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Feasibility of Novel Three-Dimensional Magnetic Resonance Fingerprinting of the Prostate Gland: Phantom and Clinical Studies

  • Dongyeob Han;Moon Hyung Choi;Young Joon Lee;Dong-Hyun Kim
    • Korean Journal of Radiology
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    • v.22 no.8
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    • pp.1332-1340
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    • 2021
  • Objective: To evaluate the feasibility of a new three-dimensional (3D) MR fingerprinting (MRF) technique for the prostate gland by conducting phantom and clinical studies. Materials and Methods: The new 3D MRF technique used in this study enables quick data acquisition and has a high resolution. For the phantom study, the MRF T1 and T2 values in an in-house phantom were compared with those of goldstandard mapping methods using linear regression analysis. For the clinical study, we evaluated 90 patients who underwent prostate imaging with MRF for suspected prostate cancer between September 2019 and February 2020. The mean T1 and T2 values were compared in the peripheral zone, transition zone, and focal lesions using paired t tests. The differences in the T1 and T2 values according to cancer aggressiveness were evaluated using one-way analysis of variance. Results: In the phantom study, the MRF T1 and T2 values showed a perfect correlation with the gold-standard T1 and T2 values (R > 0.99). In the clinical study, the T1 and T2 values in the peripheral zone were significantly higher than those in the transitional zone (p < 0.001, both). The T1 and T2 values in prostate cancer were significantly lower than those in the peripheral and transitional zones. The higher the grade of cancer, the lower the T2 values. Conclusion: The T1 and T2 values obtained from the 3D MRF showed a perfect correlation with the gold standard values in the phantom study. Differences in the T1 and T2 values among the different zones of the prostate gland were identified using 3D MRF in patients.

Design and Implementation of Low-power Neuromodulation S/W based on MSP430 (MSP430 기반 저전력 뇌 신경자극기 S/W 설계 및 구현)

  • Hong, Sangpyo;Quan, Cheng-Hao;Shim, Hyun-Min;Lee, Sangmin
    • Journal of the Institute of Electronics and Information Engineers
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    • v.53 no.7
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    • pp.110-120
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    • 2016
  • A power-efficient neuromodulator is needed for implantable systems. In spite of their stimulation signal's simplicity of wave shape and waiting time of MCU(micro controller unit) much longer than execution time, there is no consideration for low-power design. In this paper, we propose a novel of low-power algorithm based on the characteristics of stimulation signals. Then, we designed and implement a neuromodulation software that we call NMS(neuro modulation simulation). In order to implement low-power algorithm, first, we analyze running time of every function in existing NMS. Then, we calculate execution time and waiting time for these functions. Subsequently, we estimate the transition time between active mode (AM) and low-power mode (LPM). By using these results, we redesign the architecture of NMS in the proposed low-power algorithm: a stimulation signal divided into a number of segments by using characteristics of the signal from which AM or LPM segments are defined for determining the MCU power reduces to turn off or not. Our experimental results indicate that NMS with low-power algorithm reducing current consumption of MCU by 76.31 percent compared to NMS without low-power algorithm.

Wave Propagation Characteristics for Mobile Communications beyond 3G in Microcellular Environments (마이크로셀룰라 환경에서의 차세대 이등 통신을 위한 전파 전파 특성)

  • Jo Han-Shin;Yook Jong-Gwan
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.17 no.5 s.108
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    • pp.430-439
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    • 2006
  • This paper presents the a measured path-loss characteristics for mobile communications beyond 3G in microcellular residential area and street microcell at 3.4, 5.3, and 6.4 GHz band signals. The residential area is divided into two sections, one of which is composed of fifteen-story appartment buildings. The other section comprises four-story houses. The street microcell is classified line-of-sight(LOS) and nonline-of-sight(NLOS) areas. Both residential areas have standard deviations independent of the residential area classification, whereas the path loss exponents in the apartments is higher than those in area for same frequencies. A two-ray model is applied to analyse the path-loss charateristics in LOS areas. In LOS areas, an empirical breakpoint, whose distance is 6 percent shorter than a theorical breakpoint, is founded. Further, a sudden power level drop occurs at a transition point from LOS region to NLOS area. Path loss exponent is found to be significantly higher for non-LOS region than for LOS region. The power level drop due to corner loss and path-loss exponents both increase as the distance between the transmitter and the corner increases.

