• 대한영상의학회지
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• 제83권1호
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• pp.42-53
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• 2022

관상동맥질환의 임상적인 개념은 지난 10년 동안 패러다임의 변화를 보여왔다. 관상동맥질환은 대부분 진행성 질환이며, 관상동맥질환 환자는 질병 진행의 어느 시점에서도 급성 관상동맥 증후군에 직면할 수 있다. 이러한 임상적 맥락에서 2019년 유럽심장학회 가이드라인에서는 조기 진단과 꾸준한 관리가 필요한 관상동맥질환의 임상적인 중요성을 반영하여 "만성관상동맥증후군"이라는 용어의 사용을 발표하였다. 최근 관상동맥 전산화단층촬영 혈관조영술을 이용한 관상동맥질환의 평가는 많은 발전을 이루었고, 안정형 협심증 또는 만성 관상동맥증후군 환자에서 관상동맥 전산화단층촬영 혈관조영술의 임상적 유용성은 초기 무증상 관상동맥질환의 발견에서부터 죽상경화판의 특성 분석 및 관상동맥질환의 치료 전략 결정에 도움을 주는 역할까지 관상동맥질환의 다양한 단계에 걸쳐 입증되고 있다. 이 종설에서는 안정형 협심증 환자의 이해를 돕는 병태생리를 설명하고 이에 대한 관상동맥 전산화단층촬영의 임상적 적용과 역할에 대해 알아보고자 한다.

• 대한소아치과학회지
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• 제43권4호
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• pp.461-466
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• 2016

치아 우식증은 어린이와 청소년에서 일생에 거쳐 지속되는 질병이며 가장 중요한 치과질환이다. 유치열기의 치아우식증은 영구치에도 영향을 미치기 때문에 유치의 치아우식증을 조기에 진단하는 것은 매우 중요하다. 또한 예방을 하는 것이 매우 중요한데 치아 우식증을 조기에 발견하여 우식 위험율이 높은 아이들에서 적극적으로 불소 도포, 치면 열구 전색 등을 미리해주는 것이 중요하다. 치아우식증을 조기에 발견하기 위한 방법들이 많이 개발되어 왔지만 더 효율적인 방법을 찾기 위해 여전히 많은 연구가 진행 중이다. 일반적으로 시진과 방사선 사진을 많이 사용해왔지만 시진의 부정확성과 방사선의 조사량 등 많은 한계점을 보이고 있다. 이번 연구에서는 치아 우식증에 있어서 새로 개발된 DIAGNOcam의 임상적 적용에 대해 알아보고 그 활용 가능성을 알아보고자 하였다. 소아치과에 내원한 환자들을 대상으로 구치부에 DIAGNOcam을 이용하여 진단한 결과 인접면 우식, 수복물의 변연 확인 및 우식의 범위 확인에 유용하게 사용될 수 있다는 점을 확인하였다.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제3권10호
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• pp.421-428
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• 2014

파킨슨병은 뇌의 흑질 영역에서 도파민계 신경이 파괴되는 질병으로 알츠하이머병과 함께 대표적인 퇴행성 뇌 질환이다. 현재까지 병을 완치시킬 수 있는 치료법은 없지만 병의 진행을 완화시킬 수 있는 치료법이 존재하기 때문에 병의 진단이 굉장히 중요하다. 파킨슨병을 진단하기 위한 과거의 연구는 대부분 단일 바이오마커를 이용한 것으로 이러한 방법은 파킨슨병 환자를 높은 정확도로 진단할 수 있지만 정상인에 대한 진단은 상대적으로 낮은 성능의 한계성이 존재한다. 따라서 본 연구에서는 생화학적 바이오마커인 뇌척수액 내의 ${\alpha}$-synuclein 단백질 수치와 영상학적 바이오마커인 확산 텐서 영상의 여러 모수들을 결합하여 특징으로 사용하는 파킨슨병 진단 모델을 개발하고 성능을 평가하였다. 진단을 위해 개발된 모든 모델은 10-fold cross validation 성능평가에서 정확도가 최고 91.3%의 높은 성능을 보였으며, test 성능평가에서는 확산 텐서 영상의 모수들 중 FA와 ${\alpha}$-synuclein 단백질 수치가 결합된 모델, MO와 ${\alpha}$-synuclein 단백질 수치가 결합된 두 모델에서 최고 72%의 정확도 성능을 보여 파킨슨병의 진단에 유용하게 사용될 수 있는 가능성을 제시하였다. 파킨슨병의 진단을 위해 개발된 모델의 영상학적 특징 벡터를 통하여 파킨슨병 환자와 정상인의 신경섬유 경로의 특징을 분석하였다.

