• Journal of Korean Neurosurgical Society
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• v.66 no.5
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• pp.511-524
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• 2023

Objective : This animal model aimed to compare the rat group that received brain irradiation and did not receive additional treatment (only saline) and the rat group that underwent brain irradiation and received Granulocyte colony stimulating factor (G-CSF) treatment. In addition, the effects of G-CSF on brain functions were examined by magnetic resonance (MR) imaging and histopathologically. Methods : This study used 24 female Wistar albino rats. Drug administration (saline or G-CSF) was started at the beginning of the study and continued for 15 days after whole-brain radiotherapy (WBRT). WBRT was given on day 7 of the start of the study. At the end of 15 days, the behavioral tests, including the three-chamber sociability test, open field test, and passive avoidance learning test, were done. After the behavioral test, the animals performed the MR spectroscopy procedure. At the end of the study, cervical dislocation was applied to all animals. Results : G-CSF treatment positively affected the results of the three-chamber sociability test, open-space test and passive avoidance learning test, cornu Ammonis (CA) 1, CA3, and Purkinje neuron counts, and the brain levels of brain-derived neurotrophic factor and postsynaptic density protein-95. However, G-CSF treatment reduced the glial fibrillary acidic protein immunostaining index and brain levels of malondialdehyde, tumor necrosis factor-alpha, nuclear factor kappa-B, and lactate. In addition, on MR spectroscopy, G-CSF had a reversible effect on brain lactate levels. Conclusion : In this first designed brain irradiation animal model, which evaluated G-CSF effects, we observed that G-CSF had reparative, neuroprotective and anti-neurodegenerative effects and had increased neurotrophic factor expression, neuronal counts, and morphology changes. In addition, G-CSF had a proven lactate-lowering effect in MR spectroscopy and brain materials.

• Journal of agriculture & life science
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• v.45 no.6
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• pp.213-226
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• 2011

This study was performed to investigate the effect of essential oils and ethanolic extracts of approximately 650 plant species on acetylcholine esterase (AChE) enzyme activity using Ellman's colorimetric method in 96-well microplates. The results showed that the ethanolic extracts from twig of Sophora subprostrata, twig of Phellodendron amurense, seed of Corylopsis coreana, and essential oil (EO) from Citrus paradisi, Cupressus sempervirens, Ocimum basilicum, Pinus sylvestris and Rosmarinus officinalis inhibited more than 80% of AChE activity. Among these, EO from Pinus sylvestris, C. sempervirens and C paradisi exhibited higher values of AChE inhibitory activity, which were 75, 84 and 99% at a concentration of 50 ug/ml, respectively. Finally, EO from C paradisi (grapefruit, GEO) showed the highest inhibitory activity towards AChE, which showed 91% of inhibition at a concentration of 20 ug/ml. We also examined the anti-dementia effects of GEO in mouse by passive avoidance test and Morris water maze test. The model mouse (male, ICR) of dementia (negative control) was induced by administration of scopolamine (1 mg/kg body weight). The latency time of sample group administrated with GEO (100 mg/kg, p.o.) increased significantly as compared with negative control on passive avoidance test. There were significant recovery from the scopolamine-induced deficits on learning and memory in water maze test through daily administrations with GEO (100 mg/kg, p.o.). From these results, we conclude that GEO treatment might enhance the cognitive function, suggesting that the EO of C. paradis may be a potential candidate for improvement of perceptive ability and dementia.

• The Korea Journal of Herbology
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• v.36 no.2
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• pp.1-9
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• 2021

Objectives : Gossypium arboreum (cotton) is traditionally used to treat various health disorders. However, anti-amnesic effect of G. arboreum has not been reported. The objective of this study was to investigate in-vivo the anti-amnesic effects along with in vitro antioxidant and acetylcholinesterase (AChE) inhibition potential in G. arboreum seed essential oil. Methods : The essential oil of G. arboreum obtained by solid phase microextraction (SPME) techniques were identified by gas chromatography-mass spectroscopy (GC-MS). 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay were performed to determine the antioxidant activity at various concentrations (312.5, 625, 1250, 2500, 5000, 10000 ㎍/㎖. Y-maze, passive avoidance and Morris water maze tests were carried out to evaluate improved effect on scopolamine (1 mg/kg)-induced memory dysfunction at the dose level of 50, 100 and 200 mg/kg. Donepezil (5 mg/kg) was used as a positive drug control. We performed acetylcholinesterase (AChE) activity assay in ex vivo. Results : Five volatile compounds were identified in G. arboreum. The assays of DPPH and ABTS revealed that G. arboreum increased antioxidant activity in a dose-dependent manner. G. arboreum ameliorated the percent of spontaneous alternation in the Y-maze test, shortened step-through latency in the passive avoidance test, and increased swimming time in the target zone in the Morris water maze test. In addition, G. arboreum inhibited the AChE activity. Conclusions : Based on these findings, G. arboreum may aid in the prevention and treatment of learning and memory-deficit disorders through antioxidant and AChE inhibitory activities.

