• 약학회지
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• 제22권3호
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• pp.115-119
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• 1978

The effects of ginseng saponin on the transport of 3-O-methylglucose (=3-O-MG) in an isolated rat intestine were studied by using modified Wiseman's circulating unit. Gineseng saponin inhibited significantly the intestinal absorption of 3-O-MG when it was circulated together with ginseng saponin through the isolated intestine. Ginseng saponin was given to rats intraperitoneally and orally, and the intestine isolated from the rats after one and four hours was used for the study of glucose absorption. When buffer solution containing 3-O-MG was circulated through the isolated intestine isolated after one hour, whereas the absorption was increased in the intestine after four hours. The results indicate that intestinal absorption of 3-O-MG was inhibited when the saponin is contained in the same circulation medium. However, the inhibition of absorption was not significant in the intestine of rats which were previously exposed to the saponin orally or intraperitoneally.

• 약학회지
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• 제12권1_2호
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• pp.16-31
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• 1968

Comparative studies were made on some sulfonamides, used individually and combined with parasympatholytic agents as regards (1) the absorption rate through isolated rat small intestine (in vitro), (2) the absorption rate through rat small intestine (in vivo), and (3) the blood concentration of sulfonamides were examined by its oral administration with each combined drug to rabbits, and the following effects were found, parasympatholytic agents inhibit the absorption of sulfonamides from the small intestinal tract. Comparison of the inhibitic efficiency of parasympatholytic agents is as follows: oxazepam, oxyphencyclimine hydrochloride, probantheline bromide, atropine sulfate (The examples are from the weakest to the strongest). Decrement of the absorption rate of sulfonamides is as follows: sulfadiazine, sulfathiazole, sulfamethoxypyridazine, sulfadimethoxine, sulfamerazine, sulfamethazine (The example are from the strongest to the weakest). Additionally, it is assumed that if the combined drugs were absorbed from the small intestine in the original form, those inhibitic effects should be best regarding to their sulfonamide per parasympatholytic agent combined rate "25:1" than to their any other rates.her rates.

• Steel and Composite Structures
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• 제50권4호
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• pp.403-418
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• 2024

In this paper, vibration and energy absorption characteristics of a nanostructure which is composed of two embedded porous annular/circular nanoplates coupled by a viscoelastic substrate are investigated. The modified couple stress theory (MCST) and the Gurtin-Murdoch theory are applied to take into account the size and the surface effects, respectively. Furthermore, the structural damping effect is probed by the Kelvin-Voigt model and the mathematical model of the problem is developed by a new hyperbolic higher order shear deformation theory. The differential quadrature method (DQM) is employed to obtain the out-of-phase and in-phase frequencies of the structure in order to predict the dynamic response of it. The acquired results reveal that the vibration and energy absorption of the system depends on some factors such as porosity, surface stress effects, material length scale parameter, damping and spring constants of the viscoelastic foundation as well as geometrical parameters of annular/circular nanoplates. A bird's-eye view of the findings in the research paper offers a comprehensive understanding of the vibrational behavior and energy absorption capabilities of annular/circular porous nanoplates. The multidisciplinary approach and the inclusion of porosity make this study valuable for the development of innovative materials and applications in the field of nanoscience and engineering.

• 한국식품영양과학회:학술대회논문집
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• 한국식품영양과학회 2004년도 Annual Meeting and International Symposium
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• pp.47-52
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• 2004

This study was conducted to determine the effects of egg phospholipids [(Phosphatidylcholine (PC) and sphingomyelin (SM)] on intestinal absorption of cholesterol and other lipids. Each rat with Iymph cannula was infused via a duodenal catheter at 3.0 mL/h for 8 h with a lipid emulsion containing triolein, cholesterol and PC in 24 mL PBS. The PC in the lipid emulsion was egg PC (EPC), hydrogenated egg PC (HPC), or soy PC (SPC). The EPC in the lipid emulsion markedly lowered the Iymphatic absorption of cholesterol, compared with SPC and a lipid emulsion containing no PC. The HPC further lowered the absorption of cholesterol. The phospholipid output was not affected by the source of PC infused. The total Iymphatic output of oleic acid (18: 1), the major fatty acid infused in the form of triolein, did not differ among the NPC, SPC and EPC groups, but was significantly lower in the HPC group. The findings provide the first evidence that EPC markedly lowers the Iymphatic absorption of cholesterol under in vivo conditions. The inhibitory effect of EPC appears to be due to the higher degree of saturation of its acyl groups relative to SPC, suggesting that the intestinal absorption of egg cholesterol may be reduced by the presence of PC in e99 yolk. Experiment 2 was designed to determine whether egg SM, structurally similar to PC, also inhibits the Iymphatic absorption of cholesterol. Egg SM lowered the Lymphatic absorption of cholesterol in a dose dependent manner. Likewise, SM lowered the Iymphatic absorption of oleic acid, whereas it had no effect on retinol absorption. SM at a high dose lowered the Iymphatic outputs of both PC and SM, whereas there was no such effect at a lower dose. These results also indicate that luminal egg SM has an inhibitory effect on the intestinal absorption of cholesterol and other lipids of relatively high hydrophobicity.

