• Tuberculosis and Respiratory Diseases
• /
• 제78권4호
• /
• pp.459-462
• /
• 2015

Ankylosing spondylitis is a chronic inflammatory multisystem disease that primarily affects the axial joints. Pleuropulmonary involvement is an uncommon extra-articular manifestation of ankylosing spondylitis. There is a wide spectrum of pulmonary parenchymal changes in ankylosing spondylitis, beginning in the early stages of the disease and increasing over time. The lesions are usually asymptomatic, and not visible on chest radiographs in early stages. We reported a case of advanced ankylosing spondylitis in a 56-year-old man with progressive pulmonary bullous fibrocystic changes on both upper lobes that were misdiagnosed as tuberculosis in the early stages of the disease.

• Annals of Clinical Neurophysiology
• /
• 제4권2호
• /
• pp.98-107
• /
• 2002

Multifocal motor neuropathy (MMN) is a chronic immune-mediated peripheral myelinopathy. The major clinical features include slowly progressive, painless, and asymmetric weakness, usually of distal limb muscle. Early in the course of the disease, weakness is not necessarily associated with muscle atrophy, owing to the initial primary involvement of peripheral myelin. Chronic progressive weakness is often associated with some degree of concurrent axonal loss and subsequent muscle atrophy. Sensory symptoms are usually mild or absent, and involvement of cranial and respiratory muscles is rare. The findings of multifocal motor conduction block, abnormal temporal dispersion, and focal conduction slowing at segments not at risk for common entrapment or compression injury, associated with normal sensory conduction studies along the same segments, are the hallmark electrophysiologic features of MMN. The slow progression and absence of upper motor neuron signs are the major clinical points that separate MMN from amyotrophic lateral sclerosis. The role of GM1 antibodies, found in high titers in 22~84% of MMN patients, remains uncertain. The contention that MMN is an autoimmune disorder is largely based on the often dramatic improvement in symptoms following the administration of intravenuos immunoglobulin or cyclophosphamide.

• Industrial Engineering and Management Systems
• /
• 제10권3호
• /
• pp.191-196
• /
• 2011

The purpose of this paper is to study user's involvement in new product development (NPD). It seeks to identify the factors involving user and design practices in the design process of new product development. A survey was conducted on 20 respondents consisting of designers involved in product development from various industries. The study focused on the early activities of the product design process which is called product specification. The analysis performed considers the importance of involving users in design decision. The outcome of this research is the significance of involving users and its effect on product development activities. The research also provides a model for an integrated user, designer and product knowledge activity in the product development process.

• Journal of Korean Neurosurgical Society
• /
• 제56권1호
• /
• pp.61-65
• /
• 2014

Neurocutaneous melanosis (NCM) is a rare congenital syndrome consisting of benign or malignant melanotic tumors of the central nervous system with large or numerous cutaneous melanocytic nevi. The Dandy-Walker complex (DWC) is characterized by an enlarged posterior fossa with high insertion of the tentorium, hypoplasia or aplasia of the cerebellar vermis, and cystic dilatation of the fourth ventricle. These each two conditions are rare, but NCM associated with DWC is even more rare. Most patients of NCM with DWC present neurological symptoms early in life such as intracranial hemorrhage, hydrocephalus, and malignant transformation of the melanocytes. We report a 14-year-old male patient who was finally diagnosed as NCM in association with DWC with extensive intracerebral and spinal cord involvement.

• Parasites, Hosts and Diseases
• /
• 제51권3호
• /
• pp.349-352
• /
• 2013

We present here a 44-year-old male patient with hydatid disease who was referred to our hospital due to dyspnea and chest pain for the last 2 month before admission. Using echocardiography and contrast-enhanced computed tomography the heart hydatid was diagnosed. However, hydatid disease of the interventricular septum is rare; particularly, the involvement of mitral apparatus with mitral regurgitation (MR) is an exceptionally rare presentation. Early diagnosis and an integrated treatment strategy are crucial. Surgical excision was performed and the patient had an uneventful recovery and follow-up at 3 months.

• Archives of Pharmacal Research
• /
• 제3권1호
• /
• pp.51-55
• /
• 1980

Thiamine, in the form of its diphosphate (TDP), is well known to act as a coenzyme, and during the early stage in the study of thiamine it had been believed that the symptoms of thiamine-deficiency were resulted secondarily from the disturbance of metabolic processes in which TDP participated as a coenzyme. However, the neurological symptoms in thiamine deficiency are now separated from the metabolic disturbances in thiamine deficiency. On the other hand, the specific involvement of phosphorylated thiamine in nerve conduction has been suggested by von Muralt, but nature of this involvement has not been elucidated at a molecular level. Recently the possible significance of thiamine triphosphate (TTP) in nervous tissue was suggested by the demonstration that TTP is not present in the brain of patients with subacute necrotizing encephalomyelitis, a fatal disease associated with an abnormality in thiamine metabolism. Furthermore, the studies using membrane fragments of rat brain strongly indicated that ion movement across the nerve membrane is associated with dephosphorylation of phosphorylated thiamine.

