• The Journal of Internal Korean Medicine
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• v.42 no.3
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• pp.323-339
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• 2021

Objectives: This study investigates the effect of electro-acupuncture on aphasia after stroke. Methods: A search of OASIS, NDSL, PubMed, Cochrane, and CNKI was executed between 4 January 2021 and 4 February 2021, with no limitation on publication year. Extraction and selection from the studies were made by 3 authors. The quality of the studies was evaluated using Cochrane's risk of bias (RoB) tool. Results: 10 studies met the selection criteria. As the treatment site for electro-acupuncture, GV20 (Baihui) was used the most. In all studies, the region located on the head was used for treatment without distinguishing between acupoints and areas of scalp acupuncture, and the stimulation was organized into 3 conditions: speed, intensity, and time. The outcome indicators used before and after treatment focused on the evaluation of language function and the degree of aphasia. The results showed that using electro-acupuncture with speech rehabilitation therapy for aphasia after stroke was more effective than using speech rehabilitation therapy alone. Conclusions: In this review, electro-acupuncture for aphasia after stroke was found to have a significant effect compared to the previous treatment alone. However, because of limitations, information was not reliable enough. Additional research is needed to produce more objective evidence.

• Journal of Acupuncture Research
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• v.24 no.5
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• pp.137-150
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• 2007

Objectives : To find effects of acupuncture, electro-acupuncture, low level He-Ne laser therapy(LLLT) at $TE_5$, $GB_{41}$ in the neuropathic pain. We made experiment on rats ligated L5 spinal nerve like general herniation of nucleus pulposus(HNP). Methods : A model of neuropathic pain was made by isolating Left 5th lumbar spinal nerve of rats. Three days after the neuropathic surgery, acupuncture and LLLT, electro-acupuncture was injected at $TE_5$, $GB_{41}$ one time a day for a week. Each group was divided two. one is opposite side performed the surgery which is right, another is left side performed the surgery. After that, the author examined the withdrawal response of neuropathic rats' legs by van Frey filament and acetone stimulation. And also the author examined c-Fos, Nociceptin and KOR-3 in the midbrain central gray of neuropathic rats. Results : As we have observed the effect of mechanical allodynia, LT-R group were diminished on 6th day compared with control group, EA-L group, EA-R group and LT-L group were diminished on 7th day compared with control group. As we have observed the effect of cold allodynia, EA-R group were diminished on 6th day, 7th day compared with control group. As we have observed the effect of activity of c-Fos in the central gray part, EA-R group and LT-R group were diminished compared with control group. As we have observed the effect of activity of Nociceptin in the central gray part, EA-R group were a little increased compared with control group but it is not reliability. As we have observed the effect of activity of KOR-3 in the central gray part, EA-R group were significantly increased compared with control group. Conclusions : We have noticed that effect of acupuncture at opposite side of sickness and powerful stimulation could be more effective, because of EA-R group have more controllable effect all test we have done on the other hand EA-L group have only effect on mechanical allodynia. This study can be used in clinical therapy for neuropathic pain. But it is not reliability that Nociceptin have effectively to control pain. Therefore We have to follow up about that.

• Journal of Acupuncture Research
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• v.22 no.3
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• pp.23-35
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• 2005

Objective : The aim of the study is to investigate the effect of electro-acupuncture (EA) on ST36 to modulate immune reaction in BALB/c mice immunized intraperitoneally with 2,4-dinitrophenylated keyhole limpet protein(DNP-KLH). Methods : Experimental mice were divided into four groups : 1) Normal group was not performed by any operation. 2) IM(Immunized) group was immunized intraperitoneally with DNP-KLH and aluminum hydroxide without electro-acupunture stimulation. 3) IM-EA(immunized-elctro- acupuncture) group was performed by successive electro-acupuncture on the ST36 acupoint after immunization. 4) IM-NA(immunized-naloxone) group was performed by immunization and electro-acupuncture with same method, but naloxone was injected intraperitoneally 30 minutes before eletro-acupuncture to inhibit the opiate receptor in spleen. Serum total immunoglobulin I(IgE) and antigen-specific IgE was measured in each group. The expression of interferon-${\gamma}$ and interleukin-4 mRNA in spleen was researched by real-time RT-PCR Results : Serum total-IgE and antigen-specific IgE were significantly decreased only in IM-EA group. The expression of interleukin-4 in spleen cell was significantly reduced not only in IM-EA group, but also in IM-EA group. Conclusions : Above results indicate that the mechanism of immunomodulatory effect of electro-acupuncture is related to opioid system especially in B-cell immune reaction. Further research on the T-cell immunity is necessary to explain the mechanism of immunomodulatory effect of electro-acupuncture.

