• Polymer(Korea)
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• v.31 no.3
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• pp.215-220
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• 2007

The control of the surface energy by electrohydrodynamic force provides electrospraying with various potential advantages such as simple particle size control, mono-dispersity, high recovery, and mild processing conditions. The advantages are quite helpful to improve the stability of protein drug and control its release. Herein, the nano-encapsulation of protein drugs using electrospraying was investigated. Albumin as a model protein was processed using uniaxial and co-axial electrospraying, and chitosan, polycaporlactone (PCL), and poly (ethylene glycol) (PEG) were used as encapsulation materials. The major processing parameters such as the conductivity of spraying liquids, flow rate, the distance of electrical potential gradient, etc were measured to obtain the maximum efficiency. In the chitosan systems, mean particles size decreases as flow rate and the distance between nozzle and the collecting part decreases. In the uniaxial technique of the PCL systems, mean particles size decreases as flow rate decreases. In the coaxial technique of the PCL systems, it was found that the particles size gets larger under the application of the higher ratio of inner-to-outer liquid flow rates. The primary particles formed out of an electrospraying nozzle showed narrow particle size distribution, but once they arrived to the collecting part, aggregation behavior was observed obviously. Efficient nano-encapsulation of albumin with PCL, PEG, and chitosan was conveniently achieved using electrospraying at above 12 kV.

• Transactions of the Korean Society of Mechanical Engineers
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• v.19 no.6
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• pp.1518-1528
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• 1995

The deformation and departure processes of a bubble attached to the wall are studied experimentally and numerically to understand the phenomena of the nucleate boiling heat transfer enhancement under DC electric field. An air-bubble is injected in a dielectric liquid with different electric fields generated by changing three types of electrode system (Type 1,2 and 3) in the bubble generator. Experimental variables are the electric field strength and the distance and the shape of the electrodes under DC electric field. From experimental results, it is observed that the bubble under Dc electric field is elongated in the same direction as the electric field and the contact angle increases. For the parallel plate electrode which generates a uniform electric field, bubble departure volume doesn't seem to decrease within our experimental range. However, when a needle is raised a few millimeters from the lower electrode to make a nonuniform electric field around the needle, bubble departure volume decreases continuously with the increase of an applied voltage. The reduction effect of bubble departure volume is the most effective under a strong nonuniform electric field generated with Type 3. As the nonuniformity of the electric field due to the shape of a electrode increases, the terminal velocity and the acceleration of a bubble increase largely. For the comparison with visualization results, the deformation of a bubble attached to the electrode is carried out by a numerical method. Numerical results show good agreement qualitatively with experimental results.