• Journal of Korean Medical Ki-Gong Academy
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• v.18 no.1
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• pp.1-26
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• 2018

The objective of this study is to verify the effects of Moosim-Gi-Gong Doinbeop on low back pain targeting low back pain patients hospitalized in Korean medicine hospitals. For the study, 44 adult female and male patients hospitalized with low back pain at M Korean Medicine Hospital and H Korean Medicine Hospital located in Gimpo, Gyeonggi Province were recruited. The subjects had a temperature difference between left and right 湧泉(KI1) of over 0.5℃ through infrared thermographic imaging, and 23 of them were classified in the control group for retrospective analysis based on the test records. Infrared thermographic imaging, X-ray pelvic AP view - standing position, a sit-and-reach test and a VAS survey were employed for detection, and IBM SPSS Statistics 24 for the statistical process. The results were rounded down to three decimal places as in an average±standard deviation, and the significance level was 0.05 to be evaluated significant if p<0.05. The result of the study is as follows: 1. In the comparison between before and after conducting Moosim-Gi-Gong Doinbeop, the meaningful difference was shown in the experimental group in all indicators. But Indicators except for the temperature difference between right and left 湧泉(KI1)(difference between before and after) and In displaced pelvic correction indicators on the X-ray showed a significant difference in the control group. 2. As for the variation widths of the experimental group and the control group, the former showed significant temperature differences between 印堂(EX-HN3) and 關元(CV4) and right and left 湧泉(KI1); difference variations of anteflexion; and changes in PI and In displacement on the X-ray. 3. As for changes in the experimental group according to demographic characteristics, gender, age and degree of obesity did not show significant differences in all indicators. However, those who experienced back pain for more than six months in the experimental group showed the biggest body temperature differences between 印堂(EX-HN3) and 關元(CV4), while other indicators had no significant difference. As a result, patients who received Korean medicine treatment showed relieved back pain and improvement in pelvic correction and sports activity; however, those who got Moosim-Gi-Gong Doinbeop together showed more clearer improvement effects in pelvic correction and sports activity.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.12
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• pp.5229-5235
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• 2016

Prostate cancer (PCa) remains one of the most widespread and perplexing of all human malignancies. Assessment of gene expression is thought to have an important impact on cancer diagnosis, prognosis and therapeutic decisions. In this context, we explored combined expression of PCa related target genes AMACR and PCA3 in 126 formalin fixed paraffin embedded prostate tissues (FFPE) from Moroccan patients, using quantitative real time reverse transcription-PCR (RT-qPCR). This quantification required data normalization accomplished using stably expressed reference genes (RGs). A panel of twelve RG was assessed, data being analyzed using GenEx V6 based on geNorm, NormFinder and statistical methods. Accordingly, the hnRNP A1 gene was identified and selected as the most stably expressed RG for reliable and accurate gene expression quantification in prostate tissues. The ratios of both PCA3 and AMACR gene expression relative to that of the hnRNP A1 gene were calculated and the performance of each target gene for PCa diagnosis was evaluated using receiver-operating characteristics. PCA3 and AMACR mRNA quantification based on RT-qPCR may prove useful in PCa diagnosis. Of particular interesting, combining PCA3 and AMACR quantification improved PCa prediction by increasing sensitivity with retention of good specificity.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.23 no.1
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• pp.182-198
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• 2010

Background : The varieties of manifestations referred to oral, glottal, labial and dental diseases has been long complicated physicians in the efficient diagnosis and treatment of these diseases. Acupuncture has been widely used in Korea throughout the history and provides an efficient method in the treatment of them Objectives : Establish a distinctive and efficient acupuncture method for the treatment of oral, glottal, labial and dental diseases based in literature research Method : We reviewed four Korean medical literature, "Guide to Swollen Sore Treatment", "Treasured Mirror of Eastern Medicine", "Experiential Prescriptions of Acupuncture and Moxibustion", and "Essential Rhymes on Acupuncture and Moxibustion by Master Sa-am", and analyzed the therapeutic characteristics in the treatment of oral, glottal, labial and dental diseases Result : 1. According to "Guide to Swollen Sore Treatment", we could noted frequent application of blood letting methods in the affected area, then rinse ones mouth with salty water and further application of taro plaster. Also found acupuncture methods utilizing heated mole cricket or silkworm in the sublingual region. Regarding herbal method, Realgar was rubbed in the affected area. Mainly used acupuncture points in the treatment of oral, glottal, labial and dental diseases were GV20, GB20, LU5, and auricular anterior hairline 2. In "Treasured Mirror of Eastern Medicine", blood letting method in the sublingual region and burning needle searing method were the most frequently applied in the treatment of oral, glottal, labial and dental diseases. Moxibustion was also applied in the treatment of labial and dental diseases. Particularly, said to apply 3 moxa cones in ear zones of both sides, when no medicine is effective. This demonstrates how emphasized the importance of moxibustion in this kind of disease. Mainly used acupuncture points were GV16, CV24, LI4, EX-HN12, and EX-HN13 3. In "Experiential Prescriptions of Acupuncture and Moxibustion", no other methods beside wrist. Superstitious methods like applying moxibustion on the tooth picture drawn on the roofing tile need further confirmation. Mainly used acupuncture points were LI4, ST36, and HT7. 4. "Essential Rhymes on Acupuncture and Moxibustion by Master Sa-am", identified the cause of diseases according to visceral pattern identification. Stomach and Spleen in charge of vocal, lingual, and labial disease, Kidney for dental disease, and further scrutinizing identification according to Liver, Heart, Stomach, Lung, and Kidney manifestations. Used supplementation and draining needling methods of self meridians and other correlating meridians. Conclusions : After previous study on stroke and eye diseases, we could also find various efficient methods according to oral, glottal, labial and dental diseases, through literature research of korean medical classics. This study will concurrently result in establishing distinctive therapeutic method characteristic of Korea.

