the standardization and quality control of herbal medicine.

• Applied Biological Chemistry
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• 제47권2호
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• pp.274-278
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• 2004

참소리쟁이 뿌리의 $CHCl_3$ 추출물에서 4종의 anthraquinone계 화합물을 분리하였다. 이들 화합물들(1-4)은 physcion, emodin, chrysophanol-10,10'-bianthrone과 physcion-10,10'-bianthrone로 각각 구조동정되었다. 분리된 화합물 중 physcion-10,10'-bianthrone는 인체암 세포주(UACC62, HCT15, UO-31, PC-3, A549)에 강한 활성$(IC_{50}=0.45{\sim}1.33\;{\mu}g\;{\cdot}\;ml^{-1})$을 나타내었다.