• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5455-5461
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• 2012

Luteolin is a plant flavonoid which exhibits anti-oxidative, anti-inflammatory and anti-tumor effects. However, the antiproliferative potential of luteolin is not fully understood. In this study, we investigated the effect of luteolin on cell cycling and apoptosis in human esophageal squamous carcinoma cell line Eca109 cells. MTT assays showed that luteolin had obvious cytotoxicity on Eca109 with an $IC_{50}$ of $70.7{\pm}1.72{\mu}M$ at 24h. Luteolin arrested cell cycle progression in the G0/G1 phase and prevented entry into S phase in a dose- and time-dependent manner. as assessed by FCM. Luteolin induced apoptosis of Eca109 cells was demonstrated by AO/EB staining assay and annexin V-FITC/PI staining. Moreover, luteolin downregulated the expression of cyclin D1, survivin and c-myc, and it also upregulated the expression of p53, in line with the fact that luteolin was able to inhibit Eca109 cell proliferation.

• The Journal of Korean Academic Society of Nursing Education
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• v.22 no.3
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• pp.396-407
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• 2016

Purpose: This study aimed to identify the effectiveness of educational Electronic Nursing Record System in terms of nursing process preparation ability and satisfaction about the system itself. Methods: A one group pre-post experimental study design was utilized in this study. The effectiveness of the system was examined through quality of nursing diagnoses, interventions, and outcomes and electronic nursing record system satisfaction inventory. Junior and senior nursing students were the potential study respondents and evaluation instruments were applied only for the one who agreed to participated in the study. Education about nursing process and electronic nursing record system was carried out as part of regular classes and students were guided to prepare nursing process upon the scenarios developed earlier. Results: 29 juniors and 33 seniors prepare nursing process documentation related to each scenario and both groups showed significant improvement upon nursing process documentation (t=7.53, p<.001, t=3.23, p=.003, respectively) compared to paper based nursing process preparation. Satisfaction about system itself was 2.78(0.81). Conclusion: Educational electronic nursing record system seems to be effective to train nursing students for nursing process preparation ability. Effort to enhance its utility are called in the area of education and system itself.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.5
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• pp.2037-2041
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• 2015

Background: Relationships between poor prognosis of ovarian malignancies and changes in complete blood count parameters have been proposed previously. In this work, we aimed to evaluate clinicopathologic features in adolescents with adnexal masses and sought to establish any predictive value of the platelet to lymphocyte ratio (PLR) in diagnosis. Materials and Methods: This retrospective study was conducted on 196 adolescent females with adnexal masses. Three groups were constituted with respect to clinical or histopathology results: group 1, non-neoplastic patients (n:65); group 2, neoplastic patients (n:68); and group 3 expectantly managed patients (n:63). The main parameters recorded from the hospital database and patient files were age, body mass index (BMI), chief symptoms, diameter of the mass (DOM), tumor marker levels, complete blood count values including absolute neutrophil, lymphocyte, and platelet counts, mean platelet volume, platelet distribution width, and platecrit, surgical features, and postoperative histopathology results. Results: The expectantly managed patients were younger than the other groups (p=0.007). The mean body mass index (BMI) was higher in the neoplastic group (p=0.016). Preoperative DOM, CA125, mean platelet volume and PLR were statistically significantly different between the groups (p<0.05). ROC curve analysis demonstrated that increased PLR (AUC, 0.609; p=0.011) and BMI (AUC, 0.611; p=0.011) may be discriminative factors in predicting ovarian neoplasms in adolescents preoperatively. When the cut-off point for the PLR level was set to 140, the sensitivity and specificity levels were found to be 65.7% and 57.6%, respectively. Conclusions: We suggest that beside a careful preoperative evaluation including clinical characteristics, ultrasonographic features and tumor markers, PLR may predict ovarian neoplasms in adolescents.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.3
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• pp.886-900
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• 2015

Small cells are deployed in Heterogeneous Networks (HetNet) to improve overall performance. These access points can provide high-rate mobile services at hotspots to users. In a Small Cell Network (SCN), the good deployment of small cells can guarantee the performance of users on the basis of average and cell edge spectrum efficiency. In this paper, the performance of small cell deployment is analyzed by using system-level simulations. The positions of small cells can be adjusted according to the deployment radius and angle. Moreover, different Inter-Cell Interference Coordination (ICIC) techniques are also studied, which can be implemented either in time domain or in frequency domain. The network performances are evaluated under different ICIC techniques when the locations of Small evolved Nodes (SeNBs) vary. Simulation results show that the average throughput and cell edge throughput can be greatly improved when small cells are properly deployed with the certain deployment radius and angle. Meanwhile, how to optimally configure the parameters to achieve the potential of the deployment is discussed when applying different ICIC techniques.

• The Journal of the Korea Contents Association
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• v.15 no.7
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• pp.684-697
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• 2015

The purpose of the present study was to examine the images of children possessed by applicants for the department of early childhood education and find out how the images of children have been changed when the applicants have entered the department from successful applicants. Study subjects were 328 applicants for the department of early childhood education and 25 students who passed the entrance examination and completed the first year. Data were collected by painting metaphors and the contents of the collected data were analyzed. According to the results of analysis, the images of children possessed by applicants for the department of early childhood education were 'beings that require sincerity, love, and attention', 'beings that must be taught and led', 'beings that are liberal and characterful', 'beings that are bright and pure and give happiness', 'beings that have potential for learning and growth' and 'beings that are soft and weak' and when one year had passed after the entrance into the department, the images of children possessed by the students were changed into the subjects of teaching by the students as teachers and images based on developmental knowledge of childhood.

