• Title/Summary/Keyword: Effect of alcohol

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Highly purified chitosan reduce blood alcohol concentration, aspartate aminotransferase, and alanine aminotransferase levels in human

  • Chung, Hwan-Suck;Koo, Hyun-Na;Moon, Young-Hoe;Kim, Hyung-Min
    • Advances in Traditional Medicine
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    • v.3 no.1
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    • pp.18-20
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    • 2003
  • The purpose of this study was to examine the effect of supplementary highly purified chitosan (HPC) on blood alcohol concentration in healthy human. The human study was performed with two sections. Each section of the study was conducted by two-phase cross-over design with a week wash-out period. All volunteers took HPC in one phase, and took a placebo in the next phase. Blood alcohol concentrations were different between in those taking HPC and in those taking the placebo in the human. And the concentration of serum aspartate aminotransferase (AST, GOT) and alanine aminotransferase (ALT, GPT), the indicator of liver cell damage, was lowered in those taking HPC, compared to those taking the placebo. In conclusion, taking HPC prior to drinking alcohol can somewhat reduce alcohol concentration in human blood and liver cell damage.

Hepatoprotective Effects of Hovenia dulcis Extract on Acute and Chronic Liver Injuries induced by Alcohol and Carbon Tetrachloride (알코올 및 사염화탄소에 의해 유발된 급만성 간손상에 대한 지구자 열수추출물의 보호효과)

  • Kim, Young-Sik;Park, Juyeon;Kwon, Yongbeom;Lim, Dong Wook;Song, MiKyung;Choi, Ho-Young;Kim, Hocheol
    • The Korea Journal of Herbology
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    • v.28 no.4
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    • pp.25-32
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    • 2013
  • Objectives : The purpose of this study was to evaluate the hepatoprotective effect of Hovenia dulcis extract on acute and chronic liver injuries induced by alcohol and $CCl_4$ in mice and rats. Methods : In acute alcohol-induced liver injury, mice were administered Hovenia dulcis extracts (60 and 200 mg/kg) orally before and after alcohol administration. In chronic alcohol-induced liver injury, mice were administered alcohol containing liquid diet for 4 weeks. The mice were administered H. dulcis extracts (60 and 200 mg/kg) mixed with the liquid diet. In acute $CCl_4$-induced liver injury, rats received a single dose of $CCl_4$ (2 mL/kg in olive oil, intraperitoneally). Rats were administered H. dulcis extracts (30, 100 and 300 mg/kg) before and after $CCl_4$ administrations. After the ends of the administrations, the serum levels of AST and ALT were measured using chemical analyzer, and ${\gamma}$-GTP levels were measured using spectrophotometer. Results : In acute alcohol-induced liver injury, H. dulcis extracts treated group showed significant reduction in ALT levels compared to those of control group. In chronic alcohol-induced liver injury, it inhibited weight-loss compared to normal group and showed significant reduction in AST, ALT and ${\gamma}$-GTP levels compared to control group. In acute $CCl_4$-induced liver injury, it also showed significant reduction in AST, ALT levels compared to control group. Conclusions : The results show that H. dulcis extract has hepatoprotective effect in acute and chronic alcohol-induced liver injury and acute $CCl_4$-induced liver injury. These findings suggest that H. dulcis could be a potent hepatoprotective agent.

AN EXPERIMENTAL STUDY ON THE EFFECT OF ALCOHOL INJECTION IN RAT ORAL MUCOSA (알콜(Alcohol)주사가 구강조직에 미치는 영향에 관한 실험적 연구)

  • Min, Byong-Il
    • The Journal of the Korean dental association
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    • v.15 no.12
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    • pp.957-962
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    • 1977
  • The author has observed the tissue reaction of the absolute alcohol infection of rat oral mucosa. 0.5ml absolute alcohol was injected subcutaneously on the mucobuccal fold of rat. And the rats were sacrifieced at intervals of one day, 3rd, 1 week, 2 week and 4 week after alcohol injection. The microscopic tissue sections were made and stained with hematoxylin and eosin. The results were are as follows; 1. Degeneration and shrinkage of fibroblasts and coagulative necrosis were observed one day to and three day after alcohol injection. 2. Although coagulative necrosis and tissue degeneration occurred, the inflammatory infiltration was not prominent especially there were scarcely any polymorphonuclear leukocytes in that field. 3. Granulation tissue with moderate small round cell infiltration were replaced the necrotic area at one week after injection and the fibroblast proliferate into the granulation tissue at two week group. 4. At four week after injection, the damaged area recovered by fibroblastic proliferation and collage formation, but there were

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The Protective Effects of Acupressure at Feng Shi against Chronic Alcohol-induced Muscle Atrophy in Rats (흰쥐의 풍시(風市)혈(GB31) 자극이 알콜성 근위축에 미치는 효과)

