• Journal of Ginseng Research
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• v.48 no.4
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• pp.395-404
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• 2024

Background: Ginsenoside Rg₁ (Rg₁) is one of the main active components in Chinese medicines, Panax ginseng and Panax notoginseng. Research has shown that Rg₁ has a protective effect on the cardiovascular system, including anti-myocardial ischemia-reperfusion injury, anti-apoptosis, and promotion of myocardial angiogenesis, suggesting it a potential cardiovascular agent. However, the protective mechanism involved is still not fully understood. Methods: Based on network pharmacology, ligand-based protein docking, proteomics, Western blot, protein recombination and spectroscopic analysis (UV-Vis and fluorescence spectra) techniques, potential targets and pathways for Rg₁ against myocardial ischemia (MI) were screened and explored. Results: An important target set containing 19 proteins was constructed. Two target proteins with more favorable binding activity for Rg₁ against MI were further identified by molecular docking, including mitogen-activated protein kinase 1 (MAPK1) and adenosine kinase (ADK). Meanwhile, Rg₁ intervention on H9c2 cells injured by H₂O₂ showed an inhibitory oxidative phosphorylation (OXPHOS) pathway. The inhibition of Rg₁ on MAPK1 and OXPHOS pathway was confirmed by Western blot assay. By protein recombination and spectroscopic analysis, the binding reaction between ADK and Rg₁ was also evaluated. Conclusion: Rg₁ can effectively alleviate cardiomyocytes oxidative stress injury via targeting MAPK1 and ADK, and inhibiting oxidative phosphorylation (OXPHOS) pathway. The present study provides scientific basis for the clinical application of the natural active ingredient, Rg₁, and also gives rise to a methodological reference to the searching of action targets and pathways of other natural active ingredients.

• Animal Bioscience
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• v.37 no.7
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• pp.1156-1167
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• 2024

Objective: MicroRNAs (miRNAs) are endogenous non-coding RNAs that can play a role in the post-transcriptional regulation of mammalian preadipocyte differentiation. However, the precise functional mechanism of its regulation of fat metabolism is not fully understood. Methods: We identified bta-miR-365-3p, which specifically targets the 3' untranslated region (3'UTR) of the FK506-binding protein 5 (FKBP5), and verified its mechanisms for regulating expression and involvement in adipogenesis. Results: In this study, we found that the overexpression of bta-miR-365-3p significantly decreased the lipid accumulation and triglyceride content in the adipocytes. Compared to inhibiting bta-miR-36 5-3p group, overexpression of bta-miR-365-3p can inhibit the expression of adipocyte differentiation-related genes C/EBPα and PPARγ. The dual-luciferase reporter system further validated the targeting relationship between bta-miR-365-3p and FKBP5. FKBP5 mRNA and protein expression were detected by quantitative real-time polymerase chain reaction and Western blot. Overexpression of bta-miR-365-3p significantly down-regulated FKBP5 expression, while inhibition of bta-miR-365-3p showed the opposite, indicating that bta-miR-365-3p negatively regulates FKBP5. Adenosine 5'-monophosphate (AMP)-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) signaling pathway is closely related to the regulation of cell growth and is involved in the development of bovine adipocytes. In this study, overexpression of bta-miR-365-3p significantly inhibited mRNA and protein expression of AMPK, mTOR, and SREBP1 genes, while the inhibition of bta-miR-365-3p expression was contrary to these results. Overexpression of FKBP5 significantly upregulated AMPK, mTOR, and SREBP1 gene expression, while inhibition of FKBP5 expression was contrary to the above experimental results. Conclusion: In conclusion, these results indicate that bta-miR-365-3p may be involved in the AMPK/mTOR signaling pathway in regulating Yanbian yellow cattle preadipocytes differentiation by targeting the FKBP5 gene.

• Journal of Nutrition and Health
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• v.57 no.3
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• pp.307-319
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• 2024

Purpose: This study compared the differences in health and dietary characteristics between middle-aged men and women according to their health-related quality of life. Methods: This study used the data from the 2019 and 2021 Korea National Health and Nutrition Examination Survey (KNHANES). The participants were men (n = 1,571) and women (n = 2,179) aged 40-59. A health-related Quality of Life Instrument with eight items (HINT-8) was used to measure the health-related quality of life. The participants were divided into four groups based on their HINT-8 total scores (high, mid-high, mid-low, and low). The general and health characteristics, mental health, and dietary behaviors were compared according to the quality of life. Results: Men with a lower quality of life had lower incomes, were more likely to be single, smoked and drank more, and perceived themselves as slim or obese. Women with a lower quality of life had a higher proportion of older age, obesity, lower education and income, hypercholesterolemia, and hypertriglyceridemia. Both men and women with a lower quality of life had higher proportions of subjectively perceiving poor health, weight gain over the past year, and considering themselves as obese. Both men and women with a lower quality of life had lower consumption frequencies of vegetables/mushrooms/seaweed and fruits. Conclusion: Both men and women with lower health-related quality of life had lower incomes, higher rates of perceiving their health as poor, and consumed vegetables/ mushrooms/seaweed and fruits less frequently, but they showed different characteristics in other aspects. Therefore, policy development tailored to men and women is necessary.

