• Clinical and Experimental Reproductive Medicine
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• v.29 no.1
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• pp.13-20
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• 2002

Objective: This study was carried out to establish the effectiveness of the vitrification method and the optimal cryoprotectants in the cryopreservation of human embryonic stem cells (ESC). Materials and Methods: Human ESC clumps established at Seoul National University Hospital (SNUhES 1) were cryopreserved with the vitrification method using the EM grid. EDS and EFS40 were used as vitrification solutions. Results: Between the EDS and EFS40 groups, there was no significant difference in the recovery rate after cryopreservation of human ESC. The formation rates of ESC colonies in the vitrified groups were significantly lower than those in the control ESC group (p<0.05, p<0.05). In addition, the formation rate of ESC colonies in the EDS group was significantly higher than that in the EFS40 group (p<0.05). The ESC colonies in the vitrified groups were significantly smaller after culture duration of 2 and 4 days, respectively, compared with the control ESC group (p<0.1, p<0.05). However, these effects could be reduced to nonsignificant level by the additional culture of ESC colonies. The vitrified human ESC retained the properties of pluripotent cells, including the expression of cell surface. markers for the undifferentiated cells such as alkaline phosphatase and SSEA-4 (stage-specific embryonic antigen-4), and the expression of transcription factor Oct-4 (octamer-binding transcription factor-4), and the normal karyotype. Conclusion: The vitrification method using the EM grid and EDS solution was confirmed to be very effective for the cryopreservation of human ESC.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.22 no.1
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• pp.57-67
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• 2018

Objectives The objective of this study is to examine the interpretability of the questionnaire-based pattern identification in terms of biosignals. For this purpose, we investigate the relationship between electrochemical skin conductance (ESC) and Qi-Blood-Yin-Yang Deficiency Questionnaire (QBYY-Q) in diabetic patients. Methods A total of 40 patients with diabetes mellitus answered the QBYY-Q and their ESC were measured by SUDOSCAN device (a diabetes screening device, France). To analyze the relationship between QBYY-Q and ESC, ANOVA analysis and Scheffe test were performed and Pearson correlation coefficients were obtained. Results Of the 40 diabetic patients, 23 (57.5%) were males and 17 (42.5%) were females. According to the QBYY-Q, 9 patients were classified into Qi deficiency pattern (QD), 9 patients were Blood deficiency pattern (BD), 10 patients were Yin deficiency pattern (YiD) and 12 patients were Yang deficiency pattern (YaD). Demographic information (age, body mass index, duration of illness, etc.), signs of vitality (blood pressure, body temperature, etc.), fasting plasma glucose and glycated hemoglobin were not significantly different in each deficiency pattern. The ESC of the right leg was significantly lower in the BD group compared to the YiD group (p<0.022). Pearson's correlation coefficient was negatively correlated with the BD questionnaire score (r=-0.343, p <0.05). Finally, ESC showed a positive correlation with hemoglobin and erythrocyte levels in all limbs (r=0.483, p<0.01). Conclusions We showed that ESC could be used to classify the Deficiency pattern identifications in diabetic patients. Especially, the ESC was significantly lower in the BD group and was negatively correlated with the BD scores. It implies the potential utility of the ESC to understand the BD in terms of modern biosignals.

• Journal of Advanced Navigation Technology
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• v.27 no.2
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• pp.214-220
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• 2023

Because there exist a region in the rotational speed and torque map that the a particular combination of a motor and an ESC (Electronic Speed Control) can maintain its peak efficiency, identifying this region is important for designing an efficient system. Firstly the accuracy of the measurement device is verified using the published propeller measurement data. And then, the combined motor-ESC efficiencies of an individual propeller are measured at a wide range of rotational speeds. With measurements obtained from a large number of different propellers, efficiency contours are obtained. It is shown that there exist a significant difference between the measured combined efficiency and the motor efficiency computed using a simple model. In addition, with the same motor, the combined efficiency can have a meaningful variation depending on the model of the ESC. The efficiency contours derived from this study will be useful for the design and optimization of electric propulsion systems of an aircraft where propulsion efficiency is critical.