  • Bum-Hoi Kim
    • Journal of The Korean Society of Integrative Medicine
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    • v.11 no.1
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    • pp.63-70
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    • 2023
  • Purpose : Excessive alcohol causes damage to skeletal muscles, leading to the development of a specific disease entity called alcoholic myopathy. Chronic inflammation is related as an underlying mechanism for the loss of muscle mass induced by alcohol. Pro-inflammatory cytokines such as TNF-α (tumor necrosis factor-α) and IL-6 (interleukin-6) play a role in this process. The acupuncture point Feng Shi (GB 31) is located on the midline of the lateral aspect of the thigh, above the transverse popliteal crease. This acupoint is used for the treatment of weakness, atrophy, numbness, and post-stroke symptoms of lower limbs. The purpose of this study was to investigate the effect of Feng Shi stimulation on muscle atrophy caused by chronic alcohol administration. Method : Young male Sprague-Dawley rats were randomly divided into three groups of eight each: Normal, Control, and GB31. The rats in the Control and GB31 groups were orally given 25 % ethanol (5 ㎖/kg, body weight) daily for 4 weeks. The Normal group was similarly administered saline. The acupressure at Feng Shi was treated to rats in the GB31 group. After 4 weeks, the body weight, muscle weight and cross-sectional area of gastrocnemius were assessed and the histological changes in gastrocnemius muscle fiber were observed by hematoxylin and eosin staining. Moreover, TNF-α and IL-6 expressions were immunohistochemistrically evaluated. Results : Acupressure stimulation at Feng Shi had a protective effect on the weight reduction of the gastrocnemius muscle caused by alcohol intake, and had an effect of suppressing anatomical change in muscle fiber and decreasing the average cross-sectional area. Also, the immunoreactivities of TNF-α and IL-6 in the GB31 group were decreased. Conclusion : These results suggest that acupressure at Feng Shi has protective effects on chronic alcohol-induced muscle atrophy by inhibiting pre-inflammatory proteins such as TNF-α and IL-6.

Drinking Status and Effects of School-based Alcohol Prevention Programs in Middle and High School Students: Using the 2015 Youth Risk Behavior Web-based Survey Data (중·고등학생의 음주 실태와 학교 음주예방 교육의 영향: 2015년 청소년건강행태온라인조사를 활용하여)

  • Doo, Young-Taek
    • Journal of the Korean Society of School Health
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    • v.29 no.1
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    • pp.42-52
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    • 2016
  • Purpose: The purpose of this study was to examine effects of school-based alcohol prevention programs on drinking statuses of adolescents. Methods: The findings of this study was based on the data obtained from the '2015 11th Korea Youth Risk Behavior Web-based Survey. The number of study subjects were 68,043. Results: It was figured that 35.6% of the study subjects had experienced school-based alcohol prevention programs within the last 12 months. As the students got older, the chances to participate in the programs decreased (p<.01). For both middle and high school students, current drinking rates for the educated was lower than those of the uneducated students(6.6% vs 8.0%; 22.2% vs 25.9%) and it was statistically significant. A similar pattern was found for high-risk drinking rates. Those educated showed lower rates than the uneducated with statistical significance of p<.001. In addition, the educated had lower problem drinking rate than the uneducated for both middle (p<.05) and high school students (p<.001). The results of logistic regression analysis showed that school-based alcohol prevention programs had statistically significant effect on current drinking status of adolescents (p<.05). However, it had significant effect only on high-risk drinking status of high school students (p<.05) and had no effect on problem drinking. Conclusion: This study addressed effectiveness of school-based adolescent alcohol prevention programs and that it is important to develop means to implement school health education.

Effects of Ginseng Extract on Biological Cell Membrane and Artificial Lipid Monolayer (인삼추출물이 생체 세포막 및 artificial lipid monolayer에 미치는 영향)

  • Paik, Kwang-Sei;Lee, Chul-Young;Lee, Kyung-Nam;Song, Sun-Ok;Kang, Doo-Hee
    • The Korean Journal of Physiology
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    • v.10 no.1
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    • pp.7-14
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    • 1976
  • The Present study was conducted to investigate the effects of Ginseng extract on the tension-area curve for stearic acid monolayer. At the same time, the effects of Ginseng extract on osmotic and mechanical fragility of human red cells and histamine release from rabbit leukocytes were studied, The results are summarized as follows. 1. The Ginseng alcohol extract was found to expand liquid expanded phase of stearic acid monolayer, thus it is speculated that this agent may be acting as a surface active substance. 2. Osmotic hemolysis was inhibited by the Ginseng alcohol extract and the same effect was also observed in the presence of Ginseng saponin. However, the Ginseng alcohol extract was found to decrease hematocrit ratio of the RBC suspension, therefore, the inhibition of the osmotic hemolysis by this agent may be secondary effect to the reduced cell volume. 3. The mechanical hemolysis was also inhibited by the Ginseng alcohol extract but the inhibition was independent of changes in hematocrit ratio. 4. Histamine release from rabbit leukocytes was significantly increased in vitro in the presence of the Ginseng alcohol extract.(p<0.05)

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Liposoluble portion of the red alga Pyropia yezoensis protects alcohol induced liver injury in mice