• Journal of Acupuncture Research
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• v.36 no.2
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• pp.59-71
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• 2019

Acupuncture treatment for oculomotor nerve palsy has been increasing recently. This study analyzed randomized controlled trials (RCTs) and case reports, using the Cochrane risk of bias tool to investigate the efficacy of acupuncture therapy for oculomotor nerve palsy. This analysis was performed on March 7, 2019, using online databases (PubMed, Cochrane, NDSL, OASIS, CNKI) where 208 articles were retrieved. Of these, there were 18 case reports and 18 RCTs that matched the inclusion criteria, of which 32 studies used acupuncture as the primary intervention, 1 used pharmacopuncture, 1 used fire-needling, and 1 used electroacupuncture. The most commonly used acupoints were BL1, BL2, ST2, TE23, Ex-HN5, LI4, GB14, ST36, GB20 and GB1. Significant findings were reported in all RCTs. Six adverse events were reported in 3 RCTs, with no effect on the outcome. No side effects were reported in the case reports. The risk-of-bias analysis showed that the articles did not report the experimental protocol used and it was not clear whether the study was blinded. Hence, it was difficult to assess the risk of bias. Analysis of 36 studies showed that acupuncture therapy for oculomotor nerve palsy was effective in many cases. It was difficult to evaluate the potential bias.

• The Journal of Pediatrics of Korean Medicine
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• v.30 no.2
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• pp.23-30
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• 2016

Objectives The purpose of this study is to investigate recent clinical studies on effect of acupuncture for strabismus in Korea and other countries. We have analyzed 10 years (from 2006 to 2015) of case studies and randomized controlled trials (RCT) on effect of acupuncture for strabismus. Methods The search database includes Oasis, KTKP (Korean Traditional Knowledge Portal), Medline, Embase, and Cochrane library. To narrow the search, the following key search terms were used: 'strabismus, acupuncture'. The search was limited to the publication date from 2006 to 2015. 7 case studies and 5 control studies were selected for analysis. Results and Conclusions 1. The acupuncture treatment is effective for paralytic strabismus 2. The studies used BL1, GB1, ST2, TE23, GB15, EX-HN5, ST1, and LI4 acupoints and also an electroacupuncture treatment, which is 15 minutes of extraocular muscle stimulation, was used. 3. Degree of strasbismus was tested by Ocular motor range test, Corneal light reflex test, Ocular abducent scale test (Scott and Kraft, Diploptic range test).

• Journal of Haehwa Medicine
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• v.22 no.1
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• pp.91-104
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• 2013

Objective : This study was designed to analyze the clinical studies on Tic disorder in traditional Korean medicine and traditional Chinese medicine. Methods : To figure out the Tic disorder, Korean medical studies from Oriental Medicine Advanced Searching Integrated System (OASIS) and Chinese Medical Journals from Wangfang data and China National Knowledge Infrastructure (CNKI) which published in 2008 to 2012 were analyzed. Results & Conclusions : 1. DSM-IV(7 studies), CCMD(3 studies) were frequently used in the diagnosis of tic disorder. 2. The herbs used for the treatment of tic disorder are Uncariae ramulus et Uncus(釣鉤藤), Paeoniae Radix Alba(白芍藥), Poria(白茯苓), Buthus martensi Karsch(全蝎) etc. 3. Acupuncture points frequently used were Paek'oe(GV20), Pungji(GB20), Naegwan(PC6), Sasinchong(EX-HN1), T'aech'ung(LR3), Joksamni(ST36), Hapgok(LI4) and so on. 4. The cause of Tic disorder is connected with liver, heart, spleen, kidney, gall bladder among the internal organs and Fire(火), Wind(風), Dampness(濕) of external causes.

