• Title/Summary/Keyword: EQ

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Estimating Quality Adjusted Life Year Loss of Persons Disabled by Stroke Using EQ-5D in Korea (EQ-5D를 이용한 뇌졸중 장애인의 질보정수명 감소분 추정)

  • Jo, Min-Woo;Kim, Sang-Kyu;Lee, Jin-Yong;Lee, Kyeong-Soo
    • Journal of agricultural medicine and community health
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    • v.36 no.2
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    • pp.120-129
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    • 2011
  • The purposes of this study were to measure health related quality of life (HRQOL) of persons disabled by stroke dwelling in Gyeongju-si using EQ-5D and to estimate total QALYs loss of persons disabled by stroke in Korea. The eligible subjects were 982 persons with stroke aged 50 and over in Gyeongju-si disabled registry, as of March, 2008. Interviewers measured HRQOL of study subjects using EQ-5D. EQ-5D index, utility weight, was derived from the Korean valuation set. In order to compare the results of this study, we selected two comparison groups representing Korean healthy population and general population of Korean using the 4th Korean National Health & Nutrition Examination Survey. Finally, after age and gender standardization, we estimated the total QALYs losses of persons disabled by stroke in Korea. Of 982 eligible subjects, 566 persons participated in the survey (response rate: 57.6%). In both of female and male, utility weights in the 70s or 80s were lower than those of the 50s or 60s. Utility weights differences among persons with disability, general population, and healthy population in male were larger than those differences in female. Total estimated QALY losses of persons disabled by stroke were 67,011.6 QALYs lower than healthy control group and 54,167.1 QALYs lower than general population, respectively.

Measuring Quality of Life in Cerebral Palsy Children According to the Severity Using the Visual Analogue Scale, Time Trade-Off, and EQ-5D-Y Proxy (뇌성마비 환아 중증도별 시각화척도, 시간교환법, EQ-5D-Y Proxy를 이용한 삶의 질 측정)

  • Lee, Go-Eun;Kim, Nam Kwen;Yun, Young Ju;Wang, Hye Min;Kim, Jeong Hun;Lee, Dong Hyo
    • Journal of Oriental Neuropsychiatry
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    • v.28 no.2
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    • pp.49-59
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    • 2017
  • Objectives: To measure the quality of life in patients according to virtual cerebral palsy severity by using the Korean version of EQ-5D-Y proxy, Visual Analogue Scale (VAS), and Time Trade-Off method (TTO). Methods: The study was conducted in parents of children and adolescents aged 4 to 15 years in Seoul. We analyzed the difference in the utility value according to five levels of cerebral palsy severity in the Gross Motor Function Classification System (GMFCS) and test-retest reliability. Results: 1. There were significant differences in VAS, TTO, and EQ-5D-Y proxy according to the cerebral palsy severity (p<.001). 2. VAS was significantly different according to the respondent's visit to the medical institution, the presence of disease in the respondent, a visit to the child's medical institution, the age of the child, and the sex of the child. The value of TTO was significantly different according to the respondent's visit to the medical institution, respondent's sex, and the age of the child. Also, EQ-5D-Y proxy was significantly different according to the age of the child. 3. Intraclass correlation coefficient values were more than 0.6 for both VAS and TTO at all stages. But for the EQ-5D-Y proxy, the value was less than 0.6 at all stages. Conclusions: The quality of life assessment using EQ-5D-Y proxy showed significant differences in the severity of cerebral palsy. However, large-scale studies using EQ-5D-Y proxy are needed because of low test-retest reliability.

Ammonia oxidation activity of nitrifying bacteria and effects of some environmental factors (질화세균의 암모니아 산화능과 이에 미치는 환경요인의 영향)

