• Journal of the FoodService Safety
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• v.2 no.2
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• pp.91-96
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• 2021

This study was performed to provide fundamental data on hygiene and quality control of ready-to-eat sandwiches. Predictive models were developed to the kinetics of Staphylococcus aureus growth in these sandwiches as a function of temperature (10, 15, 25, and 35℃). The result of the primary model that used the Gompertz equation showed that the lag phase duration (LPD) and generation time (GT) decreased and the exponential growth rate (EGR) increased with increasing storage temperature. The secondary model showed an R² for M and B of 0.9967 and 09916, respectively. A predictive growth model of the growth degree as a function of temperature was developed. L(t)=A+Cexp(-exp(-B(t-M))) (A=Initial contamination level, C=MPD-A, B=0.473166-0.045040*Temp-0.001718*Temp*Temp, M=19.924824-0.627442*Temp-0.004493*Temp*Temp, t=time, Temp=temperature). This model showed an R² value of 0.9288. All the models developed in this study showed a good fit.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.36 no.11
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• pp.1065-1072
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• 2012

Due to its oxygen (O) content, biodiesel (BD) is advantageous in that it lowers PM emissions in CI engines. Therefore, BD is considered one of the best candidates for low temperature combustion (LTC) operation because its use can extend the regime for simultaneous reduction of PM and $NO_x$. Thus, in this study, LTC operation was realized using BD and diesel with a 5~7% $O_2$ fraction. Engine test results show that the use of BD increased the efficiency and reduced emissions such as PM, THC, and CO; furthermore, IMEP reduced by 10~12% owing to the lower LHV of the fuel. In particular, smoke was suppressed by up to 90% because O atoms in the BD enhanced the soot oxidation reaction. To compensate the IMEP loss, turbocharging (TC) was then tested, and the results showed that the power output increased and PM was reduced further. Moreover, TC in BD engine operation allowed a similar level of reduction in both $NO_x$ and PM at 11~12% $O_2$ fraction, suggesting that there is a potential to widen the operating range by the combination of TC and BD.

• Journal of Convergence for Information Technology
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• v.10 no.10
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• pp.115-122
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• 2020

Due to the climate change, torrential rain downpours unprecedentedly, and urban areas repeatedly suffer from the inundation damages, which cause miserable loss of property and life by flooding. Two major reasons of urban flooding are river inundation and inland submergence. However, most of previous studies ignored the comprehensive mechanism of those two factors, and showed discrepancy and inadequacy due to the linear summation of each analysis result. In this study, river inundation and inland flooding were analyzed at the same time. Petrov-stabilizing scheme was adopted to capture the shock wave accurately by which river inundation can be modularized. In addition, flux-blocking alrotithm was introduced to handle the wet and dry phenomena. Sink/source terms with EGR (Exponentially Growth Rate) concept were incorporated to the shallow water equations to consider inland flooding. Comprehensive simulation implementing inland flooding and river inundation at the same time produced satisfactory results because it can reflect the counterbalancing and superposition effects, which provided accurate prediction in flooding analysis.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.2
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• pp.193-201
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• 2018

Connective tissue growth factor (CTGF) is a novel fibrotic mediator, which is considered to mediate fibrosis through extracellular matrix (ECM) synthesis in diabetic cardiovascular complications. Statins have significant immunomodulatory effects and reduce vascular injury. We therefore examined whether fluvastatin has anti-fibrotic effects in vascular smooth muscle cells (VSMCs) and elucidated its putative transduction signals. We show that advanced glycation end products (AGEs) stimulated CTGF mRNA and protein expression in a time-dependent manner. AGE-induced CTGF expression was mediated via ERK1/2, JNK, and Egr-1 pathways, but not p38; consequently, cell proliferation and migration and ECM accumulation were regulated by CTGF signaling pathway. AGE-stimulated VSMC proliferation, migration, and ECM accumulation were blocked by fluvastatin. However, the inhibitory effect of fluvastatin was restored by administration of CTGF recombinant protein. AGE-induced VSMC proliferation was dependent on cell cycle arrest, thereby increasing G1/G0 phase. Fluvastatin repressed cell cycle regulatory genes cyclin D1 and Cdk4 and augmented cyclin-dependent kinase inhibitors p27 and p21 in AGE-induced VSMCs. Taken together, fluvastatin suppressed AGE-induced VSMC proliferation, migration, and ECM accumulation by targeting CTGF signaling mechanism. These findings might be evidence for CTGF as a potential therapeutic target in diabetic vasculature complication.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.21 no.5
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• pp.691-699
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• 1997

