• Preventive Nutrition and Food Science
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• 제15권3호
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• pp.189-195
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• 2010

Water extracts from 20 medicinal plants, traditionally used for postmenopausal symptoms in Korea, were examined for their vasorelaxant activity in isolated rat thoracic aorta rings precontracted with norepinephrine (NE). Among the 20 medicinal plants, Cornus officinalis (CoEx, 0.3 mg/mL), Schisandra chinensis (ScEx, 0.3 mg/mL), Erythrina variegate (EvEx, 0.3 mg/mL), and Epimedium koreanum (EkEx, 0.3 mg/mL) showed rapid relaxation of endothelium-intact aorta ($69\pm4%$, $40\pm3%$, $25\pm2%$, and $23\pm3%$ of active tone induced by NE, respectively). In contrast, the extracts of Erythrina variegata (EvEx), Angelica gigas (AgEx), Pueraria thunbergiana (PtEx), and EkEx lead to gradual (i.e., long-term) relaxation to baseline in endothelium-intact vessels. The time to complete relaxation was 20～40 min. These 6 plant extracts were selected for the investigation of possible underlying mechanisms. The CoEx-, ScEx-, or EkEx-induced rapid relaxations were virtually abolished by endothelium denudation, and were significantly inhibited by pretreatment with nitric oxide (NO) synthase inhibitor $N^G$-nitro-L-arginine (L-NNA, 10 ${\mu}M$), indicating that increased formation of NO might contribute to the endothelium-mediated relaxation. In long-term responses, the endothelium denudation did not affect PtEx-induced relaxation, whereas it delayed responses by EvEx and AgEx, and significantly inhibited the effect of EkEx. Among EvEx, AgEx, and PtEx, EvEx attenuated the $CaCl_2$-induced vasoconstriction in high-potassium depolarized medium, implying that EvEx is involved in inhibition of the extracellular calcium influx to smooth muscle through voltage dependent calcium channels. These results provide the scientific rationale for the interrelationships between the use of 20 medicinal plants and their effects on cardiovascular health in estrogen deficient conditions.

• 한국식생활문화학회지
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• 제22권4호
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• pp.454-461
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• 2007

본 연구 결과 동결건조된 감귤과피 70% 메탄올 추출물의 총 폴리페놀 함량은 836.8 ㎎%였으며 감귤과피 추출물 0.01, 0.02와 0.1%의 EDA는 각각 89.6, 86, 81.3%로 높았으며 아질산염 소거능은 pH 1.2에서 34.4%, pH 7.0에서 19.5%를 나타내어 산성 영역에서 높은 소거작용을 보였다. 또한 이들 추출물의 항산화효과는 옥배유의 경우 TBHQ > BHT > TOC > ChEx > EaEx > EtEx > WaEx > Control 순이었고, 채종유의 경우 TBHQ > ChEx > EaEx > BHT > EtEx > WaEx > TOC > Control 순이었다. 두 유지모두에서 에틸아세이트추출물(EaEx)과 클로로포름추출물(ChEx)이 에탄올추출물(EtEx)과 물추출물(WaEx) 보다 항산화 효과가 높았으며 첨가농도가 증가함에 따라 항산화 효과도 증가하는 경향을 보였다. 그리고 감귤과피의 각 용매별 추출물의 공액이중산가도 에틸아세테이트추출물(EaEx)과 클로로포름추출물(ChEx)이 높았으며 이들의 항산화 효과는 TBHQ보다는 낮았으나 BHT, tocopherol과 비교하였을 때 거의 유사하거나 좀 더 높은 경향을 보였다. 한편 감귤과피 추출물은 우수한 항균력을 보여주었고 농도가 상승함에 따라 항균효과도 상승하였으며 이 효과는 그램 양성, 음성균주에서 고르게 나타나 천연 항균소재로서의 이용가능성을 확인하였다. 이상의 결과에서 감귤 과피는 총 폴리페놀 함량과 전자공여능 활성이 높아 항산화효과와 항균효과가 우수하게 나타나 감귤 과피의 기능성 이용도가 매우 높을 것으로 생각되며 감귤 가공 후 생기는 부산물들의 식품산업에서의 유용성도 높을 것으로 사료된다.

