• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2001년도 제6차 학술대회 초록집
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• pp.137-137
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• 2001

Purpose： The purpose of this study was to identify cerebral cortices related with sexual arousal fro visual sexual stimulation in healthy males using BOLD-based functional MR imaging Method： Sixteen male volunteers with sexually potent(mean age：24) were examined for thi study. Functional MRI was performed on a 1.5T MR scanner(GE Signa Horizon) with birdcage-type head coil. In this study, blood oxygenation level dependent(BOLD) technique was utilized to create fMR image reflecting local brain activities. The BOLD-based fMRI d were obtained from 7 oblique planes using gradient-echo EPI with $90^{\circ}$flip angle, 50ms TE 6000ms TR, $26cm{\times}26$ cm FOV, $128{\times}128$ matrix, and 10mm slice thickness. The sexual stimulation paradigm consisted of two alternating periods of rest and activati and it began with a 1 minute rest, followed by a 2 minute stimulation by a documentary a erotic video film. Brain activation maps were generated by cross-correlation of imag acquired during rest and activation periods. The index of activation was used to compare t number of pixels activated by each task in each volunteer, where the significance of th differences was evaluated by using Students t-test.

• Ocean and Polar Research
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• 제27권1호
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• pp.75-86
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• 2005

Acoustic survey for density and biomass estimate of Antarctic krill, Euphausia superba, was conducted in the large area between South Shetland Islands and South Orkney Islands, during November 30-December 30, 2002. Considering oceanographic and geographic properties, the study area was divided into six sub-regions. Acoustic system and frequency used in the survey were quantitative echo sounder (Simrad Ek 500) and 38, 120-kHz split beam transducers. In order to discriminate krill aggregations in all acoustic signal, difference of mean volume backscattering strength $({\Delta}MVBS)$ method of the two frequencies was introduced. Averaged krill density for the overall surveyed area was $23.5g/m^2$, and spatially averaged estimates of krill density were $44.9g/m^2$ (north of the South Shetland Islands), $30.3g/m^2$ (Bransfield Strait), $11.3g/m^2$ (near the Elephant Island), $13.6g/m^2$ (north of the Elephant Island), $18.1g/m^2$(between Elephant Island and South Orkney Islands) and $21.7g/m^2$(northwest of the South Orkney Islands) at each sub-area. In the two sub-regions with surveyed area, estimated krill biomass in the north of the Elephant Island was 0.315 million tones with a CV of 18.35% $(6,766mile^2)$, and between Elephant Island and South Orkey Islands was 1.26 million tones with a CV of 9.45% $(20,299mile^2)$. As a whole, the krill density in the early summer season was low level, comparing with that of January-February. This suggested that major krill swarms in the around South Shetland Islands were reached in the mid-summer seasons from western part of the Antarctic Peninsula, and the low krill density also affects the density variation of the krill between Elephant Island and South Orkney Islands.

• Investigative Magnetic Resonance Imaging
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• 제7권1호
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• pp.12-21
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• 2003

목적 : 기존의 일반적인 스펙트로미터보다 향상된 성능을 가진 새로운 스펙트로미터를 설계 및 제작하였다. 대상 및 방법 : 초당 10억번의 부동 연산 능력을 갖춘 TMS320C6701 DSP를 이용하여 연속적으로 변하는 복잡한 경사자계파형을 실시간으로 계산하여 출력할 수 있고, 선택 단면을 interactive하게 조절할 수 있는 스펙트로미터를 설계, 제작하였다. 설계된 스펙트로미터는 DSP 기반의 디지털 제어부와 파형을 만들고 변조 및 복조를 수행하는 아날로그부로 구성되어 있다 RF 신호의 변조 및 복조는 디지털 기술을 사용하여 정밀도와 안정성을 높였다. 고속 병렬영상을 위하여 하나의 측정 보드당 4채널까지 측정할 수 있도록 하였고, 고속 DSP를 이용하여 빠른 재구성이 가능하도록 하였다. 결과 : 제작된 스펙트로미터를 1.5 테슬라 전신자기공명영상 시스템에 장착하여 다양한 방법으로 성능을 시험하였다. 디지털 변조/복조 방식에서 요하는 정밀한 위상 제어를 확인할 수 있었고, phase array 코일 영상을 통하여 다중 채널 측정시스템의 성능을 검증할 수 있었다. 개발된 스펙트로미터를 기존의 상품화된 스펙트로미터와 비교해 볼때 보다 정밀한 위상 제어가 가능한 것으로 나타났다. 결론 : Interactive하게 영상의 단면을 선택하고, 실시간 계산에 의한 파형출력은 나선주사 심장영상과 같은 첨단의 영상기법에 요구되는 스펙트로미터의 기능이다 또한 다채널 측정시스템도 병렬영상을 위한 필수적인 기능이다. 본 논문에서는 초당 10억번의 부동소수점 연산이 가능한 TMS320C6701 디지털신호처리기를 사용하여 이러한 기능들을 가진 스펙트로미터를 설계, 제작하였다. 디지털 방식의 변조/복조 기술을 채택하여 정밀한 위상제어가 가능하였다. 개발된 스펙트로미터를 FSE, GE, angiography 등 다양한 영상방법에 적용하여 성능을 확인하였으며, 기존의 제품보다 뛰어난 화질의 영상을 얻을 수 있었다.