  • 송홍규;하영칠;홍순우
    • Korean Journal of Microbiology
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    • v.21 no.2
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    • pp.79-85
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    • 1983
  • Ammonia oxidation activity of polluted water samples in Jinhae Bay and isolated strain from the seawater was investigated, and effects of environmental factors such as temperature, salinity, substrate concentration to the ammonia oxidation were also investigated. The ammonia oxidation activities of sediments, 0.01-0.04mg eq. $NO_2-N/l/h$, were exceptionally higher than that of sea water, $0.5{\sim}1{\mu}g$ eq. $NO_2-N/l/h$. the activities of muddy sediments at station 4 and 2 were 0.03~0.04mg eq. $NO_2-N/l/h$ and that of sandy sediment at station 3 was 0.002mg eq. $NO_2-N/l/h$. In the case of sea water, the activity of polluted area, station 1, was 2 times higher than that of offshore, station 4. The isolated strain reached log phase after 30days culturs and its oxidation activity was $2{\sim}3{\mu}g$ eq. $NO_2-N/day$. The maximum oxidation of ammonia by IA 13 strain occured at 30mg/l oxidation increased with the salinity rising up to 100% seawater concentraion. And temperature for maximum oxidation of ammonia was $35^{\circ}C$. the oxidation increased with the salinity rising up to 100% seawater concentration.

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The Actual Conditions and Characteristics of Railroad Noise Level in Taegu Area in the Seoul-Pusan Line (대구지역 경부선 철도주변의 소음실태와 특성)

  • 민경섭;송희봉
    • Journal of Environmental Science International
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    • v.6 no.1
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    • pp.9-16
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    • 1997
  • We investigated and analysed the actual conditions and characteristics of railroad noise levels for 17 sites in the vicinity of the Seoul-Pusan Line. The results i,we summarized as follows : 11 Railroad noise level ranged to 64 ~ 74 $L_{eq}$ dB(A) at day time and ranged to 60 ~ 72 $L_{eq}$ dB(A) at night time. 21 Increased night noise level depend on the increase of trains passing at night time. 31 The major factor of Increased noise level in the vicinity of stations are using loudspeakers and stream whistle on trains. 4) Decreased effect of noise according to distance is able to be described quantitatively using regression equations of multiplicative model. $L_{eq}$=$78.59^{X-0.056}$, n =25, r=-0.994, s.e. =1.007 $P_{av}$ = $105.68X^{-0.073}$, n =25, r =-0.997, s.e. = 1.007 Also increased and decreased effect of noise according to floor in apartment Is able to be described quantitatively using regression equations of multiplicative model. $L_{eq}$ = $64.238X^{0.0567}$, n = 39, r = 0.787, s.e. = 1.004 $P_{av}$ =79.963X0.0524, n =39, r =0.689, s.e. = 1.056 5) Average noise level in high floor is over 70 $L_{eq}$ dB(A) at day and night time. so more detailed soundproofing countermeasured in high floors apartment is required.

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Effect of Individual Low Sodium Dialysate on Blood Pressure, Interdialytic Weight Gain, Thirst and Intradialytic Discomfort In End-Stage Renal Disease Patients (개별적 저 나트륨 투석 액 적용이 말기 신부전증 환자의 혈압, 투석 간 체중 증가, 갈증 및 투석 중 불편감에 미치는 영향)

  • Kim, Sangsuk;Choi, Youngsil
    • Journal of Korean Biological Nursing Science
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    • v.21 no.3
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    • pp.169-177
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    • 2019
  • Purpose: The purpose of this paper was to identify blood pressure, interdialytic weight gain, thirst and intradialytic discomfort in subjects after applying individual low-sodium dialysis fluid (1,2,3 mEq/L) to hemodialysis patients for 12 weeks. Methods: This study was a non-equivalent pre-post design. For 12 weeks, dialysate concentration was maintained at 1 mEq/L or 2 mEq/L or 3 mEq/L based on average sodium concentration of each individual, and the difference was compared after applying individually. Results: Change in blood pressure significantly decreased in the group where in pre-hemodialysis systolic pressure decreased the gradient of sodium concentration in serum sodium and dialysis solution by 2mEq/L. Interdialytic weight gain, and thirst showed significant decrease in all three groups. But in all three groups, intradialytic discomfort among dialysis showed no significant changes. Conclusion: Although application of low sodium dialysis fluid showed no change in intradialytic discomfort, lowered blood pressure, thirst, and interdialytic weight gain, which could be used for individual showing increased interdialytic weight gain and increased blood pressure. There is need for continued study on this.

