• Applied Biological Chemistry
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• v.11
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• pp.137-141
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• 1969

In order to obtain amino acids and nucleic acid derivatives from adenine auxotrophic mutants of Bacillus subtilis and Escherichia coli, vitamin, nucleic acid analogue, streptomycin as well as ultraviolet light were adopted for the production of adenine auxotrophic mutants and the results showed efficient production of desired mutants. 1. Ultraviolet ray $(2530\;{\AA}\;2080\;erg/mm^2)$ irradiation to Bacillus subtilis and E. coli at a distance of 30 cm for 80-90 sec. and for 15-20 sec. respetively induced four and eight strains of auxotrophic mutants. 2. Treatment of aminopterine$(200\;{\mu}g/ml)$ inhibited the growth of Bacillus sultilis significantly but a subsequent irradiation of ultraviolet light at the above mentioned conditions induced six times as much mutants as compared to the irradiation alone. In case of E. coli a similar tendency was observed with treatment of streptomycin$(200\;{\mu}g/ml)$ with doubled induction rate of adenine auxotrophic mutants as compared to the irradiation alone.

• Biomolecules & Therapeutics
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• v.23 no.4
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• pp.386-389
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• 2015

Sibutramine is an anorectic that has been banned since 2010 due to cardiovascular safety issues. However, counterfeit drugs or slimming products that include sibutramine are still available in the market. It has been reported that illegal sibutramine-contained pharmaceutical products induce cardiovascular crisis. However, the mechanism underlying sibutramine-induced cardiovascular adverse effect has not been fully evaluated yet. In this study, we performed cardiovascular safety pharmacology studies of sibutramine systemically using by hERG channel inhibition, action potential duration, and telemetry assays. Sibutramine inhibited hERG channel current of HEK293 cells with an $IC_{50}$ of $3.92{\mu}M$ in patch clamp assay and increased the heart rate and blood pressure ($76{\Delta}bpm$ in heart rate and $51{\Delta}mmHg$ in blood pressure) in beagle dogs at a dose of 30 mg/kg (per oral), while it shortened action potential duration (at $10{\mu}M$ and $30{\mu}M$, resulted in 15% and 29% decreases in $APD_{50}$, and 9% and 17% decreases in $APD_{90}$, respectively) in the Purkinje fibers of rabbits and had no effects on the QTc interval in beagle dogs. These results suggest that sibutramine has a considerable adverse effect on the cardiovascular system and may contribute to accurate drug safety regulation.

• Journal of Intelligence and Information Systems
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• v.28 no.3
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• pp.81-103
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• 2022

It recognizes the importance of mental health and well-being worldwide and consistently records public happiness figures through the World Happiness Report. COVID-19, which occurred in China in 2019, has changed people's daily lives a lot. The accumulation of stress caused by the prolonged epidemic is affecting people's happiness. The present research has revealed negative mental health effects such as "depression" and "anxiety" after the pandemic. In this regard, it was revealed that the happiness index was also lowered numerically. It is insufficient to analyze specific issues about changes in the issue of happiness felt by the public in Korean society after the epidemic. Therefore, this study aims to identify changes in the happiness issue of Koreans after COVID-19 and find ways to improve happiness. Data were collected from various aspects by searching 32 sub keywords based on ERG theory by dividing the period before and after COVID-19. The results of topic modeling before and after COVID-19 were classified into seven areas of happiness index 2.0 published by the National Assembly Future Research Institute and compared and analyzed. Based on the results of comparing the results of the before and after topic from the perspective of each area, a plan to improve happiness was presented. The academic implications of this paper are that the research on psychological changes caused by COVID-19 was expanded by mining the opinions of the actual public on 'happiness'. In addition, it has practical implications in that it specifically presented measures to promote happiness by utilizing the area of objective happiness indicators based on the existing research on ways to reduce happiness promotion unhappiness.

• Journal of the Korean Society of Radiology
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• v.85 no.1
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• pp.240-246
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• 2024

Epithelioid angiosarcoma is a rare variant of angiosarcoma characterized by an epithelioid morphology that mimics carcinoma. Therefore, multicentric epithelioid angiosarcoma is easily misdiagnosed as bone metastasis from carcinoma and has an aggressive clinical course. Here, we present a rare case of a 61-year-old male with multicentric epithelioid angiosarcoma of the bone. Plain radiography, CT, and MRI revealed multiple osteolytic lesions in both femurs; some lesions showed soft tissue extension with cortical bone destruction. Interestingly, PET-CT revealed that the lesions were only distributed along the bones of the lower extremities, including the pelvic bones, femurs, and tibiae. Despite histological analysis initially suggesting metastatic carcinoma, after additional immunohistological staining, including that for vascular markers (CD31 and ERG), the final diagnosis was epithelioid angiosarcoma. A better understanding of the clinicoradiological features of this disease may help eliminate diagnostic confusion and provide better management.

