• KSCE Journal of Civil and Environmental Engineering Research
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• v.36 no.4
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• pp.659-665
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• 2016

The limit equilibrium method (LEM) is commonly used for slope design and stability analysis because it is easy to simulate slope and requires short calculating time. However, LEM cannot adequately simulate ploughing failure in a footwall slope with a joint set dipping parallel with slope, e.g. bedding joint set. This study performed parametric study to analyze the influence factors on ploughing failure using UDEC which is a commercial two-dimensional DEM (Distinct Element Method)-based numerical program. The influence of joint structure and properties on stability of a footwall slope against ploughing failure was investigated, and the factor of safety was estimated using the shear strength reduction method. It was found that the stability of footwall slope against ploughing failure strongly relies on dip angle of conjugate joint, and the critical bedding joint spacing and the critical length of slab triggering ploughing failure are also affected by dip angle of conjugate joint. The results obtained from this study can be used for effective slope design and construction including reinforcement.

• Journal of Korean Society of Steel Construction
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• v.20 no.3
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• pp.389-398
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• 2008

The current design practice of electric transmission tower is based on the allowable stress design. However, it is difficult to find the cause behind a transmission tower's collapse by the above design approach as the collapse is caused by large secondary deformations based on and geometrical nonlinear behavior.influence factor for the nonlinear behavior is mainly residual stress, initial imperfection and end restraints on members. In this study, the necessity of the nonlinear analysis is examined through the comparison between elastic ana the nonlinear analysis, a new analytical method (equivalent nonlinear analysis technique) is proposed. To confirm the reliability of the proposed method, the computed ultimate load of the transmission tower using the method was compared with that of the nonlinear finite element analysis. Effects of parameters, such as compressive force and the slenderness ratio of the brace member on the main post member, were investigated. The effective member length according to influential parameters was formulated in table form for practical purposes.

• Environmental and Resource Economics Review
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• v.15 no.5
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• pp.827-858
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• 2006

The paper presents game theoretic models for self-enforcing coalition formation in order to sustain effective international environmental agreements(IEAs). The model analyzes how the intrinsically strategic nature of a government's environmental policies(the emission allowance standard) calls for rules to sustain an IEA. Focusing on the recent theoretical developments in the infinitely repeated game, the paper introduces some mechanisms to show how self-interested sovereign countries are cooperatively able to maintain an IEA rather than defect to initially profit at the expense of a pollution heaven later on. For a more realistic case needed to sustain an IEA, an optimal international environmental policy with both signatories and non-signatories under imperfect monitoring is also explored. In this extension of the model, the derivation process for a critical discount factor, a trigger price level and the length of punishment period is briefly discussed.

• Journal of Nutrition and Health
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• v.31 no.1
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• pp.21-27
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• 1998

The objective of this study was to observe the effect of dietary calcium(Ca) level on colonic mucosal levels of cell proliferation, 1, 2-diacylglycerol(DAG), TXB2, PGE2 and phospholipid fatty acid composition which have been known as biomarkers for colon cancer. One hundred male Sprague Dawley rats, at 7 weeks of age, were divided into two fat type groups. Each group of which was further divided into two Ca level groups. Each rt was intramuscularly injected with 1, 2,-dimenthylhydrazine(DMH) for 6 weeks (total dose of 180mg/kg body weight) and simultaneously fed one of four experimental diets containing 15% dietary fat(corn oil or perilla oil )and 0.3% or 1.0% Ca by weight for 20 weeks. Compared to corn oil, perilla oil significantly reduced cell proliferation by decreasing labeling index, proliferating zone, crypt length in colonic mucosa and colonic mucosa and colonic mucosal levels of DAG, TXB2 . PGE2 and phospolipid (PL) arachidonic acid distribution. The effect of Ca on biomarketrs was different depending on the type of dietary fat comsumed . Ca effect of Ca on biomarkers was different depending on the type of dietary fat comsumed. Ca effect was not significantly shown in the PO group, but it was significant in the CO group in which high Ca(1.0%) decreased the levels of levels of PL-C20 : 4(%), DAG and PGE2 . However , high Ca supplementation had shown only the trends of improving cell proliferation. Overall , high dietary Ca significantly reduced cell proliferation by inhibiting the synthesis of eicosanoid and DAG with reduced distribution of PL-C20 : 4 , which may have resulted in lower activation of PKC through reduced signal transduction. Since a high level of dietary Ca was more effective in reducing the risk factor against colon cancer in corn oil fed rats, it could be suggested that a higher amount of dietary Ca be consumed , especially when more vegetable oil rich in linoleic acid is included in the diet.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2971-2974
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• 2015

