• 한국화재소방학회논문지
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• 제20권2호
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• pp.21-30
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• 2006

2003년 대구지하철 방화사고 이후 서울의 도시철도 7호선 방화를 비롯해 해외에서도 이와 유사한 모방 범죄가 발생하고 있다. 지하철의 방화사고는 대부분 유류나 가스 등을 이용한 방화유형이 대표적으로 발화 후 수분 내에 차량 내부가 전소될 수 있어 궁극적으로 지하철 전노선을 마비시키는 결과를 초래할 수 있다. 따라서 화재발생과 확산을 단계적으로 차단하거나 화재로부터 신속히 격리할 수 있는 효과적 초기 대응의 대안을 제시함으로서 대형 재난을 피할 수 있다. 본 연구에서는 국내외 지하철 방화 사고의 진행과정을 분석하여 대응 단계별로 방화 상태의 피해확인 및 인지 여부, 초기진화 여건 판단, 대응 조직의 상황전파 및 피난유도과정을 비상상황 등급별로 시나리오상에 전개했다.

• 대한의생명과학회지
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• 제13권2호
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• pp.157-160
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• 2007

Endoplasmic reticulum (ER) plays formation of disulfide bonds and proper folding of secretory proteins. Cellular responses to ER stress enhances the stress-activated kinase pathway and the induces a lot of immediate-early genes. Among of them, the early growth response-1 (Egr-1), a transcription factor, which plays an important role in cell growth, development, differentiation, apoptosis and various types of injury. For that reason, we have tested the expression of Egr-1 against ER stress inducible drugs (tunicamycin, DTT, A23187 and BFA) to understand what kind of aspect occurred by ER stresses.

• Journal of Plant Biology
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• 제39권3호
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• pp.215-221
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• 1996

Sorghum leaf tissues showing the early acute response of systemic infection with maize dwarf mosaic virus (MDMV) strain A, contained unusual virus-induced cytological modifications including cell wall thickenings and protrusions, intercellular vesicles termed as "paramural bodies", modified plasmodesmata, abnormal plastids, and cylindrical inclusion bodies. Abnormal cell wall, some of which associated with paramural bodies, was frequently contained modified plasmodesmata. Various abnormal plastids were located within infected cells of leaf tissues showing the early acute response. The most important changes in chloroplast seen in the tissues are the presence of small vesicles, deformation of membranes, reduction in granal stack height, disappearance of osmiophilic globules and degeneration of stuctures. The cytological modification was not occurred in nucleus but a group of degenerated mitochondria with abnormal membranes attached to cylindrical inclusion bodies were observed. It was hard more or less to prove the relationship clearly between virus and cellular organelles in virus replication.plication.

• International journal of advanced smart convergence
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• 제10권4호
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• pp.117-123
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• 2021

This study aims to analyze working hours of sprinkler heads when a fire occurs at an indoor gymnasium while sprinkler heads are installed in division of standard response type, special response type, and earlier response type. The fire scenario was designed under the assumption that the fire started from overheating of a heater in the indoor gymnasium has transferred on to a couch to spread. The analysis on the operation time of the standard response type sprinkler head, the special response type sprinkler head and the early response sprinkler head was conducted. The result showed that, in case of fire in a gymnasium, the time for opening of the heat sensor due to the heat from the fire varies by the type of the sprinkler head. When a special response type sprinkler is installed, it worked below the assessment standards. When an early response sprinkler head is installed, it worked appropriately according to assessment standards. Based on the results, we found that sprinkler heads will work properly when installed according to design relevant to laws and regulations. This means that there is a limit in installation of sprinkler heads based on the existing law-based design as for indoor gymnasiums. Again, we conclude that if sprinkler heads are installed based on design made through laws and regulations, more time will be needed for operation, making it highly likely to fail to stop a fire at an earlier point of time.

• The Korean Journal of Physiology and Pharmacology
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• 제25권6호
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• pp.525-532
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• 2021

We have investigated the relative roles of α₁-adrenoceptors and purinoceptors in contractions to low and high frequency stimulation of the mouse vas deferens, in terms of the time course of responses. In separate experiments, isometric contractile responses were obtained to 10 pulses at 1 Hz and 40 pulses at 10 Hz. Responses to 1 Hz stimulation consisted of a series of discrete peaks. The α_1A-adrenoceptor antagonist RS100329 (10^-9M-10^-7M) significantly reduced the response to the first pulse, the α_1D-adrenoceptor antagonist BMY7378 (10^-7M-10^-6M) significantly reduced the response to the first two pulses, and the non-selective α₁-adrenoceptor antagonist prazosin (10^-8M) reduced the response to the first 4 pulses at 1 Hz. Responses to 10 Hz stimulation consisted of an early peak response and a maintained plateau response. RS100329 significantly reduced the peak response but did not significantly affect the plateau response. Prazosin, significantly reduced both the peak and plateau responses. The α_1A-adrenoceptor antagonist RS17053 in high concentrations reduced mainly the plateau response leaving a clear early peak response. The plateau response of contraction was almost abolished by the purinoceptor antagonist suramin. These results suggest that there is a relatively minor early α_1D-adrenoceptor and a larger early α_1A-adrenoceptor component to stimulationevoked contractions of mouse vas deferens, but the major α₁-adrenoceptor component is revealed by prazosin to be α_1B-adrenoceptor mediated. α_1B-Adrenoceptor activation probably facilitates contractions mediated by other α₁-adrenoceptors and by purinoceptors. These results suggest that combined non-selective α₁-adrenoceptor blockade, particularly α_1B-adrenoceptor blockade, in addition to P2X1-purinoceptor blockade is useful in reducing male fertility.

