• 대한화학회지
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• 제62권3호
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• pp.191-202
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• 2018

The aim of this work is to study Monte Carlo simulation of ethylene (co)polymerization over Ziegler-Natta catalyst as investigated by Chen et al. The results revealed that the Monte Carlo simulation was similar to sum square error (SSE) model to prediction of stage II and III of polymerization. In the case of activation stage (stage I) both model had slightly deviation from experimental results. The modeling results demonstrated that in homopolymerization, SSE was superior to predict polymerization rate in current stage while for copolymerization, Monte Carlo had preferable prediction. The Monte Carlo simulation approved the SSE results to determine role of each site in total polymerization rate and revealed that homopolymerization rate changed from site to site and order of center was different compared to copolymerization. The polymer yield was reduced by addition of hydrogen amount however there was no specific effect on uptake curve which was predicted by Monte Carlo simulation with good accuracy. In the case of copolymerization it was evolved that monomer chain length and monomer concentration influenced the rate of polymerization as rate of polymerization reduced from 1-hexene to 1-octene and increased when monomer concentration proliferate.

• 대한한의학회지
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• 제17권2호
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• pp.264-276
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• 1996

This study was carried out to evaluate the effect of Samhwasan on the Na-K-ATPase activity of heart muscle. The Na-K-ATPase activity was prepared from rabbit heart ventricles. Samhwasan markedly inhibited the Na- K - ATPase activity in a dose-dependent manner with an estimated $I_{50}$ of 0.56%. Hill coefficient was 1.70, indicating that the enzyme has more than one binding site for the Samhwasan. Inhibition of enzyme activity by Samhwasan increased as pretreatment time was prolonged. Inhibition by the drug was not affected by a change in enzyme protein concentration. Kinetic studies of substrate activation of the enzyme indicated classical noncompetitive inhibition, showing significant reduction in Vmax without a change in Km value. Inhibitory effect by Samhwasan was not altered by changes in concentration of $Mg^{2+}$, $Na^+$ or $K^+$, dithiothreitol. a sulfhydryl reducing reagent, did not protect the inhibition of Na-K-ATPase activity by Samhwasan combination of Samhwasan and ouabain showed a cumulative inhibition fashion. These results suggest that Samhwasan inhibits Na-K-ATPase activity of heart ventricles with an unique binding site different from that of ATP, $Mg^{2+}$, $Na^+$ or $K^+$ and ouabain.

• Asian Journal of Atmospheric Environment
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• 제6권2호
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• pp.118-126
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• 2012

To investigate the effect of aircraft traffic emissions on soil pollution, metal levels were analyzed for 8 metals (Fe, Cr, Pb, Zn, Cu, Ni, Mn and Cd) from the vicinity of the Indira Gandhi International (IGI) airport in Delhi, India. The texture of the airport soil was observed to be sandy. Among the metals, Cd showed minimum concentration ($2.07{\mu}g\;g^{-1}$), while Fe showed maximum concentration ($4379{\mu}g\;g^{-1}$). The highest metal accumulation was observed at the landing site. Significant correlations were observed between metals and different textures (sand, silt, and clay) as well as with organic carbon (OC). The results indicate that grain size play a major role in OC retention in soil and subsequently helps in adsorption of metals in soil. M$\ddot{u}$ller's geoaccumulation index (I-geo) showed that airport soil was contaminated due to Cd and Pb with the pollution class 2 and 1, respectively. Pollution load index of the airport site was 1.34-3 times higher than the background site. The results of factor analysis suggested that source of the soil metal is mainly from natural weathering of soil, aircraft exhaust, and automobile exhaust from near by area. With respect to Dutch target values, the airport soils showed ~3 times higher Cd concentration. The study highlighted the future risk of enhanced metal pollution with respect to Cd and Pb due to aircraft trafficking.