• Proceedings of the Korean Vacuum Society Conference
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• 2016.02a
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• pp.203.1-203.1
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• 2016

Poly etch 설비에서 발생하는 dechuck 불량에 의한 Dynamic Alignment(DA) error는 poly etch 설비에서의 고질 적인 문제이다. 발생 원인은 ElectroStatic Chuck(ESC)의 노후화 혹은process plasma에 의한 attack 등으로 ESC와 wafer간 dechucking이 진행될 때 wafer내의 전하가 완전히 discharge되지 못하여 wafer Sticking에 의한 sliding이 발생되며 심해지면 Dynamic Alignment(DA) Error가 발생한다. DA error 발생 되면 particle down으로 wafer는 scrap 되며 DA error가 지속적으로 발생하는 설비는 ESC 교체를 하고 있다. ESC 교체비용도 매우 크며 교체 전까지 설비가 멈추어있는 시간적인 손실이 발생하게 된다. Dechucking을 진행할 때 Wafer에 잔존하는 전하를 제거 하여 Wafer의 sticking을 줄여 DA error를 근원적으로 방지하기 위해 plasma를 이용하여 wafer와 ESC를 하나의 electric circuit으로 연결시키는 방법으로 wafer에 잔존하는 전하를 제거 시키고자 하였다.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.59 no.12
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• pp.2306-2313
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• 2010

This paper describes a model based fault detection algorithm for an Advanced ESC System which consists of Hydraulic Control Unit (HCU) with built-in wheel pressure sensors. Advanced ESC System can be used for various value-added functions such as Stop & Go Function and Regenerative Brake Function. Therefore, HCU must have a reliable fault detection. Due to the huge amount of sensor signals, existing specific sensor based fault detection of HCU cannot guarantee the safety of vehicle. However, proposed algorithm dose not require the sensors. When model based fault detection algorithm detects severe failures of the HCU, it warns the driver in advance to prevent accidents due to the failures. For this purpose, a mathematical model is developed and validated in comparison to actual data. Simulation results and data acquired from an actual system are compared with each other to obtain the information needed for the fault detection process.

• Journal of Auto-vehicle Safety Association
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• v.6 no.2
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• pp.23-28
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• 2014

Commercial vehicle ESC assessment for curvature road was conducted. The previous study of ESC activation condition for losing controllability utilizing the test protocols of double lane change and sine with dwell method was conducted without considering the geometric complexity of roadway design. Since critical rollover accidents were frequently observed in the exit ramp zone, variety of curve, slope and bank have been added for analysis conditions. Detailed feature of the ramp including location, dimension and design characteristics have been analyzed from the typical trumpet type ramp design. Analyzing accident data from 2008, two specific ramps have been selected due to their complexity in design and severity in steering operation.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.50 no.2
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• pp.160-168
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• 2017

Optimizing the conditions for stem cell culture is an essential prerequisite for the efficient utilization of stem cells. In the culture of fish embryonic stem cells (ESCs) or ESC-like cells, embryo extracts are important for stable growth, but there is no rule for determining the developmental stage of the embryos used to obtain extracts. Therefore, this study investigated the effects of the developmental stage of extract donor embryos on the culture of Oryzias dancena ESC-like cells. O. dancena ESC-like cells were cultured in different media containing each of four types of embryo extract depending on the developmental stage of the extract donor embryos. Growth, morphology, colony-forming ability, alkaline phosphatase (AP) activity, and embryoid body (EB) formation of the cells were investigated. While the developmental stage of the extract donor embryos did not influence the growth, morphology, AP activity, or EB formation of ESC-like cells, colony-forming ability was affected and the pattern of the effects differed completely between the two ESC-like cells investigated. These results suggest that the developmental stage of extract donor embryos should be selected carefully for the culture of ESC-like cells, according to the research purpose and type of cell line.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2017.05a
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• pp.473-487
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• 2017

