• Journal of the Korean Society of Food Science and Nutrition
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• v.24 no.3
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• pp.434-439
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• 1995

Chinese radish juice(CRJ) was used as a culture medium for the production of Candida utilis ATCC 42416 biomass. Soluble solid and total sugar contents of Chinese radishes were in the range between 5.5 and $8.8^{\circ}$Brix and 3.5 and 6.5%, respectively. Since sugar in radishes are in readily usable forms, pretreatm ent procedures were not necessary after the extraction of juice from fresh radishes. In shake flask experimetns, C. utilis ATCC 42416 grew well in CRJ and completed growth in 24 hrs at $30^{\circ}C$ and 200 rpm. Maximum cell dry weight obtainable from a liter of CRJ(1.0% sugar $DCRJ{\times}5$) was 21.5g, when the yeast was grown on CRJ diluted 5 times or more with tap water to make sugar content to be eual to or less than 1.0%. Supplementation of 5-fold diluted CRJ with some nutrients did not greatly influence the growth rate, yeast biomass production, or cell protein content significantly, indicating that CRJ itself was a good substrate for the production of biomass by C. utilis ATCC 42416.

• Proceedings of the SCSK Conference
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• 1999.10a
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• pp.111-121
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• 1999

Acne vulgaris, the most common skin disease. can be formed as only a few comedons or severe inflammatory lesions. The pathogenesis of acne involves various factors; excessive androgen, excessive sebum production, abnormal alteration of follicular epithelium, proliferation of Propionibacterium acnes, and inflammation. We investigated acne therapy using oriental herbs described in the Korean traditional medical book (Dong-ui-bo-gam). Oriental herbs (Angleica daurica. Arctium lappa. Coptidis rhizoma, and glycyrrhiza glabra) were chosen based on their respective property of sebum control, anti-inflammatory activity, and anti-bacterial activity. We examined the effect of acne treatment, in terms of chemotactic inhibition, lipogenesis inhibition, and anti-bacterial activity for P. acnes. 1. Neutrophil chemotaxis assay ; P acnes secrete chemotactic factors and other pro-inflammatory extracellular products. Neutrophil chemotactic activity of P. acnes was measured by 48-well chemotaxis method. Angelica daurica clearly suppressed chemotactic activity of P. acens. 2. Using sebaceous gland of hamster ear lipogenesis assay; Sebaceous lipogenesis was measured using ear biopsies by incubation of $C^{14}$ -acetate in culture media. The $C^{14}$ -labeled lipids were extracted and determined by liquid scintilation counting, Coptidis rhizoma markedly inhibited sebum production, 3. Anti-bacterial assay for P. acnes (MIC test) Glycyrrhiza glabra showed anti-bacterial activity. P. acnes did not develop resistance against Glycyrrhiza glabra. Retinoids are effectively to inhibit sebum production and regulate follicular keratinization process, with little anti-inflammatory activity. Angelica daurica suppressed neutrophil chemotaxis. Coptidis rhizoma inhibited sebum production, and Glycyrrhiza glabra showed anti-bacterial activity against P. acnes. A combined formulation of Angelica daurica. Coptidisr hizoma and Glycyrrhiza glabra is expected to provide effective acne treatment.ent.ive acne treatment.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1977.06a
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• pp.7.3-8
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• 1977

In the ENT fields, epidermoid cysts occur infrequently in the oral region and often situated on the floor of the mouth or the submental region. Moreover, epidermoid cyst on the laryngeal surface of the epiglottis occurs rarely. Authors experienced a case of epiglottic epidermoid cyst and treated successfully by transhyoid pharyngotomy approach and marsupialization. It was 46 years old male patient who has been suffered from intermittent sorethroat for 2 years prior to admission, hoarseness for 2 months and dyspnea for 1 month. Indirect laryngoscopy revealed a pigeon egg-sized, round, smooth tumor mass on the laryngeal surface of the epiglottis which had soft consistency on digital examination. Biopsy proved epidermoid cyst. Marsupialization of the cyst by transhyoid pharyngotomy approach was performed and the postoperative course was uneventful.

