• 제목/요약/키워드: Eastern Asia

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Comparing Role of Two Chemotherapy Regimens, CMF and Anthracycline-Based, on Breast Cancer Survival in the Eastern Mediterranean Region and Asia by Multivariate Mixed Effects Models: a Meta-Analysis

  • Ghanbari, Saeed;Ayatollahi, Seyyed Mohammad Taghi;Zare, Najaf
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권14호
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    • pp.5655-5661
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    • 2015
  • Purpose: To assess the role of two adjuvant chemotherapy regimens, anthracycline-based and CMF on disease free survival and overall survival breast cancer patients by meta-analysis approach in Eastern Mediterranean and Asian countries to determine which is more effective and evaluate the appropriateness and efficiency of two different proposed statistical models. Materials and Methods: Survival curves were digitized and the survival proportions and times were extracted and modeled to appropriate covariates by two multivariate mixed effects models. Studies which reported disease free survival and overall survival curves for anthracycline-based or CMF as adjuvant chemotherapy that were published in English in the Eastern Mediterranean region and Asia were included in this systematic review. The two transformations of survival probabilities (Ln (-Ln(S)) and Ln(S/ (1-S))) as dependent variables were modeled by a multivariate mixed model to same covariates in order to have precise estimations with high power and appropriate interpretation of covariate effects. The analysis was carried out with SAS Proc MIXED and STATA software. Results: A total of 32 studies from the published literature were analysed, covering 4,092 patients who received anthracycline-based and 2,501 treated with CMF for the disease free survival and in order to analyze the overall survival, 13 studies reported the overall survival curves in which 2,050 cases were treated with anthracycline-based and 1,282 with CMF regimens. Conclusions: The findings illustrated that the model with dependent variable Ln (-Ln(S)) had more precise estimations of the covariate effects and showed significant difference between the effects of two adjuvant chemotherapy regimens. Anthracycline-based treatment gave better disease free survival and overall survival. As an IPD meta-analysis in the Italy the results of Angelo et al in 2011 also confirmed that anthracycline-based regimens were more effective for survival of breast cancer patients. The findings of Zare et al 2012 on disease free survival curves in Asia also provided similar evidence.

Illiberalism, Post-liberalism, Geopolitics: The EU in Central Asia

  • MAKARYCHEV, ANDREY
    • Acta Via Serica
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    • 제5권1호
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    • pp.1-22
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    • 2020
  • The paper discusses how the new EU Strategy towards Central Asia issued in May 2019 might be analyzed through the lens of the intensely debated transformations from the liberal to a post-liberal international order. The author claims that the EU's normative power is transforming from the post-Cold War predominantly liberal/ value-based approach, with democracy and human rights at its core, to a set of more technical tools and principles of good governance and effective management of public administration. The paper problematizes a nexus between the dynamics of the EU's nascent post-liberalism and the geopolitical challenges of the EU's growing engagement with illiberal regimes, focuses on direct encounters between the post-liberal EU and the illiberal elites in Central Asia, and seeks to find out the impact of these connections upon the EU's international subjectivity. In this context geopolitical dimensions of EU foreign and security policies, along with the specificity of the EU's geopolitical actorship in Central Asia, are discussed.

Our Scholarly 'Pivot To Asia'

  • Xu, Weiai Wayne
    • Journal of Contemporary Eastern Asia
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    • 제18권1호
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    • pp.1-6
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    • 2019
  • During the Obama administration, America made a shift in its foreign policies to re-focus on Asia. The strategy, known as 'Pivot to Asia', was used to contain a rising China. In this editorial note, I appropriate the geopolitical term to call for a scholarly refocus on Asia (and the broader Asia Pacific region). JCEA started as an area journal. While it has become more technology-focused and less geographically-bounded in its coverage of topics, the journal recognizes the centrality of the region's political economy and technological forces in setting (and upsetting) global norms and rules. The Asia Pacific contains the world's freest economies as well as the most oppressive regimes. It breeds both technology giants and laggards. As new geopolitical tensions loom, it is where the digital iron curtain is drawn, and where the vice and virtue of innovations debated. Social scientists in the English world, who lend extensively on European and American cases, can benefit from studying the Asia Pacific by testing whether and how local experience conforms to or confronts with universal theories. Very likely, western-centric norms and models become morphed and entangled in the grounded local particularity, reflecting many shades of this diverse place. In my arguments below, I highlight the Asia Pacific as a site of contradiction, as well as a site of contention and negotiation. My emphasis is that regional particularity holds the key to answer concurrent debates in the West concerning governance and accountability in the digital age.

Japan's "Last Hope": Myanmar as an arena for Sino-Japanese competition, coordination and global standardization

  • Zappa, Marco
    • Journal of Contemporary Eastern Asia
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    • 제20권2호
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    • pp.278-297
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    • 2021
  • Despite competing strategical interests over Southeast Asia that have emerged in the last decade, with the launch of wide scope geopolitical strategies Chinese and Japanese initiatives have been characterized by a certain degree of implicit coordination, particularly in offering support to the Myanmar state's territorializing strategies for economic development. The case of the Thilawa Special Economic Zones (SEZ) is exemplary, as it was a Japan-led project which became a model and benchmark example for similar development initiatives supported by the People's Republic of China.