• Nuclear Engineering and Technology
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• v.25 no.1
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• pp.51-62
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• 1993

A computational program ［TDET］ of the particle transport equation is developed on radiation shielding problem in two-dimensional cartesian geometry based on the discrete element method. Not like the ordinary discrete ordinates method, the quadrature set of angles is not fixed but steered by the spatially dependent angular fluxes. The angular dependence of the scattering source term in the particle transport equation is described by series expansion in spherical harmonics, and the energy dependence of the particles is considered as well. Three different benchmark tests are made for verification of TDET : For the ray effect analysis on a square absorber with a flat isotropic source, the results of TDET calculation are quite well conformed to those of MORSE-CG calculation while TDET ameliorates the ray effect more effectively than S$_{N}$ calculation. In the analysis of the streaming leakage through a narrow vacuum duct in a shield, TDET shows conspicuous and remarkable results of streaming leakage through the duct as well as MORSE-CG does, and quite better than S$_{N}$ calculation. In a realistic reactor shielding situation which treats in two cases of the isotropic scattering and of linearly anisotropic scattering with two groups of energy, TDET calculations show local ray effect between neighboring meshes compared with S$_{N}$ calculations in which the ray effect extends broadly over several meshes.eshes.

• Journal of Life Science
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• v.22 no.10
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• pp.1316-1323
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• 2012

The present study was conducted to investigate whether myoblasts can be transdifferentiated into adipocytes by ectopic expression of adipogenic transcription factors, including peroxisome proliferator-activated receptor-${\gamma}$ ($PPAR{\gamma}$), CCAAT/enhancer-binding protein-${\alpha}$ (C/$EBP{\alpha}$), sterol regulatory element binding protein-1c (SREBP1c), and Krueppel-like factor 5 (KLF5), in primary bovine satellite cells. Transcription factors were transiently transfected into primary bovine myoblasts, and the cells were cultured with adipogenic differentiation medium for 2 days and then cultured on growth medium for an additional 8 days. Ectopic expression of $PPAR{\gamma}$ or C/$EBP{\alpha}$ alone was insufficient to induce adipogenesis in myoblasts. However, overexpression of both $PPAR{\gamma}$ and C/$EBP{\alpha}$ in myoblasts was able to induce adipogenic transdifferentiation as indicated by the appearance of mature adipocytes, the induction of adipogenic gene expressions, and the suppression of myogenic gene expressions. In addition, KLF5 and $PPAR{\gamma}$ co-transfected bovine myoblasts were converted to adipocytes but not in cells transfected with only KLF5 expression vector. Overexpression of SREBP1c alone was sufficient to induce transdifferentiation from myoblasts into adipocytes. These results demonstrate that primary bovine satellite cells can be transdifferentiated into adipocytes either by single ectopic expression or combined expression of adipogenic transcription factors in a culture system.

• Molecules and Cells
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• v.43 no.3
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• pp.228-235
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• 2020

The Drosophila transmembrane semaphorin Sema-1a mediates forward and reverse signaling that plays an essential role in motor and central nervous system (CNS) axon pathfinding during embryonic neural development. Previous immunohistochemical analysis revealed that Sema-1a is expressed on most commissural and longitudinal axons in the CNS and five motor nerve branches in the peripheral nervous system (PNS). However, Sema-1a-mediated axon guidance function contributes significantly to both intersegmental nerve b (ISNb) and segmental nerve a (SNa), and slightly to ISNd and SNc, but not to ISN motor axon pathfinding. Here, we uncover three cis-regulatory elements (CREs), R34A03, R32H10, and R33F06, that robustly drove reporter expression in a large subset of neurons in the CNS. In the transgenic lines R34A03 and R32H10 reporter expression was consistently observed on both ISNb and SNa nerve branches, whereas in the line R33F06 reporter expression was irregularly detected on ISNb or SNa nerve branches in small subsets of abdominal hemisegments. Through complementation test with a Sema-1a loss-of-function allele, we found that neuronal expression of Sema-1a driven by each of R34A03 and R32H10 restores robustly the CNS and PNS motor axon guidance defects observed in Sema-1a homozygous mutants. However, when wild-type Sema-1a is expressed by R33F06 in Sema-1a mutants, the Sema-1a PNS axon guidance phenotypes are partially rescued while the Sema-1a CNS axon guidance defects are completely rescued. These results suggest that in a redundant manner, the CREs, R34A03, R32H10, and R33F06 govern the Sema-1a expression required for the axon guidance function of Sema-1a during embryonic neural development.