• Spatial Information Research
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• v.3 no.1
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• pp.1-18
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• 1995

Despite the widespread use of GIS over the past ten years, it has been limited application for regional modeling of pollutant loadings such as sediment, nitrogen, and phosphorus(non-point source pollution), The goals of this study were to: select important processes and parameters of watersheds that contribute to non-point source pollution degradation, develop a ranking model to use the environmental geologic data and verify the model by comparing results with existing water quality data(Chung-ju Lake) for specific watersheds, The GIS database consisted of topography, geology, soils, precipitation, rainfall erosivity, land use, and watershed boundaries. The index(NPSP) for assessing non-point source pollution was comprised in the following three seperate components: soil loss index(SLI) assesses the potential soil erosion and sedim-ent delivery from field to stream; run-off potential ratio(R.P.R) predicts the potential production of surface runoff; chloropgyll-a index ranks the potential manure(animal or human) production within a watershed. The GIS model was a valuable tool to assess the impact of environmental pollation in watersheds.

• Korean Journal of Microbiology
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• v.33 no.2
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• pp.125-130
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• 1997

Microbial reduction of hexava1ent(VI) to trivalent(lII) chromium is regarded as one of the mechanisms that confers resistance to bacteria. In order to verify this hypothesis, we compared Cr(VI) resistance with Cr(VI) reduction among 20 phenotypically distinct environmental isolates from Cr-contaminated and uncontaminated soils. With glucose as an electron donor, Cr(VI) reduction by washed cell suspensions ranged from 0.014 to 0.305 mM Cr(VI) reduced $h^1$. Cr(VI) resistance of the isolates were measured by growth inhibitions on a liquid medium containing 2 mM Cr(VI) based on their decrease of $A_{630}1$ as compared to the controls without Cr(VI). The isolates had a broad range of resistance from no inhibition to 93.4% inhibition of their growth. Upon correlation analysis, there was no significant relationship between those two phenomena. At a population level, a comparison of % resistant viable counts among the Cr-contaminated and uncontaminated soils showed 19.1 % and 0.4% of their total viable counts, respectively. The difference of % resistance between two site,. strongly suggested that the Cr(VI) present in the soils influences natural selection for resistant phenotypes. However, it is unlikely that the Cr(VI) resistance is dependent solely on the reduction as judged by the correlation analysis.

• Journal of the Korea Concrete Institute
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• v.13 no.2
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• pp.146-152
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• 2001

The fractal geometry is a non-Euclidean geometry which discribes the naturally irregular or fragmented shaps, so that it can be applied to fracture behavior of materials to investigate the fracture process. Fractal curves have a characteristic that represents a self-similarity as an invariant based on the fractal dimension. This fractal geometry was applied to the crack growth of cementitious composites in order to correlate the fracture behavior to microstructures of cemposite composites. The purpose of this study was to find relationships between fractal dimensions and fracture energy. Fracture test was carried out in order to investigate the fracture behavior of plain and fiber reinforced cement composites. The load-CMOD curve and fracture energy of the beams were observed under the three point loading system. The crack profiles were obtained by the image processing system. Box counting method was used to determine the fractal dimension, D$_{f}$. It was known that the linear correlation exists between fractal dimension and fracture energy of the cement composites. The implications of the fractal nature for the crack growth behavior on the fracture energy, G$_{f}$ is appearent.ent.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.15 no.1
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• pp.70-77
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• 2001

This paper present a fuzzy mxlel of describing reacton features for ozon contactor in advanced water treatn-ent systems. Input and output variables are chosen by considenng the object of ozon processing and several parameters related to management of water quahty. Dissolved organic carbon concentration, $UV_{254}$ absorptIon and $KM_NO_4$ consumption are proposed as common variables in input and outp.lt variables. Furthermore own concentration, raw water's temperature and contact time are suggested as input variables, Membership hmctions for input variables have triangular type share and the grades in each lrembership function are determined by investigating process data gathered at pilot planl The decision parts of fuzzy model have linear combination form of input variables and coefficients included in such linear equations are computedd with process clata in the sense of least square error Also fuzzy trodel suggested in this paper is partitioned by 3 independent fuzzy rnxlels using the characteristics of having no interactions armng output variables. As a result, such fuzzy mxlel has rrerits in computation and comprehension. According to simulatIon results, fuzzy moIel's outputs give almost similar data to process output under same input conditions.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.18 no.3
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• pp.66-74
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• 2005