• Journal of Dental Anesthesia and Pain Medicine
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• 제18권5호
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• pp.295-300
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• 2018

Background: Removal of the plate following Le Fort I osteotomy and BSSO (bilateral sagittal split osteotomy) is a common procedure. However, patients who undergo plate removal experience intense pain and discomfort. This study investigated the half-maximal effective concentration ($Ce_{50}$) of remifentanil in the prevention of plate removal pain under sedation using dexmedetomidine. Methods: The study evaluated 18 patients, between 18 and 35 years of age, scheduled for elective surgery. Remifentanil infusion was initiated after sedation using dexmedetomidine, and started at a dose of 1.5 ng/mL on the first patient via target-controlled infusion (TCI). Patients received a loading dose of $1.0{\mu}g/kg$ dexmedetomidine over 10 min, followed by a maintenance dose of $0.7{\mu}g/kg/h$. When the surgeon removed the plate, the patient Modified Observer's Assessment of Alertness/Sedation (MOAA/S) score was observed. Results: The Ce of remifentanil ranged from 0.9 to 2.1 ng/mL for the patients evaluated. The estimated effect-site concentrations of remifentanil associated with a 50% and 95% probability of reaching MOAA/S score of 3 were 1.28 and 2.51 ng/mL, respectively. Conclusion: Plate removal of maxilla can be successfully performed without any pain or adverse effects by using the optimal remifentanil effect-site concentration ($Ce_{50}$, 1.28 ng/mL; $Ce_{95}$, 2.51 ng/mL) combined with sedation using dexmedetomidine.

• Korean Chemical Engineering Research
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• 제43권6호
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• pp.662-667
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• 2005

HMCM-41 중간세공 물질(mesoporous material) 촉매를 사용하여 aryl methallyl ether로부터 의약품과 농약의 주요 중간체인 2,3-dihydrobenzofuran 유도체를 합성하였다. 산점 농도가 촉매 활성에 미치는 영향을 비교하기 위하여 Si/Al 몰비가 40과 50으로 다른 촉매를 제조하였으며, aryl methallyl ether에 다양한 치환기를 도입하여 벤젠 고리의 전자 밀도가 전환율과 수율에 미치는 효과를 조사하였다. 산점이 많아질수록 전환율은 높아졌으나, 2,3-dihydorbenzofuran 유도체의 수율과 직접 연관짓기는 어려웠다. 전자공여기의 치환으로 벤젠 고리의 전자 밀도가 높아지면 claisen 자리 옮김 반응이 빨라져서 2,3-dihydrobenzofuran 유도체가 많이 생성되었다. 반면, 전자흡인기가 치환되어 벤젠 고리의 전자 밀도가 낮아지면 산 촉매에 의해 aryl methallyl ether 분해 반응이 촉진되어 2,3-dihydrobenzofuran 유도체 대신 phenol 유도체가 생성되었다.

• 한국대기환경학회지
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• 제9권4호
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• pp.303-309
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• 1993

An observational study of urban heat island was carried out using field data obatined during 6 days in May and August 1992 in Chunchon(population size 180.000). Air temperature was measured at 64 points along two sampling ruoutes by themisters attached to cars. Both routes cover urban and rural area and across the cneter of urban area. Continuous observation of air sonde was perfomed to clarify heights of nocturnal boundary layer(NBL) at the center of urban area. Surface meteorological observations were performed at both urban and rural sites. This study showed that heat island phenomena was obviously observed at the urbanized area during the night time with low wind speed. The average NBL heights exteded to about 10 meters, but varied with meteorological conditions. After sunset, the air temperature decreased with time at both sites and cooling rate at the urban site was greater than the rural site. The maximum heat island intensity was 7.5$^{\circ}$C at 21 LST, May 4. Usingthe two meteorological data sets obtained from urban and rural sites, the air pollutant concentration was calculated by Gaussian plume model which can obtain not only horizontal distribution of concentration but also vertical distribution. The result indicated that the concentration resulted from urban meteorological data set was lower than that from rural meteorological data set. It was also calculated that the air pollutant extended to higher level in urban meteorological data set than that in rural meteorological data set.

• 한국농촌건축학회논문집
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• 제26권2호
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• pp.65-72
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• 2024

