• Journal of Preventive Medicine and Public Health
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• 제43권2호
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• pp.125-130
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• 2010

Objectives: The current study was performed to assess the distribution of intraocular pressure (IOP) and its association with metabolic syndrome (MS) in a community. Methods: We measured IOP and MS components from 446 adults, age 20 or more years old, who reside in a community in Kyunggi Province, South Korea. We compared the level of IOP according to the number of metabolic abnormalities and between normal and abnormal metabolic components. Linear regression analyses were used to determine the relationship between IOP and metabolic components. Results: No significant difference in IOP (mean${\pm}$SE) was found between men ($12.24{\pm}2.42$) and women ($12.55{\pm}2.41$ mmHg, p > 0.1), while IOP of men tended to decrease as age increased (p for trend < 0.01). After adjusting for age, IOP of subjects with abdominal obesity in men and high blood pressure in women were significantly higher than those without abdominal obesity or high blood pressure (p < 0.05). Female subjects with MS showed significantly higher IOP than those without MS. Participants with more metabolic disturbances tended to have a greater IOP elevation with a linear trend after adjusting for age and sex. In the univariate regression analysis, age and waist circumference were significantly associated with IOP in men, but systolic and diastolic blood pressure were associated with IOP in women. In final multiple regression model, age, systolic blood pressure, and triglyceride were associated with IOP in women, and age in men. Conclusions: These findings suggest that MS and its components may be important determinants of elevated IOP.

• 한국안광학회지
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• 제15권3호
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• pp.293-297
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• 2010

목적: 본 연구는 안압 상승의 예측인자로서의 비만 지표인 체질량지수(body mass index: BMI)와 허리둘레 중 어떤 지표가 예측인자로서 더 적절한지를 판단하기 위하여 수행되었다. 방법: 본 연구에 참여한 20세 이상의 성인 458명을 대상으로 분석을 시행하였다. BMI를 삼분위로 층화한 후 허리둘레(삼분위)에 따른 안압을 비교하였으며, 다음으로 허리둘레를 삼분위로 층화한 후 BMI(삼분위)에 따른 안압을 비교하였다. 또한, BMI, 허리둘레와 안압 간의 선형회귀분석을 각각 시행하였다. 결과: 허리둘레 층화 후 BMI에 따른 안압의 증가는 관찰되지 않았지만, BMI $24.9kg/m^2$ 이상의 대상자들에게서는 허리둘레와 안압이 양의 상관관계를 가지는 것을 확인할 수 있었다. 성별과 연령을 보정한 경우에는 허리둘레만이 안압과 유의한 양의 상관관계를 보였고, 여기에 생활변수까지 보정한 다중선형회귀분석결과 BMI와 허리둘레는 모두 안압과 유의한 양의 상관관계를 보였다. 그러나 허리둘레 증가가 안압 상승에 대해서 보다 높은 설명력과 유의수준을 보이는 것으로 평가되었다. 결론: 본 연구결과, BMI와 허리둘레 모두 안압과 양의 상관관계가 있는 것으로 확인되었으며, 허리둘레가 BMI보다 안압에 더 큰 영향을 미치는 것으로 나타났다.

• 한국임상수의학회지
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• 제40권4호
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• pp.283-287
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• 2023

A 10-year-old spayed female beagle dog presented with a 2-month history of third-eyelid elevation in the left eye (OS). Ophthalmic examination revealed slightly diminished corneal and palpebral reflexes along with exophthalmos in the OS. Schirmer's tear test and intraocular pressure values were within the normal range for the OS. Slit-lamp biomicroscopy revealed protrusion of the third eyelid and corneal opacity in the OS. Fundoscopy revealed a prominent black mass in the OS covering the optic nerve. Tapetal hyper-reflectivity was also observed around the mass. Ocular ultrasonography showed a 0.74 × 0.67 cm echogenic posterior segment mass around the optic nerve protruding into the retrobulbar space. Computed tomography revealed a contrast-enhanced soft tissue lesion in the posteromedial aspect of the left eyeball protruding into the retrobulbar region, and the optic nerve was suspected to be involved. No evidence of osteolytic changes in the adjacent bone or distant metastasis was observed. Enucleation was performed to prevent potential metastasis or local invasion of the mass and to relieve discomfort due to exposure to keratopathy resulting from lagophthalmos. Histopathological examination revealed a central choroidal melanocytoma extending into the optic nerve. No local recurrence was detected until 16 months postoperatively.

• The Korean Journal of Physiology and Pharmacology
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• 제28권4호
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• pp.345-359
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• 2024

Deposition of extracellular matrix (ECM) in the trabecular meshwork (TM) increases aqueous humour outflow resistance leading to elevation of intraocular pressure (IOP) in primary open-angle glaucoma, which remains the only modifiable risk factor. Resveratrol has been shown to counteract the steroid-induced increase in IOP and increase the TM expression of ECM proteolytic enzymes; however, its effects on the deposition of ECM components by TM and its associated pathways, such as TGF-β-SMAD signalling remain uncertain. This study, therefore, explored the effects of trans-resveratrol on the expression of ECM components, SMAD signalling molecules, plasminogen activator inhibitor-1 and tissue plasminogen activator in dexamethasone-treated human TM cells (HTMCs). We also studied the nature of molecular interaction of trans-resveratrol with SMAD4 domains using ensemble docking. Treatment of HTMCs with 12.5 µM trans-resveratrol downregulated the dexamethasone-induced increase in collagen, fibronectin and α-smooth muscle actin at gene and protein levels through downregulation of TGF-β1, SMAD4, and upregulation of SMAD7. Downregulation of TGF-β1 signalling by trans-resveratrol could be attributed to its effect on the transcriptional activity due to high affinity for the MH2 domain of SMAD4. These effects may contribute to resveratrol's IOP-lowering properties by reducing ECM deposition and enhancing aqueous humour outflow in the TM.