• 식물병연구
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• 제20권3호
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• pp.173-181
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• 2014

The early and accurate detection of plant viruses is an essential component to control those. Because the globalization of trade by free trade agreement (FTA) and the rapid climate change promote the country-to-country transfer of viruses and their hosts and vectors, diagnosis of viral diseases is getting more important. Because symptoms of viral diseases are not distinct with great variety and are confused with those of abiotic stresses, symptomatic diagnosis may not be appropriate. From the last three decades, enzyme-linked immunosorbent assays (ELISAs), developed based on serological principle, have been widely used. However, ELISAs to detect plant viruses decrease due to some limitations such as availability of antibody for target virus, cost to produce antibody, requirement of large volume of sample, and time to complete ELISAs. Many advanced techniques allow overcoming demerits of ELISAs. Since the polymerase chain reaction (PCR) developed as a technique to amplify target DNA, PCR evolved to many variants with greater sensitivity than ELISAs. Many systems of plant virus detection are reviewed here, which includes immunological-based detection system, PCR techniques, and hybridization-based methods such as microarray. Some of techniques have been used in practical, while some are still under developing to get the level of confidence for actual use.

• 방사선산업학회지
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• 제17권4호
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• pp.391-396
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• 2023

Currently, state-of-the-art devices such as SPECT, PET/CT, and PET/MRI are rapidly spreading nationwide, and the penetration rate of nuclear medical devices is also ranked fifth in the world. However, PET/MRI's system is slower and less common because it is more complex than PET/CT. The purpose of this study is to provide optimal information on PET/MRI according to the patient's disease. The subjects obtained information on head and neck cancer, pediatric patients, breast cancer patients, heart disease patients, lung cancer patients, and rectal cancer patients. We tried to accumulate protocols by obtaining a lot of information about each disease. In diagnosing head and neck cancer, it is believed that it is highly likely to be used in evaluating preoperative stage determination, recurrence and remote metastasis after treatment, and unclear primary cervical lymph node metastasis. Diagnosis and continuous follow-up of pediatric patients can increase patient benefits by minimizing radiation exposure. Breast cancer provides a comprehensive evaluation of the clinical need to determine the extent of disease in breast and local lymph nodes and the systematic stages of early diagnosis or recurrence. In diagnosing heart disease patients, MR-based PET motion correction helps to realize the full potential of PET images. For lung cancer patients, the clinical value and usefulness of the resolution and detection ability of integrated PET/MRI for soft tissues such as lung cancer will be sufficient. In diagnosing rectal cancer patients, the detection of missing residual diseases can change the clinical response evaluation for rectal cancer patients treated with TNT, and both the initial stage and treatment response evaluation are possible. Therefore, this literature study provided basic clinical data for PET/MRI tests.

• 한국균학회소식:학술대회논문집
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• 한국균학회 2014년도 추계학술대회 및 정기총회
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• pp.36-36
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• 2014

Apple blotch, caused by Marssonina coronaria, induce early defoliation in apple and leading to critical economic losses in apple orchards in Korea. Since M. coronaria is difficult to culture, we developed isolation and cultural method. We collected M. coronaria isolates from Gyeongbuk Province and then constructed phylogentic tree based on ITS regions. As the results, phylogenetic relationship indicated that all Korean isolates formed a same cluster and closely related to Chinese isolates [1]. Ecological characteristic of M. coronaria have been observed in apple orchards which located in Gyeongbuk Province from 2011 to present. As the results, the typical apple blotch symptoms were observed from July, and then the infected leaves were discolored and formed acervuli on the leaves. After rainfall, severe infection of symptoms such as discoloration and early defoliation were continuously observed until October. Also overwintered conidia were observed in next March on the fallen diseased leaves [2]. In the last 5 years, ascopores of M. coronaria were not observed in apple orchards which were severely infected by M. coronaria in Korea. Thus, it is assumed that overwintered conidia could be a primary inoculum of M. coronaria. Meanwhile, apple blotch has long latent periods compare to other apple disease. During the latent period, early diagnosis of apple blotch is the most important to control the disease by spray fungicide. In this reason, we developed novel diagnostic method to detect M. coronaria during latent period using optical coherence tomography (OCT) and Loop-mediated isothermal amplification (LAMP) method [2, 3]. In this presentation, it will introduce ecological characterization of M. coronaria in Korea and unique detection technique of M. coronaria in apple. It will be helpful to develop new strategies to control apple blotch in Korea.

