• The Korean Journal of Pain
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• v.35 no.4
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• pp.383-390
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• 2022

Background: The treatment of trigeminal neuralgia remains a challenging issue. Stem cells from human exfoliated deciduous teeth (SHED) provide optimized therapy for chronic pain. This study aimed to investigate the mechanisms underlying the attenuation of trigeminal neuralgia by SHED. Methods: Trigeminal neuralgia was induced by chronic constriction injury of the infraorbital nerve. The mechanical threshold was assessed after model establishment and local SHED transplantation. Endoplasmic reticulum (ER) morphology and Caspase12 expression in trigeminal ganglion (TG) was evaluated as well. BiP expression was observed in PC12 cells induced by tunicamycin. Results: The local transplantation of SHED could relieve trigeminal neuralgia in rats. Further, transmission electron microscopy revealed swelling of the ER in rats with trigeminal neuralgia. Moreover, SHED inhibited the tunicamycin-induced up-regulated expression of BiP mRNA and protein in vitro. Additionally, SHED decreased the up-regulated expression of Caspase12 mRNA and protein in the TG of rats caused by trigeminal neuralgia after chronic constriction injury of the infraorbital nerve mode. Conclusions: This findings demonstrated that SHED could alleviate pain by relieving ER stress which provide potential basic evidence for clinical pain treatment.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2021.04a
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• pp.60-60
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• 2021

Non-alcoholic fatty liver disease (NAFLD), especially including non-alcoholic steatohepatitis (NASH) is one of the common diseases with 25% of prevalence globally, but there is no thera-peutic access available. Amomum villosum var. xanthioides (Wall. ex Baker) T.L.Wu & S.J.Chen (AX), which is a medicinal herb and traditionally used for treating digestive tract disorders in Asia countries. We aimed to examine pharmacological effects of ethyl acetate fraction of AX (AXEF) against ER stress-induced NASH mice model using C57/BL6J male mice by tunicamycin (TM, 2 mg/kg) injection focusing on the oxidative stress. Mice were orally administrated AXEF (12.5, 25, or 50 mg/kg), silymarin (50 mg/kg) or distilled water daily for 5 days, and outcomes for fatty liver, inflammation, and oxidative stress were measured in serum or liver tissue levels. AXEF drastically attenuated hepatic ER stress-induced NASH which were evidenced by decreases of li-pid droplet accumulations, serum liver enzymes, hepatic inflammations, and cell death signals in the hepatic tissue or serum levels. Interestingly, AXEF showed potent antioxidant effects by quenching of reactive oxidative stress and its final product of lipid peroxide in the hepatic tissue, specifically increase of metallothionein (MT). To confirm underlying actions of AXEF, we ob-served that AXEF increase MT1gene promoter activities in the physiological levels. Collectively, AXEF showed antioxidant properties on TM-induced ER stress of NASH by enhancement of MTs.

• The Korean Journal of Applied Statistics
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• v.33 no.4
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• pp.421-437
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• 2020

This paper implemented a method to predict the fertility rate, mortality rate, and international migration rate using the R program, which has been widely used in recent years, that calculates population projection by substituting the results into the Leslie matrix. In particular, the generalization log gamma model for the fertility rate by Kaneko (2003), LC-ER model for mortality rate by Li et al. (2013), and functional data model for international migration rates proposed by Ramsay and Silverman (2005) and Hyndman and Booth (2008), Hyndman et al. (2013) can be directly demonstrated with R programs. Demography and bayesPop have been introduced as a representative demographic package implemented in R; however, it can be analyzed only for data uploaded to Human Mortality Database (HMD) and Human Fertility Database (HFD) with data changes and modifications requiring application of other data. In particular, in Korea, there is a limitation in applying this package because it is provided only for short-term data in HMD. This paper introduces an R program that can reflect this situation and the different patterns of low fertility, aging, migration of domestic and foreigners in Korea, and derives a population projection for the year 2117.

• Journal of the Society of Naval Architects of Korea
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• v.36 no.2
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• pp.61-71
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• 1999

This paper resents a novel cargo system adapted for a sea port subjected to severe time-varying tide. The proposed system can perform loading or unloading by using a sort of hydraulic elevator associated with real-tim position control. As a preliminary phase, a small-sized model of the cargo system is designed and constructed. The model consists of three principal components ; container palette transfer(CPT) car, platform with lifting columns and cargo ship. The platform activated by the electro-rheological(ER) valve-cylinder is actively controlled to track the position of the cargo ship subjected to be varied due to the time-varying tide and wave motion. Following the derivation of the dynamic model for the platform and cargo ship motions, an appropriate control scheme incorporating time sequence and PID(proportional-integral-derivative) controller is formulated and implemented. Both the simulated and the measured control results are presented to demonstrate the effectiveness of the proposed cargo system.

• The Transactions of the Korea Information Processing Society
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• v.4 no.11
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• pp.2745-2755
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• 1997

Many large-scale enterprises have developed software systems to build management information system for their business. However, it is hard to maintain share ability of data, compatibility of operation methedology, and interoperability among subsystems when the development project progresses since each distributed team prepares a development plan for its subsystem and must have poor communication problem among those teams. We must apply software configuration management to the whole life cycle of the software system in order to solve those Problems. We need a model and a repository in order to execute configuration management on configuration products like document, data, and source code which are generated through the life cycle of software development. In this paper, we suggest a model for configuration change control where cross- referencing among life cycle Phases and data-sharing are highlighted, and define ER model to use IRDS(Information Resource Dictionary system) and IRD schemas.

