• 공업화학
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• 제34권3호
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• pp.318-325
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• 2023

The detection of antibiotics in treated wastewater is a global concern as it enters water bodies and causes the development of antibiotic resistance genes in humans and marine life. The study specifically aims to explore the potential of ferrate (VI) in eliminating tetracycline (TCL). The degradation of TCL is optimized with parametric studies, viz., the effect of pH and concentration, which provide insights into TCL elimination. The increase in pH (from 7.0 to 10.0) favors the percentage removal of TCL; however, the increase in TCL concentrations from 0.02 to 0.3 mmol/L caused a decrease in percentage TCL removal from 97.4 to 29.1%, respectively, at pH 10.0. The time-dependent elimination of TCL using ferrate (VI) followed pseudosecond-order rate kinetics, and an apparent rate constant (kapp) was found at 1978.8 L² /mol² /min. Coexisting ions, i.e., NaNO₃, Na₂HPO₄, NaCl, and oxalic acid, negligibly affect the oxidation of TCL by ferrate (VI). However, EDTA and glycine significantly inhibited the elimination of TCL using ferrate (VI). The mineralization of TCL using ferrate (VI) was favored at higher pH, and it increased from 18.57 to 32.52% when the solution pH increased from pH 7.0 to 10.0. Additionally, the real water samples containing a relatively high level of inorganic carbon spiked with TCL revealed that ferrate (VI) performance in the removal of TCL was unaffected, which further inferred the potential of ferrate (VI) in real implications.

• Journal of Periodontal and Implant Science
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• 제26권1호
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• pp.202-215
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• 1996

The purpose of this study was to an in estigate the antibiotic susceptibiliity of Actinoobacillus actinomycetemcomitans isolated from the subgingival plaque to adult periodontitis. Seven bacterial strains were tested for their susceptibility to 10 antimicrobial agents under disk diffusion method and broth dilution methold, Seven patients with deep pocket(6mm) were selected for this study. They had not taken antibiotics for 6 months and no history of dental treatment for 6 months and no history of dental treatment for 6 months before this study. The results were as follows : 1. For the antibiotic disk diffusion method, seven A. actinimycetemcomitans were tested with 10 antimicrobial agents which comprised penicillin, gentamycin, clindamycin, lincomycin, ampicillin, erythromycin, tetracycline, amikacin, chloramphenicol, and vancomycin. The sensitive antibiotics were tetracycline, vancomycin, and chloramphenicol and the resistant antibiotics were clindamycin, and lincomycin. The other antimicrobial agents were less active. 2. From the study of determination on the minimal inhibitory concentration(MIC) by broth dilution method, the MIC of tetracycline to seven strains of the A. actinomycetemcomitans was $0.5-1.0{\mu}g/ml$, that of clindamycin was $32{\mu}g/ml$. These data suggest that tetracycline may be valuable drugs in the elimination of A. actinimycetemcomitans from the patients with adult periodontitis

• 대한미생물학회지
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• 제21권1호
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• pp.33-45
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• 1986

On hundred and forty stains of shigella cultures isolated from the twelve hygiene laboratories of cities and provincial general hospital laboratories in 1983 were tested for their resistance to thirteen antimicrobial drugs and their R-plasmid transfer. Antimicrobial drugs were used amikacin, ampicillin, cephalothin, chloramphenicol, gentamicin, kanamycin, nalidixic acid, rifampicin, streptamycin, tetracycline, tobramycin, cefoperazone and piperacillin. All strains were resistant to one or more of thirteen antimicrobial drugs but 94.3% were susceptible to amikacin, gentamicin and tobramycin of total isolated. The most strains commonly found resistance was to chloramphenicol (94%) followed by streptamycin (93%), tetracyline (92%) piperacillin (90%) ampicillin (83%), cefoperazone (42%), nalidixic acid (14%), cephalothin (17%), rifampicin (22%) and kanamycin (6%), sixty percent of strains among 140 were resistance to ampicillin, chloramphenicol, streptomycin, tetracycline at the same time. The transfer of drug resistance by conjugation was tested and ninety four strains (94.3%) were resistant to one or more drugs were found to transfer their drug resistance of E. coli. percentage of transfer frequency by conjugation was one strains (54%), the transfer frequency of drug resistance varied by donor strains and recipients, but not by selecting drugs. Resistance to nalidixic acid was not transferred by conjugation to recipients. Percentage of plasmid curing after the treatment of acriflavine, acridine orange was about 8%. Among strains cured two strains were tested compare original strains with them in biochemical properties in arginine dihydrolase and arabinose fermentation reaction. It was found to growth curves of No.2 shigella flexneri, serotype 1b, and its derivatives cured with acriflavine in $M{\ddot{u}}ller$ Hinton broth medium (pH 7.4, $38^{\circ}C$) by temperature Gradient Biophoto Recorder TN-1120 (Tokyo, Japan).

• 대한미생물학회지
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• 제14권1호
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• pp.27-37
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• 1979

1978년(年)에 분리(分離)한 9주(株)의 Shigella, 70주(株)의 Salmonella paratyphi A 및 230주(株)의 S. typhi의 약제내성(藥劑耐性), 내성화방지(耐性化防止) 및 제거(除去)에 대(對)하여 실험(實驗)하여 다음과 같은 성적(成績)을 얻었다. Shigella는 79주(株)가 Sh. flexneri, 16주(株)가 Sh. sonnei였는데 1주(株)를 제외(除外)한 94주(株)가 chloramphenicol tetracycline, streptomycin, sulfisomidine에 다약제내성(多藥劑耐性)이었으며 그중(中) 70주(株)는 ampicillin과 carbenicillin에, 80주(株)는 trimethoprim-sulfamethoxazole에, 22주(株)는 nalidixic acid에, 1주(株)는kanamycin에도 내성(耐性)이었다. Gentamicin, amikacin, cephaloridine, rifampin에 내성(耐性)인 균주(菌株)를 없었다. S. paratyphi A와 S. typhi는 공시약제(供試藥劑)에 감수성(感受性)이었으나 다만 rifampin, 또는 sulfisomidine에 약(弱)한 내성(耐性)을 가진 것이 있었다. 다약제내성(多藥劑耐性)인 shigella의 약(約) 80%가 전달성(傳達性) R plasmid를 가지고 있어서 그 내성(耐性)을 E. coli에 전달(傳達)시킬 수 있었다. 내성전달빈도(耐性傳達頻度)는 공시균주(供試菌株) 및 피전달균(被傳達菌)에 따라 차이(差異)가 있었다. 보존(保存)한 내성균주(耐性菌株)는 그 비율(比率)은 균주(菌株)에 따라 차이(差異)가 있으나 내성균(耐性菌)과 감수성균(感受性菌)으로 구성(構成)되어 있었으며 계대배양(繼代培養)에 의하여 내성(耐性)이 쉽게 탈락(脫落)되지는 안하였다. Acriflavine은 내성(耐性)을 탈락(脫落)시키는 효과(效果)는 있었으며 균주(菌株)에 따라 그 차이(差異)가 심(甚)하였고 atabrine은 효과(效果)가 없었다. 약제(藥劑)의 병용(倂用)은 Shigella에 대(對)한 작용(作用)을 증강(增强)시키는 경우(境遇)가 많으며 대체(大體)로 상승작용(相乘作用)을 나타냈고 상가작용(相加作用)을 나타내는 경우(境遇)가 있었으나 길항작용(拮抗作用)은 볼 수 없었다.