• Journal of Life Science
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• v.29 no.5
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• pp.564-569
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• 2019

Heavy drinking disrupts the nervous system by activation of GABA receptors and inhibition of glutamate receptors, thereby preventing short-term memory formation. Degradation of cognition by alcohol induces blackouts, and it can lead to alcoholic dementia if repeated. Therefore, drugs need to be developed to prevent alcohol-induced blackout. In this study, we confirmed the effect of an ethanol extract of Cassia obtusifolia seeds (COE) on alcohol-induced memory impairment. The effects of COE and ethanol on cognitive functions mice were examined using the passive avoidance and Y-maze tests. The manner in which alcohol affects long-term potentiation (LTP) in relation to the learning and memory was confirmed by electrophysiology performed on mouse hippocampal slices. We also measured N-methyl-D-aspartate (NMDA) receptor-mediated field excitatory synapses (fEPSPs), which have a known association with cognitive impairment caused by ethanol. Ethanol caused memory impairments in passive avoidance and Y-maze tests. COE prevented these ethanol-induced memory impairments in these tests. Ethanol also blocked LTP induction in the mouse hippocampus, and COE prevented this ethanol-induced LTP deficit. Ethanol decreased NMDA receptor-mediated fEPSPs in the mouse hippocampus, and this decrease was prevented by COE. These results suggest that COE might be useful in preventing alcohol-induced neurological dysfunctions, including blackouts.

• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.3
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• pp.97-103
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• 2021

Perilla frutescens (P. frutescens) is an important herb used for many purposes such as medicinal, aromatic, and functional food in Asian countries and has beneficial effects such as antioxidant activity, anti-inflammation activity, anti-depression activity, and anxiolytic activity. However, there have been no studies on the protective effect of P. frutescens extract (PFE) on amnesia in vivo. The present study aimed to investigate whether PFE protects memory deficit using a scopolamine-induced mice model and elucidate the underlying mechanisms involved. The protective effect of PFE against scopolamine-induced memory deficits was investigated using Y-maze, passive avoidance, and Morris water maze tests. Furthermore, the potential mechanisms of PFE in improving memory capabilities related to the cholinergic system and antioxidant activity were examined. PFE significantly increased spontaneous alternation in the Y-maze test, step-through latency in the passive avoidance test, and swimming time in the target quadrant in the probe test when compared to the scopolamine-treated group. Likewise, PFE significantly decreased escapes latency in the Morris water maze test. PFE could not regulate cholinergic function in acetylcholine level and acetylcholine esterase activity. However, PFE increased DPPH radical scavenging activity dose-dependently and total polyphenol content was 127.7±1.2 ㎍ GAE/mg. The results showed that the PFE could be a preventive and/or therapeutic candidate for memory and cognitive dysfunction in Alzheimer's disease.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.11 no.2
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• pp.1-8
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• 2016

Self Regulatory Focus Theory explained two different self-regulatory systems(promotion focus and prevention focus) to achieve a goal. According to this theory, people have different type of goal(approach pleasure and avoid pain) and use different type of strategy to achieve the goal. Promotion focus targets their attention to positive outcomes and the achievement of gains. On the other hand, prevention focus targets attention more to negative outcomes and the avoidance of losses. Also, promotion focus tends to use approach and eager strategy to achieve the goal and prevention focus tends to use avoidance and vigilant strategy. This study examined the effects of self regulation focus on attitude and intention toward business start-up. We proposed that promotion focused people will respond more positively to the attitude and intention toward business start-up than prevention focused people. This likely because promotion focused people tend to focus more ideals and gains, where prevention focused people tend to focus more safety and risk. And also we proposed that these effect will be influenced by psychological distance. This study investigated these relationships using 186 under graduate students. The result of analysis indicated that promotion focused people responded more positively on the intention toward business start-up than prevention focused people. But it had not any effect on the attitude toward business start-up than prevention focused people. Self regulation focus and psychological distance turns out to be a significant factors that influence attitude and intention toward business start-up. Finally, we concluded with a discussion of the implications of the research findings and directions for future research.