• Journal of the Korean Wood Science and Technology
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• 제48권4호
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• pp.488-502
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• 2020

In this study, the moisture absorption and desorption properties presented by the Health-Friendly Housing Construction Standards of South Korea were compared using the wood of three tree species (Douglas-fir, Hinoki, Larch) and two types of wood-based materials(Plywood, WML Board^Ⓡ). The national standards for functional building materials present that the amounts of moisture absorption and desorption should be at least 65g/㎡ on average, respectively according to the test method under KS F 2611:2009. Therefore, in this study, the moisture absorption/desorption properties of materials with no treatment (Control), with punching, and with surface stain finishing and the moisture absorption/desorption property improvement effects of the treatments were compared and analyzed. According to the results of this study, it was evaluated that all five types of wood and wood-based materials tested did not satisfy the amount of moisture absorption/desorption of at least 65g/㎡, which is the performance standard for moisture absorption/desorption functional building materials, indicating that untreated wood and wood-based materials cannot be applied as functional finishing materials according to the Health-Friendly Housing Construction Standards. The surface stain finishing greatly reduced the moisture absorption and desorption rates of the materials, and the amounts of moisture absorbed and desorbed were also shown to decrease by at least two times on average. When the surfaces of the materials were punched with Ø4mm holes at intervals of 20 mm, the moisture absorption/desorption areas increased from 18% to 51%, and this increase was shown to be capable of increasing the amounts of moisture absorbed/desorbed by 29% on average at the minimum, and 81% on average at the maximum. The effects of punching were shown to be identical even in cases where the materials were stain finished. For the application of wood or wood-based materials as eco-friendly, health-friendly, and moisture absorption/desorption functional building materials hereafter, it is judged that new physical and chemical improvement studies should be conducted, and treatment methods should be developed.

• Journal of Pharmaceutical Investigation
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• 제1권1호
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• pp.78-84
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• 1971

The comparative studies were made on Salicylamide, used individually and compounded with antihistaminics as regards. (1) the absorption rate through isolated rat small intestine (in vitro) (2) the absorption rate through rat small intestine (in vivo), and the following effects were found. 1. The Absorption velosity of 2 m Mole gm. of salicylamide in the small intestine were decreased, when the agents compounded with tripelennamine indicating the greatest absorption inhibition in the case of m Mole gm. of tripelennamine. 2. The Absorption velosity of 2m Mole gm. of salicylamide in the small intestine were decreased, when the agents compounded with diphenhydramine indicating the greatest absorption inhibition in the case of 2m Mole gm. of diphenhydramine. 3. The Absorption velosity of 2m Mole gm. of salicylamide in the small intestine were increased, when the agents compounded with chlorpheniramine indicating the greatest absorption augmentation in the case of 0.2m Mole gm. of chlorpheniramine.

• 한국의류학회지
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• 제20권5호
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• pp.711-717
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• 1996

This study was carried to figure out the effect of washing on the cationic surfactant (DSDMAC) absorption by nylon fabrics washed with anionic surfactant(SDBS). Cationic surfactant absorption, static electricity, and fabric stiffness of washed and unwashed nylon fabrics were estimated. And to check the correlation between DSDMAC absorption and SDBS absorption, SDBS absorption by nylon fabrics were measured The results were as follows; 1. Nylon fabrics washed with SDBS absorbed more DSDMAC than unwashed fabrics. The more SDBS absorbed by nylon fabrics, the more DSDMAC absorbed. This is account for the increase in negative zeta potential of washed nylon fabrics. 2. Absorption of SDBS by nylon fabrics increased static electricity. Absorption of DSBMAC by washed and unwashed nylon fabrics greatyl decreased static electricity, and static electricity of washed nylon fabrics more decreased than that of unwashed nylon fabrics. 3. When washing cycles were under 20, DSDMAC absorption decreased fabric stiffness. As washing cycles were over 20, DSDMAC deposited as particles acted as points of weak adhesion between adjacent fibers, so increased the fabric stiffness.