• The KIPS Transactions:PartD
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• v.15D no.2
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• pp.187-196
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• 2008

The system development approach method of the new paradigm, as being standardizing MDA(Model Driven Architecture) in OMG(Object Management Group), the core technique of MDA definite technique structure for system materialization focusing on Model, is to build the design and the statement for system in PIM(Platform Independent Model), Materialization technique, and to build PSM(Platform Specific Model) adapt to materialization environment, and then to be the technique transforming into language Platform suitable to materialization environment. It includes MOF(Meta-Object Facility), UML, XMI(XML Metadata Interchange), CWM(Common Warehouse Metamodel), the core of MDA. Though these operations MDA support automatic tools product the practicable system after carrying out transform operation with the above information. In this thesis, it will be approached how to design and materialize the Bachelor management system based on MDA and the importance of modeling should be emphasized by applying to the approach method based on MDA. It should be suggested how to develop software efficiently, written it out in PIM, and suggested the process transforming PSM into EJB by J2EE Platform. The system is designed and implemented using automatic tool, edit machine(Together Architect 2006 for Eclipse, Edit plus2) supporting MDA and Database Modeling tool(ER/WIN 4.1). In conclusion, it should be suggested the efficiency analysis result for development process of traditional and based on MDA.

• Preventive Nutrition and Food Science
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• v.6 no.3
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• pp.163-169
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• 2001

To produce expanded, minimally hard extrudates from blends of raw pork meat (20%), defatted soy flour (25%), and corn starch using a single-screw extruder, various combinations of feed moisture, process temperature, and screw speed were evaluated. First series of extrusion runs were conducted according to a central composite rotatable design/response surface methodology (RSM). Upon assessing the full model for each response, insignificant terms were eliminated to determine final response surface models. Screw speed within the range evaluated was found to have no significant effect on expansion ratio (ER) or shear force (SF) of extrudates. Since examinations of the response surfaces and their generated grids of predicted values indicated that maximum ER and minimum SF were likely to be attained with a moisture-temperature combination outside the RSM experimental range, the second series of extrusion runs were conducted with several selected combinations of moisture and temperature to determine a practical optimum extrusion condition. The combination of 22.78% feed moisture, 16$0^{\circ}C$ process temperature, and 170 rpm screw speed was chosen as such a condition, and used in the final extrusion. The final product required less force to break than did commercial pretzel sticks.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.39 no.8
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• pp.7-13
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• 2002

In this paper, we propose an traffic control algorithm for efficient link utilization of ATM-ABR service based on fuzzy logic. The proposed algorithm, controls transmission rates of source according to switch buffer size and input cell tate by using the fuzzy rate . For this method we developed a model and algorithm of fuzzy traffic control method and fuzzy traffic controller which based on ER of VS/VD. For the fuzzy traffic controller, we also designed a membership function, fuzzy control rules, and a max-min inferencing method.

• BMB Reports
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• v.50 no.8
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• pp.411-416
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• 2017

The endoplasmic reticulum (ER) membrane protein complex subunit 6 (EMC6) is a novel human autophagy-related molecule. Here, using tissue microarray and immunohistochemistry, we report that EMC6 protein is lost or reduced in glandular cells of patients with gastric adenocarcinoma, compared to normal stomach mucosa. Overexpression of EMC6 in gastric cancer cells inhibited cell growth, migration, invasion, and induced apoptosis and cell cycle arrest at S-phase. Further investigation suggested that EMC6 overexpression in BGC823 human adenocarcinoma gastric cancer cells reduced tumorigenicity in a xenograft model, demonstrating that EMC6 has the characteristics of a tumor suppressor. This is the first study to show that EMC6 induces cell death in gastric cancer cells. The molecular mechanism of how EMC6 functions as a tumor suppressor needs to be further explored.

• BMB Reports
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• v.53 no.2
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• pp.88-93
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• 2020

Cisplatin is a widely used anti-cancer agent. However, the effectiveness of cisplatin has been limited by the commonly developed drug resistance. This study aimed to investigate the potential effects of endoplasmic reticulum (ER) stress to overcome drug resistance using the cisplatin-resistant A2780/CisR ovarian cancer cell model. The synthetic chalcone derivative (E)-3-(3,5-dimethoxyphenyl)-1-(2-methoxyphenyl)prop-2-en-1-one (named DPP23) is an ER stress inducer. We found that DPP23 triggered apoptosis in both parental cisplatin-sensitive A2780 and cisplatin-resistant A2780/CisR ovarian cancer cells due to activation of reactive oxygen species (ROS)-mediated unfolded protein response (UPR) pathway in the endoplasmic reticulum. This result suggests that ROS-mediated UPR activation is potential in overcoming drug resistance. DPP23 can be used as a target pharmacophore for the development of novel chemotherapeutic agents capable of overcoming drug resistance in cancer cells, particularly ovarian cancer cells.