• The Journal of the Convergence on Culture Technology
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• v.10 no.2
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• pp.383-390
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• 2024

We conducted this study to identify factors that influence college students' willingness to perform CPR. The subjects of the study were 229 college students from J City and D City. A URL was distributed to those who agreed to the study and a non-face-to-face survey was conducted using a questionnaire form. The research results were analyzed using SPSS/WIN 23.0. 155 out of 229 people (67.7%) responded that they would perform CPR if they found a patient suffering from cardiac arrest. Factors that differences between the CPR performing group and the non-performing group include gender, grade, experience of practice, number of CPR training, period of last CPR training, Have a CPR certification, and knowledge of CPR, Confidence of CPR. There was a statistically significant difference(p<0.05). Factors affecting the willingness to perform CPR include those who have actual experience of CPR, those who have CPR certification, and the higher their confidence in CPR, the higher the willingness to perform CPR. Accordingly, in order to increase confidence in CPR, we emphasize the importance of realistic performance experience and propose the development and application of various educational methods to increase the implementation rate through sufficient simulation learning.

• The Journal of the Convergence on Culture Technology
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• v.10 no.2
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• pp.343-348
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• 2024

Today, AI image creation programs are optimized for various and specialized purposes such as fashion product advertising, customized fashion style suggestions, and design development, and are actively utilized in the fashion industry. Meanwhile, color is a powerful formative element and plays an important role in expressing images for suggesting products or fashion styles. This study seeks to expand understanding of the use of Midjourney by identifying the characteristics of color combinations that appear in clothing images created using Midjourney among AI image creation tools. The results of this study are as follows. First, the initial image created in Midjourney reflects the existing image color used to create the image more than the color specified in the command. Second, the color combinations that appear in the clothes of the images created in Midjourney are divided into separate and mixed colors. The ratio of colors expressed in a separate color scheme is affected by the color order specified in the command. The number of colors combined in a mixed color scheme appears as a combination of fewer colors than the total number of colors of clothing in the existing image used to create the image in Midjourney and the number of colors specified in the command. Third, caution is needed because changes in background color can affect the user's color perception of the clothes in the image and the formation of the costume image. It is hoped that the results of this study will be helpful in fashion design education and practice.

• Journal of the Korean Society for information Management
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• v.41 no.1
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• pp.367-387
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• 2024

This study aims to identify the recent trends and intellectual structure of international research in the field of catalog, which is undergoing a major change due to the enactment of new standards and rules and the anticipated future. For this purpose, we collected 680 articles published in the 14 years since 2010 and analyzed 1,942 author keywords extracted from them after preprocessing. The main findings of the analysis are as follows First, overseas cataloging research has seen notable growth since 2017. Second, the most frequent research topics were: cataloging, metadata, RDA, university libraries, authority control, linked data, FRBR, catalog, LCSH, libraries, andonline cataloging. Third, the research themes were divided into two clusters, one related to the traditional aspects of library cataloging and the other related to the more recently discussed topics of authority control, cooperative cataloging, RDA, and linked data, which were further subdivided into 14 subclusters. Fourth, we looked at the growth index and standard performance index of the 14 keyword clusters and found that all but one cluster showed growth in terms of discipline growth. This study is significant in that it can be used as a basis for predicting the future development of inventories for Korean academia and the field and for related education.

• Journal of the Korean Society for information Management
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• v.41 no.1
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• pp.389-409
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• 2024

The purpose of this study is to identify the factors affecting female college students' behaviors in seeking reproductive health information on the Internet and to explore the relationships among these factors. Based on the Health Belief Model(HBM) and the Theory of Planned Behavior(TPB), perceived sensitivity, perceived severity, perceived benefit, perceived barriers, subjective norms, perceived behavioral control, and affective evaluation were defined as key factors, and the study was designed accordingly. An online survey was distributed to female college students in Seoul through the university student's online community, 'Everytime.' The results showed that the intention of female college students to seek reproductive health information via the Internet was associated with higher perceived sensitivity, perceived benefit, and subjective norms, and lower perceived barriers. There were statistically significant differences between groups in terms of sexual experiences, experience with reproductive system disorders, and the level of health interest. We believe that this research outcome will contribute to assessing the level of awareness regarding reproductive health among female college students, thereby aiding in the development of online health information literacy education or related service programs by university libraries, health institutions, and similar entities targeting female college students.

