• Clinical and Experimental Reproductive Medicine
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• v.23 no.1
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• pp.81-86
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• 1996

The assessment of acrosomal status is important in evaluating the ability of sperm to fertilize the egg. The acrosomal status of sperm from 47 normal volunteers with proven fertility and 167 subfertile men with not to achieve pregnancy for at least 1 year were evaluated with Acrobeads test(FUSO Pharmaceutical Industries, Ltd, Japan) using immunobeads coated with MH61 monoclonal antibody, which is specific for acrosome-reacted sperm. The mean${\pm}$SD of acrobeads score in 47 volunteer group was $2.8{\pm}0.7$, of which 46(97.9%)cases were ${\geq}$ 2. The mean${\pm}$SD of acrobeads score in 167 subfertile group was $1.7{\pm}0.8$, of which 73(79.3%)cases were ${\leq}$ 1. The aerobe ads score in subfertile group were significantly lower(r=0.294, p<0.05) than those in volunteer group. In subfertile group, acrobeads score were well correlated with the sperm density and motility(r=0.275, r=0.281, p<0.01), but not with semen volume(r=0.16) and serum hormone level(FSH r=0.084, LH r=0.036, testosterone r=0.058, prolactin r=0.006 and estradiol r=0.060)(p>0.05). Of 63 subfertile cases with normozoospermia, 22(34.9%)cases showed 0 or 1 of acrobeads score, which means to accompany with a functional defect in spite of normal morphology. As a results, Acrobeads test is not only a technically simple sensitive procedure with good reproducibility in evaluating the sperm fertilizing capacity but also an useful in the evaluation of effectiveness in the treatment of infertility and the separation of acrosome-reacted sperm in the assisted reproductive technique.

• Korean Institute of Interior Design Journal
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• v.27 no.3
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• pp.79-89
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• 2018

This study aims at evaluating the characteristics and the preference on the sign design in the industrial heritages space. The research were performed by the process of literature review, case study, and survey of questionnaire. Seven industrial heritage space in Korea and China regenerated as art and cultural space after 2000 were selected and evaluated by 6 criteria including integrity, continuity, simplicity, aesthetics, legibility and historic aspects. The findings were the following. First, the six criteria factors were evaluated as the similar scores in the assessment of 7 sites without extremity. Simplicity was the highest score while historicality was the lowest one. It means that the characteristics of the sign systems of the heritage sites were focused on the simple, contemporary and effective design. Second, integrity, continuity, aesthetics, legibility were evaluated as the medium score in the sign design. While, in the evaluation on the aesthetics the score differences were comparatively high. Sanhai M50 which got the highest score showed the integrity of contrast using yellow and grey color with minimal design. However, Sanghai M50 got the lowest score in the historic aspects and was evaluated as the most favorite sign design in the preference. It means that the historic aspects have no direct relationship with the preference for the sign design. It shows that the effectiveness with integrity and the aesthetic aspects are considered more importantly than the application of the historic identity of the site in sign design.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.4
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• pp.142-155
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• 2016

Objectives: The purpose of this study is to examine whether there is a significant efficacy difference on infant and young child atopic dermatitis patients treated with Korean Medicine Treatment through 6 months between topical steroid used group and non-steroid group. Methods: The degree of atopic dermatitis was measured by the Objective SCORAD Index (OSI) with photographs of patients. Detailed analysis of the OSI score was compared based on the use of topical steroid. Results: 1. There was not a significant difference between the topical steroid group and the non-steroid group in regards of gender, age and initial OSI score. 2. The non-steroid group's OSI score decreased significantly from 50.17 to 29.20. 3. The topical steroid group's OSI score decreased significantly from 54.21 to 34.95. 76.19% of the patients in the topical steroid group discontinued steroid use within the 6-month period. The average time of discontinuation since the beginning of treatment was 3.36 months. 4. The OSI Improvement rate comparison of topical steroid group with non-steroid group did not show a significant difference over a 3-month and 6-month period. 5. Distribution of severe cases decreased in Both topical steroid and non-steroid group after 6 month treatment. Conclusions: The OSI score of infant and young child atopic dermatitis patients in both topical steroid and non-steroid group was decreased significantly with Korean medicine treatment through 6 months. There was no significant difference between topical steroid group and non-steroid group in OSI improvements over a 3-month period and 6-month period.