• 천문학회보
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• 제37권2호
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• pp.66-66
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• 2012

We describe the space project of Ultra-Fast Flash Observatory (UFFO), which will observe early optical photons from gamma-ray bursts (GRBs) with a sub-second optical response, for the first time. The UFFO will probe the early optical rise of GRBs, opening a completely new frontier in GRB and transient studies, using a fast-response rotatable mirror system which redirects opitical path to telescope instead of slewing of telescopes or spacecraft. In our small UFFO-Pathfinder experiment, scheduled to launch aboard the Lomonosov satellite in June 2012, we use a motorized mirror in our Slewing Mirror Telescope instrument to achieve less than one second optical response after X-ray trigger. We describe the science and the mission of the UFFO project, including a serious version called UFFO-100 which will be launched in 2014. With our program of ultra-fast optical response GRB observatories, we aim to gain a deeper understanding of GRB mechanisms, and potentially open up the z>10 universe to study via GRB as point source emission probes.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6263-6267
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• 2014

Background: It is standard treatment to combine chemotherapy (CT) and thoracic radiotherapy (TRT) in treating patients with limited stage small cell lung cancer (LS-SCLC). However, optimal timing of TRT is unclear. We here evaluated the survival impact of early versus late TRT in patients with LS-SCLC. Materials and Methods: Follow-up was retrospectively analyzed for seventy consecutive LS-SCLC patients who had successfully completed chemo-TRT between January 2006 and January 2012. Patients received TRT after either 1 to 2 cycles of CT (early TRT) or after 3 to 6 cycles of CT (late TRT). Survival and response rates were evaluated using the Kaplan-Meier method and comparisons were made using the multivariate Cox regression test. Results: Median follow-up was 24 (5 to 57) months. Carboplatin+etoposide was the most frequent induction CT (59%). Median overall, disease free, and metastasis free survivals in all patients were 15 (5 to 57), 5 (0 to 48) and 11 (3 to 57) months respectively. Late TRT was superior to early TRT group in terms of response rate (p=0.05). 3 year overall survival (OS) rates in late versus early TRT groups were 31% versus 17%, respectively (p=0.03). Early TRT (p=0.03), and incomplete response to TRT (p=0.004) were negative predictors of OS. Significant positive prognostic factors for distant metastasis free survival were late TRT (p=0.03), and use of PCI (p=0.01). Use of carboplatin versus cisplatin for induction CT had no significant impact on OS (p=0.634), DFS (p=0.727), and MFS (p=0.309). Conclusions: Late TRT appeared to be superior to early TRT in LS-SCLC treatment in terms of complete response, OS and DMFS. Carboplatin or cisplatin can be combined with etoposide in the induction CT owing to similar survival outcomes.

• 한국화재소방학회논문지
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• 제22권5호
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• pp.99-104
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• 2008

최근 우리나라는 고령화 사회에 빠르게 진입되었다. 농촌지역의 노인 응급환자 초기 대응 시스템 개선을 위해 마을 방송 장비의 활용과 노인을 위한 응급처치 교육방법의 개선으로 보다 많은 민간구조자원을 확보하여 응급상황 발생시 초기대응 능력을 향상시키고자 본 연구를 실시하였다. 현재 우리나라 119의 노인 응급의료서비스 실태를 살펴보고, 고령화 시대 사회적 안전장치의 역할을 충실히 수행할 수 있는 노인 안전을 위한 구급서비스 개선 방안 및 노인안전 센터 개설로 인한 노인안전 인프라 구축 방안을 모색하고자 하는데 본 연구의 목적이 있다.

• 약학회지
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• 제43권6호
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• pp.843-850
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• 1999

We investigated whether endothelium-derived NO and endothelin-1 might result enhanced vasoconstriction induced by administration of norepinephrien (NE) at the early stage of one-kidney, one-clip (1K1C) renal hypertensive rats. We also studied the relation ship of renin-angiotensin system (RAS) using rat aorta in this hypothesis. L-NMMA (30$\mu$M) and L-NAME(30${\mu}M$) enhanced vasoconstriction induced by NE in thoracic aorta of control rats. However angiotensin converting enzyme (ACE) inhibitor didn't. The aorta of 1KIC rats showed a singnificantly exaggerated contractile response to NE as compared with control rats. Rub-bing the endothelium abolished this difference. Ach and SNP-induced vasorelaxation show no significant difference between 1KIC and control rats. The treatment of phosphoramidon (10${\mu}M$) and oral administration of captopril (0.05, w/v%) abolished the exaggerated contractile response to NE at early stage of 1KIC rats. These results suggest that the increase of contractile response at the early phase in 1KIC rat is partially involved in the activation of ACE.

• Restorative Dentistry and Endodontics
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• 제12권1호
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• pp.149-153
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• 1986

Clinical analysis on early evidence of the pulp response to composite resin filling (27 cases) was made and reached to the results as follow; 1. Under age 40's early symptome was reported within the 1st, 2nd, 3rd and 4th week after composite filling evenly and age 50's reported after 4th week. 2. Sensitive response to cold were 11 cases, to warm 3 cases and to both (cold, warm) were 9 cases. 3. Tenderness to percussion and light pressure on apical area were 5 cases.