• Nuclear Engineering and Technology
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• v.50 no.6
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• pp.937-943
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• 2018

Background: This work presents the performance of a novel electronic brachytherapy (EBT) device and radiotherapy (RT) experiments on both skin cancer cells and animals using the device. Methods and materials: The performance of the EBT device was evaluated by measuring and analyzing the dosimetric characteristics of X-rays generated from the device. The apoptosis of skin cancer cells was analyzed using B16F10 melanoma cancer cells. Animal experiments were performed using C57BL/6 mice. Results: The X-ray characteristics of the EBT device satisfied the accepted tolerance level for RT. The results of the RT experiments on the skin cancer cells show that a significant apoptosis induction occurred after irradiation with 50 kVp X-rays generated from the EBT device. Furthermore, the results of the animal RT experiments demonstrate that the superficial X-rays significantly delay the tumor growth and that the tumor growth delay induced by irradiation with low-energy X-rays was almost the same as that induced by irradiation with a high-energy electron beam. Conclusions: The developed new EBT device has almost the same therapeutic effect on the skin cancer with a conventional linear accelerator. Consequently, the EBT device can be practically used for human skin cancer treatment in the near future.

• Progress in Medical Physics
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• v.25 no.4
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• pp.248-254
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• 2014

The purpose of this study is to develope a control system for a small X-ray tube generator and investigate control methods for the X-ray generator. The small X-ray tube was developed for electronic brachytherapy, and thus, the new control method should be investigated, if the small X-ray tube is used for the imaging system. The Axxent S700 X-ray tube and the XF060NZZ485 high voltage generator were used to compose a X-ray imaging system and control board was developed by using AT90CAN128 MCU. The two control methods were investigated after tube voltage was set to 50 kV, one was filament current control method and the other was beam current control method. The former was subdivided into two methods according to the filament heating time, the 5 and the 10 seconds respectively. In the filament current method, the beam current did not rise up to the desired value, if the filament current had not been maintained for at least 10 seconds. The onset filament currents to generate beam current were varied from 1,300 to 1,350 mA and over 5 seconds were needed in order to reach the desired tube current value after beam current was generated. However, in the tube current control method, the beam current reached to the desired value without any time delay with the filament current of 1,500 mA. In this study, we found that the beam current control method was appropriate for the use of small X-ray tube developed for brachytherapy in the X-ray imaging system.

• Radiation Oncology Journal
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• v.19 no.4
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• pp.369-380
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• 2001

Purpose : By developing on-line statistics program to record the information of radiation oncology to share the information with internet. It is possible to supply basic reference data for administrative plans to improve radiation oncology. Materials and methods : The information of radiation oncology statistics had been collected by paper forms about 52 hospitals in the past. Now, we can input the data by internet web browsers. The statistics program used windows NT 4.0 operation system, Internal Information Server 4.0 (IIS4.0) as a web server and the Microsoft Access MDB. We used Structured Query Language (SQL), Visual Basic, VBScript and JAVAScript to display the statistics according to years and hospitals. Results : This program shows present conditions about man power, research, therapy machines, technics, brachytherapy, clinic statistics, radiation safety management, institution, quality assurance and radioisotopes in radiation oncology department. The database consists of 38 inputs and 6 outputs windows. Statistical output windows can be increased continuously according to user's need. Conclusion : We have developed statistics program to process all of the data in department of radiation oncology for reference information. Users easily could input the data by internet web browsers and share the information.