• Parasites, Hosts and Diseases
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• v.54 no.6
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• pp.759-768
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• 2016

Cystic echinococcosis (CE) treatment urgently requires a novel drug. The p38 mitogen-activated protein kinases (MAPKs) are a family of Ser/Thr protein kinases, but still have to be characterized in Echinococcus granulosus. We identified a 1,107 bp cDNA encoding a 368 amino acid MAPK protein (Egp38) in E. granulosus. Egp38 exhibits 2 distinguishing features of p38-like kinases: a highly conserved T-X-Y motif and an activation loop segment. Structural homology modeling indicated a conserved structure among Egp38, EmMPK2, and H. sapiens $p38{\alpha}$, implying a common binding mechanism for the ligand domain and downstream signal transduction processing similar to that described for $p38{\alpha}$. Egp38 and its phosphorylated form are expressed in the E. granulosus larval stages vesicle and protoscolices during intermediate host infection of an intermediate host. Treatment of in vitro cultivated protoscolices with the p38-MAPK inhibitor ML3403 effectively suppressed Egp38 activity and led to significant protoscolices death within 5 days. Treatment of in vitro-cultivated protoscolices with $TGF-{\beta}1$ effectively induced Egp38 phosphorylation. In summary, the MAPK, Egp38, was identified in E. granulosus, as an anti-CE drug target and participates in the interplay between the host and E. granulosus via human $TGF-{\beta}1$.

• Journal of Ocean Engineering and Technology
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• v.33 no.5
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• pp.479-485
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• 2019

As exhaust gas systems of ships become more complicated, it is necessary to calculate an accurate pressure loss at their design stage. If the dynamic loss coefficients of non-standard fittings mainly used in exhaust gas pipe (EGP) are well-documented, it would be possible to calculate precise pressure loss more readily than using the conventional method that analyzes the entire system. In the case of a ship's EGP, the flow rates and temperatures of exhaust gas are determined by engine specifications, and the range of the flow rate and temperature is limited according to operating conditions. In addition, as it is possible to define non-standard fittings frequently used in an EGP, a database can be easily constructed and effective. This paper illustrates effective parameters and analysis cases of several types of non-standard fittings mounted in ship EGPs. The analysis procedure proposed in this paper is verified using existing research results on HVAC fittings. The numerical procedure, which is minimally affected by manpower and grid, is established such that it can be applied at the industry level.

• Journal of Life Science
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• v.25 no.6
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• pp.663-672
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• 2015

The study was performed to investigate the effects of enzyme treated garlic (EG) and its natural resources composites on lipid levels in serum and liver of rats fed a high fat diet. Four different types of EG-composite extracts prepared: EG and EG + grape peel (EGG), EG + Persimmon (EGP) and EG + Catechu (EGC) by mixed 9.5:0.5, 9:1 and 8:2 (w/w) ratios, respectively. DPPH and ABTS radical scavenging activity in vitro, show the highest in EG + Catechu (EGC) composite by mixed 8:2 (w/w). EG and EG-composites extracts (8:2, w/w) were administered orally to SD-male rats at a concentration of 2.5 g/kg/day for 5 weeks. Total lipid and cholesterol contents in serum were significantly lower in EGC group than control group, and triglyceride content was the lowest in EGP group by 54.29 mg/dL. HDL-cholesterol contents were significantly higher in EGP and EGC groups. LDL-cholesterol content was lower in EG group than EG-composite groups, and VLDL cholesterol content was the lowest in EGP group. GOT, GPT and ALP activity was significantly lower in EGP group. Total lipid, cholesterol and triglyceride contents in liver were significantly lower in EGP and EGC group than control group. Antioxidant activity in serum was the highest in EGC groups by 50.86%, in liver was the highest in EGP groups. TBARS content in serum and liver was the lowest in EGP group. In these results, we suggest that EGP composites could have hypolipidemic and anti-obesity effects in rats fed a high fat diet.

• Journal of Navigation and Port Research
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• v.38 no.2
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• pp.127-134
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• 2014

This paper aims to identify what is needed to improve the English for Specific Purposes(ESP) curriculum for English as a Foreign Language(EFL) college learners at navigation school. Different needs from learners and experienced professionals are identified through diversified methods, and the findings from these are analysed and consolidated from a balanced point of view. For this purpose, putting learners at the centre of analysis, identifying their subjective and objective needs serves as a point of departure in formulating the curriculum. Then, the target situation is analysed according to the short-term aim of getting a job, followed by long-term needs for successfully fulfilling future duties as a pilot. Based on findings, it is suggested that ESP curriculum for learners in navigation studies should be focused on the successful language performance of their actual duties and tasks to be given in the future working situations, rather than on immediate needs for getting a job. In particular, special attention needs to be paid to enhancing learners' productive language competences through a series of hands-on trainings and a wide range of extra-curricular activities, specifically for a higher command of oral communication. For this, not only ESP, curriculum for EGP(English for General Purposes) should be systematically structured as ESP-oriented EGP, and naturally move onto areas of ESP in a coherent manner.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.14 no.3
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• pp.283-289
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• 2003

