• 기술혁신학회지
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• 제10권2호
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• pp.284-309
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• 2007

본 연구는 2002년부터 5년간 운영된 권역별 공공기술이전컨소시엄의 실증분석을 통하여 기술이전컨소시엄의 유효성과 주요 특성요인을 살펴보고자 한다. 유효성 검정은 기술이전프로세스를 토대로 하여 개발된 기술이전효율성지수가 컨소시엄의 운영기간 동안 변화한 정도로 판단하였고, 특성요인의 탐색은 기술이전 메커니즘 연구의 핵심변수인 가입동기, 촉진요인, 장애요인 및 극복과제를 사용하여 이루어졌다. 그 결과, 기술이전컨소시엄에 참여한 대학 또는 정부연구기관의 기술 이전효율성지수가 참여하지 않은 기관에 비하여 더욱 큰 증가를 보였으며, 조사된 특성요인들도 컨소시엄의 직접참여자 그룹과 간접참여자 그룹간에 인식 차가 거의 없는 것으로 판명되었다. 본 연구는 기술이전컨소시엄이 새로운 기술이전 메커니즘으로서의 유의미성과 공통적 특성을 갖는지를 탐색해 보았다는 것에 그 의의가 있다.

• 한국가축번식학회지
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• 제24권4호
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• pp.357-364
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• 2000

Members of the glycoprotein family, which includes CG, LH, FSH and TSH, comprise two noncovalently linked $\alpha$- and $\beta$-subunits. Equine chorionic gonadotropin (eCG), known as PMSG, has a number of interesting and unique characteristics since it appears to be a single molecule that possesses both LH- and FSH-like activities in other species than the horse. This dual activity of eCG in heterologous species is of fundamental interest to the study of the structure-function relationships of gonadotropins and their receptors. CG and LH $\beta$ genes are different in primates. In horse, however, a single gene encodes both eCG and eLH $\beta$ -subunits. The subunit mRNA levels seem to be independently regulated and their imbalance may account for differences in the quantities of $\alpha$ - and $\beta$-subunits in the placenta and pituitary. The dual activities of eCG could be separated by removal of the N-linked oligosaccharide on the $\alpha$-subunit Asn 56 or CTP-associated O-linked oligosaccharides. The tethered-eCG was efficiently secreted and showed similar LH-like activity to the dimeric eCG. Interestingly, the FSH-like activity of the tethered-eCG was increased markedly in comparison with the native and wild type eCG. These results also suggest that this molecular can implay particular models of FSH-like activity not LH-like activity in the eCG/indicate that the constructs of tethered molecule will be useful in the study of mutants that affect subunit association and/or secretion. A single-chain analog can also be constructed to include additional hormone-specific bioactive generating potentially efficacious compounds that have only FSH-like activity. The LH/CG receptor (LH/CGR), a membrane glycoprotein that is present on testicular Leydig cells and ovarian theca, granulosa, luteal, and interstitial cells, plays a pivotal role in the regulation of gonadal development and function in males as well as in nonpregnant and pregnant females. The LH/CGR is a member of the family of G protein-coupled receptors and its structure is predicted to of a large extracellular domain connected to a bundle of seven membrane-spanning a-helices. The LH/CGR phosphorylation can be induced with a phorbol ester, but not with a calcium ionophore. The truncated form of LHR also was down-regulated normally in response to hCG stimulation. In contrast, the cell lines expressing LHR-t631 or LHR-628, the two phosphorylation-negative receptor mutant, showed a delay in the early phase of hCG-induced desensitization, a complete loss of PMA-induced desensitization, and an increase in the rate of hCG-induced receptor down-regulation. These results clearly show that residues 632~653 in the C-terminal tail of the LHR are involved in PMA-induced desensitization, hCG-induced desensitization, and hCG-induced down-regulation. Recently, constitutively activating mutations of the receptor have been identified that are associated with familial male-precocious puberty. Cells expressing LHR-D556Y bind hCG with normal affinity, exhibit a 25-fold increase in basal cAMP and respond to hCG with a normal increase in cAMP accumulation. This mutation enhances the internalization of the free and agoinst-occupied receptors ~2- and ~17- fold, respectively. We conclude that the state of activation of the LHR can modulate its basal and/or agonist-stimulated internalization. Since the internalization of hCG is involved in the termination of hCG actions, we suggest that the lack of responsiveness detected in cells expressing LHR-L435R is due to the fast rate of internalization of the bound hCG. This statement is supported by the finding that hCG responsiveness is restored when the cells are lysed and signal transduction is measured in a subcellular fraction (membranes) that cannot internalize the bound hormone.

