• Journal of Applied Biological Chemistry
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• v.58 no.4
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• pp.363-368
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• 2015

The pharmacokinetics of florfenicol were studied in healthy and vibriosis-infected large yellow croaker (Pseudosciaena crocea) following administration of a single oral dose of $20mg{\cdot}kg^{-1}$ at $25{\pm}2^{\circ}C$. After oral administration, florfenicol levels in tissues (liver, kidney, muscle, serum, and skin) were analyzed using high-performance liquid chromatography. A two-compartment open model was used to describe the pharmacokinetics of florfenicol following oral administration. Compared to the healthy group, the absorption rate of vibriosis-infected fish significantly decreased, peak-time ($T_{max}$) delayed, maximum concentration ($C_{max}$) declined, total body clearance decreased, the elimination half-life ($T_{1/2{\beta}}$) was extended, and the area under the curve increased. These results indicate that a $20mg{\cdot}kg^{-1}$ oral dose of florfenicol administered once daily continuously for 4 or 5 days can be used for the treatment of Vibrio alginolyticus infection in large yellow croaker (Pseudosciaena crocea).

• Journal of Environmental Science International
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• v.14 no.1
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• pp.33-40
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• 2005

The size of minimum order stream has a very sensitive effect on runoff analysis model using the divergence characteristic of stream. Therefore, in this study, the threshold area of minimum order stream has been examined the change characteristic of topographical parameters. The subject basin of the research was the upper basin of the Kumho water gage station which is located in the middle of the Kumho river. The 1:25,000 numerical geography which was constructed $10{\times}10m$ mesh was used. The range of investigation of topographical parameters are number of stream order, length, area, slope, basin relief, sinuosity ratio, drainage density and total stream length etc. It was found from the result of analysis that the threshold value of minimum order stream has a very big effect on topographical parameters of basin. It was found that the threshold area of minimum ord er stream revealed under $0.10km^{2}.$ Furthermore, the parameters showed a serious change except for over $0.10km^{2}.$

• The Journal of Advanced Prosthodontics
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• v.5 no.4
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• pp.434-439
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• 2013

PURPOSE. The aim of the present study was to evaluate the effects of posts with different morphologies on stress distribution in an endodontically treated mandibular premolar by using finite element models (FEMs). MATERIALS AND METHODS. A mandibular premolar was modeled using the ANSYS software program. Two models were created to represent circular and oval fiber posts in this tooth model. An oblique force of 300 N was applied at an angle of $45^{\circ}$ to the occlusal plane and oriented toward the buccal side. von Mises stress was measured in three regions each for oval and circular fiber posts. RESULTS. FEM analysis showed that the von Mises stress of the circular fiber post (426.81 MPa) was greater than that of the oval fiber post (346.34 MPa). The maximum distribution of von Mises stress was in the luting agent in both groups. Additionally, von Mises stresses accumulated in the coronal third of root dentin, close to the post space in both groups. CONCLUSION. Oval fiber posts are preferable to circular fiber posts in oval-shaped canals given the stress distribution at the postdentin interface.

• Structural Engineering and Mechanics
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• v.50 no.2
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• pp.151-161
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• 2014

In this paper, fuel tank of the locomotive ER 24 has been studied. Firstly the behavior of fuel and air during the braking time has been investigated by using a two-phase model. Then, the distribution of pressure on the surface of baffles caused by sloshing has been extracted. Also, the fuel tank has been modeled and analyzed using Finite Element Method (FEM) considering loading conditions suggested by the DIN EN 12663 standard and real boundary conditions. In each loading condition, high stressed areas have been identified. By comparing the distribution of pressure caused by sloshing phenomena and suggested loading conditions, optimization of the tank has been taken into consideration. Moreover, internal baffles have been investigated and by modifying their geometric properties, search of the design space has been done to reach the optimal tank. Then, in order to reduce the mass and manufacturing cost of the fuel tank, Non-dominated Sorting Genetic Algorithm (NSGA-II) and Artificial Neural Networks (ANNs) have been employed. It is shown that compared to the primary design, the optimized fuel tank not only provides the safety conditions, but also reduces mass and manufacturing cost by %39 and %73, respectively.

• Journal of the Korean Society for Library and Information Science
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• v.33 no.4
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• pp.133-156
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• 1999

The purpose of this paper is to show how conceptual data modeling can enhance current information retrieval (IR) systems. The conceptual database design provides for: 1) data mining capability to discover new knowledge based on the relationships between entities, and 2) integrating current separate databases into one IR system (e.g., integrating ISI Citation, a thesaurus, and bibliographic databases into one retrieval system) . Further, as new user requirements are unfolded, modifications of IR systems based on conceptual data modeling will be much easier to make than they were in the current IR systems because conceptual modeling facilitates flexible modifications. The enhanced Entity-Relationship (ER) model was employed in this study to develop conceptual schemas of IR data.

• Smart Structures and Systems
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• v.1 no.3
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• pp.235-256
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• 2005

The non-linear behaviour of electrorheological (ER) and magnetorheological (MR) dampers makes it difficult to design effective control strategies, and as a consequence a wide range of control systems have been proposed in the literature. These previous studies have not always compared the performance to equivalent passive systems, alternative control designs, or idealised active systems. As a result it is often impossible to compare the performance of different smart damper control strategies. This article provides some insight into the relative performance of two MR damper control strategies: on/off control and feedback linearisation. The performance of both strategies is benchmarked against ideal passive, semi-active and fully active damping. The study relies upon a previously developed model of an MR damper, which in this work is validated experimentally under closed-loop conditions with a broadband mechanical excitation. Two vibration isolation case studies are investigated: a single-degree-of-freedom mass-isolator, and a two-degree-of-freedom system that represents a vehicle suspension system. In both cases, a variety of broadband mechanical excitations are used and the results analysed in the frequency domain. It is shown that although on/off control is more straightforward to implement, its performance is worse than the feedback linearisation strategy, and can be extremely sensitive to the excitation conditions.