The effects of concave hemispherical surface curvature on the local heat transfer from a turbulent round impinging jet were experimentally investigated. The liquid crystal transient method was used for these measurements. This method, which is a variation on the transient method, suddenly exposes a preheated wall to an impinging jet while video recording the response of liquid crystals for the measurement of the surface temperature. The Reynolds number ranges from Re=11,000 to 50,000, the nozzle-to- surface distance from L/d=2 to 10, and the surface curvature from D/d=6 to 12.The present results are also compared to those for the flat plate case. In the experiment, the local Nusselt numbers tend to increase in all regions with an increasing surface curvature. The maximum Nusselt number for all Reynolds numbers occurred at L/d .ident. 6 and a second maximum in the Nusselt number occurred at R/d .ident. 2 for both Re=23,000 and Re=50,000 in the case of L/d=2 and for Re=50,000 only in the case of L/d=4. Meanwhile, as the surface curvature increases, the value of the secondary maximum Nusselt number decreases. All the other cases exhibit monotonically decreasing values of the Nusselt number along the curved surface. The stagnation point Nusselt numbers are well correlated with Re, L/d, and D/d.

• Korean Journal of Environmental Biology
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• v.21 no.1
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• pp.52-55
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• 2003

There is considerable evidence that ionizing radiation (IR) mediates checkpoint control, repair and cell death. In this study, we have used a high density microarray hybridization approach to characterize the transcriptional response of human breast carcinoma MCF-7 cell line to ${\gamma}$-radiation, such as 4 Gy 4 hr, 8 Gy 4 hr, and 8 Gy 12 hr. We found that exposure to ${\gamma}$-ray alters by at least a $log_2$ factor of 1.0 the expression of 115 known genes. Of the 66 genes affected by ${\gamma}$-radiation, 49 are down-regulated. In our results, the cellular response to irradiation includes induction of the c-jun and EGR1 early response genes. The present work has examined potential cytoplasmic signaling cascades that transduce IR-induced signals to the nucleus. 40S ribosomal protein s6 kinase modulates the activities of the mitogen activated protein kinase (MAPK) and c-Jun $NH_2$-terminal kinase (JNK1) cascades in human monocytic leukemia (U937/pREP4) cells. 14-3-3 family members are dimeric phosphoserine -binding proteins that participate in signal transduction and checkpoint control pathways.

• Transactions of the Korean Society of Automotive Engineers
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• v.17 no.4
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• pp.93-100
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• 2009

Intake/exhaust valve timing and exhaust cam lift were changed to control the internal exhaust gas recirculation (IEGR) and combustion phase of homogeneous charge compression ignition (HCCI) engine. To measure the IEGR rate, in-cylinder gas was sampled during from intake valve close to before ignition start. The lower exhaust cam made shorter valve event than higher exhaust cam and made IEGR increase because of trapping the exhaust gas. IEGR rate was more affected by exhaust valve timing than intake valve timing and increased as exhaust valve timing advanced. In-cylinder pressure was increased near top dead center due to early close of exhaust valve. Ignition timing was more affected by intake valve timing than exhaust valve timing in case of exhaust valve lift 8.4 mm, while ignition timing was affected by both intake and exhaust valve timing in case of exhaust valve 2.5 mm. Burn duration with exhaust valve lift 2.5 mm was longer than other case due to higher IEGR rate. The fuel conversion efficiency with higher exhaust valve lift was higher than that with lower exhaust valve lift. The late exhaust and intake maximum open point (MOP) made the fuel conversion efficiency improve.