• KIEAE Journal
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• v.11 no.4
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• pp.29-36
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• 2011

The aim of this study was to study the functions and roles of Green Community Rediscovery Center (GCRC) in terms of community integration, to design GCRC with various types of green roofs, and to investigate the possibility of applying a renewable energy system (e.g., PV) to the building greenery systems. The four major functional modules for GCRC were suggested: implementation of ecopark and community gardens with environmental education programs, implementation of green housing model with education programs, Discover Science Center, and implementation of green business model with education programs. Three major functions of the center are also presented in terms of design: 1) functions of community gardens; 2) establishment of a green business model, community composting system and an urban farming system; and 3) roles of community gardens in social interactions within GCRC. GCRC provides residents with the opportunities of community gardens, urban farming based on a successful recycling system, as well as a green business model and environmental education programs near their homes. The air temperature of the green roof (utilizing Sedum sarmentosum as a cover plant) was approximately $3^{\circ}C$ lower than that of the non-green roof, indicating a potential efficiency increase in PV systems for GCRC. It was concluded that the GCRC suggested would enhance the neighborhood satisfaction, improve the quality of life and contribute to social integration and community regeneration.

• Analytical Science and Technology
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• v.28 no.2
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• pp.98-105
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• 2015

The development of an enzymatic biosensor for dopamine determination based on multiwall carbon nanotubes (MWCNTs) and peroxidase obtained from the crude extract of burley tobacco (Nicotiana tabacum L.) was proposed. Peroxidase catalyzes the oxidation of dopamine to dopamine quinone. The influence on the response of analytical parameters of biosensors such as enzyme concentration, dopamine concentration, pH, and phosphate buffer solution concentration were investigated. The analytical parameters obtained, including sensitivity, linearity, and stability, were investigated. The proposed method for dopamine determination presented good selectivity even in the presence of uric acid and ascorbic acid. The sensor presented a higher response for dopamine in 0.010 M phosphate buffer at pH 6.50, with an applied potential of -0.15 V. The detection limit of the electrode was 2.7×10⁻⁶ M (S/N = 3) and the relative standard deviation of the measurements, which were repeated 10 times using 5.0×10⁻² M dopamine, was 1.3%.

• Archives of design research
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• v.16 no.4
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• pp.335-344
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• 2003

Creativity has become a buzzword in the 21s1 century to the extent that it is considered as one of the criteria for a nation's competitiveness. In the cultural industry, one of the industries with the highest growth potential, creativity is the decisive factor Nevertheless, we have to admit that there is a serious lack of this quality in the planning area. Everyone is born with creativity and creative way of looking at things can be developed through training and education. Most of universities now classify digital contents within the realm of design, therefore, emphasizing only the formal or the artistic side of it. However, the study of digital contents requires creative thinking processes that are oriented to problem-solving, for which one needs to put together his/her planning (socio-cultural), expressive (artistic) and technological (scientific) capabilities at the same time. Also, the education of digital contents should be focused not only on acquiring the knowledge and skills, but also on developing individual creativity and learning to increase one's creativity working in a team of an organization. For the environmental aspect, education for creativity should take into account social and cultural specificities of Korea. Therefore, continuous studies must be done to explore more concrete ways of developing creativity on the individual, organizational and environmental levels.

• Proceedings of the Korea Contents Association Conference
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• 2009.05a
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• pp.1070-1075
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• 2009

Design sector, one of the key factors defining national competitiveness and one of the creative industry, needs multi-functional and differentiated designers as its structure has changed to knowledge-intensive industry. Design sector is now following the trend of social change through frequent exchanges and joint researches with other sectors. However, education for human resource nurturing in the sector falls far short of social demand for change. As the industry still focuses on educating modeling issue handlers, the problems of excessive supply of human resources in particular sector and imbalance of supply and demand of human resources are adding extra difficulties to the already competitive designer employment market. Against this backdrop, this study recognized that design service sector, which began to be established as a new industry sector, has potential of becoming one of the new domains of movement for designers, explained the necessity of education in the field, and specified practical contents of design work. Also, It analyzed work contents of design service sector, classified them into each stage, and presented them to use in design professional nurturing education.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.21
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• pp.9049-9058
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• 2014

Casticin (3', 5-dihydroxy-3, 4', 6, 7-tetramethoxyflavone) is an active compound isolated from roots, stems, leaves, fruits and seeds of a variety of plants. It is well known for its pharmacological properties and has been utilized as an anti-hyperprolactinemia, anti-tumor, anti-inflammatory, neuroprotetective, analgesic and immunomodulatory agent. Recently, the anticancer activity of casticin has been extensively investigated. The resulkts showed that it exerts protective potential by targeting apoptosis, considered important for cancer therapies. In this article, our aim was to review the pharmacological and therapeutic applications of casticin with specific emphasis on its anticancer functions and related molecular mechanisms. Chemotherapeutic effects are dependent on multiple molecular pathways, which may provide a new perspective of casticin as a candidate anti-neoplastic drug. This review suggests that additional studies and preclinical trials are required to determine specific intracellular sites of action and derivative targets in order to fully understand the mechanisms of its antitumor activity and validate this compound as a medicinal agent for the prevention and treatment of various cancers.