• Tribology and Lubricants
• /
• v.11 no.1
• /
• pp.5-11
• /
• 1995

This paper addresses the lubrication analysis of a short squeeze film damper operating with electro-rheological (ER) fluids which have large and reversible changes in yield shear stresses with respect to an applied electric field. The ER fluids are assumed to be modeled as Bingham fluids. The governing lubrication equation for the ER short squeeze film damper is developed on the basis of a Bingham fluid model, and the equation is subsequently solved in order to investigate the effects of the ER fluids on the damping capability of the damper. It is shown that a substantial increase in damping (both direct and cross coupled) is accomplished by increasing the yield shear stress of the ER fluids. This significant improvement of the damping capability suggests that the ER short squeeze film damper could be very effective for reducing the vibration and controlling the critical speeds of a rotor system.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.28 no.1
• /
• pp.72-80
• /
• 2004

Steady flow of an ER (electro-rheological) fluid in a two-dimensional electrode channel is studied by using FEM. Hydrodynamic interactions between the particles and the fluid are calculated by solving the Navier-Stokes equation combined with the equation of motion for each particle, where the multi-body electrostatic interaction is described by using point-dipole model. Motion of the particles in the ER fluid is elucidated in conjunction with the mechanisms of the flow resistance and the increase of viscosity. The ER effects have been studied by varying the Mason number and volume fraction of particles. These parameters have an influence on the formation of the chains resulting in the changes of the fluid velocity and the effective viscosity of ER fluids.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2000.06a
• /
• pp.612-618
• /
• 2000

The underwater explosion which has the high energy brings about the shock wave and the pulsating gas bubble. In general, structural vibration from the shock wave is more serious than the pulsating gas bubble. This shock wave may damage the important fragile structures and equipment in ship. This paper demonstrates that the shock wave propagating the structure can be reduced by ER inserts. The wave transmission of ER inserted beam is theoretically derived using Mead & Markus model, and the theoretical results are composed with the finite element analysis results. To experimentally verify the ER insert, ER insert in an aluminum plate is made and two piezoceramic disks are used as transmitter and receiver. Details of the experiment are addressed.

• Korean Chemical Engineering Research
• /
• v.58 no.3
• /
• pp.480-485
• /
• 2020

The extended Maxwell-Wagner polarization model is employed to describe the ER behavior of the conducting particle ER suspensions, and solutions to the equation of motion are obtained by dynamic simulation. The simulation results show the nonlinear ER behavior (Δτ∝Eⁿ, n≈1.5) of the conducting particle ER suspensions. The response point, where shear stress reaches steady-state, is the point where stable break-up and rebuild of the chain-like structure of particles reaches. Also, it shows the minimum of shear stress, which corresponds the start-up of random particle configuration. The shear stress reaches plateau as particle volume fraction increases.

• Journal of the Korean Society for Precision Engineering
• /
• v.10 no.1
• /
• pp.134-141
• /
• 1993

Electro-Rheological(ER) fluids undergo a phase-change when subjected to an external electic field, and this phase-change typically manifests itself as a many-order-of-magnitude change in the rheological behavior. This phenomenon permits the global stiffness and energy- dissipation properties of the beam structures to be tuned in order to synthesize the desired vibration characteristics. This paper reports on a proof-of-concept experimental investigation focussed on evaluation the vibration properties of hollow cantilevered beams filled with an ER fluid. and consequently deriving an empirical model for predicting field-dependent vibration characteristics. A hydrous-based ER fluid consisting of corn starch and silicone oil is employed. The beams are considered to be uniform viscoelastic materials and modelled as a viscously-damped harmonic oscillator. Natural frequency, damping ratio and elastic modulus are evaluated with respect to the electric field and compared among three different beams: two types of different volume fraction of ER fluid and one type of different particle concentration of ER fluid by weight. Transient and forced vibration responses are examined in time domain to demonstrate the validity of the proposed empirical model and to evaluate the feasibility of using the ERfluid as an actuator in a closed-loop control system.