• Journal of Environmental Health Sciences
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• v.36 no.5
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• pp.360-372
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• 2010

Concentrations of ambient air particles such as total suspended particulates (TSP), particulate matter $(PM)_{10}$, and $PM_{2.5}$, were monitored simultaneously from May to June, 2007, at four locations at Alashan and Beijing in China, and Seoul and Gosan in South Korea. These monitoring sites are in the pathway of Asian dust (AD) storms traveling from China to the Korean peninsula. An AD event was observed in the Korean peninsula on May 25-26. During the sampling period, the average concentrations of TSP and PM10 were each higher than $150\;{\mu}g/m^3$ in Alashan and Beijing, but not in Seoul and Gosan. The concentration of TSP in Alashan (where the dust storm originated) on the day of the AD event reached $1824.7\;{\mu}g/m^3$, this being the highest concentration of air particles observed during the sampling period. The level was decreased to 15% of this ($274.7\;{\mu}g/m^3$) in Seoul and to 8.7% ($159.0\;{\mu}g/m^3$) in Gosan when the AD was observed two days later in Korea. Gosan, a representative background site in East Asia, displayed the lowest concentration of particles, with this maximal TSP concentration of $159\;{\mu}g/m^3$. Inorganic element contents in the air particles were also measured, and the concentrations in the four different regions compared. Concentrations of anthropogenically-enriched heavy metals in $PM_{10}$ and $PM_{2.5}$, such as lead, arsenic, cadmium, and mercury, were higher in the metropolitan cities of Beijing and Seoul compared to non-industrialized regions of Alashan and Gosan. However, the concentrations of inorganic soil elements including iron, magnesium, aluminum sodium, and manganese, were higher in Alashan compared to those in other sampling sites.

• Journal of Biomedical Engineering Research
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• v.25 no.6
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• pp.519-523
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• 2004

This study investigates micro-structural and mechanical properties of trabecular bone in human femoral head with and without osteoporosis using Micro-CT and finite element-model. 15 cored trabecular bone specimens with 20min of diameter were obtained from femoral heads with osteoporosis (T-score > -2.5 ) resected for total hip arthroplasty, and 5 specimens were removed from femoral head of cadavers, which has no history of musculoskeletal diseases. A high-resolution micro-CT system was used to scan each specimen to obtain histomorphometry indices. Based on obtained micro-images(pixel size=21.31㎛), a FE-model was created to determine mechanical property indices. While non-osteoporosis group had increases trabecular thickness, bone volume, bone volume fraction, degree of anisotropy and trabecular number compared with those of non-osteoporotic group, the non-osteoporotic group showed decreases in trabecular separation and structure model index. Regarding the mechanical property indices, reaction force, apparent stress and young's modulus were 1ower in osteoporotic group than in non-osteoporotic group. Our data shows salient deteriorations in trabecular micro-structural and mechanical properties in human femoral head with osteoporosis.

• Journal of the Microelectronics and Packaging Society
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• v.17 no.1
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• pp.9-17
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• 2010

In this study, von Mises stress and total strain energy density characteristics of lead pin in PGA (Pin Grid Array) packages have been calculated by using the FEM (Finite Element Method). FEM computation is carried out with various heat treatment conditions of lead pin material under $20^{\circ}$ bending and 50 mm tension condition. Results show that von Mises stress locally concentrated on lead pin corners and interface between lead pin head and solder. von Mises stress and total strain energy density decrease as heat treatment temperature of lead pin increases. Also, round shaped corner of lead pin decreases both von Mises stress and total strain energy density on interface between lead pin head and solder. This means that PGA package reliability can be improved by changing the mechanical property of lead pin through heat treatment. This has been known that solder fatigue life decreases as total strain energy density of solder increases. Therefore, it is recommended that both optimized lead pin shape and optimized material property with high lead pin heat treatment temperature determine better PGA package reliability.

