• Molecules and Cells
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• 제41권3호
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• pp.179-187
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• 2018

Proteomic analysis of extracellular vesicles (EVs) from biological fluid is a powerful approach to discover potential biomarkers for human diseases including cancers, as EV secreted to biological fluids are originated from the affected tissue. In order to investigate significant molecules related to the pathogenesis of bladder cancer, EVs were isolated from patient urine which was analyzed by mass spectrometry based proteomics. Comparison of the EV proteome to the whole urine proteome demonstrated an increased number of protein identification in EV. Comparative MS analyses of urinary EV from control subjects and bladder cancer patients identified a total of 1,222 proteins. Statistical analyses provided 56 proteins significantly increased in bladder cancer urine, including proteins for which expression levels varied by cancer stage (P-value < 0.05). While urine represents a valuable, non-invasive specimen for biomarker discovery in urologic cancers, there is a high degree of intra- and inter-individual variability in urine samples. The enrichment of urinary EV demonstrated its capability and applicability of providing a focused identification of biologically relevant proteins in urological diseases.

• 한국인터넷방송통신학회논문지
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• 제17권5호
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• pp.199-208
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• 2017

리튬 폴리머 배터리는 높은 안전성, 빠른 충전 및 긴 라이프 사이클 등으로 인해 에너지 저장치(ESS: Energy Storage System), 전기자동차(EVs: Electric Vehicles)등에 채택이 되어 사용되고 있으며, 그리고 현재는 농업용 드론에서 까지 사용이 되고 있다. 그러나 리튬 폴리머 배터리는 과충 방전에는 리튬-이온 배터리 내의 격차구조가 파괴되어 배터리 수명이 줄어들게 되며, 과충 방전을 방지하기 위해 불균등한 셀 전압을 균등 제어 할 수 있는 셀 밸런싱 시스템이 필수적이다. 본 논문은 각 셀의 충 방전할때의 전압차이를 검출하여 불균형된 셀을 확인하여 비선형 시스템에 적합한 퍼지 제어기를 개발하여 적용한 셀별 밸런싱 알고리즘을 제안한다. 본 논문은 농업용 드론의 배터리팩의 셀 밸런싱을 퍼지제어를 하여 셀 간 균등 제어를 위해 설계하였으며, 최종 결과로 셀 간 밸런싱이 잘 되는지 확인하고 자 셀이 2개 있을 때와 6개 그리고 최종적으로 12개의 각 셀 밸런싱이 되는지를 확인하였다. 이는 다른 제품에도 사용할 수 있는지를 실험하고자 하였으며, 확인결과 사용된 셀의 개수와는 관계없이 셀별 밸런싱이 잘 되고 있음을 확인하였다.

• 한국전기전자재료학회논문지
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• 제29권5호
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• pp.298-302
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• 2016

In this work, $LiMn_2O_4$ and $LiNi_{1/3}Mn_{1/3}Co_{1/3}O_2$ cathode materials are mixed by some specific ratios to enhance the practical capacity, energy density and cycle performance of battery. At present, the most used cathode material in lithium ion batteries for EVs is spinel structure-type $LiMn_2O_4$. $LiMn_2O_4$ has advantages of high average voltage, excellent safety, environmental friendliness, and low cost. However, due to the low rechargeable capacity (120 mAh/g), it can not meet the requirement of high energy density for the EVs, resulting in limiting its development. The battery of $LiMn_2O_4-LiNi_{1/3}Mn_{1/3}Co_{1/3}O_2$ (50:50 wt%) mixed cathode delivers a energy density of 483.5 mWh/g at a current rate of 1.0 C. The accumulated capacity from $1^{st}$ to 150th cycles was 18.1 Ah/g when the battery is cycled at a current rate of 1.0 C in voltage range of 3.2~4.3 V.