• International Journal of Advanced Culture Technology
• /
• 제6권4호
• /
• pp.45-51
• /
• 2018

The purpose of the study was to examine the effects of family related factors (mothers' self-esteem, mothers' parenting stress, mothers' marital satisfaction, fathers' parenting involvement, and social support) on mothers' postpartum depression. The subjects were 797 households that were extracted from the $1^{st}$ wave of the Panel Study of Korean Children (PSKC). The study variables were measured using the survey questionnaires, and analyses of Pearson's correlation and multiple regression were conducted. Results showed that family related factors significantly predicted mothers' postpartum depression. Moreover, the most significant predictor was mothers' parenting stress, followed by marital satisfaction, self-esteem, fathers' parenting involvement, and social support. Study findings indicate that mothers' postpartum depression is attributed to not only personal but also family related factors. Our results suggest importance of parent education and family support along with social support.

• Investigative Magnetic Resonance Imaging
• /
• 제23권2호
• /
• pp.100-113
• /
• 2019

Sarcoidosis is a multisystem disease characterized by noncaseating granulomas. Cardiac involvement is known to have poor prognosis because it can manifest as a serious condition such as the conduction abnormality, heart failure, ventricular arrhythmia, or sudden cardiac death. Although early diagnosis and early treatment is critical to improve patient prognosis, the diagnosis of CS is challenging in most cases. Diagnosis usually relies on endomyocardial biopsy (EMB), but its diagnostic yield is low due to the incidence of patchy myocardial involvement. Guidelines for the diagnosis of CS recommend a combination of clinical, electrocardiographic, and imaging findings from various modalities, if EMB cannot confirm the diagnosis. Especially, the role of advanced imaging such as cardiac magnetic resonance (CMR) imaging and positron emission tomography (PET), has shown to be important not only for the diagnosis, but also for monitoring treatment response and prognostication. CMR can evaluate cardiac function and fibrotic scar with good specificity. Late gadolinium enhancement (LGE) in CMR shows a distinctive enhancement pattern for each disease, which may be useful for differential diagnosis of CS from other similar diseases. Effectively, T1 or T2 mapping techniques can be also used for early recognition of CS. In the meantime, PET can detect and quantify metabolic activity and can be used to monitor treatment response. Recently, the use of a hybrid CMR-PET has introduced to allow identify patients with active CS with excellent co-localization and better diagnostic accuracy than CMR or PET alone. However, CS may show various findings with a wide spectrum, therefore, radiologists should consider the possible differential diagnosis of CS including myocarditis, dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy, amyloidosis, and arrhythmogenic right ventricular cardiomyopathy. Radiologists should recognize the differences in various diseases that show the characteristics of mimicking CS, and try to get an accurate diagnosis of CS.

• International Journal of Human Ecology
• /
• 제17권1호
• /
• pp.39-51
• /
• 2016

This pilot study examined programs for early childhood education and care in three Chinese cities. The samples for this study were one university-based kindergarten, one private kindergarten (rural area), and one public kindergarten (urban area). Six types of instruments were used to assess early childhood education and care services regarding quality matters. Most questions asked were open-ended; consequently, the interview answers by kindergarten directors or teachers (as well as observations made by the researcher) formed the basis for collecting the data. Quality components for each program were determined by a comparison method. The comparison allowed the researcher to understand the range of quality education and care available as well as the variability of existing kindergarten programs in China. The findings of the investigation revealed important information on; (a) demographic information (fees, class hours, total weeks of class, vacation, number of children and staff, class size, and teacher-child ratio) (b) teacher characteristics, (c) health practices, (d) safety practices, (e) work environment, (f) physical settings, (g) play materials, (h) parent involvement, (i) nutrition, (j) daily schedule. Implications within the Chinese context for quality practices and issues to further develop and strengthen early childhood education and care systems are discussed.

• 대한가정학회지
• /
• 제50권2호
• /
• pp.25-38
• /
• 2012

The purpose of this study was to investigate how parents saw the relationship between early years educational institutions and parents, and how these perceptions were influenced by parental background factors. A total of 334 parents who sent their child to a kindergarten participated in this study. The collected data were analyzed by Chisquared test, t-test, and one-way ANOVA. The results of this study were as follows. First, parents had a high level of interest in their child's education, but little actual knowledge about the contents and strategies of education in the kindergarten setting. Second, regarding parental participation in early childhood education institutions, necessity for parents's involvement in the institutions was relatively higher than the average. Third, when considering the relationship between staff in early childhood education institutions, i.e. kindergartens, and parents both teachers and parents hoped to form a relationship in which they could freely exchange their opinions.