TP53 is assumed to be a very important tumour suppressor gene, as illustrated by recent reports that have shown effects of its polymorphisms on breast cancer risk. Arg72Pro and PIN3(16bp duplication) polymorphisms are proposed to have an effective role in structural changes of p53 and have therefore attracted interest as a risk factor for breast cancer in different populations. The aim of this study was to examine and determine whether p53 codon 72 and PIN3 Ins16 bp may be associated with an increased risk for breast cancer in female patients from the northwest of Iran. Genotyping was performed by PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) method for a total of 100 women with breast cancer and 100 healthy women without any background of cancer, focusing on the TP53 Arg72Pro-16Del/Ins haplotypes and the combined genotypes. The results in this study established no statistical significant distinctions between the genotypes and a llele frequency were found for Arg72Pro and PIN3 Ins 16 bp polymorphisms between patients and controls.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.14
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• pp.5787-5791
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• 2014

Background: With increasing survival periods and diversification of treatment methods, treatment of critically ill cancer patients has become an important factor influencing patient prognosis. Patients with cancer are at high risk of infections and subsequent complications. This study investigated the incidence and factors contributing to the development of ventilator-associated pneumonia (VAP). Materials and Methods: This retrospective study investigated the incidence of VAP and factors leading to infection in patients admitted to the intensive care unit (ICU) of a cancer center from January 1, 2012 to December 31, 2013. Results: The incidence of VAP was 2.13 cases per 1,000 days of intubation, and 13 of 288 patients (4.5%) developed VAP. Lung cancer was the most common cancer associated with VAP (N=7, 53.9%), and longer hospital stays and intubation were associated with increased VAP incidence. In the group using a "ventilator bundle," the incidence was 1.14 cases per 1,000 days compared to 2.89 cases per 1,000 days without its use; however, this difference was not statistically significant (p=0.158). Age (${\geq}65$, OR=5.56, 95% confidence interval [CI]=1.29-23.95), surgery (OR=3.78, 95%CI=1.05-13.78), and tracheotomy (OR=4.46, 95%CI=1.00-19.85) were significant VAP risk factors. The most common causative organisms were methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (N=4, 30.8% each), followed by Acinetobacter baumannii and Candida albicans (N=2, 15.4% each). Conclusions: The incidence of pneumonia among critically ill cancer patients is highest in those with lung cancer, but lower than among non-cancer patients. The length of hospital stay and time on mechanical ventilation are important risk factors for development of VAP. Although not statistically significant, "ventilator bundle" care is an effective intervention that delays or reduces incidence of VAP. Major risk factors for VAP include age (${\geq}65$ years), surgery, and tracheostomy, while fungi, gram-negative bacteria, and multidrug-resistant organisms were identified as the major causative pathogens of VAP in this study.

• Journal of Korean Society of Steel Construction
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• v.14 no.5 s.60
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• pp.603-612
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• 2002

Numerical analyses have been carried out in order to check the applicability of high-strength steel to a medium-sized steel bridge. Using the yield strength of steel, Average Daily Truck Traffic (ADTT), and fatigue grade of structural detail as analytical parameters, the minimum weight sections that satisfy the limit states of the AASHTO LRFD design specification were determined through an optimization scheme. Likewise, the effects of the number of girders and span length on the applicability of high-strength steel were evaluated. Results show that high-strength steel may be employed in the steel bridge, since steel weight decreases with increasing yield strength regardless of the fatigue effect. Nonetheless, appropriate countermeasures against fatigue should be determined since it is a major factor in the effective use of high-strength steel in steel bridges.