• 산업기술연구
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• 제41권1호
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• pp.15-20
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• 2021

This work proposes a simple method to use the added absorption per person values to predict the expected values of the acoustical conditions in occupied classrooms. This method is based on the effects of the values of added absorption per person on the unoccupied total absorption values of the classrooms and on other room acoustical parameters. The total sound absorption in an unoccupied classroom can be calculated from measured reverberation times in the classroom. The expected occupied absorption can be calculated using equation which was obtained in a previous study (Choi, 2017) by fitting a linear regression line to a plot of total occupied absorption versus the corresponding unoccupied total absorption values measured in 12 university classrooms. The ratios of occupied-to-unoccupied sound absorption are used to predict increments in the values of acoustical parameters that result when occupants are added to the rooms.

• 대한의용생체공학회:의공학회지
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• 제44권4호
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• pp.275-283
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• 2023

The demand for skincare has increased due to the end of the COVID-19 pandemic, leading to a focus on skincare devices and technologies designed to improve the delivery of cosmetics. Among these technologies, skincare medical devices that utilize plasma therapy (Plasma) and sonophoresis (Sono) are commonly used in dermatology clinics. However, there is still a lack of quantitative analysis for transdermal absorption effects of Plasma and Sono skincare medical devices. In this study, we quantified enhanced transdermal absorption effects of Plasma and Sono devices through in-silico and ex-vivo studies. The Sono treatment demonstrated an increased transdermal absorption effect, showing a 10~13% difference in penetration compared to the control group in the in-silico experiment, and 159% and 184% increase in the ex-vivo experiment. The Plasma treatment revealed increased transdermal absorption effects, with a 1.0~2.5% penetration difference in the in-silico experiment, and a 124% increase in the ex-vivo experiment compared to the control group. We also observed a synergistic effect from the combined treatment of Plasma and Sono, as indicated by the highest increases of 197% and 242% in penetration. Furthermore, we have determined the optimal device settings and treatment conditions for Plasma-Sono skincare medical devices. Notably, higher on/off durations (Intensity levels) and longer Sono treatments resulted in greater transdermal absorption effects.

• Journal of Pharmaceutical Investigation
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• 제34권2호
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• pp.115-123
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• 2004

Geniposide and its related iridoid compounds have been used in traditional herbal medicine for thε treatment of Jaundice hepatic diseases and various inflammatorys. For the purpose to increase trandsdermal absorption, the hydrolyzed products of Gardeniae Furctus were identified and assayed of active ingredients and investigated trandsdermal absorption and anti-inflammatory effects. Geniposide was hydrolyzed to genipin by ${\beta}-glucosidase$ and it was suggested that genipin was more suitable form than geniposide for transdermal absorption by its lipophilic property. Using Franz type diffusion cell and the skin of hairless mouse, the permeation rate of hydrolyzed products and their emulsion preparation were determined. Genipin have more increased absorption ratio through the skin of hairless mouse than geniposide. Also, the emulsion of hydrolyzed products of extracts showed higher permeability than that of nonhydrolyzed preparations. After 9 hours $280.85\;{\mu}g/cm^2$ of genipin was absorbed and $193.52\;{\mu}g/cm^2$ in case of geniposide. The Js of geniposide and genipin were $26.27{\pm}4.11\;{\mu}g/cm^2/hr$ and $40.35{\pm}5.04\;{\mu}g/cm^2/hr$ respectively. After carrageenan injection, the swelling was increased repidly to 24 hr and maintained as plateau. but emulsion group weer reached about 2.5 mL and the swelling decreased successively form 24 hr to 72 hr. The anti-inflammation effects of extracts and hydrolyzed products emulsion were increased with significant difference with control group after 24 hr, 48 hr and 72 hr. In carrageenan induced edema, inhibition of swelling was increased in case of hydrolyzed product emulsion compare with nonhydrolyzed group at 24 hr, 48 hr and 72 hr after swelling. In histological study, the anti-inflammatory effects of hydrolyzed products were remarkable at 48 hr and 72 hr compare with nonhydrolyzed. Hydrolyzed products of Gardeniae Fructus extracts containing genipin would be a suitable preparation to increase the transdermal absorption and anti-inflammatory effects.