• 대한교통학회지
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• 제36권2호
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• pp.129-140
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• 2018

본 연구에서는 이항로짓모형 기반의 시장분할을 고려한 전기차 선택모형을 추정하여 전기차 잠재 수요층의 전기차 구매행태를 분석하였다. 모형 구축을 위하여 서울시에 거주하는 차량운전자를 대상으로 전기차 구매가격, 공용 충전인프라 구축 수준, 1회 충전 주행가능거리 등의 가상 시나리오에 대하여 전기차 선택여부를 조사하였다. 차급별로 구분하면 경 소형 차급 보유자는 차량 구매가격이 가장 큰 영향을 미치며, 중 대형 차급 보유자는 공용 충전인프라 구축 수준을 중요시하는 것으로 나타났다. 주택유형으로 분할한 경우 공동주택 거주자는 전기차 선택 시 공용 충전인프라 구축 수준을 가장 크게 고려하지만, 단독주택 거주자는 차량 구매가격에 가장 민감한 것으로 분석되었다. 이상의 결과를 토대로 자동차 제작사의 전기차 보급 전략이 전략적 구매층을 어디로 설정하느냐에 따라 달라져야 함을 보여주며, 정부의 전기차 보급정책으로는 공용 충전인프라의 확대가 가장 우선적으로 추진되어야 할 필요가 있다.

• 인터넷정보학회논문지
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• 제21권5호
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• pp.39-48
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• 2020

Recently, the study and development of environment-friendly energy technique have increased in worldwide due to environmental pollution and energy resources problems. In vehicle industry, the development of electric vehicle(EV) is now on progress, and also, many other governments support the study and development and make an effort for EV to become widely available. In addition, though they strive to construct the EV infra such as a charge station for EV, the techniques related to managing charge demand and peak power are not enough. The standard of EV communication has been already established as ISO/IEC 15118, however, most of implemented EVs and EV charge stations do not support any communication between each of them. In this paper, an improved slow charge scheme for non-communication EVs is proposed and designed by using predicting charge demand. The proposed scheme consists of distributed charge model and charge demand prediction. The distributed charge model is designed to manage to distribute charge power depending on available charge power and charge demand. The charge demand prediction is designed to be used in the distributed charge model. The proposed scheme is based on the collected data which were from EV slow charge station in business building during the past 1 year. The system-level simulation results show that the waiting time of EV and the charge fee of the proposed scheme are better than those of the conventional scheme.

• 문화기술의 융합
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• 제6권4호
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• pp.429-434
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• 2020

전 세계적으로 전기차 판매가 급속도로 증가하고 있으며 이로 인해 환경오염물질 배출(CO2, 질산화물 등)을 줄이는 데 큰 도움이 되고 있다. 하지만 일반적으로 전기차 충전기는 비즈니스 지구 및 주택 지구등을 포함하는 도심 지역에 설치되어 있기에 교외에 거주하는 전기차 사용자들은 정기적 충전 루틴을 확립하기가 매우 어려운 상황이다. 상황 개선을 위해 국내 거주 전기차 사용자들이 손쉽게 접근할 수 있는 거리 범위 내에 위치한 편의점 및 식당(주차장을 보유한) 등과 연계한 생활 밀착형 전기차 충전 서비스를 제안하였다. 사람들이 카페나 식당에서 짬짬이 스마트폰을 충전하는 것처럼 쇼핑과 식사를 하면서 전기차를 충전할 수 있도록 하는 것이 본 서비스가 지향하는 목표이다. 전기차의 충전과 유지보수에 관한 현재 사용자의 니즈를 파악하기 위해 유저 다이어리 연구와 포커스 그룹 인터뷰 연구를 진행하였고, 그 결과를 본 서비스 디자인 개발과정에 적용하였다. 추가적으로 본 서비스가 타게팅하는 상업시설에 손쉽게 설치할 수 있도록 디자인된 두 가지 유형의 충전 장치인 벽걸이형 스마트 소켓 및 폴형 스마트 소켓장치를 설계 및 제작하였다.

• 대한의용생체공학회:의공학회지
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• 제21권3호
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• pp.225-231
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• 2000

표면에 의한 3차원 재구성 방법 중 Delaunay 삼각형 분할 방법은 기존의 기하학적 연결성 문제를 해결하고 영상의 질도 높은 것으로 평가받고 있다. 그러나 이 방법은 윤곽선의 위치에 따른 비 입체적 연결성 문제를 갖고 있다. 본 논문에서는 PC환경에서 이러한 문제를 개선한 Delaunay 삼각형 분할 재구성 방법을 제안하였다. 제안된 방법은 기존의 방법에서 나타나는 '비 입체(non-solid)‘ 사면체의 효과적인 처리를 위하여 수정된 External Voronoi Skeleton(EVS)을 이용한 제거 알고리즘을 사용하였다. 이를 적용한 결과. 원 객체 형태에 영향을 주지 않으면서 '비 입체' 사면체만이 제거됨을 확인할 수 있었다. 그리고 재구성된 영상의 표면이 사면체로 촘촘하게 연결되므로 복잡한 형태를 갖는 입체의 표면을 효과적으로 재구성할 수 있었다.

