• Transactions of the Korean Society of Automotive Engineers
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• v.5 no.1
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• pp.15-26
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• 1997

The present study is mainly motivated to numerically simulate the autoignition and combustion process of a diesel spray in RCM and effects of design parameters on combustion and engine performance in the DI diesel engine using EGR. In case of the burning spray in RCM, special emphasis is given to the autoignition process coupled with the fluid mechanics and chemical reaction. Computations are carried out for a wide range of operating condition in terms of temperature, concentration of oxygen and carbon dioxide of the intake gas in the DI diesel engine. Numerical results indicate that the mixing process along the edges of spray jet has a crucial role for autoignition and combustion process. Temperature and concentration of O2 and CO2 of intake gas significantly influence the combustion characteristics and engine performance in the diesel/EGR environment.

• Transactions of the Korean Society of Automotive Engineers
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• v.12 no.1
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• pp.55-60
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• 2004

Residual gas acts as a diluent which results in reducing the in-cylinder temperature as well as the flame speed, significantly affecting fuel economy, NOx emissions and combustion stability. Therefore it is important to determine the residual gas fraction as a function of the engine operating parameters accurately. However, the determination of the residual gas fraction is very sophisticated due to the unsteady state of induction and exhaust process. There has been little work toward the development of a generally applicable model for quantitative predictions of residual gas fraction. In this paper, a simple model for calculating the residual gas fraction in SI engines was suggested. The amount of fresh air was evaluated through AFR and fuel consumption. After this, from the intake temperature and pressure, the amount of total cylinder-charging gas was estimated. The residual gas fraction was derived by comparing the total charging and fresh air. This results coincide with measured EGR value very well.

• Journal of ILASS-Korea
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• v.20 no.3
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• pp.149-155
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• 2015

With increasing of GDP, the registration number of passenger cars has exceeded 20 million last year in Korea. Especially, the registration number of the diesel engine vehicles has been increasing. However, the WHO(World Health Organization) IARC (International Agency for Research on Cancer) has reported that diesel engine exhaust gas is an one of HAPs, which has carcinogenic for human, and they have designated it to Group 1. To solve this problem, exhaust gas from diesel engines has to be controlled. Thus, it has been controlling by European regulatory standard in Korea. On the other hand, in order to meet the enhanced emission regulations, all manufacturing company applied $NO_x$ control device to vehicles such as EGR (Exhaust Gas Recirculation), SCR (Selective Catalytic Reduction) and so on. However, these devices (EGR, SCR) were operated by difference reaction mechanism respectively, and the composition of exhaust gas would be differenced from that of them. In this study, it was conducted to evaluate variety characteristics on changing of exhaust gas composition by each $NO_x$ control device, and the heavy duty diesel trucks were chosen as experimental vehicles. From the result, it revealed that vehicles (with EGR) were discharged higher THC as 52.5% than that of others (with SCR). However, it did not followed that trend, in the case of CO; it was discharged as 57.2% lower than that of others (with SCR). In the future, these data would be used to apply to efficient $NO_x$ control device for meeting to EURO 6.

• Molecules and Cells
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• v.26 no.5
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• pp.468-473
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• 2008

Low-density lipoprotein (LDL) induces cell proliferation in human aortic smooth muscle cells (hAoSMCs), which may be involved in atherogenesis and intimal hyperplasia. Recent studies have demonstrated that $Cl^-$ channels are related to vessel cell proliferation induced by a variety of stimuli. In this study, we investigated a potential role of $Cl^-$ channels in the signaling pathway of LDL effects on hAoSMC proliferation with a focus on the activation of Erk1/2-PI3K/Akt and the subsequent upregulation of Egr-1. $Cl^-$ channel blockers, DIDS, but neither NPPB nor Furosemide, completely abolished the LDL-induced DNA synthesis and cell proliferation. Moreover, DIDS, but not NPPB, significantly decreased LDL-stimulated $Cl^-$ concentration, as judged by flow cytometry analysis using MQAE as a $Cl^-$-detection dye. DIDS pretreatment completely abolished the activation of Erk1/2 and PI3K/Akt in a dose-dependent manner that is the hallmark of LDL activation, as judged by Western blot and proliferation assays. Moreover, pretreatment with DIDS ($Cl^-$ channel blockers) but not LY294002 (PI3K inhibitors) completely abolished the LDL-induced upregulation of Egr-1 to the same extent as PD98059 (MEK inhibitors to inhibit Erk), as judged by Western blot and luciferase reporter assays. This is the first report, to our knowledge, that DIDS-sensitive $Cl^-$-channels play a key role in the LDL-induced cell proliferation of hAoSMCs via the activation of Erk1/2 and PI3K/Akt and the upregulation of Egr-1.

• Parasites, Hosts and Diseases
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• v.50 no.1
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• pp.7-13
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• 2012

$Toxoplasma$ $gondii$ can modulate host cell gene expression; however, determining gene expression levels in intermediate hosts after $T.$ $gondii$ infection is not known much. We selected 5 genes ($ALDH1A2$, $BEX2$, $CCL3$, $EGR2$ and $PLAU$) and compared the mRNA expression levels in the spleen, liver, lung and small intestine of genetically different mice infected with $T.$ $gondii$. ALDH1A2 mRNA expressions of both mouse strains were markedly increased at day 1-4 postinfection (PI) and then decreased, and its expressions in the spleen and lung were significantly higher in C57BL/6 mice than those of BALB/c mice. BEX2 and CCR3 mRNA expressions of both mouse strains were significantly increased from day 7 PI and peaked at day 15-30 PI ($P$<0.05), especially high in the spleen liver or small intestine of C57BL/6 mice. EGR2 and PLAU mRNA expressions of both mouse strains were significantly increased after infection, especially high in the spleen and liver. However, their expression patterns were varied depending on the tissue and mouse strain. Taken together, $T.$ $gondii$-susceptible C57BL/6 mice expressed higher levels of these 5 genes than did $T.$ $gondii$-resistant BALB/c mice, particularly in the spleen and liver. And ALDH1A2 and PLAU expressions were increased acutely, whereas BEX2, CCL3 and EGR2 expressions were increased lately. Thus, these demonstrate that host genetic factors exert a strong impact on the expression of these 5 genes and their expression patterns were varied depending on the gene or tissue.

