• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.3 no.2
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• pp.135-148
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• 2005

In the stage of conceptual design for the construction and operation of the geologic repository for radioactive wastes, it is important to consider a repository ventilation system which serves the repository working environment, hygiene & safety of the public at large, and will allow safe maintenance like moisture content elimination in repository for the duration of the repositories life, construction/operation/closure, also allowing safe waste transportation and emplacement. This paper describes the possible ventilation system design criteria and requirements for the prospective Korean radioactive waste repositories with emphasis on the underground rock cavity disposal method in the both cases of low & medium-level and high-level wastes. It was found that the most important concept is separate ventilation systems for the construction (development) and waste emplacement (storage) activities. In addition, ventilation network system modeling, natural ventilation, ventilation monitoring systems & real time ventilation simulation, and fire simulation & emergency system in the repository are briefly discussed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.2
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• pp.39-47
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• 2020

The fire protection system for high-rise buildings is currently confined to the preparation of sprinklers, emergency stairs, and exit and monitoring systems. On the other hand, an integrated system, including the model with scenario-based actions, is required for effective fire protection. An integrated fire protection system is needed to operate and manage the total cycle of the fire protection. In this study, an integrated fire protection system, which included sensing and consequent processes related to fire emergencies, was designed and implemented. The designed scheme can gather and analyze the data of the production, operation, and consumption patterns as it integrates fire protection systems for fire fighters and evacuating people. The integrated fire protection technology and system, which has target performance with satisfied 1/2 sec transaction response time and 1.2 transactions per second, is expected to contribute to market creation in converged technology-based fire protection fields.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.46 no.2
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• pp.111-118
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• 2013

The Norwegian coastal area is the most efficient region for fishery production in the world's oceans, the Norway is the world's top 10 fisheries countries through efficient fishing and fishing aquaculture technology and its scientific management of fisheries bio-resources, with Norwegian salmon having attained the world's highest level. In the late 1980s, fisheries resources were depleted due to overfishing and fish diseases, resulting in a crisis in the fishing industry that lasted until the early 1990s. Since the national fishery emergency, people involved in the fishing industry, including fishermen, research scientists, and government officers, have tried to overcome the challenges facing the industry and identify an appropriate management model for fisheries bio-resources in the Norwegian coastal area. First, research vessels were used to monitor water and sediment conditions and fishery species, with the long-term aim of predicting fishery resources in real time and collecting information on species diversity, abundance, and distribution. Second, a "Healthy Fish Project" was promoted to counter natural disasters and fish disease problems with the development of vaccines against viruses and bacteria, eventually allowing for a decrease in the use of antibiotics and the production of notably healthier fish in the 2000s. Third, a systematic management model was developed to help with preparations for decreases in the total number of fishermen and increases in the proportion of elderly fishermen in the fishery industry using the development of automatic fishing aquaculture systems and short-chain systems. We could learn from the Norwegian model of fisheries bio-resources, management and could adopt it for the preparation of fishery bio-resources management policy for South Korean coastal areas in the near future.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.6
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• pp.447-456
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• 2014

Until now, a disease-modifying therapy (DMT) that has an ability to slow or arrest Alzheimer's disease (AD) progression has not been developed, and all clinical trials involving AD patients enrolled by clinical assessment alone also have not been successful. Given the growing consensus that the DMT is likely to require treatment initiation well before full-blown dementia emerges, the early detection of AD will provide opportunities to successfully identify new drugs that slow the course of AD pathology. Recent advances in early detection of AD and prediction of progression of the disease using various biomarkers, including cerebrospinal fluid (CSF) $A{\beta}_{1-42}$, total tau and p-tau181 levels, and imagining biomarkers, are now being actively integrated into the designs of AD clinical trials. In terms of therapeutic mechanisms, monitoring these markers may be helpful for go/no-go decision making as well as surrogate markers for disease severity or progression. Furthermore, CSF biomarkers can be used as a tool to enrich patients for clinical trials with prospect of increasing statistical power and reducing costs in drug development. However, the standardization of technical aspects of analysis of these biomarkers is an essential prerequisite to the clinical uses. To accomplish this, global efforts are underway to standardize CSF biomarker measurements and a quality control program supported by the Alzheimer's Association. The current review summarizes therapeutic targets of developing drugs in AD pathophysiology, and provides the most recent advances in the clinical utility of CSF biomarkers and the integration of CSF biomarkers in current clinical trials.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.12
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• pp.2371-2379
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• 2017

For the drone that is active in a wide search area, the time to grasp the target in the field of applications such as searching for emergency patients, monitoring of natural disasters requiring prompt warning and response, that is, the speediness of target detection is very important. In the actual operation of drone, the time for target detection is highly related to collaboration between drones and search algorithm to efficiently search the navigation area. In this research, we will provide a search method with cooperation of drone based on target existence probability to solve the problem of quickness in drone target search. In particular, the proposed method increases the probability of finding a target and shorten the search time by transmitting high-altitude drone search results to a low-altitude drone after searching first and performing more precise search. We verify the performance of the proposed method through several simulations.