• 대한핵의학회지
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• 제33권1호
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• pp.40-48
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• 1999

목적: 운동부하 심전도검사에 나타나는 ST-분절의 하강은 운동부하의 정도에 영향을 받는다. 그러나 운동부하의 정도가 운동부하 심근관류영상의 관동맥 질환 진단능에 미치는 영향은 보고자마다 달라 아직도 논란이 되고있다. 본 연구는 운동부하의 정도가 심근관류 영상의 관상동맥 질환 진단능에 미치는 영향을 규명하고자 시행하였다. 대상 및 방법: 111명(남자 73명, 여자 38명, 평균연령: 56세)의 안정된 환자를 대상으로 운동부하검사와 함께 Tc-99m MIBI를 이용한 심근관류 스캔을 실시하고 3개월 이내에 관상동맥촬영술을 실시하였다. 운동부하의 정도는 운동시 최대 예측 심박수의 85%에 도달했는가를 기준으로 하고, 운동심전도 소견을 첨가하여 4군으로 구분하고 각각의 군에서의 진단능을 비교하였다. 결과: 1) Tc-99m MIBI 심근관류스캔의 예민도와 특이도는 심전도검사의 소견이나 심박수의 증가정도에 따른 차이는 없었다. 2) 운동부하 Tc-99m MIBI SPECT의 예민도는 87%, 특이도는 79%였고 전례를 대상으로 한 경우 운동부하 심전도는 예민도 55%, 특이도 74%로서 예민도는 SPECT가 운동부하 심전도보다 유의하게 높았으며 특이도는 유의한 차이는 없었으나 SPECT가 더 높은 경향을 보였다. 3) 최대 예측 심박수의 85% 이상의 운동량에 도달한 경우의 관동맥 질환 진단 예민도는 85% 이하의 운동량에 도달한 군과 유사하였다(88% vs 87%, p=NS). 4) 운동부하 정도가 적었으나 조기에 심전도 검사상 양성 소견을 보인 경우에는 다혈관 질환에서 개개 혈관의 협착 진단능은 낮은 경향을 나타내었다. 결론: 이상의 결과로 볼 때 운동부하 Tc-99m MIBI 심근관류 스캔의 관동맥 협착 진단능은 운동부하 심전도검사보다 높았고, 답차를 이용한 증상 제한적 운동부하검사에서 심박동수의 증가로 평가란 운동 정도가 운동 목표량에 도달하지 않아도 진단능이 감소되지 않음을 알 수 있었다.

• 암석학회지
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• 제15권4호
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• pp.180-193
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• 2006

경상분지 의성지괴의 중앙 북부에 위치하는 안동시 길안면 지역은 선캠브리아기 변성암류, 트라이아스기 청송화강암, 백악기 초 하양층군, 백악기 말-고제3기 화성암류 등으로 구성되어 있다. 이 지역에는 다양한 방향의 단층(남북 내지 북북서 방향의 옥산단층, 북서 방향의 길안단층, 서북서 방향의 황학산단층, 그리고 동서 방향의 임봉산단층)들이 발달하고, 경상분지의 기반암류에 해당하는 청송화강암내에는 다수 단열조의 상대적 시간관계(선후관계 및 공존관계)와 전단단열의 운동감각을 결정하는데 이용되는 기하학적 지시자가 잘 관찰된다. 본 논문은 이들 단열조의 기하학적 특성(연결, 종료, 교차형상 및 절단관계)에 대한 정밀한 분석을 통하여 경상분지 의성지괴 길안면 지역에 발달하는 인장단열의 발달사와 전단단열의 운동성을 연구하였다. 그 결과, 길안면 지역에 발달하는 단열계는 적어도 7회의 변형단계(Dn 이전 단계에서 Dn+5 단계로 명기)를 걸쳐 형성되었고, 단열조의 우세 방향성은 길안면 주변지역에 발달하는 지질도 규모의 단층 우세 방향성과 거의 일치하는 (서)북서, 북북서, 북북동, 동서, 북동 순서로 나타난다. 단열조의 발달사와 운동성를 요약하면 다음과 같다. (1) Dn이전 단계: 남북 내지 북북서 또는 서북서 내지 동북동 방향의 인장단열 형성기. 이후 응력장 변화와 함께 남북 내지 북북서 방향의 절리조는 좌수향 ${\rightarrow}$우수향${\rightarrow}$좌수향 전단단열운동으로 그리고 서북서 내지 동북동 방향의 절리조는 (우수향${\rightarrow}$)좌수향 전단단열운동으로 각각 재활동하였다. (2) Dn 단계: 북서 방향의 인장단열 형성기. 이 단계의 절리조는 이후 좌수향${\rightarrow}$우수향 순서의 전단단열운동을 경험한다. (3) Dn+l 단계:북북동 내지 북동 방향의 인장단열 형성기. 이후, 좌수향 전단단열운동으로 활동하게 된다. (4) Dn+2 단계: 동북동 내지 동서 방향의 인장단열 형성기. (5) Dn+3 단계: 서북서 내지 북서 방향의 인장단열 형성기. (6) Dn+4 단계: 북북서 방향의 인장단열 형성기. 이후, 우수향 전단단열운동으로 활동하였다. (7) Dn+5 단계: 북북동 방향의 인장단열 형성기.

