• Title/Summary/Keyword: Electronic Evidence

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Which is the Best Chinese Herb Injection Based on the FOLFOX Regimen for Gastric Cancer? A Network Meta-analysis of Randomized Controlled Trials

  • Wang, Jian-Cheng;Tian, Jin-Hui;Ge, Long;Gan, Yu-Hong;Yang, Ke-Hu
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.12
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    • pp.4795-4800
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    • 2014
  • Background: Few studies have directly compared clinical efficacy and safety among Chinese herb injections (CHIs) for gastric cancer (GC). The present study aimed to compare CHIs combined with FOLFOX regimens for GC to show which provides the best CHIs results. Materials and Methods: 9 electronic databases and 6 gray literature databases were comprehensive searched in April 20, 2013. According to inclusion and exclusion criteria, two reviewers independently selected and assessed the included trials. The risk of bias tool described in the Cochrane Handbook version 5.1.0 and CONSORT statement were used to assess the quality of the trials. All calculations and graphs were performed and produced using ADDIS 1.16.5 software. Results: A total of 541 records were searched and 38 RCTs met the inclusion criteria (2,761 participants), involving 10 CHIs. The results of network meta-analysis showed that compared with FOLFOX alone, combinations with Kanglaite, Astragalus polysaccharides, Cinobufacini, or Yadanziyouru injections could furthest strengthen ORR, improve the quality of life, reduce nausea and vomiting, and reduce the incidence of leukopenia (III-IV). Conclusions: Kanglaite injection, Astragalus polysaccharides injection, Yadanziyouru injection were superior to other CHIs in clinical efficacy and safety for GC. The conclusions now need to be confirmed by large sample size direct head-to-head studies.

Pharmacopuncture for Stroke: An Overview of Meta-Analyses (뇌졸중의 약침 치료에 대한 메타분석의 통합적 고찰)

  • Kim, Mikyung;Han, Chang-ho
    • The Journal of Internal Korean Medicine
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    • v.40 no.6
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    • pp.1081-1100
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    • 2019
  • Objectives: This study is an overview of the meta-analysis and systematic review of randomized controlled trials investigating the clinical effectiveness and safety of pharmacopuncture for patients with stroke. Methods: Core electronic databases were searched from their inception to 21 May 2019. A measurement tool to assess systematic reviews (AMSTAR 2) was applied to screen high-quality studies. The results of these studies were summarized, and additional meta-analysis was conducted. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to evaluate the certainty of evidence. Results: Sixteen studies met eligibility criteria. Four were excluded owing to insufficiency of AMSTAR 2 or low data reliability. The finally selected 12 studies were about pharmacopuncture using either a single herb extract, such as Dengzhan xixin, Sanch, Ginkgo biloba, or Acanthopanax, or a mixture of herbs, such as Compound danshen, Shenxiong, Xingnaojing, or Mailuoning. Most of the patients were from China, with acute ischemic stroke. All the studies using a pharmacopuncture versus a non-pharmacopuncture design reported the significant superiority of pharmacopuncture on every outcome measure. On the other hand, in a few studies, pharmacopuncture was inferior to active control in improving neurological deficit. Few studies reported adverse events. Conclusions: It is difficult to apply the results of this study directly to Korea, because the level of evidence is generally low and the clinical settings and social acceptance of pharmacopuncture therapy differ in Korea and China. Further studies are warranted to confirm the domestic applicability of evidence generated in China and to create evidence that supports the domestic situation.

Acupuncture Treatment of Plantar Fasciitis: A Literature Review (족저근막염의 침치료에 대한 국내외 연구동향 분석)

