• 한국대기환경학회지
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• 제32권2호
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• pp.193-207
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• 2016

This study discusses the present status of mercury emission and distribution from major anthropogenic sources in Korea and the future trend of mercury emission by activity changes and application of BATs. Atmospheric mercury emission from major anthropogenic sources based on Annex D of Minamata convention was estimated to around 4.89 tonne in 2012. Emission ratios of cement clinker production, coal-fired power plant, waste incineration and non-ferrous metal smelting were 68.68%, 24.75%, 6.29% and 0.28%, respectively. High mercury emission regions were characterized by the presence of cement clinker production facilities and coal-fired power plants. Prediction of future activities was carried out by linear regression of the previous year data. The (total) mercury emission was estimated to decrease up to 48% Under the scenario of BATs to be applied and the change of future activities. Emissions from coal-fired powerplants and cement clinkers were expected to decrease significantly.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2023년도 임시총회 및 춘계학술대회
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• pp.55-55
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• 2023

With the COVID-19 pandemic, there is increasing interest in anti-obesity strategies. According to the National Statistical Office, the obesity rate in Korea was 38.3% in 2020 and 37.1% in 2021. Obesity is a risk factor for several severe diseases, including stroke, heart disease, type 2 diabetes, and certain types of cancer. Pinus rigida × Pinus taeda is a hybrid of Pinus rigida Mill and Pinus taeda Linn, and its cones are considered a by-product. Although previous studies have investigated their pharmacological effects on antioxidant activity and protection against oxidative DNA damage, few researchers have explored their potential as functional natural materials. Therefore, we evaluated the anti-obesity effects of the cone of ethyl acetate fraction of P. rigida × P. taeda (ERT), specifically its ability to inhibit lipid accumulation. Our analysis showed that ERT contains phytochemicals (catechin and caffeic acid) which are known to improve immune function and inhibit cell damage. ERT inhibited lipid droplet accumulation at the cellular levels through Oil Red O staining. Furthermore, ERT suppressed the expression of adipogenic transcription factors (PPARγ and CEBP/α) as well as downstream lipogenic target genes (FAS and SREBP-1) thereby inhibiting adipogenesis. ERT also down-regulated key adipogenic markers, including aP2α, while inducing the phosphorylation of AMPK. It has been reported that PPARγ and CEBP/α are expressed in the early stages of adipose differentiation, while SREBP-1 is expressed in the late stage. Therefore, our findings suggest that ERT activates AMPK signaling pathways, which inhibits adipogenic transcription factors (PPARγ, C/EBPα, and SREBP1) and lipogenic genes (FAS and aP2α), thereby blocking lipid accumulation and preventing obesity and related disorders. ERT showed potential as a new resource for developing a functional material for anti-obesity agents.

• 한국산학기술학회논문지
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• 제14권7호
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• pp.3460-3467
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• 2013

본 논문에서는 2차원 대지구조를 분석하기 위해 ERT(electrical resistance tomography) 방법을 사용하여 대지모델을 영상복원하는 방법들을 수치적인 실험방법들을 통해 비교분석한다. 영상복원을 위한 역산방법으로는 Gauss-Newton, TLS(truncated least squares), 그리고 SIRT(simultaneous iterative reconstruction technieque) 알고리즘들이 제시되고 대지저항을 측정하기 위한 전극법은 대표적인 웨너와 슐럼버거 측정방법을 사용한다. 컴퓨터 시뮬레이션을 통해 Gauss-Newton과 TLS 알고리즘이 대지모델의 2차원 영상복원에서 적합하다는 것을 보인다.

• 지구물리와물리탐사
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• 제7권3호
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• pp.184-190
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• 2004

불포화대 토양특성 분석을 목적으로 토양단면의 고해상도 영상을 얻을 수 있는 전기비저항 토모그래피를 적용하였다. 전극설치 지점에서 심도별로 채취한 토양시료를 대상으로 토양 공극수의 전기전도도, 수분함량, 이온함량을 측정한 결과, 토양특성과 전기비저항 토모그래피 결과의 상관성이 토성별로 선형적인 관계가 나타남에 따라 전기비저항 토모그래피 결과를 보다 효과적으로 해석할 수 있었다. 따라서 불포화 토양층을 대상으로 한 전기비저항 토모그래피를 이용하여 시추공 사이의 토양특성을 파악할 수 있으며, 토양의 산도, 유기물 함량 등의 간접적 평가가 가능할 것으로 판단된다.