• Journal of Nutrition and Health
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• 제39권1호
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• pp.3-10
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• 2006

Effects of garlic powder supplementation on blood lipid profile and antioxidant system were investigated in rats with and without swimming exercise. Sprague-Dawley rats of four experimental groups were fed for 4 weeks diets containing $15\%$ beef tallow and $1\%$ cholesterol; control without garlic and exercise, Go with $2\%$ garlic alone, Ex with exercise alone, GoEx with $2\%$ garlic and exercise. Rats were trained 40 min a days a days a week. Group Ex and GoEx showed significant lowering in body weight gain and fat accumulation. In Go, Ex and GoEx, plasm TG and LDL-C were lower and HDL-C was higher, although not significantly, compared to levels in control. Total cholesterol was significantly reduced in group Go, and Ex and GoEx were lower than control. The total/HDL cholesterol ratio was also found to be significantly different, decreasing the ratios in Go, Ex and GoEx. The hepatic TBARS increased significantly in group Ex $(51.7{\pm}3.43nM/g\;liver)$, while TBARS in Go and GoEx were low $(35.68{\pm}3.61,\;39.30{\pm}5.55nM/g\;liver)$ and similar to control's one. The activity of hepatic SOD in Go and GoEx tended higher than control and Ex without garlic. The hepatic catalase showed significantly the highest activity in Go. Activity of GSH-px was significantly low in Ex with $0.14{\pm}0.03$ unit/mg protein, and control, Go and GoEx had higher activities of $0.23{\pm}0.08,\;0.20{\pm}0.07,\;0.22{\pm}0.01\;unit/mg$ protein, respectively. Lower activities of antioxidant enzymes in Ex are likely to associated with the highest level of TBARS. It seems that a decrease in TBARS in GoEx relative to Ex was related to the increase in GSHpx and SOD with garlic supplemented, which led to compensate the oxidative stress from exercise. The results suggests that exercise or garlic supplement exerts blood lipid attenuating effect. In adition, garlic supplementation could strengthen the antioxidant potential against exercise-induced oxidants, partly by modulating oxidant enzyme activity. These effects of garlic may make it a beneficial agent on CVD.

• 한국식품과학회지
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• 제36권2호
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• pp.262-267
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• 2004

아마란스를 식품가공용 중간소재로 개발하기 위해 아마란스 종실을 1차 가공처리한 후 전분과 각 가루의 가공특성을 조사 하였다. 아마란스는 전분, 무처리(UT), 탈지(DF), 발아(GM), 로 스팅(RT), 팽화(POP), 압출성형(EK1, EX2)하여 시료로 사용하였다. 아마란스 가루의 결정형은 전형적인 A형을 보였고 탈지, 발아, 로스팅 처리에 의한 결정형과 결정강도의 변화는 없었다. 그러나 팽화 처리와 압출성형에 의해서는 결정형이 사라졌다. 시료의 물 결합능력은 가공방법에 따라 차이가 있어 POP 시료의 물 결합능력이 740.3%로 가장 컸고, EX1이 35.5%로 가장 낮았다. 아마란스 가루의 광투과도 특성은 $60^{\circ}C$에서 차이가 있어 RT, POP, EX1, EX2 시료의 광투과도가 높게 나타났다. RVA로 측정한 아마란스 시료의 호화온도는 POP와 EX1, EX2를 제외하고 $68.1-73.0^{\circ}C$이었고, 피크점도는 GM이 31.6 RVU, RT가 401.1 RVU로 큰 차이가 있었다. DSC결과 또한 RVA 결과와도 일치하여 POP, EX1, EX2는 milling endotherm이 나타나지 않았다.

• 한국균학회지
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• 제13권1호
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• pp.27-40
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• 1985

1982년 3월부터 1984년 7월까지 경기도(京畿道) 광릉시험림(光陵試驗林)을 주로하고, 덕유산, 설악산, 전주 성수산, 수원 팔달산에서 채집(採集)된 250여점의 반균강을 동정(同定)한 결과 2목(目) 9과(科) 18속(屬) 23종(種)을 분류(分類)하였는데 그중에서 Helvella pezizoides Afz. ex Fr., Peziza celtica (Boud.) Moser, Humaria hemisphaerica (Wiggers ex Fr.) Funckel, Trichophaea gregaria (Rehm) Boud., Trichoglossum walteri (Berk.) Durand, Spathularia flavida Pers. ex Fr., Arachnopeziza aurelia (Pers. ex Fr.) Fuckel, Rutstroemia americana (Duran) White, Rutstroemia macrospora (Peck) Kanouse apud Wehmeyer forma gigaspora Korf, Ascocoryne cylichnium (Tul.) Korf et Carpenter, Chlorosplenium chlora (Schw. ex Fr.) Curtis, Chlorociboria aeruginascens (Nyl.) Kanouse ex Ramamurthi, Korf et Batra subsp. aeruginascens, Hymenoscyphus scutula (Pers. ex Fr.) Phillips, Cyathicula cyathoidea (Bull. ex Fr.) de Thumen는 한국미기록종(韓國未記錄種)이며, 그 보통명(普通名)과 기재(記載)를 보고(報告)한다.

