• Clinical and Experimental Pediatrics
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• 제61권4호
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• pp.132-134
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• 2018

We report a unique case of intestinal duplication detected on posterior reversible encephalopathy syndrome (PRES) in a 13-year-old girl. She was admitted to the pediatric Emergency Department because of generalized seizures. Radiological assessment revealed a large, well-defined, thick-walled cystic lesion in the mid abdomen, suggestive of duplication cyst associated to a PRES. Exploration confirmed the diagnosis of ileal duplication cyst, and the mass was resected. The postoperative course was uneventful. Both hypertension and neurological dysfunction resolved after the mass resection. A follow-up brain magnetic resonance imaging was performed 9 months later and showed complete resolution of the cerebellar changes. Although extrinsic compression of the retroperitoneal structures has not been reported in the literature as a complication of duplication cyst, we strongly believe that this is the most logical and plausible hypothesis that would explain the pathogenesis of PRES in our patient.

• Biomolecules & Therapeutics
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• 제27권4호
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• pp.386-394
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• 2019

Trypanosoma cruzi infection results in debilitating cardiomyopathy, which is a major cause of mortality and morbidity in the endemic regions of Chagas disease (CD). The pathogenesis of Chagasic cardiomyopathy (CCM) has been intensely studied as a chronic inflammatory disease until recent observations reporting the role of cardio-metabolic dysfunctions. In particular, we demonstrated accumulation of lipid droplets and impaired cardiac lipid metabolism in the hearts of cardiomyopathic mice and patients, and their association with impaired mitochondrial functions and endoplasmic reticulum (ER) stress in CD mice. In the present study, we examined whether treating infected mice with an ER stress inhibitor can modify the pathogenesis of cardiomyopathy during chronic stages of infection. T. cruzi infected mice were treated with an ER stress inhibitor 2-Aminopurine (2AP) during the indeterminate stage and evaluated for cardiac pathophysiology during the subsequent chronic stage. Our study demonstrates that inhibition of ER stress improves cardiac pathology caused by T. cruzi infection by reducing ER stress and downstream signaling of phosphorylated eukaryotic initiation factor ($P-elF2{\alpha}$) in the hearts of chronically infected mice. Importantly, cardiac ultrasound imaging showed amelioration of ventricular enlargement, suggesting that inhibition of ER stress may be a valuable strategy to combat the progression of cardiomyopathy in Chagas patients.

• 한국정보통신학회논문지
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• 제20권11호
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• pp.2085-2092
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• 2016

IC 기판의 가장 중요한 성질들의 하나는 넓은 영역에 걸쳐 균일해야만 한다는 것이다. 웨이퍼 결함 분석의 다양한 물리적 접근 방법 중에서 적외선 조사 기법에 특별한 관심이 모아지고 있다. 특히, 높은 공간적 분해력을 가지고 있는 근적외선 흡수 방법은 반-절연 GaAs 내의 결함들을 직접적으로 관찰하는데 이용되고 있다. 적외선 전송에 기초를 둔 이 기법은 신속하고 비파괴 적이다. 이 방법은, 직접적으로 GaAs 반도체의 적외선 영상은 결함의 광흡수 작용에 기인한 것임을 밝히고 있다. 반-절연 GaAs 내의 EL2에 관련된, 비 균일 적으로 분포된 결함들의 적외선 흡수 영상에서 콘트라스트가 반전되는 현상에 대해 새로운 모델을 제시하고 있다. 저온 포토퀀칭 실험은, 직접적인 방법으로, GaAs 웨이퍼의 콘트라스트 반전 영상은 밴드갭의 지엽적인 변동이나 전하 재분포에 의한 것이 아니라 흡수와 산란의 두 메커니즘에 의한 것임을 증명하고 있다.