  • Koh, Nak-Yong;Kim, Chang-Gon;Ko, Youn-Suk;Lee, Jung-Han
    • Journal of Korean Medicine Rehabilitation
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    • v.25 no.2
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    • pp.97-110
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    • 2015
  • Objectives Plantar fasciitis is one of the most common causes of heel pain. Plantar fasciitis can be managed with acupuncture, but the evidence for its effectiveness is uncertain. The aim of this review was to assess the effectiveness of acupuncture for plantar fasciitis. Methods I searched specific Korean and foreign electronic databases (KCI, RISS, NDSL, OASIS, KTKP, National Assembly Library, KMbase, PubMed, The Cochrane Library and China National Knowledge Infrastructure). The key search terms were 'heel pain', 'plantar fasciitis' and 'acupuncture'. Twenty-seven trials were included; eleven case reports, fourteen randomized controlled trials (RCTs) and two non-randomized controlled trials (NRCTs). Results Twenty-seven studies reported that acupuncture treatment reduced plantar fasciitis pain. However, the evidence provided by the case reports was regarded as weak because the methodological quality was poor, and the placebo effect of acupuncture was not accounted for in the RCTs and NRCTs. Overall, the methodological quality of the RCTs and NRCTs was weak. Conclusions There is some evidence for the effectiveness of acupuncture for plantar fasciitis. However, in order to reinforce the evidence for acupuncture's effectiveness, additional placebo-controlled trials with well-designed methodologies are required.

A Systematic Review on the Treatment of Post-Stroke Patients Based on Sasang Constitutional Medicine (사상의학적 중풍 후유증 치료에 대한 체계적 문헌 고찰)

  • Oh, Hyunjoo;Lee, Jeongyun;Lee, Hyeri;Lee, Junhee
    • Journal of Sasang Constitutional Medicine
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    • v.34 no.2
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    • pp.48-64
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    • 2022
  • Objectives The purpose of this study was to review and evaluate the clinical evidence of the efficacy and safety of treatment based on Sasang constitutional medicine (SCM) for post-stroke patients by systematic review and meta-analysis. Methods Randomized controlled trials (RCTs), published in 10 electronic databases up to December 2020, were searched. For the included studies, Cochrane's risk of bias assessment was performed to analyze the methodological quality. The strength of evidence was evaluated using the grading of recommendations assessment, development, and evaluation system based on the results of analyses. All review processes were performed by two independent researchers. Results Five RCTs were finally included. All included RCTs were conducted for one month on post-stroke patients in 60-80s, four studies on Tae-Eum patients and one study on So-Yang patients. Four types of constitution-specific herbal medicine (Chungpyesagan-tang, Cheongsimsanyak-tang, Yeoldahanso-tang, and Yangkyuksanhwa-tang) and constitution-specific acupuncture therapy were identified as interventions. More than half of the included studies were evaluated as low quality due to the high-risk of bias in selection, performance, and detection. The combination of constitution-specific herbal medicine, acupuncture, and conventional treatment was more effective in improving the patients' motor impairment, dysphagia, aphasia, and depression than conventional treatment alone. No serious adverse events by SCM treatment were reported. Conclusions SCM treatment may improve the sequelae of post-stroke patients safely in combination with conventional treatment. Since the quality of clinical evidence included in this study was low, higher quality clinical evidence obtained in well-designed clinical studies will be needed.

Periodontal parameters in orthodontically tractioned teeth: A systematic review and meta-analysis

  • de Mattos, Paola Marques;Goncalves, Flavio Magno;Basso, Isabela Bittencourt;Ferraz, Aline Xavier;Zeigelboim, Bianca Simone;Stechman-Neto, Jose;Santos, Rosane Sampaio;de Araujo, Cristiano Miranda;Guariza-Filho, Odilon
    • The korean journal of orthodontics
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    • v.52 no.6
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    • pp.420-431
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    • 2022
  • Objective: This systematic review aimed to evaluate periodontal parameters in orthodontically tractioned teeth compared with the respective non-tractioned contralateral teeth. Methods: Search strategies were developed for six electronic databases and gray literature. Random-effects meta-analyses were performed for the outcomes of interest. Furthermore, the certainty of the evidence was assessed using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) tool. Results: Overall, 2,082 articles were identified, of which 24 were selected for the qualitative synthesis. A significant difference was observed between the impacted and contralateral teeth (mean difference [MD] = 0.25; 95% confidence interval [CI] = 0.10-0.40; I2 = 0%) when the gingival index was evaluated. Additionally, impacted teeth showed a greater probing depth, with a significant mean difference between the groups (MD = 0.14; 95% CI = 0.07-0.20; I2 = 6%). Most studies had a low risk of bias; however, the certainty of the evidence was very low owing to the design of existing studies. Conclusions: The evidence in the literature indicated that tractioned teeth might show worsening of periodontal parameters related to the gingival index and probing depth; however, the evidence remains uncertain about this outcome. Furthermore, probing depth should be considered regarding its clinical significance because of the small effect size observed.