• 한국응용과학기술학회지
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• 제40권5호
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• pp.925-935
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• 2023

PPARα activator가 고지방 사료를 섭취한 운동하지 않은 쥐에 비해 고지방 사료를 섭취한 운동 쥐에서 백색지방조직의 혈관신생을 보다 효과적으로 억제하는지를 조사하였다. 수컷 쥐는 무작위로 PPARα activator인 fenofibrate와 운동을 모두 처리하지 않은 대조군(Con), fenofibrate 단독처리군(FF), 운동 단독처리군(Ex) 및 fenofibrate와 운동의 조합처리군(Ex+FF)으로 나누어 8주간 고지방 사료를 섭취시켰다. 백색지방조직의 무게와 백색지방세포의 크기는 Con에 비해 FF, Ex 및 Ex+FF 모두 감소하였으며, Ex+FF는 FF에 비해 더욱 감소하였다. 백색지방조직에서 MMPs와 혈관신생 인자의 유전자 발현은 Con에 비해 FF, Ex 및 Ex+FF 모두 감소하였으며, Ex+FF는 FF에 비해 더욱 감소하였다. 그러나 혈관신생 억제인자의 유전자 발현은 Con에 비해 FF, Ex 및 Ex+FF 모두 증가하였고, Ex+FF는 FF에 비해 더욱 증가하였다. 따라서 본 연구는 fenofibrate 단독처리보다는 fenofibrate와 운동의 조합처리가 효과적으로 백색지방조직의 혈관신생을 억제함으로써 백색지방조직의 증가를 감소시키고 복부비만을 억제한다는 것을 밝혔다.

• Journal of Information Technology Applications and Management
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• 제19권2호
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• pp.59-78
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• 2012

The purpose of this longitudinal case study is to shed light on the reliability problems of IS performance evaluation by analyzing the discrepancy between ex ante evaluation in 2011 and ex post evaluation in 2012. Through an information system development project of a public enterprise, the gap between ex ante and ex post evaluation was ascertained and the causes as to why such gap occurs and the success factors that can solve the problems were derived. The ex ante evaluation of IS performance was performed based on both IS success model and BSC model and the ex post evaluation was carried out at the time after the target system has been built up by applying the evaluation measures and process that are similar to the ex ante evaluation. In the ex ante evaluation the business performance improved by the target system was estimated to 18.2%. On the other hand, it was seen as being low at 15.2% in the ex post evaluation and the differences were found to be statistically significant in 6 out of 10 measures. The reasons as to why such gap occurs were diagnosed as being of 2 types : (1) changes in the evaluation psychology according to the differences in the evaluation objectives; and (2) excessive expectation levels of the target system that is formed at the time of the ex ante evaluation. In other words, the users who have excessive expectations tend to overestimate in the ex ante evaluation and, in the ex post evaluation, tend to underestimate lower than the actual performance mainly due to disappointment on the results that do not meet the early expectations. As solutions to overcome the reliability problem of ex ante evaluation, 3 factors were derived : (1) the temperance of excessive expectation levels of the users; (2) a clear definition of the scope and functionality of the target system; and (3) actual commitments for the evaluations of IT performance.

