• Korean Chemical Engineering Research
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• v.48 no.1
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• pp.121-127
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• 2010

This study is to optimize the enzyme(lipase) activity for biodiesel production. The ion-exchanged non-woven fabrics(EtA, DEA-EtA non-woven fabric) containing ethanolamine, diethylamine groups are used by radiation induced grafted polymerization onto a non-woven fabric for more effective immobilization of lipase. Since the porous hollow fiber membranes are showed the low throughputibehe non-woven fabric membranes are used for biodiesel production. The physical charateristics of enzyme immobilized and the enzyme activity to EtA and DEA-EtA non-woven fabrics are studied. The EtA non-woven fabrics are quite similar to DEA-EtA non-woven fabric for the amount of enzyme immobilized(EtA non-woven fabric:15.69 mg/g, DEA-EtA non-woven fabric:14.45 mg/g) but DEA-EtA non-woven fabrics have shown the lower permeabiliquite the organic solvent than the EtA non-woven fabrics(EtA non-woven fabric:$3.50mol/h{\cdot}kg$, DEA-EtA non-woven fabric:$0.38mol/h{\cdot}kg$). Optimum characteristics of ehe non-woven fabric membranes and the limilaractivity are also investigated for the effective biodiesel production.

• Journal of Chest Surgery
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• v.25 no.6
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• pp.650-660
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• 1992

To elucidate a potential contribution of endotheline-1[ET-1] to the genesis of pulmonary hypertension and postoperative pulmonary hypertensive crisis in the patients with heart disease, we measured plasma levels of the ET-1 during perioperative period of open heart surgery. In addition, we examined changes of ET-1 during perioperative period and correlations between ET-1 levels and hemodynamic variables. 12 patients including 5 acquired heart disease and 7 congenital heart disease patients were selected randomly as a study group, Group A and B, respectively. 6 patients proved not having heart or hemodynamic problem were selected as a control, Group C. 110 blood samples from pulmonary artery[ET-P] and radial artery[ET-S] were taken and assayed by Sep-pak extraction and RIA. ET-1 levels of Group A were ET-P, 3.94$\pm$5.31pg /ml, ET-S, 3.10$\pm$2.90pg/ml[p>0.05], Group B were ET-P, 1.63$\pm$0.62pg/ml, ET-S, 1.99$\pm$2.45pg/ml[p>0.05], Group C were ET-P, 1.97$\pm$2.02pg/ml, ET-S, 1.72$\pm$0.77pg/ml[p>0.05]. There were no statistically significant differences of ET-1 levels among the Group A, B, C[p>0.05]. There was no correlation between pulmonary artery pressure[PAP] and ET-1 level[p>0.05], and ET-1 levels were not increased even in the cases of pulmonary hypertensive criwis or low cardiac output syndrome, whereas significant correlation between ET-S and pulmonary vascular res-istance[Rp] [r=0.36, p<0.05], and negative correlation between ET-S and OS saturation of pulmonary artery[OS-P][r= -0.49, p<0.01] were identified. Another significant finding was peak increase of ET-1 levels in the postoperative period 1 hour[p<0.05] and then gra-dualy decrease through the postoperative period. In conclusion, ET-1 has no correlation with PAP, whereas correlation with Rp, and inverse correlation with OS-P. It is suggested that ET-1 is neither the direct causative substance of pulmonary hypertension nor pulmonary vasospasm but there must be increased production of ET-1 in chronic pulmonary hypertensive state. Counter-regulatory mechanism to ET-1 is speculated during the pulmonary vasospasm.

• Proceedings of the Ginseng society Conference
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• 2002.10a
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• pp.366-375
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• 2002

There has been continuing interest in the development of synthetic and natural compounds that modify the immune response particularly for the treatment of AIDS and cancer. During the past fifty years, numerous scientific studies have been published on ginseng (Foster and Chongxi, 1992). Modern human studies have investigated preventive effect of ginseng on several kinds of cancer (Yun et al, 1993,Yun, 1995,Yun and Choi, 1998), its long term immunological effect on HIV patients (Sankang, 1989, Cho et al, 1997), its effect on cell mediated immune functions in healthy volunteers (Scaglione et al, 1990). Similarly non clinical studies on animal model system have studied the chemopreventive action of ginseng on cancer (Kumar, 1993,98) and immunological properties of ginseng (Kim et al, 1990, Tomoda et al, 1993, Yun et al, 1993, Mizuno et al, 1994,Lee et al, 1997, Park et al, 2001,Yoshikawa et al, 2001, Wang et al, 2001). The precise mechanism of action of ginseng, however, not clearly understood. Considering its wide-ranging therapeutic effects, this study is being undertaken to elucidate the general mode of action of ginseng, especially to test our hypothesis that its biological action may be mediated by the immune system.