• 한국중재학회지:중재연구
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• 제13권2호
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• pp.459-488
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• 2004

General interest in the out-of-court dispute resolution system are mounting in Korea, and the spread of ADR(alternative dispute resolution) is the worldwide trend. In addition, it was confirmed that the resolution of disputes by ADR such as the decision based on arbitration made by the Prime Ministerial Administrative Decision Committee is no longer in exclusive possession of the civil case. The activation of ADR could lead to the smooth agreement between parties by getting away from the once-for-all mode of decision such as the dismissal of the application or the cancellation of disposal and the like in relation to administrative cases for the years. In consequence, it is anticipated that the administrative litigation that applicants have filed by not responding to the administrative decision would greatly reduce in the future. But, it would be urgent to provide for the legal ground of the ADR system through the revision of related laws to take root in our society because ADR has no legal binding power relating to the administrative case due to the absence of its legal grounds. The fundamental reason for having hesitated to introduce ADR in relation to the administrative case for the years is the protective interest of the third party as well as the public interest that would follow in case the agreement on the dispute resolution between parties brings the dispute to a termination in the domain of the public law. The disputes related to the contract based on the public law and the like that take on a judicial character as the administrative act have been settled within the province of ADR by applying the current laws such as the Civil Arbitration Law, Mediation Law, but their application to the administrative act of the administrative agency that takes on a character of the public law has been hesitated. But as discussed earlier, there are laws and regulations that has the obscure distinction between public and private laws. But there is no significant advantage in relation to the distinction between public and private laws. To supplement and cure these defects it is necessary to include the institutional arrangement for protection of the rights and benefits of the third party, for example the provision of the imposition of the binding power on the result of ADR between parties, in enacting its related law. It can be said that the right reorganization of the out-of-court dispute resolution system in relation to the administrative case corresponds with the ideology of public administration for cooperaton in the Administrative Law. It is high time to discuss within what realm the out-of-court dispute resolution system, alternative dispute resolution system, can be accepted and what binding power is imposed on its result, not whether it is entirely introduced into the administrative case. It is thought that the current Civil Mediation Law or Arbitration Law provides the possibility of applying arbitration or mediation only to the civil case, thereby opening the possibility of arbitration in the field of the intellectual property right law. For instance, the act of the state is not required in establishing the rights related to the secret of business or copyrights. Nevertheless, the disputes arising from or in connection with the intellectual property rights law is seen as the administrative case, and they are excluded from the object of arbitration or mediation, which is thought to be improper. This is not an argument for unconditionally importing ADR into the resolution of administrative cases. Most of the Korean people are aware that the administrative litigation system is of paramount importance as the legal relief for administrative cases. Seeing that there is an independent administrative decision system based on the Administrative Decision Law other than administrative litigation in relation to administrative cases, the first and foremost task is the necessity for the shift in thinking of people, followed by consideration of the plan for relief of the rights through the improvement of the administrative decision system. Then, it is necessary to formulate the plan for the formal introduction and activation of ADR. In this process, energetic efforts should be devoted to introducing diverse forms of ADR procedures such as settlement conference, case evaluation, mini-trial, summary jury trial, early neutral evaluation adopted in the US as the method of dispute resolution other than compromise, conciliation, arbitration and mediation