• Journal of the Mineralogical Society of Korea
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• v.27 no.4
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• pp.235-242
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• 2014

Uranium can be released into the water environment from natural sources and human activities. The natural source of uranium is dominant in the Korean soil and groundwater environments. Uranium has both of radioactive and chemical toxic properties. Therefore, a drinking water contaminated with uranium has a high health risk. This study was conducted to determine the uranium concentration of water systems including small village drinking water system, groundwater for drinking water purpose, spring water, groundwater monitoring well, and emergency water suppling system. The uranium concentration was compared with domestic and other countries' standard. The contamination level was also evaluated on the basis of geological characteristics of the area. Among total 803 samples, 6 exceeded the Korean standard, $30{\mu}g/{\ell}$ and this was about 0.7% of the total sample. On the basis of geology, uranium concentration appeared to be increased in order of biotite granodiorite > biotite granite > gneissoid granite. The highest level of uranium was 12.4 in average.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1019-1022
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• 2016

Background: Diagnostic difficulties in hematological malignancies may lead to unacceptably prolonged help-seeking to diagnostic interval as well as increased complications and poor outcomes. Proactive consultation by a clinical pathologist (PCCP) may help clinical diagnosis and therapeutic strategy. Hence, the aim of this investigation was to evaluate the effect of PCCP on the help-seeking to diagnostic interval in hematological cancer cases. Materials and Methods: From January to November, 2015, abnormal results of hematological laboratory testing with added laboratory comment were selectively screened out, and patients with such abnormalities in hematological laboratory testing and accompanied laboratory comment with PCCP were enrolled. Results: A total of 125 aberrant results of hematological laboratory testing were given with accompanied laboratory comments with PCCP and 40.8% (n=51) of these patient-oriented comments had an effect on clinical diagnosis and therapeutic strategy. Twelve of the subjects belonged to newly diagnosed hematological malignancies with the assistance of PCCP, and the help-seeking to diagnostic interval was also shortened from 42 days to 26 days in chronic lymphoid leukemia (CLL), from 83 days to 11 days in multiple myeloma (MM), and from 128 days to 15 days in myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN). During the monitoring interval, neither complication events nor deaths were reported in the study group. Conclusions: It was seemingly that PCCP prevented diagnostic delay in hematological malignancies via shortening the help-seeking to diagnostic interval, particularly in CLL, MM and MDS/MPN cases. PCCP can be considered to play an essential role in prompt establishment of diagnosis in hematological malignancies for those who newly present.

• The Journal of the Korea Contents Association
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• v.11 no.10
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• pp.267-273
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• 2011

The purpose of this paper is to suggest the types of recovery activities and the major contents of preimpact recovery plan through theoretical review. Disaster recovery is to provide immediate support during the early recovery period necessary to return vital life support systems to minimum operation levels, and continuing to provide support until the community returns to normal. Disaster researchers distinguished 4 types in recovering from disaster as follows; an emergency period, a restoration period, a reconstruction period, and a developmental reconstruction period. And recovery measures are both short-term and long-term. Short-term measures are relief and rehabilitation and long-term measures include reconstruction. Finally, to design a preimpact recovery plan, we should define a disaster recovery organization that includes major stakeholders, identify the location of temporary housing, determine how to perform essential tasks, address the licensing and monitoring of contractors and retail price controls to ensure victims are not exploited, determine how recovery tasks will be carried out at historical sites, and recognize the recovery period as a unique time to enact policies for hazard mitigation and incorporate this objecive into the recovery planning process.

• Journal of Microbiology and Biotechnology
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• v.27 no.11
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• pp.2037-2043
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• 2017

The surface protein hemagglutinin (HA) mediates the attachment of influenza virus to host cells containing sialic acid and thus facilitates viral infection. Therefore, HA is considered as a good target for the development of diagnostic tools for influenza virus. Previously, we reported the isolation of single-stranded aptamers that can distinguish influenza subtype H1 from H5. In this study, we describe a method for the selective electrical detection of H1 using the isolated aptamer as a molecular probe. After immobilization of the aptamer on Si wafer, enzyme-linked immunosorbent assay (ELISA) and field emission scanning electron microscopy (FE-SEM) showed that the immobilized aptamer bound specifically to the H1 subtype but not to the H5 subtype. Assessment by cyclic voltammetry (CV) also demonstrated that the immobilized aptamer on the indium thin oxide-coated surface was specifically bound to the H1 subtype only, which was consistent with the ELISA and FE-SEM results. Further measurement of CV using various amounts of H1 subtype provided the detection limit of the immobilized aptamer, which showed that a nanomolar scale of target protein was sufficient to produce the signal. These results indicated that the selected aptamer can be an effective probe for distinguishing the subtypes of influenza viruses by monitoring current changes.

• Archives of Plastic Surgery
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• v.42 no.6
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• pp.741-745
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• 2015

Background Microvascular complications after free-flap breast reconstructions are potentially devastating problems that can increase patient morbidity and lead to flap loss. To date, no comprehensive study has examined the rates of salvage and the methods of microvascular revision in breast reconstruction. We reviewed the treatment of microvascular complications of free-flap breast reconstruction procedures over a seven-year period. Methods A retrospective review of all patients who underwent microvascular breast reconstruction at our institution between April 2006 and December 2013 was conducted. Based on their surgical records, all patients who required emergency re-exploration were identified, the rate of flap salvage was determined, the factors associated with flap salvage were evaluated, and the causes and methods of revision were reviewed. Results During the review period, 605 breast reconstruction procedures with a free lower abdominal flap were performed. Seventeen of these flaps were compromised by microvascular complications, and three flaps were lost. The overall salvage rate was 82.35%. No significant differences between the salvaged group and the failed group were observed with regard to age, BMI, axillary dissection, number of anastomotic arteries and veins, recipient vessel types, or use of the superficial inferior epigastric vein in the revision operation. Successful salvage of the flap was associated with a shorter time period between recognizing the signs of flap compromise and the take-back operation. Conclusions The salvage rate of compromised lower abdominal flaps was high enough to warrant attempting re-exploration. Immediate intervention after the onset of flap compromise signs is as important as vigilant postoperative monitoring.