• The Journal of Internal Korean Medicine
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• v.40 no.6
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• pp.1268-1277
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• 2019

Objective: The purpose of this study was to report the effectiveness of Korean medicine in the treatment of functional dyspepsia in a fibromyalgia patient with a history of long-term NSAIDs use. Methods: The patient was diagnosed as a Soeumin, one of the four constitution types in Korean medicine, and treated with herbal medicines such as Seungyangikgibuja-tang and Pyeongjinsunjeom-san. Acupuncture and moxibustion treatment were also performed. The severity of symptoms was assessed using the Numerical Rating Scale (NRS) of epigastric pain, daily oral intake changes, the Korean Gastrointestinal Symptom Rating Scale (KGSRS), the Gastrointestinal Symptom Score (GIS), and the Functional Dyspepsia-Quality of Life (FD-QOL) score. Results: After treatment for 48 days, the severity of epigastric pain decreased from NRS 8 to NRS 0, and daily oral intake was increased. The KGSRS score decreased from 55 to 43, the GIS score was reduced from 18 to 10, and the FD-QOL score also decreased from 69 to 55. Conclusions: This study suggests that Korean medical treatment could be an effective option for treating functional dyspepsia in fibromyalgia patients with a history of long-term NSAIDs use.

• The Journal of Internal Korean Medicine
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• v.41 no.6
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• pp.1223-1230
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• 2020

Objective: The purpose of this study was to report the effectiveness of Korean medicine (Beewha-eum) on the treatment of non-cardiac chest pain (NCCP) in a patient with non-erosive reflux disease (NERD). Methods: The patient was diagnosed with a spleen-stomach weakness pattern identified by Korean medicine and was treated with herbal medicine (Beewha-eum). The severity of symptoms was assessed with a numerical rating scale (NRS) for chest pain, self-reported dyspepsia degree (%), Korean gastrointestinal symptom rating scale (KGSRS), gastrointestinal symptom score (GIS), and Functional Dyspepsia-Quality of Life(FD-QOL) score. Results: After Beewha-eum treatment, the severity of chest pain was decreased from NRS 8 to NRS 0 and the self-reported dyspepsia degree also decreased from 100% to 65%. The KGSRS score was decreased from 49 to 35, the GIS score was also decreased from 16 to 9, and the FD-QOL score was increased from 20 to 25. Conclusions: The study findings suggested that Korean medical treatment with Beewha-eum could be an effective option for treating NCCP in patients with NERD.

• The Korean Journal of Pain
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• v.34 no.3
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• pp.315-321
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• 2021

Background: Pillar pain may develop after carpal tunnel release surgery (CTRS). This prospective double-blinded randomized trial investigated the effectiveness of extracorporeal shock wave therapy (ESWT) in pillar pain relief and hand function improvement. Methods: The sample consisted of 60 patients with post-CTRS pillar pain, randomized into two groups. The ESWT group (experimental) received three sessions of ESWT, while the control group received three sessions of sham ESWT, one session per week. Participants were evaluated before treatment, and three weeks, three months, and six months after treatment. The pain was assessed using the visual analogue scale (VAS). Hand functions were assessed using the Michigan hand outcomes questionnaire (MHQ). Results: The ESWT group showed significant improvement in VAS and MHQ scores after treatment at all time points compared to the control group (P < 0.001). Before treatment, the ESWT and control groups had a VAS score of 6.8 ± 1.3 and 6.7 ± 1.0, respectively. Three weeks after treatment, they had a VAS score of 2.8 ± 1.1 and 6.1 ± 1.0, respectively. Six months after treatment, the VAS score was reduced to 1.9 ± 0.9 and 5.1 ± 1.0, respectively. The ESWT group had a MHQ score of 54.4 ± 7.7 before treatment and 73.3 ± 6.8 six months after. The control group had a MHQ score of 54.2 ± 7.1 before treatment and 57.8 ± 4.4 six months after. Conclusions: ESWT is an effective and a safe non-invasive treatment option for pain management and hand functionality in pillar pain.