• 한방비만학회지
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• 제17권2호
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• pp.77-86
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• 2017

Objectives: This study examined the effects of salvianolic acid B (SAB) on exhaustive exercise-induced cardiac muscle damage to rats. Methods: The study was carried out with 12-week-old young adult male Sprague-Dawley rats. Thirty-six rats were divided into 3 groups; normal (n=12), exhaustive exercise group (ExS, n=12) and exhaustive exercise with SAB (ExS+SAB, n=12). Five days before exhaustive exercise, SAB were medicated for 5 days in ExS+SAB group. Rats in ExS and ExS+SAB group were forced to swim for 150 minutes and then they were sacrificed, while rats in normal group were sacrificed at rest. After that, blood was collected and cardiac muscle tissue damage indices were analyzed. Results: Serum aspartate transaminase activity and lactate dehydrogenase activity were significantly lower in ExS+SAB group than in ExS group. Serum creatine phosphokinase activity of ExS+SAB was significantly lower than ExS group. However, the content of serum creatinine had no difference between ExS and ExS+SAB group. In the H&E stained left ventricle myocardium, ExS group showed signs of myocardial damage such as sporadic fragmentation of myocardial fibers, interstitial edema, cytoplasmic eosinophilia and neutrophils infiltration. However, ExS+SAB group alleviated the severity of the signs of myocardial damage. In the myocardial dihydroethidium staining, optical density was remarkably decreased in ExS+SAB group compared to ExS group. Furthermore, the up-regulation of Bax/Bcl-2 ratio was observed in ExS+SAB group compared with ExS group. Conclusions: The above results suggest that SAB may protect cardiac muscle damage via antioxidant activity and prevention of apoptosis.

• 해양환경안전학회지
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• 제27권6호
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• pp.875-882
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• 2021

통상적으로 직업소음에 의한 청력손실을 최소화하기 위해서는 작업자가 8시간 동안 85 dBA 이상 소음에 노출되지 않도록 권고하고 있다. 이번 연구에서는 실습선박에서 7종류의 담당업무별 작업자들의 소음노출레벨을 측정하였다. 항해 중, 24시간 동안 작업자의 위치하는 A특성등가소음레벨(L_Aeq,i)과 소음장소의 지속기간(h) 및 소음기여도(L_ex,24h,i)를 고려한 소음노출레벨(L_ex,24h)을 측정하였다. 그 결과, 갑판사관 그룹 L_ex,24h=56.1 dB, 갑판부원 그룹은 L_ex,24h=58.9 dB, 실습항해사들은 L_ex,24h=62.0 dB, 취사부원들은 L_ex,24h=64.3 dB, 실습기관사그룹은 L_ex,24h=91.1 dB, 기관사관 그룹은 L_ex,24h=91.1 dB, 그리고 기관부원 그룹은 L_ex,24h=95.1 dB를 나타내고 있다. 따라서 기관 업무를 담당하는 기관사들, 기관부원들 그리고 기관실습생들은 반드시 청력보호구를 착용해야함을 알 수 있었다. 소음이 심한 기관실에서 청력보호구를 착용한다면 기관사관그룹은 L_ex,24h=23.1 dB, 기관부원그룹은 L_ex,24h=24.4 dB 그리고 기관실습생들은 L_ex,24h=21.5 dB의 소음노출레벨을 줄일 수 있을 것으로 추정된다. 또한 실습생들의 거주구역인 제2 강의실 겸 식당구역에 바닥시공을 64 mm, A-60-class 뜬바닥 구조로 개선했다면 실습항해사들의 소음노출도는 L_ex,24h=4.3 dB, 실습기관사들은 L_ex,24h=1.8 dB 정도 추가적인 감소가 있었을 것이다.

• 융합경영연구
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• 제3권4호
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• pp.21-27
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• 2015

With the recent increasing interest in sustainability management, the latest environmental report tends to be substituted by the expanded sustainability management report. In this work, I would like to introduce the management pattern of a global enterprise that values environmental soundness (environmental friendly) and implements eco-friendly measures. The enterprise chosen in this study is FedEx. In this article, FedEx case is presented how companies can adopt environmental friendly management in their businesses. FedEx has maintained an eco-friendly management since the introduction of the company's eco-friendly transport trucks in 2003, following its development in 2000. In 2005, it installed a solar power plant that can supply up to 80% of the electricity consumed by Oakland Logistics Center in California, USA. FedEx has published the "Global Enterprise Citizenship Report," which contains its business developments in 2009. FedEx has worked hard to minimize the influence caused by packaging of goods to the environment and appealed to customers to use recycled products as much as they can. FedEx also encourages customers to use packaging materials efficiently. A considerable amount of energy has been expended in the eco-friendly programs of FedEx. Although thousands of FedEx vehicles and aircraft operate daily with using large amounts of electricity and fuel, FedEx focuses on energy savings and global environment protection.