• Journal of the Korea institute for structural maintenance and inspection
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• v.16 no.5
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• pp.88-97
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• 2012

The objective of this research is to investigate the seismic performance and flexure-shear behavior of square reinforced concrete bridge piers with solid and hollow cross section. Test specimens were nonseismically designed with the aspect ratio 4.5 Two reinforced concrete columns were tested under constant axial load while subjected to lateral load reversals with increasing drift levels. Longitudinal steel ratio was 2.217 percent. The transverse reinforcement ratio As/($s{\cdot}h$), corresponding to 58 percent of the minimum lateral reinforcement required by Korean Bridge Design Specifications for seismic detailing, which represent existing columns not designed by the current seismic design specifications or designed by limited ductility concept. This study are to provide quantitative reference data for the limited ductility design concept and tendency for performance or damage assessment based on the performance levels such as cracking, yielding, collapse, etc. Failure behavior, ultimate displacement/drift ratio, displacement ductility, response modification factor, equivalent viscous damping ratio, residual deformation, effective stiffness, plastic hinge length, strain of reinforcements and nonlinear analysis are investigated and discussed in this paper.

• Journal of Biomedical Engineering Research
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• v.23 no.1
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• pp.27-32
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• 2002

The purpose of this study was to evacuate the effects of the number of tied hollow fibers in a novel membrane oxygenator that satisfied the limiting factor of minimizing the friction loss in the intravascular blood flow Pattern. The membrane oxygenator is a bundle consisted of several hundred ho1low fibers haying the outside diameter of 380 $\mu m$ and the axial jacket length of 600 mm. The eight different variation of tied hollow fibers in a bundle were designed. and the liquid flow pattern was controlled by a pump. The liquid pressure drop was measured by in vitro experiments using water and g1ycero1. Uniform blood flow pattern was observed for each number of tied hollow fibers. Pressure drop was 13-16 mmHg outside of the membrane oxygenator consisting of up to 700 ho1low fibers. More effective contact of liquid with the tied ho1low fibers was observed as a decrease in the number of the tied hollow fibers. and resulted in the enhancement of the friction tractor

• Journal of Korean Society for Atmospheric Environment
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• v.14 no.E
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• pp.9-17
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• 1998

Oxides of nitrogen play important roles in atmospheric chemistry. Soil has been recognized as a major natural source of NO, and its emission depends on soil parameters such as soil nitrogen availability, soil moisture and temperature. It is necessary to understand effects of these controlling parameters on soil NO emission. In order to understand soil moisture effects on NO emission, variations of NO concentration and existence of its equilibrium concentration were observed from ammonium fertilized Japanese upland soil prepared for different soil moisture conditions. The closed chamber technique was employed for this study. The significant increases in NO with soil moisture were found. Maximum was occurred at sample ID4 (55% of water-filled pore space (WFPS)), but it decreased as soil moisture increased. No significant NO concentration was emitted from soil sample without fertilizer, but there was significant NO in fertilized soil samples. The magnitudes of NO from soil increased with time and reached at steady state within ten minutes approximately. These results suggest that nitrogen input from fertilizer takes charge in the first step of sharp increase in NO emission, and then soil moisture becomes important factor to control NO emission from the soils. NO concentrations from soil were compared to those one-day after the experiment. Results from the comparison analysis suggest that the soil NO flux might have been stimulated by soil disturbances like mixing, and this is much more effective in dry soils rather than in wet soils. It was found that much less NO came out from soils after a day; suggesting that most of NO was released from the soils within a day after fertilizer application during our experiment. The length of NO releasing time span may depend on the amounts of fertilizer applied, soil moisture condition, and other soil physical parameters.