• Archives of Pharmacal Research
• /
• 제25권5호
• /
• pp.585-589
• /
• 2002

Three hairpin polyamides were designed and synthesized by a haloform reaction and DCC/HOBt coupling reaction without amino protection and deprotection. Their anticancer activity were investigated with three kinds of cell lines-hepatic carcinoma, lung carcinoma and gastric carcinoma, and the values of $IC_{50}$ were at range of $10^{-7}~10^{-8}M$.

• Bulletin of the Korean Chemical Society
• /
• 제34권4호
• /
• pp.1263-1265
• /
• 2013

• Bulletin of the Korean Chemical Society
• /
• 제34권5호
• /
• pp.1537-1540
• /
• 2013

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권19호
• /
• pp.8051-8055
• /
• 2014

Background: A common genetic variant rs3757318, located in intron of C6orf97, was firstly identified to be associated with breast cancer (BC) risk by a genome-wide association (GWA) study. However, subsequent validation studies with different ethnicities have yielded conflicting results. Materials and Methods: We performed a meta-analysis to synthesize all available data for evaluating the precise effect of this variant on BC susceptibility. Results: A total of 8 articles containing 11 studies with 62,891 cases and 65,635 controls were included in this meta-analysis. When compared to the G allele, the rs3757318-A allele was significantly associated with BC risk with the pooled OR of 1.21 (95% CI=1.15 - 1.29, P<0.001) but with obvious between-study heterogeneity (P=0.040). Stratified analysis suggested that diversity of ethnicity along with control source may explain part of the heterogeneity. Similarly, significant associations were also identified in heterozygote, homozygote, dominant and recessive genetic models. Sensitivity and publication bias analyses indicated robust stability of our results. Conclusions: Our present meta-analysis demonstrated that the variant rs3757318 is associated with increased BC risk. Nevertheless, further studies are needed to clarify the underlying biological mechanisms.

• Asian-Australasian Journal of Animal Sciences
• /
• 제20권5호
• /
• pp.627-632
• /
• 2007

FoxO1, FoxO3a and FoxO4 belong to the FoxO gene family, which play important roles in the PI3K/PKB pathway. In this study, we cloned the porcine FoxO1, FoxO3a and FoxO4 sequences and assigned them to SSC11p11-15, SSC1p13 and SSC xq13 using somatic cell hybrid panel (SCHP) and radiation hybrid panel (IMpRH). RT-PCR results showed that these three genes are expressed in multiple tissues. Sequencing of PCR products from different breeds identified a synonymous T/C polymorphism in exon 2 of FoxO3a. This FoxO3a single nucleotide polymorphism (SNP) can be detected by AvaII restriction enzyme. The allele frequencies of this SNP were investigated in Dahuabai, Meishan, Tongcheng, Yushan, Large White, and Duroc pigs. Association of the genotypes with growth and carcass traits showed that different genotypes of FoxO3a were associated with carcass length and backfat thickness between 6th and 7th ribs (BTR) and drip loss (p<0.05).

• Bulletin of the Korean Chemical Society
• /
• 제33권2호
• /
• pp.393-397
• /
• 2012

We report a new route to synthesize high quality zinc blende CdS and ZnS nanocrystals in noncoordinating solvent 1-octadecene, using dodecanethiol (DDT) molecules as both the sulfur source and surface capping ligands. Different reaction temperatures and Cd(Zn)/DDT molar ratios were tested to optimize the synthesis conditions. Absorption photoluminescence (PL) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) pattern, and transmission electron microscopy (TEM) were used to characterize assynthesized nanocrystals. The narrow half width at the half-maximum on the long wavelength side of the firstexcitonic absorption peak and TEM images demonstrated nearly monodisperse size distributions of asprepared CdS, ZnS, and CdS/ZnS core/shell nanocrystals. Only trap emissions of the nanocrystals were detected when the amount of DDT was excessive, this came from the strong quenching effect of thiol groups on the nanocrystal surfaces. After overcoating with ZnS shells, band-gap emissions of CdS nanocrystals were partially recovered.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제10권8호
• /
• pp.3568-3584
• /
• 2016