• Journal of dental hygiene science
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• v.24 no.1
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• pp.37-53
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• 2024

Background: To train dental hygienists to utilize knowledge in practice, an integrated curriculum based on the competencies of dental hygienists is expanding; however, in the field of basic dental hygiene the curriculum is still fragmented and based on segmented knowledge. This study developed an integrated curriculum based on the competencies of dental hygienists in Anatomy, Histology & Embryology, Physiology, which are subjects for basic dental hygiene that have high linkage and overlap. Methods: After selecting the learning objectives for the integrated curriculum from those of Anatomy, Histology & Embryology, Physiology, the duties of the dental hygienist in relation to the learning objectives were analyzed. Learning objectives were combined with the duties of a dental hygienist to derive competencies for an integrated curriculum. Referring to the syllabus and learning objectives for each subject, the weekly educational content, learning objectives, and credits of the integrated curriculum were derived. After conducting a Delphi survey to validate the competency and content of the derived integrated curriculum, an integrated curriculum was developed. Results: By using the first and second Delphi surveys, four competencies were developed for dental hygienists that can be achieved through an integrated basic dental hygiene curriculum. In addition, an integrated curriculum including the courses Anatomy, Histology & Embryology, Physiology, Structure and Function of the Human Body/Head/Neck, and Structure and Function of the Oral Cavity was established. Conclusion: This study presents a specific example for developing a competency-based integrated curriculum that can be used as a framework to derive a competency-based integrated curriculum among subjects that can be integrated according to the linkage of learning contents and the competencies that can be achieved.

• International Journal of Computer Science & Network Security
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• v.24 no.7
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• pp.157-169
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• 2024

The article presents an analysis of innovative teaching technologies as a way to increase students' competitiveness. The author found that innovative technologies in education are information and communication technologies relying on computer-based learning. The structure, content of educational software, organization of Web-space are important when using innovative teaching technologies in English classes. We conducted the study in several stages: comparative analysis, synthesis, classification and systematization of the results of psychological and pedagogical, educational and methodological research; study of legislative acts, periodicals in order to identify the state of the research issue, and determining the directions of its solution, as well as subject, goal and objectives of the study. We used modelling to create situations of foreign language professional communication of future IT specialists. Empirical methods involved questionnaires used for identifying the motives of professional development and determining the features of the educational activities of future IT specialists in the process of training. The methods of mathematical statistics allowed to scientifically describe and systematize the obtained data, to identify the quantitative relationship between the studied phenomena, to analyse and summarize the results. We conducted a socio-psychological study during 2016 - 2019. It involved 255 first- and fourth-year students of National Technical University of Ukraine "Igor Sikorsky Kyiv Poly-technic Institute." Innovative information and communication technologies that improve the educational and cognitive activity of students, as well as increase the level of their knowledge have become important in teaching a foreign language in higher educational institutions. These technologies include MOODLE - Modular Object-Oriented Dynamic Learning Environment, business game, integrated pedagogical technology, case study technology. Thus, the information-rich learning process in combination with the use of innovative technologies, well-organized e-learning, interactive training courses, multimedia tools improves the program of teaching and learning foreign languages in general, and English in particular, improves the level of knowledge of future IT specialists and motivation to study and learn foreign languages, allows students to use a variety of authentic materials. We state that all these factors influence the process of individualization of learning and contribute to the successful mastery of a foreign language.

• Journal of Music and Human Behavior
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• v.21 no.2
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• pp.1-30
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• 2024

The purpose of this study is to develop a rhythm-based music intervention protocol to enhance timing regulation in children with ADHD and investigate its feasibility. For this purpose, a three-phase study was conducted involving ADHD children and typically developing children. In the first phase, group-specific baseline measurements were taken for auditory attention (KAT), motor timing, and perceptual timing. In the second phase, a rhythm-based music intervention protocol incorporating key factors was developed. In the third phase, the developed protocol was applied to ADHD children to investigate the variables affecting timing regulation and to verify its effectiveness. Results from the first phase revealed significant differences in the timing values of children with ADHD, particularly in tasks requiring discrimination of sound duration and precision in rhythm patterns. Additionally, exploratory factor analysis of KAT results and motor/perceptual timing identified three clusters: attentional responsiveness, attentional synchronization, and attentional sophistication. In the second phase, a protocol consisting of tasks involving synchronization, attentional shifting, and rhythm production at various difficulty levels was developed and validated for expert validity. In the third phase, individual application of the protocol to children with predominantly inattentive and hyperactive-impulsive ADHD subtypes demonstrated changes in timing regulation tasks. This study provided basic data for using rhythm as an effective facilitation tool that leads from voluntary to involuntary attention in children with ADHD.