• Journal of Acupuncture Research
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• v.27 no.1
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• pp.137-148
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• 2010

Objectives : To research the changes of electroencephalogram(EEG) signals for acupuncture stimulation and to establish the hereafter direction for the study on EEG. Methods : We reviewed the domestic papers searched by search engine of Korean Acupuncture & Moxibustion Society and Korea Institute of Oriental Medicine. Results : We have searched 31 articles in 10 journals. The 13 articles were concerned with acupuncture. 1. All articles were published after 2001. In 2007 there were 10 articles. 2. The studies dealing with the changes of EEG signals were 24, the studies dealing with correlation of EEG signals were 5, and the studies analyzing EEG with Korean medicine were 2. 3. In the studies dealing with the changes of EEG signals, the case-control studies were 9, the non case-control studies were 14, and the case study was 1. 10 studies used electro-acupuncture, 1 study used herbal acupuncture, and 2 studies used manual acupuncture. Conclusions : We need more various kinds of studies. 1. Excited condition by acupuncture stimulation may reduce $\alpha$ wave. 2. There may be the acupuncture point-specific variation of EEG signal patterns. 3. The number of responding channels for acupuncture stimulation may correlate with the quantity or variety of acupuncture effect.

• The Journal of the Society of Stroke on Korean Medicine
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• v.15 no.1
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• pp.90-96
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• 2014

Drooling causes inconvenience and develops complications, therefore it can be very stressful to patients and caregivers. Drooling caused by neurological disabilities appears to be the consequence of dysfunction in the coordination of the swallowing mechanism. However, there is no explanation about drooling by brain injury in oriental medicine literature. This is the case report about a stroke patient with drooling improved by electro-acupuncture therapy. The patient already applied scopolamine patch, and improved drooling before admission. However, caregiver concerned about side effects, so we stopped using scopolamine patch and applied electro-acupuncture for drooling treatment. The patient was treated by 4 acupuncture points on either side of Yeomcheon(CV 23), and Jichang(ST 4), Hyeopgeo(ST 6) with mixed low frequency electro stimulation. Although we stopped using scopolamine patch, drooling maintained improved state without a change, futhermore after 16 days later, drooling had disappeared until the patient discharged. This result showed electro-acupuncture is useful method to improve drooling caused by brain injury.

• Journal of Acupuncture Research
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• v.30 no.3
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• pp.125-134
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• 2013

Objectives : We studied the effects of electro and laser acupuncture treatment with $GB_{39}$ and $GB_{34}$ on neuropathic pain in rats induced by tibial and sural nerve ligation. Methods : To produce the model of neuropathic pain, the tibial and sural nerves of rats were ligated by a 6-0 silk thread. Three days after the neuropathic surgery, only electro acupuncture(EA), electro acupuncture and 830 nm laser acupuncture(EA-LA-1), and electro acupuncture and 904 nm laser acupuncture(EA-LA-2) were treated with $GB_{39}$ and $GB_{34}$ twice a week for 8 weeks. We observed the withdrawal response of neuropathic rats' legs by von Frey filament and acetone stimulation. We also observed c-fos and nocieptin on the central gray area in the midbrain of neuropathic rats. Results : As we observed the effect of mechanical allodynia, the EA and EA-LA-1 groups in 5 and 6 weeks and the EA-LA-2 group in 6 weeks increased significantly compared with the control group. As for the effect of c-fos activity in the central gray region, the EA, EA-LA-1, and EA-LA-2 groups decreased significantly compared with the control group. The EA-LA-2 group increased significantly compared with the control group as regards the effect of nociceptin activity in the central gray region. Conclusions : We noticed the synergic effect of electro and laser acupuncture treatment because the EA-LA-1 and EA-LA-2 groups had more controllable effect compared with the control group. This study can be used in clinical therapy for neuropathic pain.

• The Journal of Korean Medicine
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• v.20 no.1 s.37
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• pp.106-112
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• 1999

The purpose of this study is to investigate the effects of Bee Venom Herb-Acupuncture on the jaw opening reflex evoked by tooth pulp stimulation. Rats were anesthetized with thiopental sodium given intraperitoneally in an initial dose of 80mg/kg. Maintenance doses of 5mg/kg thiopental sodium were given through a cannular in the femoral vein as required to maintain light anesthesia. To apply noxious stimuli, a pair of enameled wires were inserted into the tooth pulp of the lower incisor. The effects of conditioning stimuli were estimated as an indicator of the degree of suppression of the digastric muscle electromyogram(dEMG) in the jaw opening reflex. Bee Venom Herb- Acupuncture(0.2% solution 0.1ml/rat) was injected to Hapgok(LI4) loci. In addition, Normal Saline (0.1ml/rat) was injected to Hapgok loci so as to compare the degree of suppression elicited from Bee-Venom. By administration of Bee Venom Herb-Acupuncture, the amplitude of dEMG was maximally suppressed to $67.5{\pm}3.38%$ ipsilaterally, 73.33{\pm}8.00%$ contralaterally. Generally, the dEMG activities caused by electrical stimulation were gradually suppressed during the stimulation and maximal suppressive effect showed at 15min after its onset. However the dEMG activities by Be Venom Herb-Acupuncture were immediately suppressed after its onset and the suppressive effect continued for a long time compared to electrical stimulation. In conclusion, Bee Venom Herb-Acupuncture may have a different mechanism of analgesia from that of electro-acupuncture and contribute to the modulation of pain analgesia.