Systemic effects of multidose hypothermic potassium cardioplegia: an experimental study in six dogs (냉혈 K 심정지액의 반복사용시 전신적인 영향동물실험 6)

  • 기노석
    • Journal of Chest Surgery
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    • v.17 no.4
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    • pp.587-592
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    • 1984
  • Potassium cardioplegia for myocardial preservation is being used extensively in open heart surgery. This study was designed to investigate the change in serum and urine potassium before, during, after the administration of cold blood potassium cardioplegic solution containing 28-30 mEq/L [28.6\ulcorner.56 mEq/L] of potassium chloride in 6 dogs. Total potassium dose used in the study was 14.9\ulcorner.89 mEq/L [1.2 mEq/Kg]. Mean potassium level in serum was within normal limits. Urinary excretion of potassium decreased during bypass but increased after bypass and eventually exceeded the amount of potassium infused as cold blood potassium cardioplegic solution. While cold blood potassium cardioplegia is a safe and efficient method of myocardial protection, postoperative potassium level must be observed carefully in order to detect obligatory potassium excretion following open heart surgery.

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Microwave Absorbing Properties of Grid-type Magnetic Composites (격자형 자성 복합재의 전파흡수 특성)

  • Park, Myung-Joon;Kim, Sung-Soo
    • Korean Journal of Metals and Materials
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    • v.50 no.5
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    • pp.389-393
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    • 2012
  • Improvement in microwave absorbance has been investigated by insertion of a periodic air cavity in rubber composites filled with magnetic powders. A mixture of $Co_2Z$ hexagonal ferrite and Fe powders were used as the absorbent fillers in silicone rubber matrix. The complex permeability and complex permittivity of the magnetic composites were measured by reflection/transmission technique. In the grid-type magnetic absorbers, the equivalent permeability (${\mu}_{eq}$) and permittivity (${\varepsilon}_{eq}$) are calculated as a function of air volume rate (K) on the basis of effective medium theory. Reduction in the material parameters (especially, dielectric permittivity and magnetic loss) has been estimated with the increase of K. Plotting the ${\mu}_{eq}$ and ${\varepsilon}_{eq}$ on the solution map of wave-impedance matching, wide bandwidth microwave absorbance has been predicted in the magnetic composites with an optimum value of K.

Transformation of Bicyclic Ketal Compound to 1,2-Cyclopentanediol via 1,5-Diketone

  • Jun Jong-Gab;Shin Dong Gyun;Shin Hyun Shun;Kim Sung Hoon
    • Bulletin of the Korean Chemical Society
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    • v.13 no.2
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    • pp.176-179
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    • 1992
  • New method for preparing cyclopentanediol from bicyclic ketal is described. Bicyclic ketal is cleaved to give 1,5-diketone, which is then reductively coupled intramolecularly to yield 1,2-cyclopentanediol. A solution of bicyclic ketal (1a) in methylene chloride was treated with aluminum chloride(2 eq.)-sodium iodide(l.5 eq.) at ambient temperature for 3 h to give the 1,5-diketone (2a) in 71% yield after basic work-up followed by short path column chromatography. A solution of the 1,5-diketone (2a) in THF was reacted with titanium tetrachloride(6 eq.)-Mg(Hg)(0.3 eq.) at $0^{\circ}C$ for 4 h to give the 1,2-cyclopentanediol (3a) in 75% yield after basic work-up followed by short path column chromatography.

Oxidation of Benzyl Ethers in Sodium Hypochlorite Mediated Piperidine-1-oxyl System (촉매량의 Piperidine-1-oxyl과 NaOCl계에서 벤질 에테르 유도체들의 산화 반응)

  • Cho, Nam Sook;Park, Chan Heun
    • Journal of the Korean Chemical Society
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    • v.39 no.8
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    • pp.657-665
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    • 1995
  • The oxidation of various benzyl ethers and benzyl alkyl ethers to benzoates has been studied in two-phase system of $CH_3CO_2Et$ and aqueous NaOCl (6.6 mol eq.). The oxidant N-oxo-4-methoxy-2,2,6,6-tetramethylpiperidium bromide (N-oxoammonium salt) was prepared in situ and recycled by addition of 4-methoxy-2,2,6,6-tetramethylpiperidine-1-oxyl (0.03 mol eq., 4-methoxy-TEMPO), co-catalyst KBr (0.03mol eq.) and second oxidant NaOCl. Thus the catalytic amount of 4-methoxy-TEMPO was used. An adjustment of the pH value of below 8.0 was also required for this reaction with 2.5 hr of reaction time at 0∼5$^{\circ}C$. Under these conditions benzyl ethers were oxidized to benzoates. The selectivity of oxidation of benzyl alkyl ethers is dependent on the acidity of hydrogen and steric effect of alkyl group.

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