  • Lee, Ji-Hyeok;Ahn, Ginne;Ko, Ju-Young;Kang, Nalae;Jung, Kyungsook;Han, Eui-Jeong;Kim, Gwang-Hoon;Kim, Hee Jeong;Choi, Cheol Soo;Jeon, You-Jin
    • ALGAE
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    • v.36 no.3
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    • pp.219-229
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    • 2021
  • The hepatoprotective effect of liposoluble portion of Pyropia yezoensis (PYLP) was investigated against alcohol-induced liver injury in mice. Fatty acids were predominant in PYLP obtained from hexane fraction of 70% EtOH extract after ultrasonication. In particular, polyunsaturated fatty acids such as eicosapentaenoic acid and linoleic acid accounted for 56.91% of the total lipids. PYLP significantly reduced liver damage induced by the alcohol treatment in mice. PYLP treatment increased the activity of antioxidant enzymes including superoxide dismutase, catalase, and glutathion peroxidase by reducing thiobarbituric acid reactive substances. Histological observations showed that PYLP minimizes damage to living tissue induced by alcohol treatment by modulating the expression level of proteins involved in the anti-apoptotic signaling pathway. Our results suggest that PYLP, rich in polyunsaturated fatty acids extracted from the red alga P. yezoensis, will be useful as a potential liver protectant in the hangover industry.

Effect of Blast Furnace Slag, Hwang-toh and Reinforcing Fibers on The Physical and Mechanical Properties of Porous Concrete Using Blast Furnace Slag Coarse Aggregate (고로슬래그 골재를 사용한 다공성 콘크리트의 물리·역학적 특성에 미치는 고로슬래그 미분말, 황토 및 보강섬유의 효과)

  • Lee, Jin-Hyung;Park, Chan-Gi
    • Journal of The Korean Society of Agricultural Engineers
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    • v.52 no.5
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    • pp.53-60
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    • 2010
  • The effects of blast furnace slag, hwang-toh, and reinforcing fiber on the physical and mechanical properties of porous concrete using blast furnace slag coarse aggregates have been evaluated in this study. The effect of the depending on replacement ratio of blast furnace slag to cement was investigated such that the replacement ratio was varied to 0 %, 25 % and 50 %. Also, the replacement ratios of hwang-toh were 0, 20 and 30 %. The polyvinyl alcohol fiber was used for the reinforcing fiber. A series of pH, unit mass, and void ratio tests have been performed to study the physical properties of the porous concrete using blast furnace slag coarse aggregates with the polyvinyl alcohol fiber and the replacement ratios of blast furnace slag, hwang-toh, while a series of compressive tests have been performed to evaluate the strength property depending on polyvinyl alcohol fiber and the replacement ratios of blast furnace slag, hwang-toh. The test results indicated that the physical and mechanical properties of porous concrete using blast furnace slag coarse aggregates is affected by the replacement ratio of blast furnace slag, and the fiber contents. According to the tests with polyvinyl alcohol fiber contents, the void ratio was decreased and the compressive strength was upgraded.

Antioxidant activity of water and alcohol extracts of Thuja orientalis leaves

  • Nizam, Iram;Mushfiq, M
    • Advances in Traditional Medicine
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    • v.7 no.1
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    • pp.65-73
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    • 2007
  • Water and alcohol extracts were prepared from dried and powdered leaves of Thuja orientalis (T. orientalis). The reducing power, total phenolic content, the 1,1-diphenyl-2-picrylhydrazyl scavenging activity, inhibitory effect on Fe (II)-EDTA-$H_{2}O_{2}$ (Fenton reaction system) induced DNA damage and inhibitory effect on human red blood cell (RBC) hemolysis were evaluated in the present study. At a concentration of 200 mg, water and alcohol extracts of T. orientalis inhibited the hydrolysis of DNA by 72.859% and 65.312%, respectively. Water and alcohol extracts of T. orientalis also inhibited 2,2'-Azobis(2-amidinopropane) dihydrochloride induced RBC hemolysis to the extent of 69.30% and 54.55%, respectively. The reducing power and antioxidative activity of water extract was found to be more than that of alcohol extract. This is attributable to the presence of higher amount of phenolic compounds in water extract. The present results indicate that the T. orientalis extracts are rich sources of natural antioxidants and can protect DNA and human red blood cells against free radical induced oxidative damage.

Effect of Addition Soy Flour on Tapioca Non-steamed Fermentation (콩분말 첨가에 따른 타피오카의 무증자 알콜발효에 미치는 영향)

  • 하영득
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.32 no.3
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    • pp.388-392
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    • 2003
  • This study was conducted to examine the effect of soy flour on tapioca non- steamed fermentation. A whole soy flour was higher than roasting soy flour in alcohol content. Alcohol content was increased up to 2% of soy flour, and decreased after adding 3% soy flour. The pH and total acidity were showed no significant differences by adding soy flour, roasted soy flour, water and enzyme. The optimum conditions for alcohol production were 2% (w/w) of soy flour,0.5% (w/w) of enzyme and 250% (v/w) of water at 96 hr. Addition of soy flour increased yield of alcohol.