• Journal of Sensor Science and Technology
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• v.17 no.5
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• pp.350-360
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• 2008

In every large hospital, nurses must perform simple repetitive tasks such as measuring body temperature. Such tedious work reduces nurses' motivation to provide quality medical care, which is an important element of the medical services provided by a hospital. If a device were available to measure body temperature, nurses could focus on the more important aspects of providing quality medical care to the patients. However, body temperature is generally measured from the throat, anus, tympanum or armpit, where it is difficult to affix a patch type device. In addition, general body temperature measuring points shows moving artifact error; therefore, it is not good point to continually measure the temperature. In this paper, a patch type skin temperature measuring system was developed. To appropriately measure the skin temperature, a thermal transducer was implemented with a thin (0.5 mm) temperature sensor. The system is small and thin ($H6.6{\sim}5.3{\times}L35{\times}W24\;mm$), and weighs only 5 g including a battery, case and circuit; therefore, it is small and light enough to function as a patch type device. Moreover, the system worked for 5 days. To investigate differences between the experimental and conventional thermometer, simple clinical experiments were performed with 17 volunteers, and the result showed some correlation between the implemented system and conventional thermometer (Correlation coefficient = 0.647, P<0.1).

• Archives of design research
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• v.19 no.2 s.64
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• pp.129-138
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• 2006

Design securing a dominant position currently in the global market has shown inherent culture of each country, i.d. national disposition. For instancess, there are Scandinavia emphasizing humanism, America adopting pragmatism, Germany reflecting the rational principle, Spain reflecting the daily an, Italian design being rationalism and impressionism. The members of society shall be under the control of the already formed social-cultural value and character. So culture shall restrict the internal manner of social behaviour and apply pressure to the action of main body. Also culture shall be under the control of social environment and each culture shall be materialized as per the disposition of the members of society. Now korean design has been attracted lots of interests and attention from global market because it is excellent in the aspect of application capability for new technology and also suggests the image of design produced through them. Now Korean design shall run side by side the application for formative element to be recognized by technical design as well as korean identity. So dear definition for national and cultural disposition shall be required to korean design education and design development. These prescribed efforts shall be a shortcut for globalization of korean design.

• Journal of Broadcast Engineering
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• v.24 no.6
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• pp.928-938
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• 2019

Republic of Korea has established 'Transmission and Reception for Terrestrial UHDTV Broadcasting Service' standard based on ATSC 3.0, the next-generation broadcasting standard in North America and is now providing commercial services. Republic of Korea has been studying terrestrial UHDTV based disaster broadcasting service using the ATSC 3.0 AEA system's technology since 2018. ATSC 3.0 has established a standard for expanding disaster broadcasting services, which were used to be simple push-type text message broadcasting, by introducing bidirectional and rich-media transporting mechanisms. However, the disaster information is still focused on the general public, and disaster broadcasting service including detailed information for the vulnerable are still insufficient. In this paper, we proposed the optimized disaster broadcasting service for vulnerable populations based on ATSC 3.0 after defined the disaster vulnerable populations as the target of the service. And we defined the extension element of disaster broadcasting message for service provision. The proposed service can be an effective means to increase the possibility of disaster information reception and evacuation to vulnerable populations. In addition, it is expected to be used as a basic research for development of diverse and effective advanced services for vulnerable populations through linkage with existing disaster alerting and countermeasures studies.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.5
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• pp.173-178
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• 2016

When a ballast track of a high-speed train is constructed on a bridge, the displacement of the bridge decks can occur because they are not fixed to the rails. Moreover, relative displacements occur between the bridge and rails caused by temperature changes and external loads. The current longitudinal resistance criteria (UIC Code 774-3, KR C-08080) on ballast tracks with continuous welded rails (CWRs) do not take into account the longitudinal movement of the bridge and the frictional force between the ballast and slabs. In addition, the magnitude of the longitudinal resistance, k, is calculated somewhat conservatively and, (therefore?) it acts as an unfavorable element in the design of long span and continuous railway bridges. Thus, in order to replicate the actual behavior more effectively, the longitudinal resistance of CWRs should take into account the additional rigidity between the slab and track. In this study, the longitudinal resistances of the ballasted track on the bridge were analyzed by carrying out an experimental study with a test setup designed to simulate the deck and bed track. In the test results, the maximum longitudinal resistances of the tests were similar to the resistances of the current codes, however, the measured longitudinal stiffness designed to limit the displacement of the tests were much smaller in comparison with the longitudinal stiffness on the codes.