In order to analyze the impact of fine dust generated from a construction waste intermediate processing site on the surrounding areas, diverse types of samples were collected from inside the site and surrounding areas. The impact analysis results of samples are as follows. (1) Compared to the air quality management standards by the Ministry of Environment, the concentration of fine dust within the site was 30 to 46% for PM10 and 14 to 42% for PM2.5, which was not much different from the general air quality level. (2) It was found that PM10 within the site may have a partial effect on the air quality, but when the blocking facilities in the site, wheel washing facilities at vehicle entry and exit route, and sprinkler during working were maintained, the impact on the nearby area was not high. (3) In the case of PM2.5, its concentration was influenced more by the exhaust fumes from work vehicles than fine dust generated during construction waste processing. Since the PM2.5 concentrations in the site and surrounding area were not much different from the general air quality, there was little correlation with the work impact of construction waste intermediate processing sites. (4) Pb, an indicator of heavy metal components, was within 50ng/m³ in all three sites, which was 10% of the domestic management standard and equivalent to the general air quality level. The complaints from residents in nearby areas were filed using indicators based on visual and experiential information in their daily lives, so even if the survey results of environmental impact by the construction intermediate waste processing site are lower than the standard, nearby residents can feel it better than such numerical information. Therefore, specific activities to reduce find dusts should be continuously continued.

• 대한치과마취과학회지
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• 제14권3호
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• pp.167-172
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• 2014

Background: Propofol is the most commonly used anesthetic for sedation and target-controlled infusion (TCI) is useful for dental treatment. However, it is important to assess and maintain an adequate depth of sedation in patients with severe intellectual disabilities Therefore, in this study we aimed to evaluate the adequate propofol target concentration for dental treatment in severely intellectually disabled patients. Methods: We undertook retrospective review of the sedation records of severely intellectually disabled patients who underwent dental treatment under TCI propofol sedation from September 2011 to April 2012. We evaluated the initial target concentration, stabilized concentration of propofol and monitored vital signs, including BIS score using sedation records. Results: Total 20 patients (10 male and 10 female patients) were included in the study. Every participant was severely intellectually disabled. The mean sedation duration was $70{\pm}16$ (45-100) minutes. The initial propofol target concentration infusion amount was $2.7{\pm}0.45$ (2.0-3.0) mcg/ml. The propofol effect site concentration (Ce) was $2.6{\pm}0.7$ (1.0-4.0) mcg/ml. The average value of BIS was $52.6{\pm}13$ (28-81). During the treatment period, there were no severe complications. Conclusions: The average propofol Ce for deep sedation without any complications in intellectually disabled patients was 2.6 mcg/ml.

• 한국산업보건학회지
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• 제20권4호
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• pp.241-247
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• 2010

Recently, indoor air quality (IAQ) has been one of the major concerns of people. Indoor parking lots are subject to be exposed to high concentrations of air pollutants emitted from vehicles. This study was performed to investigate indoor air quality (IAQ) at indoor parking lots. Sampling sites were selected 5 indoor parking lots. Target indoor air quality parameters include a number of criteria pollutants such PM$_{10}$, CO, CO$_2$, and HCHO. In addition, a variation of IAQ according to ventilation system operating was measured at C site (underground parking lot). In general, all pollutants were maintained below indoor air quality maintenance standards. The indoor air quality at indoor parking lots was affected by the availability of the ventilation facility and their operation frequency. At the underground parking lot (C site) with ventilation system, TVOC concentration according to ventilation system operating were found to be lower operating (488.2 ${\mu}g/m^3$) than non-operating (1,401.2 ${\mu}g/m^3$).

• 한국지하수토양환경학회지:지하수토양환경
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• 제22권5호
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• pp.89-97
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• 2017

In this study, we evaluated effect of particle size on arsenic solid-state speciation and bioaccessibility in soils highly contaminated with arsenic from smelting and mining. Soils were partitioned into six particle size fractions ($2000-500{\mu}m$, $500-250{\mu}m$, $250-150{\mu}m$, $150-75{\mu}m$, $75-38{\mu}m$, <$38{\mu}m$), and arsenic solid-state speciation and bioaccessibility were characterized in each particle size fraction. Arsenic solid-state speciation was characterized via sequential extraction and XRD analysis, and arsenic bioaccessibility was evaluated by SBRC (Solubility Bioaccessibility Research Consortium) method. In smelter site soil, arsenic was mainly present as arsenic bound to amorphous iron oxides. Fine particle size fractions showed higher arsenic concentration, but lower arsenic bioaccessibility. On the other hand, arsenic in mine site soil showed highest concentration in largest particle size fraction ($2000-500{\mu}m$), while higher bioaccessibility was observed in smaller particle size fractions. Arsenic in mine site soil was mainly present as arsenolite ($As_2O_3$) phase, which seemed to affect the distribution of arsenic and arsenic bioaccessibility in different particle size fractions of the mine soil.