In mobile opportunistic networks (MONs), human-carried mobile devices such as PDAs and smartphones, with the capability of short range wireless communications, could form various intermittent contacts due to the mobility of humans, and then could use the contact opportunity to communicate with each other. The dynamic changes of the network topology are closely related to the human mobility patterns. In this paper, we propose a social motivation-aware mobility model for MONs, which explains the basic laws of human mobility from the psychological point of view. We analyze and model social motivations of human mobility mainly in terms of expectancy value theory and affiliation motivation. Furthermore, we introduce a new concept of geographic functional cells, which not only incorporates the influence of geographical constraints on human mobility but also simplifies the complicated configuration of simulation areas. Lastly, we validate our model by simulating three real scenarios and comparing it with reality traces and other synthetic traces. The simulation results show that our model has a better match in the performance evaluation when applying social-based forwarding protocols like BUBBULE.

• Journal of Microbiology and Biotechnology
• /
• 제23권9호
• /
• pp.1212-1220
• /
• 2013

Because the cholesterol oxidase from Brevibacterium sp. M201008 was not as stable as the free enzyme form, it had been covalently immobilized onto chemically modified Sepharose particles via N-ethyl-N'-3-dimethylaminopropyl carbodiimide. The optimum immobilization conditions were determined, and the immobilized enzyme activity obtained was 12.01 U/g Sepharose-ethylenediamine. The immobilization of the enzyme was characterized by Fourier transform infrared spectroscopy. The immobilized enzyme exhibited the maximal activity at $35^{\circ}C$ and pH 7.5, which was unchanged compared with the free form. After being repeatedly used 20 times, the immobilized enzyme retained more than 40.43% of its original activity. The immobilized enzyme showed better operational stability, including wider thermal and pH ranges, and retained 62.87% activity after 20 days of storage at $4^{\circ}C$, which was longer than the free enzyme.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제11권4호
• /
• pp.2020-2037
• /
• 2017

In order to improve the energy efficiency of n-Epidemic routing protocol in opportunistic networks, in which a stable end-to-end forwarding path usually does not exist, a novel adjustment strategy for parameter n is proposed using learning atuomata principle. First, nodes dynamically update the average energy level of current environment while moving around. Second, nodes with lower energy level relative to their neighbors take larger n avoiding energy consumption during message replications and vice versa. Third, nodes will only replicate messages to their neighbors when the number of neighbors reaches or exceeds the threshold n. Thus the number of message transmissions is reduced and energy is conserved accordingly. The simulation results show that, n-Epidemic routing protocol with the proposed adjustment method can efficiently reduce and balance energy consumption. Furthermore, the key metric of delivery ratio is improved compared with the original n-Epidemic routing protocol. Obviously the proposed scheme prolongs the network life time because of the equilibrium of energy consumption among nodes.

• Parasites, Hosts and Diseases
• /
• 제54권6호
• /
• pp.813-817
• /
• 2016

Armillifer agkistrodontis (Ichthyostraca: Pantastomida) is a parasitic pathogen, only reported in China, which can cause a zoonotic disease, pentastomiasis. A complete mitochondrial (mt) genome was 16,521 bp comprising 13 protein-coding genes (PCGs), 22 tRNA genes, 2 rRNA genes, and 1 non-coding region (NCR). A phylogenetic tree drawn with the concatenated amino acid sequences of the 6 conserved PCGs (atp6, cox1-3, and nad2) showed that A. agkistrodontis and Armillifer armillatus constituted a clade Pentastomida which was a sister group of the Branchiura. The complete mt genome sequence of A. agkistrodontis provides important genetic markers for both phylogenetic and epidemiological studies of pentastomids.