• The Korean Journal of Zoology
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• v.34 no.4
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• pp.500-525
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• 1991

1986년부터 1991년까지 우리나라 연안에서 채집된 베도라치아목 Blennioidei과 등가시치아목 Zoareoidei의 어류 표본을 대상으로 분류학적으로 재검토하였다. 베도라치아목 어류는 먹베도라치과 Tripterygiidae의 가막베도라치 Enneoptewgius etheostomus(Jordan et Snyder) , 비늘 베도라친과 Labrisomidae의 비늘베도라치 감eoclinus bwope(4ordan et Snyder) , 그리고 청 베도라치과 B1enniidae의 청베도라치 Pictiblennius yotobei(Jordan et Snyder), 저울베도라치Entomacrodus stellifer lighti(Herre), 대강베도라치 Istibfennius enosimae(Jordan et Snyder), 앞동갈베도라치 Omobranchus elrgons(Steindachner), 골베도라치 O. punctatus (Valenciennes) 및 두줄베도라치 Petroscines breuiceps(Valenciennes)의 7속 8종으로 분류되었다. 이 가운데 N. bwope의 표본은 우리나라에서는 본 조사기간 중 제주도 연안에서 처음으로 확인되어 한국 미기록종으로 보고한다. 한편 등가시치아목의 어류는 등가시치란 Zoarcidae의 벌레문치 Lycodes tanakoi Jordan et Thompson, 먹갈치 Lycodes nakamurai Tanaka, 등가시치 Zoarces gilrii Jordan et Starts, 실베도라치 Zoarchias aculeatus( Basilewsky), 우베도라치 Zoarchias uchidai Matsubara, 민베도라치 Zoarchias glaber Tanaka, 얼룩가시치 Neozoarces pulcher Steindachner, 칠성갈치 Petroschmidtia toyamensis Katayama, 자갈치 Gvmnelopsis brashnikoui Soldatov, 문자갈치 Dauidijordania poecilimon(Jordan et Fowler) 및 청자갈치 Allolepis hollandi Jordan et Hubbs, 장갱이란 Stichaeidae의 세줄베도라치 식nogrammus hewagrammus(Temminck et Schlegel), 장갱이 Stichaeus grigorjemi Her\ulcornerenstein, 왜도라치 Chri'olophis wui(Wang et Wang ) , 괴도라치 Chirolophis joponicus(Jordan et snyder) , 벼슬베도라치 각ectrias benjamini Jordan et Snyder, 가시베도라치 Lumpenella nigricons Matsubara, 육점날개 Ophistocentws zonope jordan et Snyder, 그물베도라치 Dictyosoma burgeri Van der Hoeven 및 황점 베도라치Dictyosoma wbrimaculata Yatsu, Yasuda et Taki, 그리고 황줄베도라치란 Pholididae의 황줄베도라치 Phoris taczanowskii(Steindachner), 오색베도라치 Phoris omotus (Girad), 베도라치 Pholis nebuloso(Temminck et Schlegel), 횐베도라치 Pholisfangi(Wang et Wang) 및 점베도라치 Pholis crossispino(Temminck et Schlegel)의 17속 25종이 분류되었다. 이중에서 Zoarchias glaber, Chirofophis oui, Alectrias benjamini, Dictyosoma mbrimaculamia 및 Pholis crassispina의 5종은 한국 미기록종으로 보고한다. 아울러 이들 미기록종을 포함한 한국산 베도라치아목과 등가시치아목 어류의 속 .종 검색선 와 종별 사진을 제시하고, 이들 표본을 근거로 하여 형태적 특징, 계수계측치, 채집지 및 서식처를 기록하였으며, 이들의 분류학적 위치에 대해 논의하였다. 우리나라에 출현하는 베도라치아권의 어류는 거의 대부분이 제주도 연안과 서남해 연안에 제한분포하는데, 등가시치아목의 어류는 주로 동해연안에서 많은 종이 출현하고 있어서 동물지리학적으로 주목된 다.

• Proceedings of the Korean Society of Fisheries Technology Conference
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• 2003.05a
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• pp.322-323
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• 2003

연쇄구균병은 담수어 및 해산어에 패혈증을 일으켜 양식산업에 막대한 피해를 주는 질병이다. 해산양식어류인 방어(Kusuda et al., 1976; Minami, et al., 1979), 넙치(Nagatsugawa, 1983; Heo et al., 2001), 터봇(Domenech et al., 1996), gilthead sea bream 및 European sea bass (Zlotkin et al., 1998a) 등의 연쇄구균병에 관한 연구가 활발히 진행되고 있고, 특히 최근에는 PCR에 의한 신속진단 및 동정에 관한 연구가 이루어지고 있다(Aoki et al., 2000; Lee et al., 2001; Nguyen et al., 2002). (중략)

• Journal of Nutrition and Health
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• v.37 no.2
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• pp.95-99
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• 2004