• Proceedings of the IEEK Conference
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• 2000.07a
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• pp.92-96
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• 2000

In this paper, we propose a call admission control(CAC) scheme fer the mixed voice/data DS-CDMA systems and analyze the Er-lang capacity under the proposed CAC scheme. Voice and data traffics require different system resources based oil their Quality of Service(QoS) requirements. In the proposed CAC scheme, some system resources are reserved exclusively for handoff calls to have high priority Over new calls. Additionally the queueing of both new and handoff data traffics that are not sensitive to delay is allowed. Ar a performance measure for the suggested CAC scheme. Erlang capacity is utilized. For the performance analysis, a four-dimensional Markov chain model is developed. Erlang capacity of a practical IS-95B type system depicts, and optimum values of system parameters such as the number of reservation channels and queue lengths are found with respect to Erlang capacity. Finally, it is observed that Erlang capacity is improved more than two times by properly selecting the system parameters with the proposed CAC scheme.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.8
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• pp.311-324
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• 2021

Investors have increasingly become interested in macroeconomic antecedents in order to better understand the investment environment and estimate the scope of profitable investment in equity markets. This study endeavors to examine the interdependency between the macroeconomic antecedents (international oil price (COP), Domestic gold price (GP), Rupee-dollar exchange rates (ER), Real interest rates (RIR), consumer price indices (CPI)), and the BSE Sensex and Nifty 50 index return. The data is converted into a natural logarithm for keeping it normal as well as for reducing the problem of heteroscedasticity. Monthly time series data from January 1992 to July 2019 is extracted from the Reserve Bank of India database with the application of financial Econometrics. Breusch-Godfrey serial correlation LM test for removal of autocorrelation, Breusch-Pagan-Godfrey test for removal of heteroscedasticity, Cointegration test and VECM test for testing cointegration between macroeconomic factors and market returns,] are employed to fit regression model. The Indian market returns are stable and positive but show intense volatility. When the series is stationary after the first difference, heteroskedasticity and serial correlation are not present. Different forecast accuracy measures point out macroeconomics can forecast future market returns of the Indian stock market. The step-by-step econometric tests show the long-run affiliation among macroeconomic antecedents.

• Journal of Life Science
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• v.14 no.3
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• pp.478-483
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• 2004

In a model reaction using lysyl oxidase purified partilally from bovine aorta, effect of L-ascorbic acid AsA on the oxidative reaction of lysine in collagen was investigated. Addition of Ash to the reaction mixture under aerobic conditions resulted in the decrease of enzymatic activity. In order to examine the specificity of AsA in the oxidative reaction of lysine, other reductants including A derivatives instead of AsA were added to the reaction mixture. Thiol such as glutathione had no effect on the activities of lysyl oxidase. on the other hand, it was observed that erythorbic acid, which was a stereoisomer of AsA, had the same inhibitory effect on this oxidative reaction as AsA. Moreover, by the addition of 3,4-dihydroxybenzoate, which was structural analog of AsA, the activities decreased in a similar manner to that of AsA. These results indicate that the regulatory effect of AsA on lysyl oxidase is attributed to characteristics of the structure. From the determination of Ash remained in the reaction mixture, it is shown that AsA concentration remarkably decreased by lysyl oxidase of the reaction mixture. It is hypothesized that endiol groups reduces the enzyme-bound $Cu^{+2}$ required for further progress of the reaction, and suggests that AsA regulates specifically the reduction of $Cu^{+2}$ required to oxidize lysyl oxidase. This findings support that AsA has an important regulatory role on the oxidative reaction of lysine and on changes of collagen cross-links with aging.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.4977-4982
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• 2014

Background: Cytochrome P450 2E1 (CYP2E1) might be involved in the development of bladder cancer. However, previous studies of any association between CYP2E1 RsaI/PstI polymorphism and bladder cancer risk have yielded conflicting results. In this study, we performed a more precise estimation of the relationship by a meta-analysis based on the currently available evidence from the literature. Method: To assess the effect of CYP2E1 RsaI/PstI polymorphism on bladder cancer susceptibility, a meta-analysis of 6 available studies with 1,510 cases and 1,560 controls were performed through Feb 2014. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to estimate the strength of association for CYP2E1 RsaI/PstI polymorphism under different genetic models. Results: When available studies were pooled into the meta-analysis, we found that the C1C2 and C2C2 genotypes of CYP2E1 RsaI/PstI polymorphism significantly decreased bladder cancer risk under different genetic models (heterozygote: OR=0.766, 95%CI=0.613-0.957, $P_{OR}$=0.019; homozygote: OR=0.51, 95%CI=0.303-0.858, $P_{OR}$=0.011; dominant: OR=0.733, 95%CI=0.593-0.905, $P_{OR}$=0.004; recessive: OR=0.565, 95%CI=0.337-0.947, $P_{OR}$=0.030). Subgroup analysis indicated that C2C2 genotype was significantly associated with decreased bladder cancer risk under the homozygote genetic model in Caucasians. There was no evidence of heterogeneity or publication bias. Conclusions: The current meta-analysis suggested that the CYP2E1 RsaI/PstI polymorphism might be associated with bladder cancer susceptibility, especially in Caucasians. Further studies are needed to validate the above conclusion.