• 대한유전성대사질환학회지
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• 제14권1호
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• pp.29-36
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• 2014

Mucopolysaccharidoses (MPSs) are a group of rare inherited metabolic diseases caused by deficiency of lysosomal enzymes. MPSs are clinically heterogeneous and characterized by progressive deterioration in visceral, skeletal and neurological functions. The aim of this article is to review the treatment of MPSs, the unmet needs of current treatments and vision for the future including recent clinical trials. Until recently, supportive care was the only option available for the management of MPSs. Hematopoietic stem cell transplantation (HSCT), another potentially curative treatment, is not routinely advocated in clinical practice due to its high risk profile and lack of evidence for efficacy. From the early 2000s, enzyme replacement therapy (ERT) was approved and available for the treatment of MPS I, II and VI. ERT is effective for the treatment of many somatic symptoms, particularly walking ability and respiratory function, and remains the mainstay of MPS treatment. However, no benefit was found in the neurological symptoms because the enzymes do not readily cross the blood-brain barrier (BBB). In recent years, intrathecal (IT) ERT, substrate reduction therapy (SRT) and gene therapy have been rapidly gaining greater recognition as potential therapeutic avenues. Although still under investigation, IT ERT, SRT and gene therapy are promising MPS treatments that may prevent the neurodegeneration not improved by ERT.

• Geomechanics and Engineering
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• 제25권4호
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• pp.295-302
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• 2021

Cross-borehole electrical resistivity tomography (ERT) is an effective groundwater detection tool in geophysical investigations. In this paper, an artificial water injection test was conducted on a small clay sample, where the high-resolution cross-borehole ERT was used to investigate the moisture migration law over time. The moisture migration path can be two-dimensionally imaged based on the relationship between resistivity and saturation. The hydraulic conductivity was estimated, and the magnitude ranged from 10^-11 m/s to 10^-9 m/s according to the comparison between the simulation flow and the saturation distribution inferred from ERT. The results indicate that cross-borehole ERT could help determine the resistivity distribution of small size clay samples. Finally, the cross-borehole ERT technique has been applied to investigate the self-sealing characteristics of clay.

• Geomechanics and Engineering
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• 제35권2호
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• pp.109-119
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• 2023

Ground subsidence in urban areas due to excessive development and degraded underground facilities is a serious problem. Geophysical surveys have been conducted to estimate the distribution and scale of cavities and subsidence. In this study, electrical resistivity tomography (ERT) was performed near an area of road subsidence in an urban area. The subsidence arose due to groundwater leakage that carried soil into a neighboring excavation site. The ERT survey line was located between the main subsidence area and an excavation site. Because ERT data are affected by rapid topographic changes and surrounding structures, the influence of the excavation site on the data was analyzed through field-scale numerical modeling. The effect of an excavation should be considered when interpreting ERT data because it can lead to wrong anomalous results. A method for performing 2D inversion after correcting resistivity data for the effect of the excavation site was proposed. This method was initially tested using a field-scale numerical model that included the excavation site and subsurface anomaly, which was a loosened zone, and was then applied to field data. In addition, ERT data were interpreted using an existing in-house 3D algorithm, which considered the effect of excavation sites. The inversion results demonstrated that conductive anomalies in the loosened zone were greater compared to the inversion that did not consider the effects of excavation.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2009년도 제40회 하계학술대회
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• pp.1751_1752
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• 2009

The accurate measurement of soil resistivity and earthing system resistance is fundamental to electrical safety. However, geological and meterological factors can have a considerable effect on the accuracy of conventional measurements and the validity of the measurement methods. This paper presents optimization method of dc resistivity data acquisition system using ERT.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.2480-2484
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• 2005

Electrical resistance tomograpy (ERT) maps resistivity values of the soil subsurface and characterizes buried objects. The characterization includes location, size, and resistivity of buried objects. In this paper, truncated least squares (TLS) is presented for the solution of the ERT image reconstruction. Results of numerical experiments in ERT solved by the TLS approach is presented and compared to that obtained by the Gauss-Newton method.

• Journal of mucopolysaccharidosis and rare diseases
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• 제2권1호
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• pp.17-18
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• 2016

Enzyme replacement therapy (ERT) is a well-established means of treating lysosomal storage disease (LSD). However, classical IV infusion based ERT method produces less than ideal results, especially, CNS defects and quality of life in patients. To improve these main problems of parental IV formulation for LSDs, we investigate modified ERT method and evaluated the efficacy in animal model.