This study was designed to investigate the effects of ethyl acetate(EtOAc) fraction of pine (Pinus densiflora Sieb et Zucc) needle on cholesterol and lipofuscin(LF) accumulations, acetylcholine(ACh) and its related enzyme activities such as choline acetyltransferase(ChAT) and acetylcholinesterase(AChE), and monoamine oxidase-B(MAO-B) activity, which destroyed the catecholamine related neurotransmitters in brain membranes of Sprague- Dawley (SD) rats. Male SD rats were fed basic diets (control group) and experimental diets (EtOAc-25, EtOAc-50 and EtOAc-100) for 45 days. Cholesterol accumulations in mitocholndria and microsomes were significantly inhibited (11.8-12.1% and 9.6-13.0%, respectvely) in EtOAc-50 and EtOAc-100 groups. ACh levels and ChAT activities were significantly increased about 10% in membranes of EtOAc-100 group compared with control group. AChE activities were significantly increased about 8 -12% in membranes of EtOAc-50 and EtOAc-100 groups compared with control group. MAO-B activities were significantly inhibited about 10% in membrane of EtOAc-l00 group compared with control group. These results suggest that ethyl acetate fraction of pine needle may play an effective role in inhibiting cholesterol and improving a membrane fluidity, and learning and memory impairments. (Korean J Nutrition 37(2): 95 -99, 2004)

• Journal of Pharmaceutical Investigation
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• v.27 no.2
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• pp.125-131
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• 1997

Ethoxycarbonyloxyethyl ester of ceftezole (CFZ-ET) was synthesized as a prodrug by esterification of ceftezole (CFZ) with ethoxycarbonyloxyethyl chloride and was confirmed by spectroscopic analyses. CFZ-ET was more lipophillic than CFZ as assessed by n-octanol and water partition coefficients at various pH. CFZ-ET itself did not show any microbiological activity in vitro, but showed substaintial microbiological activity after oral administration of CFZ-ET, indicating that CFZ-ET is converted to microbiologically active metabolite, probably CFZ, in the body. When CFZ-ET was incubated in blood, liver and intestine homogenates of rabbits, liver homogenate showed the fastest conversion of CFZ-ET. CFZ-ET appears rapidly metabolized in the liver when given orally due to the hydrolysis of the ester to CFZ, the parent drug of CFZ-ET. In vivo metabolism of CFZ-ET to CFZ was confirmed in rabbit by HPLC analysis. CFZ-ET were higher than those in the serum samples taken after oral administration of equivalent amount of CFZ. Oral bioavailability of CFZ-ET was 1.5-fold higher than that of CFZ in rabbits because of enhanced lipophilicity and absorption. Based on these findings, CFZ-ET appears useful as a prodrug of CFZ to improve the oral bioavailability of CFZ.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.37 no.3
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• pp.549-559
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• 2017

The complementary relationship hypothesis for areal evapotranspirations was validated in the regional-scale area of multipurpose dam basins in Korea and the long-term water balances were indirectly identified. Annual actual evapotranspiration ($ET_A$) was assumed the difference between total annual precipitation and total annual inflow and the available moisture was assumed the total precipitation. The seasonally varying pan coefficient (kp) is estimated as the ratio of the $ET_{pan}$ and the evapotranspiration calculated by FAO Penman-Monteith equation ($ET_{PM}$). The complementary relationships using ground observation data of $ET_P$ and $ET_A$ in the multipurpose dam basins follow generally the typical pattern that $ET_P$ and $ET_A$ is complementary and converges to equivalent evapotranspiration ($ET_W$) under the extreme wet environment. However, $ET_A$ of Juam dam was estimated relatively greater than other basins and exceeds even $ET_P$ at certain range with high moisture availability, which can be understood as the results of possible over-estimation of precipitation or under-estimation of dam inflow. It is expected that the use of evapotranspiration complementary relationship for validating hydrological water balances will contribute to controlling uncertainties in estimating dam inflows during flood season in particular.

• Analytical Science and Technology
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• v.34 no.3
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• pp.115-121
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• 2021

Ethyl glucuronide (EtG) and ethyl sulfate (EtS), which are ethanol metabolites, are direct indicators of ethanol intake; they have been studied in a variety of biological samples in forensic science. It is necessary to analyze ethanol metabolites to determine whether the ethanol detected in autopsy cases was due to alcohol consumption before death or due to the ethanol produced from post-mortem decay. In general, EtG and EtS are detected in the blood together with ethanol; however, it may be difficult to secure blood depending on the extent of decay. Therefore, the aforementioned method should be replaced by detecting the ethanol metabolites using tissue biological samples. In this study, we determined the optimal experimental conditions for detecting EtG and EtS from spleen samples using Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS). Herein, the test method was validated, and an analysis method was applied to the actual autopsy cases.

• Water Engineering Research
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• v.5 no.1
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• pp.1-16
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• 2004

The purpose of this study is to understand the characteristics of hourly PET(Potential Evapo Transpiration) variation estimated using Penman ET model. The estimated PET using Penman model was compared with measured ET. For this study, two subwatersheds were selected, and fluxes, meteorological data and soil moisture data were measured during the summer and winter days. During the winter days, the aerodynamic term of Penman ET is much greater than that of energy term of Penman ET for dry soil condition. The opposite phenomena appeared fer wet soil condition. During the summer days, energy term is much more important factor for ET estimation compared with aerodynamic term regardless of soil moisture condition. Penman ET, measured ET, and energy term show the similar hourly variation pattern mainly because the influence of net radiation on the estimation of Penman ET is much more significant compared with other variables. Even though there are much more soil moisture in the soil during the wet days, the estimated hourly ET from Penman model and measured hourly ET have smaller values compared with those of dry days, indicating the effect of cloudy weather condition.