• Earthquakes and Structures
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• 제16권3호
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• pp.311-320
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• 2019

Obelisks are historical monuments. There are several obelisks dating from ancient Egyptian period, located around various parts of the world. The city of Istanbul is a home to the Obelisk of Theodosius at the Hippodrome. Due to the expectation of a large event in the near future, the evaluation of seismic response of the Obelisk gets importance. Therefore, in this study structural dynamic behavior of the Obelisk was investigated using discrete element approach. Nonlinear dynamic analyses were performed using real and synthetic time series. Real and synthetic ground motions analyzed from this study seems consistent with the earthquake hazard levels that would be expected at the site of the Obelisk in the occurrence of an event of moment magnitude above 7.0 near Istanbul. Results are evaluated in terms of variation of displacement, relative displacement of adjacent blocks, normal stress and shear stress in time.

• Nuclear Engineering and Technology
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• 제55권12호
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• pp.4583-4590
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• 2023

This study aims at modeling the beryllium reflector poisoning under neutron irradiation conditions and calculating the impact of beryllium poisoning on the core parameters of ETRR-2 research reactor. The CITVAP code was used to calculate the neutron flux and parameters of ETRR-2 core with beryllium reflector elements. The neutron flux in each reflector element was calculated to solve the modeling equations for the atomic densities of lithium-6 (⁶Li), tritium-3 (³H), and helium-3 (³He) using the BERYL program. The results are discussed based on CITVAP calculations of the core excess reactivity and cycle length Full Power Days (FPD). Possible solutions to minimize the degradation due to beryllium poisoning are also discussed and compared based on calculations.

• 대한음성학회:학술대회논문집
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• 대한음성학회 1996년도 10월 학술대회지
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• pp.89-91
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• 1996

• Molecules and Cells
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• 제19권1호
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• pp.155-155
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• 2005

• Imaging Science in Dentistry
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• 제50권2호
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• pp.117-124
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• 2020

Purpose: The purpose of this study was to evaluate possible differences in the location of the inferior alveolar canal in male and female Egyptians. Materials and Methods: This cross-sectional retrospective study involved the evaluation of 210 CBCT scans of Egyptian individuals (18-70 years old). The inferior alveolar canal was localized by measuring 8 linear dimensions: 2 for the vertical localization of the mental foramen (superior and inferior to the mental foramen), 4 at the first molar bifurcation for the vertical and horizontal localization of the inferior alveolar canal (superior, inferior, buccal, and lingual to the inferior alveolar canal), and 2 for the horizontal localization of the mandibular foramen (anterior and posterior to the mandibular foramen). The measurements were statistically analyzed via comparative analysis, stepwise logistic regression, and receiver operating characteristic (ROC) curve analysis. Results: Six of the 8 measured distances differed to a statistically significant extent between the sexes. Regression analysis suggested a logistic function with a concordance index of 84%. The diagnostic accuracy capabilities of the linear measurements as sex predictors were calculated using ROC analysis, and the 6 best predictors for sex determination were selected and ranked from highest to lowest predictive power. Moreover, combining these 6 predictors increased the predictive power to 84%. Conclusion: The location of the inferior alveolar canal in the Egyptian population varies significantly by sex; accordingly, this anatomic landmark could be used as a reliable indicator of sexual dimorphism.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5433-5438
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• 2012

Background: Hepatocellular carcinoma (HCC) is a common and aggressive malignancy. Despite of the improvements in its treatment, HCC prognosis remains poor due to its recurrence after resection. This study provides complete genetic profile for Egyptian HCC. Genome-wide analyses were performed to identify the predictive signatures. Patients and Methods: Liver tissue was collected from 31 patients with diagnosis of HCC and gene expression levels in the tumours and their adjacent non-neoplastic tissues samples were studied by analyzing changes by microarray then correlate these with the clinico-pathological parameters. Genes were validated in an independent set by qPCR. The genomic profile was associated with genetic disorders and cancer focused on gene expression, cell cycle and cell death. Molecular profile analysis revealed cell cycle progression and arrest at G2/M, but progression to mitosis; unregulated DNA damage check-points, and apoptosis. Result: Nine hundred fifty eight transcripts out of the 25,000 studied cDNAs were differentially expressed; 503 were up-regulated and 455 were down-regulated. A total of 19 pathways were up-regulated through 27 genes and 13 pathways were down-regulated through 19 genes. Thirty-seven genes showed significant differences in their expression between HCC cases with high and low Alpha Feto Protein ($AFP{\geq}600$ IU/ml). The validation for the microarray was done by real time PCR assay in which PPP3CA, ATG-5, BACE genes showed down-regulation and ABCG2, RXRA, ELOVL2, CXR3 genes showed up-regulation. cDNA microarrays showed that among the major upregulated genes in HCC are sets. Conclusion: The identified genes could provide a panel of new diagnostic and prognostic aids for HCC.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.1971-1976
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• 2015

