• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3643-3646
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• 2016

Management of eyelid cancers is based on surgery and/or radiotherapy (RT). The treatment objective is to control tumors with acceptable functional and esthetic outcomes. The aim of this study was to evaluate the results of radiation therapy in management of epithelial eyelid cancers, reviewing retrospectively the clinical records of patients treated in our institution from January 1989 to December 2013. We focused on clinical and histological features, treatment characteristics, tolerance and disease control. One hundred and eight patients (62 men and 46 women) were enrolled, with a mean age of 61 years [ranges 15-87]. The most frequent tumor location was the inner canthus (42.6%). Median tumor size was 21 mm [ranges 4-70]. Histological type was basal cell carcinoma in 88 cases (81.5%), squamous cell carcinoma in 16 (14.8%) and sebaceous carcinoma in 4 (3.7%). Radiation therapy was exclusive in 67 cases (62%) and post-operative for positive or close margins in the remaining cases. Kilovoltage external beam radiotherapy (KVRT) was used in 63 patients (58.3%) and low-dose-rate interstitial brachytherapy in 37 (34.3%). Eight (7.4%) were treated with cobalt or with a combination of KVRT-cobalt, KVRT-electron beams, KVRT-brachytherapy or cobalt-electron beams. The total delivered radiation doses were 70 Gy (2 Gy/fraction) in 62 patients (57.4%), 66 Gy (2 Gy/fraction) in 37 (34.3%) and 61.2 Gy (3.4Gy/fraction) in 9 (8.3%). After a median follow-up of 64 months, we noted 10 cases of local recurrences(9.2%): 7 after exclusive and 3 after post-operative RT. No local recurrence occurred in patients treated with brachytherapy. Actuarial 5-year local recurrence-free rate, disease-free survival and overall survival were respectively 90%, 90% and 97%. T-stage was found to be a significant factor for recurrence (p=0.047). All acute radiation-related reactions were scored grade I or II. Delayed effects were eye watering in 24 cases (22.2%), eye dryness in 19 (17.6%), unilateral cataract in 7 (6.4%) and ectropion in 4 (3.7%). Radiation therapy and especially brachytherapy is an efficient treatment of eyelid cancers, allowing eye conservation and functional preservation with good local control rates and acceptable toxicity.

• 한국융합학회논문지
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• 제13권2호
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• pp.177-183
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• 2022

본 연구는 수용자가 포털 사이트(네이버, 다음, 줌, 네이트)를 통해 검색할 때 어떤 시선경로로 탐색하는지 아이트래킹을 통해 알아보았다. 검색엔진의 시선경로에 따른 레이아웃 분석결과, 정보검색의 관문(Porta)이라고 할 수 있는 4개의 메인 페이지는 Z자형 레이아웃 형태로 나타났다. 각 사이트의 뉴스와 검색페이지는 F자형 형태를 활용하고 있는데 이것은 사람의 시선이 F자형으로 상단에서 우측으로 이동하면 순차적으로 하단으로 이동하는 좌측에서 우측(LTR)으로 시선이 이동하면서 읽는 것을 의미한다. 아이트래킹의 시각적 분석지표인 히트맵, 게이즈 폴랏, 클러스터를 통해 분석한 결과, 히트맵에서는 사진과 헤드카피에 시선의 집중도가 가장 많이 나타났으며 이것은 그 정보에 대한 흥미도와 관심도가 높다고 말할 수 있다. 시선의 흐름은 왼쪽 상단에서 우측으로 오면서 아래로 흐르는 것 알 수 있었으며 클러스터는 검색사이트의 상단에 집중되어 있었다. 웹사이트 디자이너는 레이아웃 디자인에 있어 사용자가 원하는 정보에 대한 접근성과 가독성을 높이는데 주력해야 할 것이며, 주 사용자의 성향과 행동 패턴 등을 조사하고 분석하여 이에 맞는 주기적 인터페이스의 변화가 요구되어진다.