In this paper, we proposed novel multilayer photonic bandgap(PBG) structure using DSL(Descended Signal Line). From measurement result, the proposed PBG structure using DSL is reduced 72 % at size and increased 13 % at bandwidth compared to typical multilayer DGS(Defected Ground Structure). It is also reduced 42 % at size and increased 23 % at bandwidth compared to PBG structure using EGP(Elevated Ground Plane). In case of measurement for manufactured six PBG patterns, all patterns have the same cutoff frequency and bandstop characteristics. So it can be used for bandstop filter having very precise tolerance of below 300 MHz at 20 ㎓ if it is applied to real product and this filter will be useful for small microwave integrated circuit and module development.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.39 no.11
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• pp.34-39
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• 2002

In this paper, we proposed novel photonic bandgap(PBG) structure using EGP(Elevated Ground Plane) and via in ceramic substrate of microstrip line. From analysis result, the proposed PBG structure is reduced 52.5% at size and increased 45 % at bandwidth compared to typical planar PBG structure. It is also reduced 32 % at size and improved more than 8 dB at power loss compared to typical multilayer DGS(Defected Ground Structure). The proposed PBG structure also can be used bandstop and lowpass filter and it will be useful for small microwave integrated circuit and module development.

• Journal of Korean society of Dental Hygiene
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• v.21 no.1
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• pp.41-51
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• 2021

Objectives: This study analyzes the demands of dental hygiene college students for English courses and proposes ways to improve English courses for college students majoring in dental hygiene that would take advantage of English for specific purposes (ESP) in the future. Methods: Using a structured questionnaire, four universities by region with departments of dental hygiene were selected at random, and out of a total of 260 college students majoring in dental hygiene, data of 258 students, excluding data with missing values, were considered for investigating the needs of English curriculum development using the SPSS program. Results: Total 82.1% of the students expected English programs, and they said that English was important, The proposal for English curriculum development indicated that although the number of English programs was sufficient, diversification of English programs or changes in methods of managing classes were required. As for the need for English programs (66.4%), they required more ESP, such as practical English for dental or dental terminology, which can be used clinically and more than English for general purposes (EGP). Conclusions: Students in dental hygiene showed a higher demand for more professional ESP that can use clinically as dental hygienists in the future. It is necessary to consider the reorganization of the curriculum or changes in the method of managing English classes by reflecting one demands of dental hygiene students.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.1
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• pp.81-97
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• 2012

The objective of this paper is to investigate the 'state of the art' of the interdomain routing protocol BGP. First, BGP is critically reviewed focusing on the BGP policy and decision making process. And then the problems which still remain as open questions are investigated in the areas of 1) protocol stability, 2) traffic engineering and 3) quality of service. The recent research trend to answer the open questions is discussed.

• Proceedings of the Korea Multimedia Society Conference
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• 2003.11b
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• pp.687-690
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• 2003

오늘날 인터넷을 통한 모든 통신망이 끊임없이 발전하고 있는 가운데 IPv4가 가지는 문제점들이 치명적인 위협으로 대두되고 있다. 따라서, 폭발적인 인터넷 사용자 증가로 인한 IP address의 고갈과 느려져만 가는 인터넷 속도에 대해 대안이 필요하다. IPv4는 32bit 체계로 약 40억 개의 IP 주소를 가지고 있으나, 인터넷 초기의 무분별한 클래스를 사용하여 40억 개보다 적은 양의 주소를 사용 할 수 있게 되었다. IPv6는 128bit의 주소 체계를 가지고 있으며, 3.4 $10^{38}$개의, 천문학적인 주소를 할당 할 수 있으며, 보안성과 서비스 품질보장(QoS), 이동성 기존의 인터넷 속도의 가속 기능 등 다양한 장정들을 가지고 있다. 본 논문에서는 IPv4에서 IPv6로 진화해 가야 하는 시기적인 요소보다는 IPv6로의 공존해 나아가야 하는 기술적인 문제를 극복하기 위해 기존 IPv4망에서 IPv6 주소체계를 지원할 수 있도록 설계하고 Backbone network 구성에 일반적인 구현을 통하여 IGP와 EGP 구간의 라우팅 정보공유에 대하여 논의한다.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 2013.11a
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• pp.221-222
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• 2013

다양한 첨가제가 들어가는 고분자 화합물(compound)의 제조에 있어 난연 발포 보조제인 팽창흑연(Expandable Graphite, EGP)은 흡유가가 낮기 때문에 비교적 많은 양을 첨가해도 혼합(Mixing)이 잘 되는 것으로 알려져 있다. 본 논문에서는 대표적인 인계 난연제 APP(Ammonium Polyphosphate)를 사용한 난연 EPDM(Ethylene Propylene Diene Monomer) 폼에 팽창흑연 첨가량을 증가시키면서 산소 지수와 발열량을 통해 난연 성능의 변화를 분석하였다. 산소지수는 ISO 4589-2 상온 산소지수 방법을, 발열량 평가는 ISO 5660-1 콘 칼로리미터를 활용하였다.