• 전기학회논문지
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• 제66권12호
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• pp.1889-1894
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• 2017

Global automobile manufacturers are developing electric vehicles (EVs) to eliminate the pollutant emissions from internal combustion vehicles and to minimize fossil fuel consumptions for the future generations. However, EVs have a disadvantage of shorter traveling distance than that of conventional vehicles. To answer this shortfall, more batteries are installed in the EV to satisfy the consumer expectation for the driving range. However, as the energy capacity of the battery mounted in the EV increases, the amount of heat generated by each cell also increases. Naturally, a better battery thermal management system (BTMS) is required to control the temperature of the cells efficiently because the appropriate thermal environment of the cells greatly affects the power output from the battery pack. Typically, the BTMS is divided into an active and a passive system depending on the energy usage of the thermal management system. Heat exchange materials usually include gas and liquid, semiconductor devices and phase change material (PCM). In this study, an application of PCM for a BTMS was investigated to maintain an optimal battery operating temperature range by utilizing characteristics of a PCM, which can accumulate large amounts of latent heat. The system was modeled using Dymola from Dassault Systems, a multi-physics simulation tool. In order to compare the relative performance, the BTMS with the PCM and without the PCM were modeled and the same battery charge/discharge scenarios were simulated. Number of analysis were conducted to compare the battery cooling performance between the model with the aluminum case and PCM and the model with the aluminum case only.

• BMB Reports
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• 제55권5호
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• pp.205-212
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• 2022

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating chronic disorder characterized by suprapubic pain and urinary symptoms such as urgency, nocturia, and frequency. The prevalence of IC/BPS is increasing as diagnostic criteria become more comprehensive. Conventional pharmacotherapy against IC/BPS has shown suboptimal effects, and consequently, patients with end-stage IC/BPS are subjected to surgery. The novel treatment strategies should have two main functions, anti-inflammatory action and the regeneration of glycosaminoglycan and urothelium layers. Stem cell therapy has been shown to have dual functions. Mesenchymal stem cells (MSCs) are a promising therapeutic option for IC/BPS, but they come with several shortcomings, such as immune activation and tumorigenicity. MSC-derived extracellular vesicles (MSC-EVs) hold numerous therapeutic cargos and are thus a viable cell-free therapeutic option. In this review, we provide a brief overview of IC/BPS pathophysiology and limitations of the MSC-based therapies. Then we provide a detailed explanation and discussion of therapeutic applications of EVs in IC/BPS as well as the possible mechanisms. We believe our review will give an insight into the strengths and drawbacks of EV-mediated IC/BPS therapy and will provide a basis for further development.

• 대한간호학회지
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• 제53권4호
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• pp.371-384
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• 2023

Purpose: With an increase in the aging population, the number of patients with degenerative spinal diseases undergoing surgery has risen, as has the incidence of postoperative delirium. This study aimed to investigate the risk factors affecting postoperative delirium in older adults who had undergone spine surgery and to identify the associated biomarkers. Methods: This study is a prospective study. Data of 100 patients aged ≥ 70 years who underwent spinal surgery were analyzed. Demographic data, medical history, clinical characteristics, cognitive function, depression symptoms, functional status, frailty, and nutritional status were investigated to identify the risk factors for delirium. The Confusion Assessment Method, Delirium Rating Scale-R-98, and Nursing Delirium Scale were also used for diagnosing delirium. To discover the biomarkers, urine extracellular vesicles (EVs) were analyzed for tau, ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), neurofilament light, and glial fibrillary acidic protein using digital immunoassay technology. Results: Nine patients were excluded, and data obtained from the remaining 91 were analyzed. Among them, 18 (19.8%) developed delirium. Differences were observed between participants with and without delirium in the contexts of a history of mental disorder and use of benzodiazepines (p = .005 and p = .026, respectively). Tau and UCH-L1-concentrations of urine EVs-were comparatively higher in participants with severe delirium than that in participants without delirium (p = .002 and p = .001, respectively). Conclusion: These findings can assist clinicians in accurately identifying the risk factors before surgery, classifying high-risk patients, and predicting and detecting delirium in older patients. Moreover, urine EV analysis revealed that postoperative delirium following spinal surgery is most likely associated with brain damage.