• Asian-Australasian Journal of Animal Sciences
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• 제30권8호
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• pp.1099-1104
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• 2017

Objective: This work was to find the correlation of alcohol dehydrogenase 1C (ADH1C) genotype with vitamin A reduction and carcass traits during the vitamin A restriction period. Methods: In study 1, 60 Korean native steers were fed a diet (890 IU/kg) with 8,000 IU and 0 IU of supplemental premix vitamin A/kg of dry matter (DM) for control and treatment group, respectively. The levels of serum vitamin A were analyzed through high preparative performance liquid chromatography, and the ADH1C genotype was analyzed based on polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP; 78.1% TT type, 21.9% TC type); however, CC type was not found. Then, the interaction between ADH1C and carcass traits on the vitamin A restriction was investigated in study 2. A total of 136 Korean native steers were fed a diet that included 930 IU/kg vitamin A of DM. Results: Serum vitamin A in treatment was reduced to 112.4 IU/dL in steers with TT type of ADH1C, while for steers with TC type the concentration of serum vitamin A was dropped to 79.5 IU/dL (p<0.1) in study 1. This showed that TC type had the potential to lower serum vitamin A concentration during vitamin A restriction compared to TT type. In study 2 we found that eye muscle area, marbling and carcass weight in Korean native steers with TC type were higher than in steers with TT type (p<0.05). Conclusion: The interaction between vitamin A restriction and TC type of ADH1C gene could have the potential of increasing the marbling in Korean native steers. These results indicated that steers with TC type of the ADH1C gene were more sensitive to the change of serum vitamin A than TT types. Furthermore, this finding has the potential to enable a higher marbling score under the condition of vitamin A restriction in Korean native steers.

• 생명과학회지
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• 제16권4호
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• pp.626-631
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• 2006

밀양 토종개의 일반적인 특징을 구명할 수 있는 기초자료를 확보하고자 밀양 토종개 44두를 대상으로 형태학적 특징 및 microsatellite DNA형의 유전적 다양성의 출현빈도에 기초한 유전적인 특징을 조사한 결과 밀양 토종개의 체고는 43-55 cm(평균 49.5 cm)로서 수캐는 44-55 cm(평균 50.3 cm), 암캐는 43-52 cm(평균 48.1 cm)로 나타났고 체장은 45-60 cm(평균 54.3 cm)로서 수캐는 45-60 cm(평균 55.9 cm), 암캐는 45-57 cm(평균 52.6 cm)였다. 또한 가슴둘레는 수캐가 51-64 cm(평균 59.2 cm), 암캐는 50-62 cm(평균 56.3 cm)로 측정되었다. 머리의 형태는 정면에서 보았을 때 44두 모두에서 역삼각형 형태를 가지고 있었으며, 눈의 모양은 삼각형 형태가 40두(90.9%)였고 초승달 모양이 4두(9.1%)로 관찰되었다. 모색은 백색이 41두(93.2%), 황색이 3두(6.8%)로 나타나 두 색깔을 가지고 있었다. 혀와 발톱의 색깔은 전 두수에서 각각 연분홍색과 분홍색이 관찰되었고 항문의 색깔은 연한 흑색이 40두(90.9%), 연분홍색이 4두(9.1%)로 나타났다. 그리고 귀의 형태는 전 두수가삼각형의 곧게 서 있는 형태였으며, 꼬리의 형태는 반말린 꼬리가 25두(56.8%)로 가장 많았고 선꼬리(장대꼬리)가 15두(34.1%), 말린 꼬리가 4두(9.1%)로 나타났다. 15개의 marker로 분석한 microsatellite DNA 다형의 유전자 빈도에 기초하여 heterozygosity, PIC 그리고 PE를 분석한 결과 대립유전자의 수는 $2{\sim}14$개(평균 6.13개)로 검출되었으며 expected heterozygosity와 PIC는 각각 $0.455{\sim}0.863$ (평균 0.635), $0.348{\sim}\;0.837$(평균 0.570)으로 나타났고 PEZ 10, PEZ 13, PEZ 17, FHC 2054의 marker는 PIC 0.7이상으로 관찰되었다. PE 1은 $0.101{\sim}\;0.548$으로서 15개 marker를 조합시 0.9895, PE 2는 $0.174{\sim}\;0.710$으로서 전체 조합시 0.9996으로 나타났다.