• Journal of ILASS-Korea
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• v.24 no.4
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• pp.178-184
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• 2019

Diesel engines have the advantages of higher thermal efficiency and lower CO2 emissions than gasoline engines, but have the disadvantages that particulate matter (PM) and nitrogen oxides (NOx) emissions are greater than those of gasoline engines. In particular, nitrogen oxides (NOx) emitted from diesel engines generates secondary ultrafine dust (PM2.5) through photochemical reactions in the atmosphere, which is fatal to humans. In order to reduce nitrogen oxides (NOx), pre-treatment systems such as EGR, post-treatment systems such as LNT and Urea SCR have been actively studied. The Urea SCR consists of an injection device injecting urea agent and a catalytic device for reducing nitrogen oxides (NOx). The nitrogen oxide (NOx) reduction performance varies greatly depending on the urea uniformity in the exhaust pipe. In this study, spray characteristics according to the spray hole structure were confirmed, and the influence of spray uniformity on spray characteristics was studied through engine evaluation.

• Transactions of the Korean Society of Automotive Engineers
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• v.12 no.5
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• pp.32-39
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• 2004

HCCI (Homogeneous Charge Compression Ignition) combustion has a great advantage in reducing NOx (Nitrogen Oxides) and PM (Particulate Matter) by lowering the combustion temperature due to spontaneous ignitions at multiple sites in a very lean combustible mixture. However, it is difficult to make a diesel-fuelled HCCI possible because of a poor vaporability of the fuel. To resolve this problem, the two-stage injection strategy was introduced to promote the ignition of the extremely early injected fuel. The compression ratio and air-fuel ratio were found to affect not only the ignition, but also control the combustion phase without a need for the intake-heating or EGR (Exhaust Gas Recirculation). The ignition timing could be controlled even at a higher compression ratio with increased IMEP (Indicated Mean Effective Pressure). The NOx (Nitrogen Oxides) emission level could be reduced by more than 90 % compared with that in a conventional DI (Direct Injection) diesel combustion mode, but the increase of PM and HC (Hydrocarbon) emissions due to over-penetration of spray still needs to be resolved.

• Journal of the Korean Society of Marine Environment & Safety
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• v.21 no.2
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• pp.188-193
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• 2015

It has been generally recognized that $N_2O$(Nitrous Oxide) emission from marine diesel engines has a close correlation with $SO_2$(Sulfur Dioxide) emission, and diversity of fuel elements using ships affects characteristics of the $N_2O$ emission. According to recent reports, in case of existence of an enough large NO(Nitric Oxide) generated as fuel combustion, effect of the $SO_2$ emission in exhaust gas on the $N_2O$ formation is more vast than effect of the NO. Therefore, $N_2O$ formation due to the $SO_2$ element operates on a important factor in EGR(Exhaust Gas Recirculation) systems for NOx reduction. An aim of this experimental study is to investigate that intake gas of the diesel engine with increasing of $SO_2$ flow rate affects $N_2O$ emission in exhaust gas. A test engine using this experiment was a 4-stroke direct injection diesel engine with maximum output of 12 kW at 2600rpm, and operating condition was set up at a 75% load. A standard $SO_2$ gas with 0.499%($m^3/m^3$) was used for changing of $SO_2$ concentration in intake gas. In conclusion, the diesel fuel included out sulfur elements did mot emit the $SO_2$ emission, and the $SO_2$ emission in exhaust gas according as increment of the $SO_2$ standard gas had almost the same ratio compared with $SO_2$ rate in mixture inlet gas. Furthermore, the $N_2O$ element in exhaust gas was formed as $SO_2$ mixture in intake gas because increment of $SO_2$ flow rate in intake gas increased $N_2O$ emission. Hence, diesel fuels included sulfur compounds were combined into $SO_2$ in combustion, and $N_2O$ in exhaust gas should be generated to react with NO and $SO_2$ which exist in a combustion chamber.