Synthesis of Li2MnSiO4 by Solid-state Reaction (고상반응법을 이용한 Li2MnSiO4 합성)

  • Kim, Ji-Su;Shim, Joong-Pyo;Park, Gyung-Se;Sun, Ho-Jung
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.25 no.5
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    • pp.398-402
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    • 2012
  • Synthesis of $Li_2MnSiO_4$ was attempted by the conventional solid-state reaction method, and the phase formation behavior according to the change of the calcination condition was investigated. When the mixture of the three source materials, $Li_2O$, MnO and $SiO_2$ powders, were used for calcination in air, it was difficult to develop the $Li_2MnSiO_4$ phase because the oxidation number of $Mn^{2+}$ could not be maintained. Therefore, two-step calcination was applied: $Li_2SiO_3$ was made from $Li_2O$ and $SiO_2$ at the first step, and $Li_2MnSiO_4$ was synthesized from $Li_2SiO_3$ and MnO at the second step. It was easy to make $Li_2MnSiO_3$ from $Li_2O$ and $SiO_2$. $Li_2MnSiO_4$ single phase was developed by the calcination at $900^{\circ}C$ for 24 hr in Ar atmosphere as the oxidation of $Mn^{2+}$ was prevented. However, the $Li_2MnSiO_4$ was ${\gamma}-Li_2MnSiO_4$, one of the polymorph of $Li_2MnSiO_4$, which could not be used as the cathode materials in Li-ion batteries. By applying the additional low temperature annealing at $400^{\circ}C$, the single phase ${\beta}-Li_2MnSiO_4$ powder was synthesized successfully through the phase transition from ${\gamma}$ to ${\beta}$ phase.

Charge-discharge Characteristics of $LiCoO_2/Li$ Rechargeable Cell ($LiCoO_2/Li$ 2차전지의 충방전 특성)

  • Moon, S.I.;Doh, C.H.;Jeong, E.D.;Kim, B.S.;Park, D.W.;Yun, M.S.;Yeom, D.H.;Jeong, M.Y.;Park, C.J.;Yun, S.K.
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 1993.05a
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    • pp.79-84
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    • 1993
  • This paper describes the development of lithium rechargeable cell. $LiCoO_2$ is recently recognized as a suitable cathode active material of a high voltage, high energy lithium rechargeable batteries because $Li^+$ ion can be electrochemically deintercalated/intercalated from/to $Li_xCoO_2$. The transition metal oxide of $LiCoO_2$ was investigated for using as a cathode active material of 4V class Li rechargeable cell. $LiCoO_2$ cathode was prepared by using a active material of 85 wt%, graphite powder of 12 wt% as a conductor and poly-vinylidene fluoride of 3 wt% as a binder. The electrochemical and charge/discharge properties of $LiCoO_2$ were investigated by cyclic voltammetry and galvanostatic charge/discharge. The open circuit voltage of prepared $LiCoO_2$ electrode exhibited approximately. potential range between 3.32V and 3.42V. During the galvanostatic charge/discharge, $LiCoO_2/Li$ cell showed stable cycling behavior at scan rate of 1mV/sec and potential range between 3.6V and 4.2V. Also its coulombic efficiency as function of cycling was 81%~102%. In this study the $LiCoO_2/Li$ cell showed the available discharge capacity of 90.1 mAh/g at current density of $1mA/cm^2$ and cell discharge voltage range between 3.6V~4.2V.

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The Langmuir Adsorption Isotherms of the Electroadsorbed Hydrogens at the Single Crystal Pt(100)/Aqueous Electrolyte Interfaces (단결정 Pt(100)/수용액 계면에서 전가흡착된 수소의 Langmuir흡착등온식)

  • Chun Jang Ho;Jeon Sang Kyoo
    • Journal of the Korean Electrochemical Society
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    • v.4 no.1
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    • pp.14-20
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    • 2001
  • The Langmuir adsorption isotherms of the under-potentially deposited hydrogen (UPD H) and the over-potentially deposited hydrogen (OPD H) at the single crystal Pt(100)/0.5 M $H_2SO_4$ and 0.5 M LiOH aqueous electrolyte interfaces have been studied using the phase-shift method. The phase-shift profile $({-\varphi}\;vs.\;E)$ for the optimum intermediate frequency can be used as a useful method to estimate the Langmuir adsorption isotherm $(\theta\;vs.\;E)$ at the interfaces. The equilibrium constant (K) for the OPD H and the standard free energy $({\Delta}G_{ads})$ of the OPD H at the Pt(100)/0.5M $H_2SO_4$ aqueous electrolyte interface are $1.5\times10^{-4}$ and 21.8 kJ/mol, respectively. At the Pt(100)/0.5 LiOH aqueous electrolyte interface, K transits from 1.9(UPD H) to $6.8\times10^{-6}$(OPD H) depending on the cathode potential (E) and vice versa. Similarly, ${\Delta}G_{ads}$ transits -1.6 kJ/mol (UPD H) to 29.5 kJ/mol (OPD H) depending on E and vice versa. The transition of K and ${\Delta}G_{ads}$ is attributed to the two distinct adsorption sites of the UPD H and OPD H on the Pt(100) surface. The UPD H and the OPD H at the Pt(100) interfaces are the independent processes depending on the H adsorption sites rather than the sequential processes for the cathodic $H_2$ evolution reactions.