• Bulletin of the Korean Chemical Society
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• 제31권11호
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• pp.3309-3312
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• 2010

D-[$^{18}F$]FMAU and L-[$^{18}F$]FMAU are F-18 labeled nucleoside analogue which have been efficiently synthesized in order to be a PET imaging probe. D-[$^{18}F$]FMAU and L-[$^{18}F$]FMAU were compared as PET imaging agents using HSV1-TK gene expressing tumor-bearing mice. Their cellular uptake profiles were also compared using MCA and MCA-TK cell lines. D-[$^{18}F$]FMAU demonstrated higher cellular uptake and higher accumulation in MCA-TK tumor regions than L-[$^{18}F$]FMAU. On the other hand, L-[$^{18}F$]FMAU showed higher MCA-TK/MCA ratio of %ID/g than that of D-[$^{18}F$]FMAU. L-[$^{18}F$]FMAU can be utilized as a good candidate for HSV1-TK PET imaging. It can be used for antiviral drug evaluation.

• The Journal of Advanced Prosthodontics
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• 제14권1호
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• pp.56-62
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• 2022

PURPOSE. The aim of this study was to investigate shade changes in fully- and pre-crystalized CAD-CAM lithium disilicate crowns after the required and additional firing processes. MATERIALS AND METHODS. One hundred and five crowns of shade A1 with high translucency were milled out of CAD-CAM lithium disilicate blocks and categorized as follows (n = 15): (1) restorations fabricated from Straumann n!ce with no additional sintering process; (2) restorations fabricated from Straumann n!ce with one additional sintering process; (3) restorations fabricated from Straumann n!ce with two additional sintering processes; (4) restorations fabricated from Amber Mill with one sintering process; (5) restorations fabricated from Amber Mill with two sintering processes; (6) restorations fabricated from IPS e.max CAD with one sintering process; (7) restorations fabricated from IPS e.max CAD with two sintering processes. All restorations were evaluated with a color imaging spectrophotometer. RESULTS. All restorations presented some color alteration from the original shade both after a single and after two firing processes. CONCLUSION. The required and additional sintering processes for restorations fabricated with chairside CAD-CAM lithium disilicate blocks cause an alteration of the original shade selected. Shade A1 high translucency restorations tend to change to a more yellowish B1 shade after a sintering process.

• 천문학회보
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• 제45권1호
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• pp.29.5-30
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• 2020

We present an improved weak-lensing (WL) study of the high-z (z=0.87) merging galaxy cluster ACT-CL J0102-4915 ("El Gordo"), the most massive system known to date at z > 0.6. El Gordo has been known to be an exceptionally massive and rare cluster for its redshift in the current ΛCDM cosmology. Previous multi-wavelength studies have also found that the cluster might be undergoing a merging event showing two distinctive mass clumps and radio relics. The previous WL study revealed a clear bimodal mass structure and found that the entire system is indeed massive (M200a = (3.13 ± 0.56) × 1015 Msun). This mass estimate, however, was obtained by extrapolation because the previous HST observation did not extend out to the virial radius of the cluster. In this work, we determine a more accurate mass estimate of the cluster using WL analysis utilizing a new set of WFC3/IR and wide-field ACS observations. While confirming the previous bimodal mass structure, we find that the new data yield a ~20% lower mass for the entire system (M200a = (2.37 ± 0.28) × 1015 Msun). We also discuss the rarity of the cluster in the ΛCDM paradigm and suggest an updated merging scenario based on our new measurement.

• Imaging Science in Dentistry
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• 제38권4호
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• pp.195-202
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• 2008