• Journal of Korean Medicine Rehabilitation
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• v.33 no.4
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• pp.95-107
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• 2023

Objectives The purpose of this study is to help find the future prospects by analyzing the trends of scalp acupuncture treatment for Parkinson's disease (PD) by searching the China National Knowledge Infrastructure (CNKI) and PubMed. Methods We searched clinical studies adopting scalp acupuncture treatment as a main intervention for PD through the searching the database of CNKI and PubMed. We analyzed the characteristics of selected studies especially according to study design, publication year, sample size, treatment period, treatment methods, outcomes criteria and adverse events. Results Twelve randomized controlled trials studies published from January 1, 2012 to July 1, 2023 were selected. In these studies, two types of scalp acupuncture treatments were performed and the most common treatment was Jiao shunfa's scalp acupuncture with fine needles. The most commonly used acupoints were "Chorea tremor control area", 風池 (GB20), 四神聰 (EX-HN1) and 百會 (GV20). The most commonly used outcome measures were effective rate, unified Parkinson disease rating scale (UPDRS) and UPDRS-III. Conclusions Through these results, we found that the Chinese review literature positively reported the effects of scalp acupuncture on PD. However, more high-quality evaluation using the well-designed studies including more objective outcomes should be required.

• Korean Journal of Acupuncture
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• v.35 no.2
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• pp.105-115
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• 2018

Objectives : This research aimed to verify the validities of contraindicated acupoints in acupuncture treatment in Zhenjiudacheng. Methods : We investigated contraindicated acupoints when performing needling in Zhenjiudacheng, then verified them in today's medical knowledge and clinical studies. Results : In Zhenjiudacheng, 39 acupoints - LU2, LI4, LI13, LI14, LI16, ST1, ST9, ST12, ST17, ST25, ST30, ST42, SP6, SP11, SI18, BL8, BL9, BL56, KI11, TE7, TE8, TE19, TE20, GB3, GB18, GB21, GV10, GV11, GV17, GV22, GV24, CV1, CV4, CV5, CV8, CV9, CV15, CV17 and EX-HN11 - were described to need a careful approach in acupuncture treatment and 21 acupoints among them had contraindications. Most of the contraindications can be explained based on anatomical knowledge and results of clinical studies, and acupuncture treatment at the 39 contraindicated acupoints can induce injury of tissues or organs near the acupoints. Conclusions : The contraindicated acupoints in acupuncture treatment in Zhenjiudacheng seem to have been classified based on the adverse events experienced by doctors at that time. Therefore careful acupuncture treatment at these acupoints is needed to avoid injury to tissue or organs.

• Journal of Pharmacopuncture
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• v.24 no.3
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• pp.93-106
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• 2021

This study aimed to analyze the use of Korean medicine treatments for alopecia in among clinical studies. We identified and analyzed 22 studies from Korean databases; Oriental Medicine Advanced Searching Integrated System (OASIS), Science ON, Korean Studies Information Service System (KISS), and Research Information Sharing Service (RISS) and international database; PubMed. We analyzed the Korean medical treatment in each case and determined the tendency to use each intervention. We analyzed 1,464 patients from 22 selected studies. Herbal medicine, acupuncture, external medicine or products, pharmacopuncture, and phototherapy were used for alopecia treatment. The herbal medicines mainly used to treat alopecia were Gagam Cheongyoung-tang, Gagam Hwajung-hwan, and Yukmijihwang-tang·hwan. The acupoints primarily used were GV20, EX-HN1, GB5, KI3, PC6, ST36, GV22, and A-shi. The most commonly used pharmacopuncture therapies were Hwangryunhaedoktang (HH), Carthami Fructus (CF), Bee Venom (BV), and Hominis placenta (HP). The Korean medical treatment for alopecia improved the condition of patients. However, seven studies reported the occurrence of side effects such as pruritus, dazed, drowsiness, headache, pain, and diarrhea. This study shows the potential of Korean medicine for the treatment of alopecia. Further studies with a large sample size and long-term follow-up are warranted to establish the primary treatment guidelines and objective outcome measures for alopecia.

• The Journal of Internal Korean Medicine
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• v.39 no.4
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• pp.717-731
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• 2018

Objectives: The purpose of this research is to investigate clinical studies of essential tremor in China. Methods: We investigated clinical studies of Traditional Chinese Medicine therapies in traditional Chinese medical journals for essential tremor through the China National Knowledge Infrastructure (CNKI) database. In total, 15 clinical articles were analyzed. This study examined the authors; published years; types of study; treatment methods for the treatment and control groups; periods; outcome assessment; and results. Results: Nine articles used acupuncture, 6 articles used herbal therapy. The most commonly used acupoints were GV20, GB20, LR3, LI4, GB34, SP6, and EX-HN1. The most commonly used herbs were Paeoniae Radix Alba, Angelicae Gigantis Radix, Cnidii Rhizoma, Gastrodiae Rhizome and Uncariae Ramulus et Uncus. Total effective rate was 66.67-96.7%; the treatment group values were significantly higher than the control group values in all papers. Tremor score, HAMD, curative effect of TCM syndrome, and incidence of adverse effects were significantly more affected in the treatment group than in the control group. Conclusion: More active clinical studies are needed on essential tremor, and the results of this study can be used as a basis for future research.