• Journal of Magnetics
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• v.7 no.3
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• pp.80-93
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• 2002

The role of magnetic anisotropy of the antiferromagnetic layer on the magnetization process of exchange coupled polycrystalline ferromagnetidantiferromagnetic bilayers is discussed. In order to elucidate the magnetic torque response of Ni-Fe/Mn-Ir bilayers, the single spin ensemble model is newly introduced, taking into account the two-dimensionally random distribution of the magnetic anisotropy axes of the antiferromagnetic grains. The mechanism of the reversible inducement of the exchange anisotropy along desirable directions by field cooling procedure is successfully explained with the new model. Unidirectional anisotropy constant, J$k$, of polycrystalline Ni-Fe/Mn-Ir and Co-Fe/Mn-Ir bilayers is investigated as functions of the chemical composition of both the ferromagnetic layer and the antiferromagnetic layer. The effects of microstructure and surface modification of the antiferromagnetic layer on JK are also discussed. As a notable result, an extra large value of J$k$, which exceeds 0.5 erg/cm$^2$, is obtained for $Co_{70}Fe_{30}Mn_{75}Ir_{25}$ bilayer with the ultra-thin (50${\AA}$∼100${\AA}$) Mn-Ir layer. The exchange anisotropy of $Co_{70}Fe_{30}$ 40 ${\AA}/Mn_{75}Ir_{25}$ 100 ${\AA}$ bilayer is stable for thermal annealing up to $400{^{\circ}C}$, which is sufficiently high for the application of spin valve magnetoresistive devices.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.74.2-74.2
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• 2015

Strong outflows from active galactic nuclei (AGNs) may play a crucial role in galaxy evolution. Integral-field spectroscopy (IFS) is the most powerful tool to study the detailed kinematics of AGN outflows. We present the on-going optical 3D spectroscopic survey of ionized gas outflows. Type 2 AGN sample is uniquely selected from SDSS DR7 with a luminosity-limit (i.e., L[O III] > $10^{41.5}erg/s$) as well as strong kinematic signatures of ionized gas outflows ([O III] velocity shift > ~200 km/s or [O III] velocity dispersion (FWHM) > 1000 km/s), defining an extremely rare population (< ~0.5%). Thus, these AGNs with strong outflow signatures are one of the best suites for investigating AGN feedback. The IFS observations cover several kpc scales for the central region of the host galaxies, providing a detailed information of the kinematics and geometry of the gas outflows. In this contribution, we report the current status of the survey and the preliminary results on gas kinematics of 18 AGNs, based on the Magellan/IMACS-IFU and the VLT/VIMOS data.

• Knowledge Management Research
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• v.17 no.2
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• pp.165-185
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• 2016

Though Korea has received attention through an exceptional economic growth and the big K-POP fever all over the world, its happiness level is not so high. Therefore, this research aims to find not only the Korean' s condition of the happiness and unhappiness, but also the way to enhance their happiness. We collected various web data(89,127 cases from 2013/01 to 2014/12) through searching our own 26 keywords based on Alderfer's ERG Theory. Also, we tried to analyze the subjects related to happiness and unhappiness by using LDA topic modeling. As the result, the condition of happiness and unhappiness were the top topics extracted from each field. We conducted the second detailed analysis based on the data of condition of the happiness and unhappiness which are the top topics of the previous analysis. From the second analysis result, we proposed several ways to enhance happiness from the perspective of government, corporate, family, education, social welfare.This paper is meaningful because it catches the condition of happiness and unhappiness based on a real web data as well as transform the data into the knowledge. Also, this paper provides the practical methods from the view from all walks of life that may enhance happiness and relieve unhappiness.

• Korean Journal of Materials Research
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• v.13 no.7
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• pp.447-452
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• 2003

Effects of annealing and thickness of Co layer in Co/IrMn bilayers on the magnetic properties have been investigated. The highest interfacial exchange coupling energy($J_{K}$ = 0.12 erg/$\textrm{cm}^2$) was obtained for 10 nm Co layer thickness. Exchange bias field is inversely proportional to the magnetization, the thickness of the pinned layer, and the grain size of antiferromagnetic layer. Also it is related to the interfacial exchange energy difference, which is expected to depend on the surface roughness. These results almost agree with the random-field model of exchange anisotropy proposed by Malozemoff. Exchange bias field decreased slowly with increasing annealing temperature up to X$300^{\circ}C$. However, exchange bias field increased above $300^{\circ}C$.

• Journal of Families and Better Life
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• v.27 no.2
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• pp.77-97
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• 2009

This study evaluates the poverty experiences of low-income single mothers according to the Capability Approach of Amartya Sen. In this approach, the capability to achieve the basic functionings of life, not income itself, is the criterion of poverty. 26 single mothers were interviewed using focus-group interviews and in-depth interviews. 21 functionings on the existence level, 18 on the relatedness level, and 15 on the growth level were found in the areas of work, health, food consumption, clothing, housing, child rearing, and leisure. The results of this study suggest that low-income single mothers can achieve only some of the existence level functionings with significant help from welfare services. They can scarcely achieve higher level functionings in any of these areas.

• The Bulletin of The Korean Astronomical Society
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• v.41 no.2
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• pp.39.1-39.1
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• 2016

We report the discovery of a kiloparsec-size supershell in the outskirts of the Milky Way with the compact high-velocity cloud, HVC 040+01-282 (hereafter, CHVC040), at its geometrical center using the "Inner-Galaxy Arecibo L-band Feed Array" HI 21 cm survey data. Supershells are large gaseous shells, which could be produced by one of most energetic activities with an explosion energy more than $3{\times}1052erg$. The most promising origin is the explosion of multiple supernovae in OB associations, or alternatively, the impact of HVCs falling into the Galactic disk. We found the association between CHVC040 and the Galactic supershell by analysis of their morphological and physical properties. Our results imply that some compact HVCs can survive their trip through the Galactic halo and inject energy and momentum into the Milky Way disk.