• 대한인간공학회지
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• 제34권3호
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• pp.247-264
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• 2015

Objective: The purpose of this study is to determine the priority of information presentation and the effective menu type to be placed in the center of a gauge cluster display for commercial trucks and to present a set of ergonomic designs for the gauge cluster display. Background: An effective ergonomic design is specifically needed for the development of the gauge cluster display for the commercial trucks, because more diverse and heavier information is delivered to truck drivers, compared to the information to passenger car drivers. Method: First, all the information that must be shown on the commercial truck display was collected. Then, the severity, frequency of use, and display design parameters were evaluated for those information by commercial truck drivers. Next, an analysis on the information attributes and the heuristic evaluation utilizing the display design principles were carried out. According to the results, a design alternative of the main screen to be displayed was constructed by priority. A comparative analysis between the alternative and existing main screens was also conducted to see the efficacy of the designs. Lastly, we conducted an experiment for the selection of menu type. The experiment was conducted using the driving simulator with an eye-tracking device. The independent variables were four types of the menu reflecting the commercial truck characteristics such as grid type, icon type, list type, and flow type. We measured preference, total execution time, the total duration of fixation on the gauge cluster area, and the total number of fixation on the gauge cluster area as dependent variables. Results: Four types of driver convenience information and six types of driver assistance information were selected as the information to be placed primarily on the main screen of the gauge cluster. The Grid type was the most effective among the menu types. Conclusion: In this study, the information that appears on the main screen of the display, the division of the display and the design of the menu type for commercial truck drivers were suggested. Application: This study is expected to be utilized as guidelines on the ergonomic design of a gauge cluster display for commercial trucks.

• 한국산학기술학회논문지
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• 제13권10호
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• pp.4717-4724
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• 2012

본 연구는 한국전통발효음식과 미백치아의 색조변화와의 관련성을 알아보고자 시행하였으며, 연구방법은 전문가 치아미백을 시행한 자연치아를 한국전통발효음식에 일정기간 침전 후 치과용 측색기를 이용하여 치아색조변화의 정도를 객관적으로 측정하였다. 본 연구에 사용된 치아시편은 30개로 한 치아당 30회 측정되었으며, 전체 측정 횟수는 900회 실시되었다. 측정은 치과용 측색기 ShadeEye NCC$^{(R)}$ Dental Chroma Meter를 사용하였다. 수집된 자료는 PASW 18.0을 사용하여 분석한 결과, 미백 전, 후 명도와 황색채도에서 유의한 차이가 나타났으며(p<0.001), 용액침전 후 명도와 황색채도는 시간에 따라 변화하였다(p<0.001). 침전용액에 따른 색조변화량의 차이를 알아본 결과, 미백 후부터 1주 동안, 2주에서 3주까지의 기간 동안 각 침전용액에 따라 유의한 차이가 나타났다(p=0.001, p<0.001). 한국전통발효음식은 침전기간과 침전용액에 따라 미백치아의 색조변화에 영향이 있음을 알 수 있었다. 하지만 본 연구는 구강 내의 상태 그대로를 재연하지 못하였기에 구강 내 상태, 섭취빈도, 구강위생관리에 따라 차이가 있을 것이다.

• 한국어류학회지
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• 제29권2호
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• pp.139-145
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• 2017

최근 우리나라에서 자연발생적인 미꾸리속 알비노 개체들이 낮은 빈도로 출현하고 있으나, 색소 결핍으로 인해 형태적종 동정이 어렵다. 따라서 본 연구에서는 핵 유전자인 recombination activating gene 1 (rag1) 영역 및 미토콘드리아 유전자 cytochrome b (cytb) 영역을 이용한 분자계통학적 분석을 이용해 미꾸리속 알비노 개체의 분자동정을 수행하였다. 그 결과 rag1과 cytb의 분자계통도에서 미꾸라지, 미꾸리, 그리고 M. mohoity로 3개의 clade가 확인되었다. 확보된 M. mohoity의 염기서열을 유전자은행의 BLAST를 이용해 유사성을 검색한 결과 M. mohoity와 가장 유사하였다. 분자계통도를 기준으로 25마리의 알비노 미꾸리속 개체의 종 동정을 수행한 결과 빨간 눈 타입은 미꾸리 16마리, 미꾸라지 1마리로 판별되었고, 나머지 3개체는 미꾸라지♀${\times}$미꾸리♂ 잡종 1마리와 M. mohoity ♀${\times}$미꾸리♂ 잡종이 2마리 판별되었다. 또한 검은 눈타입 5마리는 미꾸리 1마리와 미꾸라지 3마리 및 M. mohoity 1마리로 판별되었다. 따라서 본 연구에 이용한 분자마커를 활용함으로써 미꾸리속 어류의 정확한 종 또는 잡종을 동정하기 위한 유용한 방법으로 이용될 수 있을 것이다.