Color Transient Improvement Algorithm Based on Image Fusion Technique (영상 융합 기술을 이용한 색 번짐 개선 방법)

  • Chang, Joon-Young;Kang, Moon-Gi
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.45 no.4
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    • pp.50-58
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    • 2008
  • In this paper, we propose a color transient improvement (CTI) algorithm based on image fusion to improve the color transient in the television(TV) receiver or in the MPEG decoder. Video image signals are composed of one luminance and two chrominance components, and the chrominance signals have been more band-limited than the luminance signals since the human eyes usually cannot perceive changes in chrominance over small areas. However, nowadays, as the advanced media like high-definition TV(HDTV) is developed, the blurring of color is perceived visually and affects the image quality. The proposed CTI method improves the transient of chrominance signals by exploiting the high-frequency information of the luminance signal. The high-frequency component extracted from the luminance signal is modified by spatially adaptive weights and added to the input chrominance signals. The spatially adaptive weight is estimated to minimize the ${\iota}_2-norm$ of the error between the original and the estimated chrominance signals in a local window. Experimental results with various test images show that the proposed algorithm produces steep and natural color edge transition and the proposed method outperforms conventional algorithms in terms of both visual and numerical criteria.

A Study on Problem and Improvements of Registration System in Water Leisure Crafts (수상레저기구 등록 시스템의 문제점과 개선 방안)

  • Yang, Young-Cheol;Lee, Jae-Hyung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.4
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    • pp.273-282
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    • 2016
  • This study analyzed the origin and status of the registration system of water leisure craft to suggest an improvement plan for the ocean leisure industry. To identify the transition of the registration system, related water leisure craft, registration procedures and revised acts from "water leisure safety act", which was established in the early 2000 and enacted since then were examined. To understand the problems raised, the management of the registration system and related other systems were analyzed. The results were as follows. First, the registration system was designed just to check the number of registrations of water leisure craft so it does not provide various and useful information that administrators and registrants want. Second, it is impossible to utilize and reconstruct the information regarding water leisure craft. In addition, the current registration system does not have a data sharing system with the Ministry of Government Administration and Home Affairs so self-governing administrations are not connected to each other or to other electronic government systems. To resolve these problems, the construction of a new registration system is required. The new registration system of water leisure craft should facilitate not only processing registration files and administration work, but also multiple electronic governmental services that provide the water leisure users with useful information and encourage them to learn about their craft management and so on.

Theoretical Studies of Transition Metal Carbene Complexes (Reactivities, Electronic Structures, and Diels-Alder Reaction) (전이금속의 Carbene 착물에 대한 이론적 연구 (반응성, 전자구조, Diels-Alder 반응))

  • Park Seong-Kyu;Kim IIl-Doo;Kim Joon Tae;Kim Sung-Hyun;Choi Chang-Jin;Cheun Young Gu
    • Journal of the Korean Chemical Society
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    • v.36 no.1
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    • pp.3-15
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    • 1992
  • Electronic structures and reactivities of the chromium, molybdenum, and tungsten carbene complexes, $(CO)_5Cr=CCHCH_2(XCH_3)\;,\;(CO)_5Mo=CCHCH_2(XCH_3)\;, and\;(CO)_5W=CCHCH_2(XCH_3)$, are studied by means of Extended Huckel calculations. The origin of the M=Ccarbene double bond is clarified from the diagram of the orbital correlation with the fragment orbitals. The ${\sigma}$ bond of the M=Ccarbene double bond is formed by the electron transfer interaction from the HOMO of the carbene to the LUMO of the $(CO)_5M$. The ${\pi}$ bond is formed through the back-transfer of electrons from one of the degenerated d${\pi}$ orbitals to the LUMO of the carbene. The polarization of charge of the M=Ccarbene bond is calculated to be M=Ccarbene for Mo, and W carbenes. The chemical and physical properties of these complexes are resulted from an appreciable positive charge on the carbene carbon. The electrophilic reactivity of the carbene carbon is not charge controlled, but is controlled by the frontier orbital, LUMO.

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Low-Power $32bit\times32bit$ Multiplier Design for Deep Submicron Technologies beyond 130nm (130nm 이하의 초미세 공정을 위한 저전력 32비트$\times$32비트 곱셈기 설계)

  • Jang Yong-Ju;Lee Seong-Soo
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.43 no.6 s.348
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    • pp.47-52
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    • 2006
  • This paper proposes a novel low-power $32bit\times32bit$ multiplier for deep submicron technologies beyond 130nm. As technology becomes small, static power due to leakage current significantly increases, and it becomes comparable to dynamic power. Recently, shutdown method based on MTCMOS is widely used to reduce both dynamic and static power. However, it suffers from severe power line noise when restoring whole large-size functional block. Therefore, the proposed multiplier mitigates this noise by shutting down and waking up sequentially along with pipeline stage. Fabricated chip measurement results in $0.35{\mu}m$ technology and gate-transition-level simulation results in 130nm and 90nm technologies show that it consumes $66{\mu}W,\;13{\mu}W,\;and\;6{\mu}W$ in idle mode, respectively, and it reduces power consumption to $0.04%\sim0.08%$ of active mode. As technology becomes small, power reduction efficiency degrades in the conventional clock gating scheme, but the proposed multiplier does not.