• Journal of Life Science
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• v.25 no.9
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• pp.1043-1050
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• 2015

Glutamate is one of the principle transmitters in the CNS. Ionotropic receptors of glutamate, selectively activated by N-methyl-D-aspartate (NMDA), play an important role in the processes of cell development, learning, memory, and etc. On the other hand, many studies discovered that over-activation of glutamate receptors leads to neurodegeneration and are known to be implicated in major areas of brain pathology. Any sustained effect of a transient NMDA receptor activation is likely to involve signaling to the nucleus and to trigger coordinated changes in gene expression. Classically, a set of immediate-early genes are induced first; some of genes are by themselves transcription factors that control expression of other target genes. This study provides understanding of changes of inducible transcription factors mRNA levels with RT-PCR by inducing over-activation of NMDA receptor with intraperitoneal NMDA injection. The experimental conditions were varied by 1, 5, 25, and 125 g/ of body weight NMDA and measured transcription factors mRNA levels are Egr-1, c-Jun, JunB, and FosB. Based on result obtained, inducible transcription factors mRNA in NMDA injection to mice with 5 g/body weight showed the greatest change. And ITF mRNA showed greatest change 24 hr after injection. The expression level of JunB mRNA was markedly changed. Up to the present days, no study clearly understood how ITF mRNA affected the apoptosis of purkinje cells in the cerebellum. The current study improves the understanding of the mechanism of apoptosis of purkinje cells in the cerebellum.

• Journal of the Korean Society for Precision Engineering
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• v.25 no.11
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• pp.83-89
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• 2008

The Effect of Space Velocity(SV) on NOx conversion rate was performed to develop NOx reduction after-treatment system. SV is calculated from engine exhaust gas volume and SCR catalyst volume. Found the Urea injection duty of maximum efficiency for NOx conversion if increase SV, NOx Conversion rate is down. Especially, when SV is more than $110,000h^{-1}$, NOx conversion rate decrease suddenly. Same case, if SV is lower than $40,000h^{-1}$, NOx conversion rate is down. Also, the characterization of Urea-SCR system was performed. Three candidate injectors for injecting Urea were tested in terms of 속 injection rate and NOx reduction rate. The performances of SCR catalytic converter on temperature were investigated. The performance of Urea-SCR system was estimated in the NEDC test cycle with and without EGR. It was found that nozzle type injector had high NOx conversion rate. SCR catalytic converter had the highest efficiency at the temperature of $350^{\circ}C$. EGR+Urea-SCR system achieved NOx reduction efficiency of 73% through the NEDC test cycle.

• Journal of ILASS-Korea
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• v.18 no.1
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• pp.21-26
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• 2013

Diesel low temperature combustion (LTC) is the concept where fuel is burned at a low temperature oxidation regime so that $NO_x$ and particulate matters (PM) can simultaneously be reduced. There are two ways to realize low temperature combustion in compression ignition engines. One is to supply a large amount of EGR gas combined with advanced fuel injection timing. The other is to use a moderate level of EGR with fuel injection at near TDC which is generally called Modulated kinetics (MK) method. In this study, the effects of fuel injection pressure on performance and emissions of a single cylinder engine were evaluated using the latter approach. The engine test results show that MK operations were successfully achieved over a range of with 950 to 1050 bar in injection pressure with 16% $O_2$ concentration, and $NO_x$ and PM were significantly suppressed at the same time. In addition, with an increase in fuel injection pressure, the levels of smoke, THC and CO were decreased while $NO_x$ emissions were increased. Moreover, as fuel injection timing retarded to TDC, more THC and CO emissions were generated, but smoke and $NO_x$ were decreased.

• Proceedings of the Korean Society of Life Science Conference
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• 2007.10a
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• pp.43.1-43.1
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• 2007

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• Transactions of the Korean Society of Automotive Engineers
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• v.10 no.3
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• pp.8-17
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• 2002

In this study, it was tried to analyze not only total hydrocarbon but individual hydrocarbon components from C$_1$to C$\sub$6/ in exhaust gas using gas chromatography to seek the reason fur remarkable differences of smoke emission of diesel fuel, esterfied rice bran oil and blended fuel(esterfied rice bran oil 20vo1-% + diesel fuel 80vo1-%). Individual hydrocarbons(C$_1$ ∼C$\sub$6/) as well as total hydrocarbon of esterfied rice bran oil is reduced remarkably compared with diesel fuel. Although smoke emission of esterfied rice bran oil reduced remarkably compared with commercial diesel fuel, NOx emission of esterfied rice bran oil and blended fuel was increased slightly at high loads and speeds. And, it was tried to reduced NOx emission of them by exhaust gas recirculation(EGR) method. Simultaneous reduction of smoke and NOx emission was achieved with the combination of esterfied rice bran oil and EGR method in consequence.