• Journal of the korean academy of Pediatric Dentistry
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• v.23 no.3
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• pp.717-728
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• 1996

The effects of electro-acupuncture on the pain threshold and the amplitude of dEMG(di-gastric EMG) evoked by the noxious electric stimulation on teeth and gingiva in dogs were studied. Experiments were carried out with 10 dogs weighing 5-8kg. Each animal was anestheticed with Entobar given intraperitoneally in an initial dose of 30mg/kg. Maintenance dose of 5mg/kg/hr was given through a cannula, in the femoral vein, as required to keep up light anesthesia. Bipolar stimulating wire electrodes, 0.1mm in diameter, insulated except for tips, were inserted into the upper canine and palatal gingiva. Rectangular aluminium plate electrodes (15$\times$5mm) were placed on acupuncture points, called Yin-Hsiang, located at both sides of the upper jaw. Rectangular biphasic current pulses of 2Hz, with a $250{\mu}sec$ duration, were delivered for 15 minutes. The dEMG activities were recorded from the anterior belly of the digastric muscle(one of the jaw opening muscles) using bipolar wire electrodes. The magnitude of the jaw opening reflex at different intensties of electro-acupuncture(1volt 4volt and 10volt) was estimated by averaging the 30 superimposed dEMGs recorded on an oscilloscope and audiomonitor. Data were analysed statistically with ANOV A and paired t-test. The obtained results were as follows: 1. Pain thresholds were increased 7.7 %, 15.4 %, 17.3 % in the teeth and 11.1 %, 19.0 %, 25.4 % in the gingiva as the intensities of electro-acupuncture increased incrementally. 2. Amplitudes of dEMG were decreaed 8.3%, 22.4%, 27.4% in the teeth and 9.8%, 36.5%, 42.2 % in the gingiva as the intensities of electro-acupuncture increased incrementally. 3. Inhibition of pain responses by the electroacupuncture was more effective in the gingiva than in the teeth.

• Journal of Acupuncture Research
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• v.23 no.3
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• pp.155-163
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• 2006

Objectives : This study was designed to evaluated the effect of electro acupuncture on Heart Rate Variability of Patients with functional voiding disease. Methods: Subjects were voluntarily recruited by newspapers and internet. Electro acupuncture was performed three times a week for 3 weeks. Acupuncture point for EA group was B32, Electrical stimulation frequency was 2Hz, duration 20min, and intensity was up to pain threshold according to patients. The patients' Heart Rate Variability was measured before, after 3 weeks of treatment for 5 minutes. Results : In time domain analysis, There were significant increase of SDNN and RMSSD(p<0.05) after 3 weeks treatment. In frequency domain analysis, There were significant increase of LF and LF /HF ratio(p<0.05) after 3 weeks treatment. There were no significant changes in other components of heart rate variability. Conclusion : This study suggests that electroacupuncture treatments can be applicable to improve autonomic nervous system in patients with functional voiding disease.

• Journal of Korean Physical Therapy Science
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• v.7 no.2
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• pp.523-531
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• 2000

The purpose of this study was to investigate the Effect of stimulus in the Acupuncture point with Ultrasound and Electro-acupuncture on human's Cholinesterase activity. Pain is physiological symptoms in human body. Pain stimulation transference is according to Acetylcholine that is a matter of nerve stimulation. Cholinesterase analyze the Acetylcholine and Cholin acetylase compose the Acetylcholine. To identify of Cholinesterase activity, this study attempted to Electroacupuncture and Ultrasound for 20 person. Twenty subjects participating in this consisted of A group(difference of Cholinesterase's figure make use of Electroacupuncture with Zi-Shil), B group(difference of Cholinesterase's figure make use of Ultrasound with Zi-shil), C group(difference of Cholinesterase's figure make use of Eltroacupuncture and Ultrasound with Zi-shil). As a result the following conclusion was draun: 1. A group showed significantly decreased of Cholinesterase's figure make used of Electroacupuncture with Zi-Shil(the period is between pre-application and 20minute after application, between pre-application and mean of 20minute-30minute after application). 2. B group showed significantly decreased of Cholinesterase's figure make used of Ultrasound with Zi-Shil(the period is between pre-application and 3minute after application, between 3minute after application and 7minute after application, between preapplication and 7minute after application, between pre application and mean of 3minute-7minute after application). 3. C group not showed significantly decreased of Cholinesterase's figure make used of Elcetroacupuncture and Ultrasound with Zi-Shil(the period is between pre-application, between 20minute-Eletroacupuncture and 3minute-Ultrasound after application, between 30minute-Eletroacupuncture and 7minute-Ultrasound after application). The results of this study showed that decrease of Cholinestese' s figure make used of Elctroacupuncture and Ultrasound Zi-Shil. The result mean stimulation of Elctroacupuncture and Ultrasound decreased Acetylcholin' quantity. And decrease of Acetylcholin' quantity decreased Cholinesterase' figure.