• Clinical and Experimental Pediatrics
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• 제54권8호
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• pp.322-328
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• 2011

Nephrotic syndrome (NS) is one of the most common glomerular diseases that affect children. Renal histology reveals the presence of minimal change nephrotic syndrome (MCNS) in more than 80% of these patients. Most patients with MCNS have favorable outcomes without complications. However, a few of these children have lesions of focal segmental glomerulosclerosis, suffer from severe and prolonged proteinuria, and are at high risk for complications. Complications of NS are divided into two categories: disease-associated and drug-related complications. Disease-associated complications include infections (e.g., peritonitis, sepsis, cellulitis, and chicken pox), thromboembolism (e.g., venous thromboembolism and pulmonary embolism), hypovolemic crisis (e.g., abdominal pain, tachycardia, and hypotension), cardiovascular problems (e.g., hyperlipidemia), acute renal failure, anemia, and others (e.g., hypothyroidism, hypocalcemia, bone disease, and intussusception). The main pathomechanism of disease-associated complications originates from the large loss of plasma proteins in the urine of nephrotic children. The majority of children with MCNS who respond to treatment with corticosteroids or cytotoxic agents have smaller and milder complications than those with steroid-resistant NS. Corticosteroids, alkylating agents, cyclosporin A, and mycophenolate mofetil have often been used to treat NS, and these drugs have treatment-related complications. Early detection and appropriate treatment of these complications will improve outcomes for patients with NS.

• Clinical Endoscopy
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• 제55권4호
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• pp.532-539
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• 2022

Background/Aims: Capsule enteroscopy (CE) and intestinal ultrasonography (IUS) are techniques that are currently used for investigating small-bowel (SB) diseases. The aim of this study was to compare the main imaging findings and the lesion detection rate (LDR) of CE and IUS in different clinical scenarios involving the SB. Methods: We retrospectively enrolled patients who underwent CE and IUS for obscure gastrointestinal bleeding (OGIB), complicated celiac disease (CeD), and suspected or known inflammatory bowel disease (IBD). We evaluated the LDR of both techniques. The accuracy of IUS was determined using CE as the reference standard. Results: A total of 159 patients (113 female; mean age, 49±19 years) were enrolled. The LDR was 55% and 33% for CE and IUS (p<0.05), respectively. Subgroup analysis showed that the LDR of CE was significantly higher than that of IUS in patients with OGIB (62% vs. 14%, p<0.05) and CeD (55% vs. 35%, p<0.05). IUS showed a similar LDR to CE in patients with suspected or known IBD (51% vs. 46%, p=0.83). Conclusions: CE should be preferred in cases of OGIB and CeD, whereas IUS should be considered an early step in the diagnosis and follow-up of IBD even in patients with a proximal SB localization of the disease.

• Safety and Health at Work
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• 제10권4호
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• pp.461-469
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• 2019

Background: Collisions involving workers and mobile machines continue to be a major concern in underground coal mines. Over the last 30 years, these collisions have resulted in numerous injuries and fatalities. Recently, the Mine Safety and Health Administration (MSHA) proposed a rule that would require mines to equip mobile machines with proximity detection systems (PDSs) (systems designed for automated collision avoidance). Even though this regulation has not been enacted, some mines have installed PDSs on their scoops and hauling machines. However, early implementation of PDSs has introduced a variety of safety concerns. Past findings show that workers' trust can affect technology integration and influence unsafe use of automated technologies. Methods: Using a mixed-methods approach, the present study explores the effect that factors such as mine of employment, age, experience, and system type have on workers' trust in PDSs for mobile machines. The study also explores how workers are trained on PDSs and how this training influences trust. Results: The study resulted in three major findings. First, the mine of employment had a significant influence on workers' trust in mobile PDSs. Second, hands-on and classroom training was the most common types of training. Finally, over 70% of workers are trained on the system by the mine compared with 36% trained by the system manufacturer. Conclusion: The influence of workers' mine of employment on trust in PDSs may indicate that practitioners and researchers may need to give the organizational and physical characteristics of each mine careful consideration to ensure safe integration of automated systems.

• 한국전자통신학회논문지
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• 제14권5호
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• pp.959-968
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• 2019

농업 분야에서 여러 가지 센서들과 임베디드 시스템을 활용하여 한 무선 센서 네트워크 기술이 적용되고 있는 추세이다. 특히, 센서 네트워크를 활용하여 작물의 질병을 조기에 진단할 수 있는 많은 연구가 진행되고 있다. 기존 병충해 진단 연구들은 실제 농가에 적용하기 어려운 부분이 존재한다. 본 논문은 이를 개선하고자 하였으며, 화상카메라를 통해 받아온 작물의 잎사귀 이미지를 분석하여 병충해를 초기에 감지 가능한 알고리즘을 제안한다. 실제 시설원예 및 노지 환경 농가의 캡쳐한 이미지 내에서 감염 의심 영역을 개선된 K 평균 클러스터링 기법을 통해 분류하였다. 그 후 엣지 검출, 엣지 추적 기법을 활용하여 해당 영역의 잎사귀 내부 존재 여부를 확인하였다. 인근 농가에서 촬영한 토마토 잎사귀 이미지를 이용하여 성능 평가를 수행하였다. 기존 논문의 방법 보다 제안 알고리즘의 감영 영역 분류 능력이 우수한 것으로 나타났다.