Electronic Structure, Bonding and Kithium Migration Effects of the Mixed Conductor $\beta-LiAl$ (혼합 전도체 $\beta-LiAl$의 전자구조, 결합과 Li 이온 이동에 따른 영향)

  • Jang, Gun-Eik;I.M Curelaru
    • Journal of the Korean Vacuum Society
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    • v.5 no.3
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    • pp.194-198
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    • 1996
  • Detailed expermental studies of theelectronic structure of the valence and conduction bands of the mixed conductor $\beta$-LiAlindicate that a quasi-gap opens at the Fermi level, and the conduction states are highlylocalized, as opposed to the theoretical band structure calculations that predict predominant metallic behavior. Evidence for complex lithium migration effects involving the surface of Lial , induced by particle (electron or ion) bombardment and mechanical treatment , has been obtained as a byproduct of these experiments.

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New Korean record and redescription of Dienerella (Dienerella) costulata (Reitter) (Coleoptera: Latridiidae: Latridiinae)

  • Park, Sun-Jae
    • Journal of Species Research
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    • v.2 no.2
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    • pp.185-190
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    • 2013
  • The genus Dienerella Reitter and its described species are reported for the first time in Korea. Scanning Electronic Microscope (SEM) photographs of habitus and diagnostic characters, and line drawings of male genetalia are presented. All specimens of the species were collected from inside of a building associated with dried collections, but no evidence is available of the damage caused by the species.

PDMS기판에 이온빔 처리에 따른 수평 액정의 배향 연구

  • Kim, Yeong-Hwan;O, Byeong-Yun;Kim, Byeong-Yong;Lee, Won-Gyu;Im, Ji-Hun;Na, Hyeon-Jae;Seo, Dae-Sik
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2009.11a
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    • pp.159-159
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    • 2009
  • We characterize a flexible self-assembled liquid crystal display (LCD) fabricated from a polyimide (PI) alignment layer with polydimethylsiloxane pixel walls. Ion beam (IB) irradiation aligned LC molecules in the PI layer and bonded two flexible plastic substrates in a one-step assembly of the pixel walls. X-ray photoelectron spectroscopic analysis, Fourier transform infrared spectroscopy, and scanning electron microscopy provided chemical and physical evidence for the formation of stable chemical bonds between the PI layer and the PDMS pixel walls in addition to the important maintenance of a uniform 6 um gap between the two substrates without the use of any epoxy resins or other polymers.

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Perceived Importance of B2B Electronic Commerce Success Factors: An Empirical Evidence of Enterprise′s IS and EC Characteristics (기업의 IS/EC 특성에 따른 B2B 전자상거래 성공요인의 중요도 분석에 관한 실증적 연구)

  • 정대율
    • The Journal of Information Systems
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    • v.11 no.2
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    • pp.47-72
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    • 2002
  • In the beginning of new millennium, Business-to-Business(B2B) Electronic Commerce(EC) is a hot issues of the world business and economic communities. The market of B2B EC is increasing rapidly, and become a more complex and competitive because many participants and intermediaries are play on their own objectives and strategies. To cope with the situation, participants of B2B EC market should make play with a competitive strategies. So, the participant enterprises must know the critical success factors of their own EC market. This study identifies B2B EC success factor measurement sets, and explores several success factors based on the perceived importance of B2B EC practitioner in the manufacturing enterprises. The study tests the differences of success factors by IS level, EC business model characteristics, and EC introduction and operating characteristics.

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Context Inference and Sensor Data Classification of Big Data Stream Environment (빅데이터 스트림 환경에서의 센서 데이터 분류와 상황추론)

  • Ryu, Chang-Kun
    • The Journal of the Korea institute of electronic communication sciences
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    • v.9 no.10
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    • pp.1079-1085
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    • 2014
  • The analysis of the variable continuous big data stram should reach the destination context awareness. This study presented a novel way of context inference of the variable data stream from sensor motes. For assessment of the sensor data, we calculated the difference of each measured value at the time window and determined the belief value of each focal element. It was beneficial that calculate and assessment of factor of situation for context inference with the Dempster-Shfer evidence theory.