• Medical Lasers
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• v.9 no.2
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• pp.166-171
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• 2020

Background and Objectives Melasma is an acquired pigmentary disorder characterized by brown or dark brown colored macules and patches which mostly involve the face. Compared to nanosecond lasers, picosecond lasers have fewer adverse effects on surrounding tissues and give better results for melanin fragmentation. The purpose of this study was to evaluate the efficacy of the pico-toning technique using a low fluence 1,064-nm Nd:YAG laser on melasma patients. Materials and Methods This study is a retrospective analysis of melasma cases treated using the pico-toning technique from June 2017 to November 2020. Based on photographic images, the modified Melasma Area and Severity Index (mMASI) score was blind evaluated by two independent plastic surgeons. Patient satisfaction was assessed through a 5-point Likert scale questionnaire after treatment sessions. All adverse effects and complications were reviewed based on medical records. Results A total of 23 patients were included in the study. The mMASI scores for baseline and 2 months after the last procedure were 5.1 ± 1.4 and 2.6 ± 0.4, respectively. The mean mMASI score reduced significantly after the treatment session (p < 0.05). The patient satisfaction score with the procedure was 3.8 ± 1.0. The subject satisfaction score and difference in the mMASI score before the procedure and 2 months after the last procedure showed a significant correlation. Adverse effects observed in this study were erythema (n = 1) and edema (n = 1). Conclusion The results of the study show that the pico-toning technique is effective in Asian patients with melasma. We believe that safety was enhanced by using low fluence, and thus better results were achieved with fewer adverse effects.

• Journal of Service Research and Studies
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• v.11 no.2
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• pp.95-105
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• 2021

The purpose of this study is to improve the accuracy of service satisfaction by utilizing KSC (Kano, Score Model, Concept Position) analysis methods in order to present various fitness center service models for healthy new silver generation centered on P fitness center which runs six branches in Busan. Double Diamond-based methods led to a case study focused on the P fitness center's Yeon-san branch which well leading in a wide variety of leisure infrastructures for the senior citizens. Throughout this study, based on the insights extracted from the customers were culminating in nine service design models from the perspective of administrators and trainers. The final derived nine models have been evaluated by Kano's satisfaction evaluation, Concept score, and Concept position evaluation. All of the nine models results indicated as valid except for models 3 and 6. Finally, an implementation roadmap was proposed by dividing it into investment cost and effectiveness.

• Journal of the Korea Society of Computer and Information
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• v.29 no.10
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• pp.105-111
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• 2024

In this paper, we propose methods for the named entity normalization of traditional herbal formula found in medical texts. Specifically, we developed methodologies to determine whether mentions, such as full names of herbal formula and their abbreviations, refer to the same concept. Two different approaches were attempted. First, we built a supervised classification model that uses BERT-based contextual vectors and character similarity features of herbal formula mentions in medical texts to determine whether two mentions are identical. Second, we applied a prompt-based querying method using GPT-4o mini and GPT-4o to perform the same task. Both methods achieved over 0.9 in Precision, Recall, and F1-score, with the GPT-4o-based approach demonstrating the highest Precision and F1-Score. The results of this study demonstrate the effectiveness of machine learning-based approaches for named entity normalization in traditional medicine texts, with the GPT-4o-based method showing superior performance. This suggests its potential as a valuable foundation for the development of intelligent information extraction systems in the traditional medicine domain.

• Journal of IKEEE
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• v.27 no.4
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• pp.464-471
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• 2023

In this paper, we propose a method to reduce age distortion in facial expression image generation using StyleGAN Encoder. The facial expression image generation process first creates a face image using StyleGAN Encoder, and changes the expression by applying the learned boundary to the latent vector using SVM. However, when learning the boundary of a smiling expression, age distortion occurs due to changes in facial expression. The smile boundary created in SVM learning for smiling expressions includes wrinkles caused by changes in facial expressions as learning elements, and it is determined that age characteristics were also learned. To solve this problem, the proposed method calculates the correlation coefficient between the smile boundary and the age boundary and uses this to introduce a method of adjusting the age boundary at the smile boundary in proportion to the correlation coefficient. To confirm the effectiveness of the proposed method, the results of an experiment using the FFHQ dataset, a publicly available standard face dataset, and measuring the FID score are as follows. In the smile image, compared to the existing method, the FID score of the smile image generated by the ground truth and the proposed method was improved by about 0.46. In addition, compared to the existing method in the smile image, the FID score of the image generated by StyleGAN Encoder and the smile image generated by the proposed method improved by about 1.031. In non-smile images, compared to the existing method, the FID score of the non-smile image generated by the ground truth and the method proposed in this paper was improved by about 2.25. In addition, compared to the existing method in non-smile images, it was confirmed that the FID score of the image generated by StyleGAN Encoder and the non-smile image generated by the proposed method improved by about 1.908. Meanwhile, as a result of estimating the age of each generated facial expression image and measuring the estimated age and MSE of the image generated with StyleGAN Encoder, compared to the existing method, the proposed method has an average age of about 1.5 in smile images and about 1.63 in non-smile images. Performance was improved, proving the effectiveness of the proposed method.