• 한국전문물리치료학회지
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• 제12권3호
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• pp.56-66
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• 2005

The purposes of this study were to test that complex motor training enhance motor function significantly, to test change in cerebellum, and to test the synaptic plasticity into the immunohistochemistry response of synaptophysin. Using an animal model of fetal alcohol syndrome - which equates peak blood alcohol concentrations across developmental period - the effects of alcohol on body weight during periods were examined. The effect of complex motor training on motor function and synaptic plasticity of rat exposed alcohol on postnatal days 4 through 10 were studied. Newborn rats were assigned to one of two groups: (1) normal group (NG), via artificial rearing to milk formula and (2) alcohol groups (AG), via 4.5 g/kg/day of ethanol in a milk solution. After completion of the treatments, the pups were fostered back to lactating dams, where they were raised in standard cages (two-and three animals per cage) until they were postnatal 48 days. Rats from alcohol group of postnatal treatment then spent 10 days in one of two groups: Alcohol-experimental group was had got complex motor training (learning traverse a set of 6 elevated obstacles) for 4 weeks. The alcohol-control group was not trained. Before consider replacing with "the experiment/study", (avoid using "got" in writing) the rats were examined during four behavioral tests and their body weights were measured, then their coronal sections were processed in rabbit polyclonal antibody synaptophysin. The synaptophysin expression in the cerebellar cortex was investigated using a light microscope. The results of this study were as follows: 1. The alcohol groups contained significantly higher alcohol concentrations than the normal group. 2. The alcohol groups had significantly lower body weights than the normal group. 3. In alcohol groups performed significantly lower than the normal group on the motor behavioral test. 4. In alcohol-control group showed significantly decreased immunohistochemistric response of the synaptophysin in the cerebellar cortex compared to the nomal group. These results suggest that improved motor function induced by complex motor training after postnatal exposure is associated with dynamically altered expression of synaptophysin in cerebellar cortex and that is related with synaptic plasticity. Also, these data can potentially serve as a model for therapeutic intervention.

• Bulletin of the Korean Chemical Society
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• 제20권4호
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• pp.395-396
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• 1999

• 대한약리학회지
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• 제9권2호
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• pp.29-37
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• 1973

Lampranthus spectabilis is an ornamental plant which belongs to one of the Aizoaceae family as an one-year herb. There are no illustrations on the references that Lampranthus spectabilis has been made use for the purpose of the medicinal plant among the traditional herb doctors and the laymen. However, it has the specific characteristics to be analogous to the Cactaceae family in the botanical classification. Besides, mescaline, the main ingredient of Peyote cactus, demonstrates the sympathomimetic effect as well as the psychotomimetic effect. The authors called our attention to the resemblance to the botanical family between Aisoaceae and Cactaceae, and made a survey whether the alcohol extract of Lampranthus spectabilis might possess any pharmacological effect on the isolated heart of clam or not. The results of the experiment were as follows. 1. Administration of LX to the isolated heart of clam produced an inhibitory effect on the cardiac motility in proportion to its concentration $10^{-4}$, $5{\times}10^{-4}$ and $10^{-3}\;g/ml$ respectively. 2. Administration of LX $5{\times}10^{-4$ and $10^{-3}\;g/ml$ produced the blockade effect on the cardiac motility pretreated with serotonin $10^{-7}$ and $10^{-4}\;g/ml$, as well as with methysergide $10^{-6}$ and $10^{-5}\;g/ml$. 3. Administration of LX $5{\times}10^{-4}\;g/ml$ produced no effect on the cardiac motility pretreated with acetylcholine $10^{-7}\;g/ml$. 4. Administration of LX $5{\times}10^{-4}\;g/ml$ produced the blockade effect on the cardiac motility pretreated with barium chloride $10^{-4}\;g/ml$, as well as with prostaglandin $20\;{\mu}g$. Consequently, it is concluded that the alcohol extract of Lampranthus spectabilis has an effect of depression on the motility of the isolated heart of clam. Its mechanism of action might be due to a direct action on the heart.

• 한국안광학회지
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• 제18권4호
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• pp.473-479
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• 2013

목적: 스마트폰 시청과 알코올 섭취에 따른 눈의 변화와 상관관계를 알아보고자 하였다. 방법: 안질환, 정신질환, 전신질환 그리고 알코올 대사에 관련된 약물복용의 병력이 없는 평소 건전한 음주습관을 가진 대상자 31명(남 18명, 여 13명)을 굴절검사, 각막곡률반경, 안압측정, 각막두께를 측정하고 분석하였다. 결과: 스마트폰 시청에 따른 호흡 중 혈중 알코올의 농도 변화는 15분, 30분, 45분, 60분 그리고 회복기에서 유의하게 감소하였다(p<0.01, p<0.001). 알코올 섭취 후 스마트폰 시청 전과 시청 후, 굴절검사 비교 결과 원주굴절력과 축에서 유의한 변화가 있었다(p=0.005, p=0.001). 알코올 섭취 후 스마트폰 시청에 따른 안압의 변화는 30분부터 유의하게 감소하였으며(p<0.001), 알코올을 섭취 한 상태에서 경과시간에 따른 스마트폰 시청은 각막두께에 유의한 변화를 주지 않았다. 결론: 스마트폰 시청과 알코올 섭취는 원주굴절력과 축 그리고 안압에 유의한 변화를 보인다. 시기능 피로를 초래할 수 있는 스마트폰 시청 및 알코올 섭취는 굴절검사 전 반드시 고려해야 할 요인이다.