Objective: Stress is one of the most important etiological factors in our lives. Human body makes effort to keep his homeostasis from stress by using autonomic nerve system. So we need markers which can evaluate autonomic nerve system easily. HRV represents such markers. Sympathetic and Parasympathetic nerve system are part of autonomic nerve system, related with cur body and diseases in ENT, Dermatology, Ophthalmology are also deeply related with stress, Sympathetic and Parasympathetic nerve system. So we can expect that it can help understanding patients to evaluate autonomic nerve system with HRV Research Methods and Procedures: Forty one patients who have seif-recognized stress in Dept. of Oph & Otolaryngo & Dermatology were selected. SDNN. RMSSD, LF, HF, norm-LF, norm-HF, LF/HF ratio, LnLF, LnHF were checked. Results: Men showed lower SDNN, HF, and LnHF than women(p<0.05). Age over-forty group showed significant lower SDNN, LF, HF, LnLF, LnH(p<0.01), and lower RMSSD(p<0.05) than age under-forty group. There's no big differences for age at norm-LF, norm-HF, and LF/HF ratio. Skin disease group showed higher SDNN, RMSSD, LF, HF, LnLF, LNHF than the others, facial palsy group showed higher norm-HF. LF/HF ratio, and mouth-throat group showed higher norm-LF, but there's no statically significant difference. Comparing skin disease group with the others, the others showed statically significant low SDNN(P<0.01), RMSSD, LF, HF, LnLF and LnHF(P<0.05).

• Biomolecules & Therapeutics
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• v.28 no.5
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• pp.465-472
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• 2020

Colorectal cancer (CRC) is one of the most malignant type of cancers and its incidence is steadily increasing, due to life style factors that include western diet. Abnormal activation of canonical Wnt/β-catenin signaling pathway plays an important role in colorectal carcinogenesis. Therefore, targeting Wnt/β-catenin signaling has been considered a crucial strategy in the discovery of small molecules for CRC. In the present study, we found that Nodosin, an ent-kaurene diterpenoid isolated from Isodon serra, effectively inhibits the proliferation of human colon cancer HCT116 cells. Mechanistically, Nodosin effectively inhibited the overactivated transcriptional activity of β-catenin/T-cell factor (TCF) determined by Wnt/β-catenin reporter gene assay in HEK293 and HCT116 cells. The expression of Wnt/β-catenin target genes such as Axin2, cyclin D1, and survivin were also suppressed by Nodosin in HCT116 cells. Further study revealed that a longer exposure of Nodosin induced the G₂/M phase cell cycle arrest and subsequently apoptosis in HCT116 cells. These findings suggest that the anti-proliferative activity of Nodosin in colorectal cancer cells might in part be associated with the regulation of Wnt/β-catenin signaling pathway.

• Journal of Korean Neurosurgical Society
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• v.53 no.6
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• pp.356-369
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• 2013

Objective : We performed a retrospective analysis of medical records and radiographic images of patients who never underwent spinal treatment including diagnosis. The objective of this study is to explain the biomechanical and physiologic characteristics of cervical alignment related to thoracic inlet angle including T1 slope changes in each individual. Methods : We reviewed the cervical CT radiographs of 80 patients who visited ENT outpatient clinic without any symptom, diagnosis and treatment of cervical spine from January 2011 to September 2012. All targeted people were randomized without any prejudice. We assessed the data-T1 slope, Cobb's angle C2-7, neck tilt, sagittal vertical axis (SVA) C2-7 and thoracic inlet angle by the CT radiographs. Results : The relationships between each value were analyzed and we concluded that Cobb's angle C2-7 gets higher as the T1 slope gets higher, while the SVA C2-7 value decreases. Conclusion : We propose that the T1 slope is background information in deciding how much angle can be made in the cervical spinal angle of surgical lordotic curvature, especially severe cervical deformity.