• 대한전자공학회논문지SP
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• 제48권6호
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• pp.68-76
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• 2011

본 논문에서는 기존 무안경식 3D 디스플레이의 제한된 시야각으로 인한 3D 시청에서의 불편함을 해소하기 위해 새로운 패렐랙스 배리어 방식을 제안한다. 제안된 방식은 기존 패렐랙스 배리어의 TN-LCD 구조에서 LC를 공유하는 이중 계층의 ITO 쌍을 추가하였으며, 시선 추적 장치에 의해 시청자의 위치를 감지하여 자동으로 3D 시야각을 시청자의 위치에 맞도록 변화 시킬 수 있는 이중 계층의 패렐랙스 구조를 갖는다. 제안한 이중 계층 패렐랙스 배리어 방식을 시제품으로 구현하고 실험한 결과, 제안한 방식의 유효성을 확인할 수 있었다.

• 대한인간공학회지
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• 제30권4호
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• pp.551-562
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• 2011

Objective: We proposed an effective 3D menu manipulation alternative with a usability test. This was performed in a 3D environment with 3D menu and control manipulation methods. Background: As 3D stereoscopic displays became generalized, various 3D applications were being used not just movies, games, but also mobile contents and advertisements. However, when a user interface was designed in a 3D environment, it was lacked that a clear standard and result of an efficiency and usability as like a 2D environment. Method: We implemented 9 kinds of 3D menu types based on 3D menu hierarchies, menu layouts and dimensions. And we extracted 3 representative control types in a 3D environment. We performed usability evaluation with full factorial design for 27 menu alternatives with 2 types of menu manipulation tasks. In this condition, we measured the performance time, subjective discomfort and eye-fatigue. Results: A control type had the significant effect, and the effect of menu types had the different result depending on given tasks. Conclusion: This experiment showed the interaction of menu and control types depended on 3D menu manipulation tasks were significant in a 3D user interface design. Therefore, as a purpose of a 3D menu manipulation task, 3D menu types and control types were should be considered. Application: We supposed this result was should be applied in a 3D menu contents design.

• 한국농촌생활과학회지
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• 제6권2호
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• pp.99-108
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• 1995

This study was carried out to investigate the food habit and health status of housewives in rural area of Gyonggi Province. The subjects of this study were 121 rural housewives and interviewed with a questionnaire. The results were as follows 1. In food habit items, the mean of Kimchi intake ($4.89\pm0.38$) was the highest, while that of meat processed food intake ($2.12\pm1.07$) was the lowest. The average of food habit score was $53.1\pm7.7$(out of 80) and was not significantly different with educational level, income, family type, size and agricultural type. In age, older subjects had low score. In regular mealtime, 74.4% of subjects had high score. The subjects that had good appetite were 49.6%. 2. The average of height and weight were 156.99cm and 55.5kg respectively. The appeal ratio in THI items was high in the order of musculoskeletal pain (1.62), tired (1.88), eye-fatigued (1.91), mental instability (2.03) and depression (2.07). The average of THI score was $32.7\pm5.5$(out of 45) and was not significantly different with educational level, income, family type and size, but the subjects of younger and nonagricultural belonged to high score level. The percentage of subjects in normal blood pressure, obesity and retained disease at present were 66.9%, 6.1% and 23.1% respectively. There was no significant difference except for good appetite in the relation among food habit, obesity and blood pressure. Food habit score was not significantly different with THI score, but health status seemed to be good in the better food habit.