• IMMUNE NETWORK
• /
• v.12 no.4
• /
• pp.155-164
• /
• 2012

It is well established that blocking the interaction of EGFR with growth factors leads to the arrest of tumor growth, resulting in tumor cell death. ER414 is a human monoclonal antibody (mAb) derived by guided selection of the mouse mAb A13. The ER414 exhibited a ~17-fold lower affinity and, as a result, lower efficacy of inhibition of the EGF-mediated tyrosine phosphorylation of EGFR when compared with mAb A13 and cetuximab. We performed a stepwise in vitro affinity maturation to improve the affinity of ER414. We obtained a 3D model of ER414 to identify the amino acids in the CDRs that needed to be mutated. Clones were selected from the phage library with randomized amino acids in the CDRs and substitution of amino acids in the HCDR3 and LCDR1 of ER414 led to improved affinity. A clone, H3-14, with a ~20-fold increased affinity, was selected from the HCDR3 randomized library. Then three clones, ER2, ER78 and ER79, were selected from the LCDR1 randomized library based on the H3-14 but did not show further increased affinities compared to that of H3-14. Of the three, ER2 was chosen for further characterization due to its better expression than others. We successfully performed affinity maturation of ER414 and obtained antibodies with a similar affinity as cetuximab. And antibody from an affinity maturation inhibits the EGF-mediated tyrosine phosphorylation of EGFR in a manner similar to cetuximab.

• Journal of Mechanical Science and Technology
• /
• v.18 no.8
• /
• pp.1479-1489
• /
• 2004

The effect of fluctuation of Equivalence Ratio (ER) in a turbulent reactive field has been studied in order to check the global combustion characteristics induced by the local fluctuation. When the flow is premixed on a large scale, closer examination on a small scale reveals that local fluctuations of ER exist in an imperfectly premixed mixture, and that these fluctuations must be considered to correctly estimate the mean reaction rate. The fluctuation effect is analyzed with DNS by considering the joint PDF of reactive scalar and ER, followed by modeling study where an extension of stochastic mixing models accounting for the ER fluctuation is reviewed and tested. It was found that models prediction capability as well as its potential is in favor to this case accounting the local ER fluctuation. However, the effect of local fluctuation did not show any notable changes on the mean global characteristics of combustion when statistical independence between the reactive scalar and ER field is imposed, though it greatly influenced the joint PDF distribution. The importance of taking into account the statistical dependency between ER and combustible at the initial phase is demonstrated by testing the modeled reaction rate.

• Biomolecules & Therapeutics
• /
• v.27 no.4
• /
• pp.386-394
• /
• 2019

Trypanosoma cruzi infection results in debilitating cardiomyopathy, which is a major cause of mortality and morbidity in the endemic regions of Chagas disease (CD). The pathogenesis of Chagasic cardiomyopathy (CCM) has been intensely studied as a chronic inflammatory disease until recent observations reporting the role of cardio-metabolic dysfunctions. In particular, we demonstrated accumulation of lipid droplets and impaired cardiac lipid metabolism in the hearts of cardiomyopathic mice and patients, and their association with impaired mitochondrial functions and endoplasmic reticulum (ER) stress in CD mice. In the present study, we examined whether treating infected mice with an ER stress inhibitor can modify the pathogenesis of cardiomyopathy during chronic stages of infection. T. cruzi infected mice were treated with an ER stress inhibitor 2-Aminopurine (2AP) during the indeterminate stage and evaluated for cardiac pathophysiology during the subsequent chronic stage. Our study demonstrates that inhibition of ER stress improves cardiac pathology caused by T. cruzi infection by reducing ER stress and downstream signaling of phosphorylated eukaryotic initiation factor ($P-elF2{\alpha}$) in the hearts of chronically infected mice. Importantly, cardiac ultrasound imaging showed amelioration of ventricular enlargement, suggesting that inhibition of ER stress may be a valuable strategy to combat the progression of cardiomyopathy in Chagas patients.

• Journal of the Korean Society for Precision Engineering
• /
• v.18 no.9
• /
• pp.53-60
• /
• 2001

This paper presents a position control of a platform at the seaport cargo handling system. After brief description of the operating principles of the cargo handling system, the governing equation of the moving platform is derived. The equation is described in the state space model, and a robust H$_{\infty}$ controller to achieve position tracking of the moving platform. which can carry 200ton of containers, is formulated. In the synthesis of the controller, the weight of the container is treated as uncertain parameter. Both regulating and tracking control responses are analyzed for the loading and unloading procedures of the proposed automatic cargo handling system.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2000.06a
• /
• pp.1119-1126
• /
• 2000

This paper is concerned with the design and application of an Electro-Rheological(ER) fluid damper to suppress the vibration of a rotor system. The system is flexible with a slender shaft and a thin disk, being supported by two ball bearings. In addition, to investigate the system performances also in the high speed range, the driving torque is made transmit through a speed increasing gear train. Along with the experiments, to predict and compare the ER damper effect, the rotor system is simulated as to its free and forced vibration characteristics by means of a finite element method code, which is assembled with the mathematical model of the designed ER damper.