• Applied Biological Chemistry
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• 제38권3호
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• pp.278-282
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• 1995

오미자 추출물이 Saccharomyces cerevisiae의 생리에 미치는 영향을 조사하기 위하여 포도당 기본배지에 오미자 추출물을 0, 0.01, 0.1, 0.5, 1%(w/v)씩 첨가하고 S. cerevisiae KTCC 1199를 접종하여 96시간 진탕배양하면서 균의 증식, 알콜생성, 발효율 등의 변화와 alcohol dehydrogenase, pyruvate decarboxylase활성을 조사하였다. S. cerevisiae의 증식은 전 발효기간중 추출물 0.01%및 0.1%첨가구에서 대조구보다 증가하였으며, 각 시험구의 알콜생성은 추출물 0.1%, 0.01%, 0%, 0.5%, 1% 첨가순으로 0.1%첨가구에서 가장 높았다. alcohol dehydrogenase 효소활성은 0.1%구와 0.01%구에서 대조구보다 각각 1.25배, 1.18배 높은 활성을 보였다. pyruvate decarboxylase 활성의 경우도 ADH 활성과 유사하여 각각 대조구보다 1.31배, 1.26배 높은 활성을 보였으며, 0.5%구와 1%구는 대조구보다 각각 1.3배및 1.4배 낮은 활성을 보였다.

• Archives of Pharmacal Research
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• 제27권3호
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• pp.351-356
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• 2004

A transdermal preparation containing diclofenac diethylammonium (DDA) was developed using an O/W microemulsion system. Of the oils tested, lauryl alcohol was chosen as the oil phase of the microemulsion, as it showed a good solubilizing capacity and excellent skin permeation rate of the drug. Pseudoternary phase diagrams were constructed to obtain the concentration range of oil, surfactant and cosurfactant for microemulsion formation, and the effect of these additives on skin permeation of DDA was evaluated with excised rat skins. The optimum formulation of the microemulsion consisted of 1.16% of DDA, 5% of lauryl alcohol, 60% of water in combination with the 34.54% of Labrasol (surfactant)/ethanol (cosurfactant) (1:2). The efficiency of formulation in the percutaneous absorption of DDA was dependent upon the contents of water and lauryl alcohol as well as Labrasol: ethanol mixing ratio. It was concluded that the percutaneous absorption of DDA from microemulsions was enhanced with increasing the lauryl alcohol and water contents, and with decreasing the Labrasol:ethanol mixing ratio in the formulation.

• Toxicological Research
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• 제28권4호
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• pp.249-253
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• 2012

In this study, we prepared alcohol extracts of the larva, pupa, queen, and cocoon (clony) of B. ignitus, B. terrestris, and B. h. sapporoensis, and tested the anti-inflammatory activity of the extracts by using a rat model of adjuvant-induced edema. The extracts derived from the queen of B. ignitus, the queen of B. terrestris, and the cocoon of B. ignitus decreased hind paw edema after 1 day of i.p. administration. These extracts also induced vasorelaxation and NO production in calf pulmonary artery endothelial cells. These results suggest that bumblebee alcohol extracts has anti-inflammatory and vasorelaxant properties.

• Archives of Pharmacal Research
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• 제2권1호
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• pp.25-33
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• 1979

In order to find out nutritional effects of Korean edible mushrooms on the multiplication of tissue cells, the alcohol extracts and acid bydrolysates of eleven species of mushrooms were added to Earle's ESS. A comparison of the respective multiplications of HeLa cells in this solution and in control solution of TC=199. Yielded the following result: The alcohol extracts and acid hydrolysates of a Coprinus comatur, Agaricus campestris, Agaricus bisporus, Lentinus edodes, Tricholoma matsutake, Pleurotus ostretus, Ramaria botrytis and Pholiota nameko influenced favorably the maintenance of the normal form and monolayer of HeLa cells. The growth curves of HeLa cells in the cultures containing, respectively, the alcohol extracts and acid hydrolysates of these eight mushrooms showed that five species, i.e., Coprinus comatus, Agaricus compestris, Agaricus bisporus, Lentinus edodes and Tricholoma matsutake effected an excellent multiplication and that the other three species were less effective than those five species. As to the effects on the cell multiplication, no marked difference was observed between the alcohol extracts and the acid hydrolysates of the mushrooms tested.

• Plant Resources
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• 제5권2호
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• pp.124-140
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• 2002

The effects of drying agents and ethyl alcohol treatment on the flower color of Gentiana uchiyamai. The flower color was not much changed in flower sheet, in the case of absorbtion papers only. The color was least changed in Korean and China hwasunjis, in the case of absorbtion papers and silica gel treatment. The color was less changed in flower sheets, window papers, and China hwasunjis, and was most changed in newspapers, in the case of absorbtion papers and Na$_2$SO$_4$ treatment. The color was least changed in China hwasunjis, and most changed in dampened papers, in the case of absorbtion papers and CaO treatment. The color tended to change far from the original one, as treatment time got longer, in the case of 0.01M and 0.lM of tartaric acid. The longer the treatment time and the bigger the concentration of ethyl alcohol, the bigger flower color.

• 대한임상검사과학회지
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• 제46권4호
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• pp.131-135
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• 2014

Over-consumption of alcohol leads to many side-effects such as malnutrition, liver disease, and neuronal disorders and many investigators have tried to identify methods for preventing the side-effects of drinking. This study was carried out to investigate the effect of the beverage contained green tea catechins (GTC) on the alcohol administered rats. We observed that blood alcohol concentration level decreased significantly in plasma. GTC (200 mg/kg) also reduced the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) level of the intoxicated rats. These results suggest that GTC may be useful for the prevention and therapy of hepatotoxic pathogenesis.