• International Commerce and Information Review
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• v.16 no.3
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• pp.381-412
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• 2014

Un globalization unfolds, concerns and research toward the differnces international cultures has increased. However, there is a dearth of research regarding how to nature culture align orgainzational performance with leadership style. Accordingly, this study aims to identify the relationship between leadership style and the orgainzational performance with mediating effect of national culture. Understanding the cultures of other countries is not as fast as the speed of internationalization. As globalization advances, interest and research on the characteristics of national culture differences have been increasing. One of the important challenges for business leaders is the ability to understand and deal with cross-cultural management. But there is a lack of research on cross-cultural management. In order to achieve this objective, this study, adopts Hofstede cultural dimensions, and finds the mediating effect on these transformational and transactional leadership on organizational performance.Feminism, collectivism, power distance, and uncertainty avoidance were classified into four factors of national culture has differnct mediating effect on leadership style and performance. This research has concentrated on leadership-styles and organizational performance with mediating effect of national culture.

• Journal of the Korean Applied Science and Technology
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• v.39 no.2
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• pp.324-334
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• 2022

In this study, to analyze the relationship between exercise satisfaction and exercise continuity that occurs in the interaction between leaders and participants, non-probability sampling was performed on 232 individuals from January 17 to March 9, 2022, and a structural model of 187 effective samples was used. applied and analyzed. First, the reliability and intimacy of Pilates leader-participants were found to have a significant effect on exercise satisfaction. Second, significant results were derived between Pilates exercise satisfaction and exercise continuity. Third, Pilates reliability was found to have a significant effect on exercise continuity, but intimacy was partially adopted as not having a significant effect on exercise continuity. However, the indirect effect between the mediating effects of exercise satisfaction can be seen to be statistically significant, and it can be predicted that Pilates causes positive behavior in exercise satisfaction and further reduces avoidance or indirectly affects other exercises. In addition, these performances are considered to have an impact on business performance as well as mutual relationships.

• Journal of Digital Convergence
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• v.16 no.3
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• pp.169-179
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• 2018

This study aimed to investigate the effects of user experience on Facebook acceptance behavior and advertising acceptance behavior. For the study, a survey was conducted among 367 male and female college students who use Facebook. In the results, first, functionality, usability, and pleasurable had positive effects on Facebook attitude, usability and pleasurable on flow, and reliability, usability, and pleasurable on the intent for continuous use. Second, functionality had a negative effect on advertising invasiveness while pleasurable had a positive effect on advertising attitude and no significant effect on advertising avoidance. The findings in this study provide basic data that can be used by various companies that use Facebook and advertising on Facebook for developing marketing strategy. In addition, future studies are expected on considering various variables related to user experience.

• Korean Journal of Social Welfare
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• v.63 no.2
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• pp.179-205
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• 2011

Recently, problems regarding marital adjustment of cancer patients are recognized as serious matter of concern for it had been reported that these issues have severe negative effects on relationship stability within marriage. It is noteworthy how marital adjustment is found to be critical for the cancer patient's mental stability, healing process and chances of survival as reported in the research. Thus, the ultimate goal of this research is to contribute to improvement of the stable relationship and also to formulate the social service related strategy for marriage adjustment for married cancer patient married couples in Korea. Actor and Partner Interdependence Model was formed in order to observe how the communication of the married couple affects marital adjustment and how this has an actor effect as well as partner effect. In order to authenticate this research model, dyadic data which sample the cancer patient and the spouse as a pair. Survey was conducted as the cancer patients who had been diagnosed with cancer and their respective spouses. The survey was taken from 160 married couples which totals to 320 people all together. Results indicated the cancer patient and the spouse have a significant relationship in marital adjustment. Through this, it had been concluded that marital adjustment is not separated but co-dependent with dynamic relationship. And the mutual constructive communication had proven to have a significant positive effect on one's marital adjustment. In demand-withdrawal communication, its negative effect on the self effect was found to be significant in both the patient and the spouse to both of their marital adjustment. Mutual avoidance communication had shown to only cause significant negative effect on self effect to the patient. In verifying the partner effect, significant negative effect was caused by patient's demand-withdrawal communication in partner effect on the spouse's marital adjustment. The results of this study are discussed in term of their implications for clinical interventions for the betterment of marital adjustment among cancer patients and their spouses. The suggestions for future research are discussed also.