Purpose : To characterize the effects of 2-deoxy-D-glucose (2-DG) and quercetin (QCT) on gene expression of osteonectin (ON) and osteopontin (OP) in irradiated MC3T3-El cells. Materials and Methods : When MC3T3-El osteoblastic cells had reached 70-80% confluence, cultures were transferred to a differentiating medium supplemented with 5 mM 2-DG or 10 ${\mu}M$ QCT and then irradiated with 2, 4, 6, and 8 Gy. At various times after irradiation, the cells were analyzed for the expression of bone mineralization genes such as ON and OP. Results : The mRNA expression of both ON and OP was increased according to the culture time in the differentiation medium, and the increase of the genes peaked at 14 days after the differentiation induction. In the case of OP, the increase of mRNA expression was maintained to 28 days after the differentiation, while the mRNA level of ON was reduced to the basal level at the same time. Irradiation adding 2-DG showed a significant peak value in the expression pattern of ON at 4 Gy 7 days after irradiation. Irradiation adding QCT increased the mRNA expression of ON and OP in a dose-dependant manner, but irradiation adding 2-DG did not show any differences between the control and experiments 14 days after irradiation. Irradiation adding QCT increased significantly the expression patterns of ON 21 days after irradiation. Conclusion : The results showed that QCT acted as a radiosensitizer in the gene expression of ON and OP during differentiation of the late stage of irradiated MC3T3-E1 osteoblastic cells in vitro. (Korean J Oral Maxillofac Radiol 2008; 38: 195-202)

• Imaging Science in Dentistry
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• 제35권1호
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• pp.1-8
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• 2005

Purpose : To investigate the effects of irradiation on the calcium content and calcific nodule formation in the MC3T3-E1 osteoblastic cell line. Materials and Methods : Cells were irradiated with a single dose of 2,4 and 8 Gy at a dose rate of 5.38 Gy/min using a Cs-137 irradiator. After irradiation, the calcium content and calcific nodule formation were examined on the 1 st, 2nd, 3rd and 4th week. Results : A decreasing dose-dependent tendency of the cell proliferation rate was found in all irradiated groups of this experiment when compared with the unirradiated control group. In accordance with the duration of culture, there was no significant difference in the cell proliferation rate after irradiation of 2 Gy when compared with the unirradiated group, however a decreasing tendency was found in 4 Gy- and 8 Gy-irradiated groups. While an increase in total calcium content after irradiation of 2 Gy was found at week 1, week 2, and week 4, there was a decrease in calcium content at week 1 through 4 in the 8 Gy- irradiated group. Calcific nodule formation was increased in irradiated experimental groups when compared with the unirradiated control group in the 2 Gy-irradiated group, but decreased in the 4 Gy- and 8 Gy-irradiated groups at the same stage. Conclusion : The results showed a mild increasing tendency of the calcific nodule formation after irradiation of 2 Gy. However, a decreased calcific nodule formation in 4 Gy- and 8 Gy-irradiated groups was found. Taken together, the irradiation of 2 Gy mildly activated bone formation, however 4 Gy or 8 Gy suppressed bone formation by decreasing cell numbers in the MC3T3-El osteoblastic cell line.

• Imaging Science in Dentistry
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• 제43권2호
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• pp.71-75
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• 2013

Purpose: This study was performed to determine the position of the mental foramen relative to the apices of the teeth based on panoramic radiographs in a Moroccan population. We also analyzed gender differences and the symmetry of location within individuals. Materials and Methods: Seven hundred ninety-four panoramic radiographs were evaluated with regard to the location and symmetry of the mental foramina in male and female subjects. The results were analyzed using Pearson's ${\chi}^2$ and Fisher's exact test. Results: Of the 794 panoramic radiographs, 377 met the inclusion criteria for at least one side. The mental foramen was located just below the apex of the second premolar in 62.7% of the patients and between the first and second premolars in 30%. It was symmetrically located in 79%. No statistically significant differences were found between males and females in the position and symmetry of the mental foramen. Conclusion: The most common position for the mental foramen in this sample was in line with the second premolar.

• Current Photovoltaic Research
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• 제7권4호
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• pp.85-96
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• 2019

Renewable energy is emerging as a reliable alternative source of energy, it is much safer, cleaner than conventional sources and has contributed significantly in this sector. However, there are still some challenges that needed to address this evolving technology. Artificial Intelligence (A. I.) can assess the past, optimize the present, and forecast the future. Therefore, A. I. will resolve most of these problems. Artificial intelligence is complex in nature, but it reduces error and aims to reach a greater degree of precision which make renewables smarter. This paper provides an overview of frequently used A. I. methods in solar energy applications. A sample algorithm is also provided for literature purposes and knowledge transfer.