Background: To evaluate our results in terms of response, survival and toxicity profile of sunitinib among Egyptian patients with metastatic renal cell carcinoma. Materials and Methods: Between January 2010 and December 2013, 44 patients with metastatic renal cell carcinoma who received sunitinib at an oncology center of Cairo university hospitals were enrolled in this retrospective analysis. Results: The median age of the patients was 53 years, 22 (50%) having localized disease at presentation, while the remaining half of the patients presented with metastasis. At a median follow up of 19 months, 9 (21%) patients achieved partial remission, while disease was reported stable in 20 cases (45%) and progressive in 7 (16%), 4 (9%) being lost to follow up, and 4 (9%) had discontinued therapy due to toxicity. The median overall survival was 23 months (95%CI 15.2 - 30.9), while progression free survival was 12 months (95%CI 11.6 - 12.3). The most commonly reported non hematological grade 3 adverse events included mucositis (15.9%), hand-foot syndrome (13.6%), and fatigue (9%), while the predominant grade 3 or 4 laboratory abnormalities were neutropenia (6.8%), followed by anemia in 4.5% of patients. Conclusions: Our efficacy data were comparable to the published literature in terms of progression free survival and overall survival, while toxicity profile is different from Asian and western countries. However, sunitinib adverse events were manageable and tolerable in most of our Egyptian patients.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7345-7349
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• 2013

Background: Because of the high prevalence of hepatocellular carcinoma (HCC) in Egypt, new markers with better diagnostic performance than alpha-feto protein (AFP) are needed to help in early diagnosis. The aim of this work was to compare the clinical utility of both serum and mRNA glypican3 (GPC3) as probable diagnostic markers for HCC among Egyptian patients. Materials and Methods: A total of 60 subjects, including 40 with HCC, 10 with cirrhosis and 10 normal controls were analyzed for serum GPC3 (sGPC3) by ELISA. GPC-3 mRNA from circulating peripheral blood mononuclear cells was amplified by RT-PCR. Both markers were compared to some prognostic factors of HCC, and sensitivity of both techniques was compared. Results: Serum glypican-3 and AFP were significantly higher in the HCC group compared to cirrhotic and normal controls (p<0.001). Sensitivity and specificity were (95% each) for sGlypican-3, (82.5% and 85%) for AFP, and (100% and 90%) for Glypican3 mRNA, and (80% and 95%) for double combination between sGPC3 and AFP respectively. Conclusion: Both serum GPC-3 and GPC-3mRNA are promising diagnostic markers for early detection of HCC in Egyptian patients. RT- PCR proved to be more sensitive (100%) than ELISA (95%) in detecting glypican3.

• 실천공학교육논문지
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• 제11권2호
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• pp.259-268
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• 2019

이 연구의 목적은 3 연속 사이클 교육과정과 통합 기술교육 클러스터를 기반으로 직업인을 양성하는 이집트의 직업교육 학제를 탐색함으로써 한국 직업교육 체제에 시사점을 제안하는 것이다. 이집트의 직업교육은 진학을 목적으로 하는 일반 보통교육과 노동시장 입직을 목적으로 하는 직업교육의 학제가 이원화되어 운영된다는 점에서 한국의 학제와 체제는 유사하다. 그러나, 중등 직업교육, 고등 직업교육, 대학 수준의 고급 기술교육을 통합한 3연속 사이클 교육과정을 운영하고, 이러한 교육과정 운영의 효과성을 높이기 위해 동일한 물리적 공간에 집적된 통합 기술교육 클러스터를 활용하며, 일부 유럽 국가들과 협력시스템을 구축하여 직업교육의 품질을 관리하는 점 등에서는 차이가 있다. 본 연구 분석을 통해 이집트의 직업교육 학제를 구체적으로 제시하고, 한국 직업교육의 질적 제고를 위한 다양한 혁신방안들을 제안하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3543-3549
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• 2015

Background: Bladder cancer is one of the most common cancers worldwide. Gene expression profiling using microarray technologies improves the understanding of cancer biology. The aim of this study was to determine the gene expression profile in Egyptian bladder cancer patients. Materials and Methods: Samples from 29 human bladder cancers and adjacent non-neoplastic tissues were analyzed by cDNA microarray, with hierarchical clustering and multidimensional analysis. Results: Five hundred and sixteen genes were differentially expressed of which SOS1, HDAC2, PLXNC1, GTSE1, ULK2, IRS2, ABCA12, TOP3A, HES1, and SRP68 genes were involved in 33 different pathways. The most frequently detected genes were: SOS1 in 20 different pathways; HDAC2 in 5 different pathways; IRS2 in 3 different pathways. There were 388 down-regulated genes. PLCB2 was involved in 11 different pathways, MDM2 in 9 pathways, FZD4 in 5 pathways, p15 and FGF12 in 4 pathways, POLE2 in 3 pathways, and MCM4 and POLR2E in 2 pathways. Thirty genes showed significant differences between transitional cell cancer (TCC) and squamous cell cancer (SCC) samples. Unsupervised cluster analysis of DNA microarray data revealed a clear distinction between low and high grade tumors. In addition 26 genes showed significant differences between low and high tumor stages, including fragile histidine triad, Ras and sialyltransferase 8 (alpha) and 16 showed significant differences between low and high tumor grades, like methionine adenosyl transferase II, beta. Conclusions: The present study identified some genes, that can be used as molecular biomarkers or target genes in Egyptian bladder cancer patients.