본 논문은 대한민국의 제19대 대통령 선거와 관련하여 각 후보들의 과학기술정책 공약이 과학자들의 여론을 반영하였는지 알아본다. 이를 위해서, 주요 정당(더불어민주당, 국민의당, 바른정당, 정의당)의 후보들이 과학 언론인 동아사이언스로부터 받은 과학기술정책 공약에 대한 문의에 대해 답변한 내용과 사단법인 과학자 단체인 '변화를 꿈꾸는 과학기술인 네트워크(ESC)'가 발간한 '2017 대선 과학기술지원정책 타운미팅 - 우리는 대통령 후보에게 무엇을 묻고 요구할 것인가'라는 자료집에 대해 답변한 내용을 중심으로 하였다. ESC의 해당 자료집은 ESC 소속 회원들이 주관한 타운미팅에서 참가자들이 소속 및 직위에 의한 제한 없이 반대 의견에 부딪히지 않고 자유롭게 의견을 개진함으로써 발간된 것이기 때문에, 과학기술계의 여론을 가감 없이 반영했다고 볼 수 있다. 분석을 해본 결과, 국민의당 안철수 후보의 과학기술정책 공약이 과학기술계 여론을 가장 많이 반영하였으나, 과학기술 일자리 확충 및 과학기술인재 등용과 관련해서는 더불어민주당 문재인 대통령이, 과학문화 정책과 관련해서는 바른정당 유승민 후보 및 정의당 심상정 후보가 과학기술계 여론을 잘 반영한 것으로 나타났기에, 문재인 대통령이 세부 정책별로 다른 후보의 공약을 참고할 필요가 있는 것으로 파악되었다.

• Korean Journal of Clinical Pharmacy
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• v.25 no.3
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• pp.200-208
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• 2015

Objective: Patients with acute coronary syndrome (ACS) are typically managed with dual antiplatelet therapy of acetylsalicylic acid (aspirin) and $P2Y_{12}$ receptor inhibitor. In this study, we discussed current and previous antiplatelet therapy guidelines and compared with guidelines of the USA (ACC/AHA), Europe (ESC) and Korea (KSC). Method: This study investigated from ACC/AHA Joint Guidelines (the USA), ESC Clinical Practice Guidelines (Europe) and Korea Society of Interventional Cardiology (Korea) web site, respectively. Results: It is significant that difference between the current and the previous guidelines was integration of terminology from clopidogrel to $P2Y_{12}$ receptor inhibitors since prasugrel and ticagrelor, new antiplatelet drugs, has been added. The other difference was all three guidelines has differences in dose of aspirin. The most notable difference was class of recommendation(COR) in $P2Y_{12}$ receptor inhibitors. ACC/AHA and Korean guidelines recommend clopidogrel, prasugrel, and ticagrelor with COR IB; whereas, ESC recommend prasugrel and ticagrelor with IB which is higher than clopidogrel with IC. Conclusion: This research addresses important movement to revise the Korean existing guideline recommendations. New Korean antiplatelet therapy guideline should be avoiding obvious differences in ACC/AHA and ESC guidelines and harmonizing international guidelines.

• Journal of Institute of Control, Robotics and Systems
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• v.21 no.7
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• pp.595-601
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• 2015

This paper presents an unified chassis control with electronic stability control (ESC) and active front steering (AFS) under lateral force constraint on AFS. When generating the control yaw moment, an optimization problem is formulated in order to determine the tire forces, generated by ESC and AFS. With Karush-Kuhn-Tucker optimality condition, the optimum tire forces can be algebraically calculated. On low friction road, the lateral force in front wheels is easily saturation. When saturated, AFS cannot generate the required control yaw moment. To cope with this problem, new constraint on the lateral tire force is added into the original optimization problem. To check the effectiveness of the propose method, simulation is performed on the vehicle simulation package, CarSim.