• Journal of Acupuncture Research
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• 제20권3호
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• pp.194-208
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• 2003

Objective : Recently, many studies have showed the evidences of the effect of acupuncture treatment through scientific methods. We performed electro-acupuncture on Taixi(K3) and observed the change of brain activity using fMRI. Methods : To see the effect of electro-acupuncture stimulation on Taixi(K3), the experiment was carried out on twelve healthy volunteers, using the gradient echo sequence with the 3.0T whole-body fMRI system(ISOL). After the needle insertion on K3, 2 Hz of electric stimulation was given for 30 seconds, repeated five times, with 30 seconds' intervals. Result & Conclusions : Unilateral electro-acupuncture stimulation on K3 increased the brain activity in Brodman Area 8, 6, 9, 13, 21, 22, 38, 40, 43, 2, 5, 10, 20, 24, 32, 34, 37, 39, 41, 42. and decreased the brain activity in Brodman Area 9, 13, 38, 22, 31, 3, 6, 10, 21, 25, 29, 30. Group Averaged Brain activity induced by Unilateral Electro-acupuncture Stimulation on K3 was increased in Brodman Area 10, 22, 42, 43, 44 and was decreased inn Brodman Area 6 and pyrogen test of Bee venom. Bilateral electro-acupuncture stimulation on k3 increased the brain activity in Brodman Area 22, 3, 19, 4, 13, 17, 21, 41, 42, 2, 5, 6, 7, 18, 23, 29, 30, 31, 40 and decreased the brain activity in Brodman Area 18, 6, 39, 4, 13, 2, 10, 19, 36, 40, 45, 46, 47. Group Averaged Brain activity induced by Bilateral Electro-acupuncture Stimulation on K3 was increased in Brodman Area 22, 13, 4, 3, 29, 38, 43 and was decreased in Brodman Area 18, 3, 19, 22, 39. Motor Stimulation activated Brodmann Area 6, 43, 18.

• 한국자기공명학회논문지
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• 제5권2호
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• pp.99-109
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• 2001

Authors investigated neuronal changes of local cellular metabolism in the cerebral lesions of Parkinsonian symptomatic side between before and after stereotactic neurosurgery by follow-up 1H magnetic resonance spectroscopy (MRS). Patients with Parkinson's disease (PD) (n = 15) and age-matched normal controls (n = 15) underwen MRS examinations using a stimulated echo acquisition mode (STEAM) pulse sequence that provided 2${\times}$2${\times}$2 ㎤ (8ml) volume of interest in the regions of substantia nigra, thalamus, and lentiform nucleus. Spectral parameters were 20 ms TE, 2000 ms TR, 128 averages,2500 Hz spectral width, and 2048 data points. Raw data were processed by the SAGE data analysis package (GE Medical Systems). Peak areas of N-acetylaspartate (NAA), creatine (Cr), choline-containing compounds (Cho), inositols (Ins), and the sum (Glx) of glutamate and GABA were calculated by means of fitting the spectrum to a summation of Lorentzian curves using Marquardt algorithm. After blindly processed, we evaluated neuronal alterations of observable metabolite ratios between before and after stereotactic neurosurgery using Pearson product-moment analysis (SPSS, Ver. 6.0). A significant reduction of NAA/Cho ratio was observed in the cerebral lesion in substantia nigra of PD patient related to the symptomatic side after neurosurgery (P : 0.03). In thalamus, NAA/Cho ratio was also significantly decreased in the cerebral lesion including the electrode-surgical region (P : 0.03). A significant reduction of NAA/Cho ratio in lentiform nucleus was not oberved, but tended toward significant reduction after neurosurgery (P = 0.08). In particular, remarkable lactate signal was noted from the surgical thalamic lesions of 6 among 8 patients and internal segments of globus pallidus of 6 among 7 patients, respectively. Significant metabolic alterations of NAA/Cho ratio might reflect functional changes of neuropathological processes in the lesion of substantia nigra, thalamus, and lentiform nucleus, and could be a valuable finding fur evaluation of Parkinson's disease after neurosurgery. Increase of lactate signals, being remarkable in surgical lesions, could be consistent with a common consequence of neurosurgical necrosis. Thus, IH MRS could be a useful modality to evaluate the diagnostic and prognostic implications fur Parkinsons disease after functional neurosurgery.

• Investigative Magnetic Resonance Imaging
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• 제12권1호
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• pp.1-7
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• 2008

목적: 연조직종양의 조직 성분을 자기공명영상으로 평가하는데 MEDIC과 지방억제 T2 영상을 비교하여 더 나은 검사방법을 선택하고자 하였다. 대상 및 방법: 병리조직학적으로 진단된 연조직종양 10예 (신경집종 3예, 혈관종 2예, 지방종 1예, 혈관각화종 1예, 윤활막육종 1예, 지방육종 1예 그리고 악성섬유조직구종 1예)에서 25 조직 성분 (혈관 5예, 신경 4예, 섬유성 4예, 과세포성 4예, 출혈성괴사 2예, 낭성 2예, 지방성 2예, 점액버팀질 1예, 그리고 혈전 1예)을 선택하였다. 병리조직학적 조직 성분과 일치하는 동일 단면상을 가진 MEDIC과 지방억제 T2영상에 동일한 크기의 관심영역을 그려 불균질치를 얻었다. 불균질치는 영상의 불균질성을 나타내는 표준편차 값을 관심영역에서 얻은 신호강도 평균값으로 나눈 값으로 하였다. 결과: 25 조직 성분의 불균질치는 MEDIC 보다 지방억제 T2영상에서 높게 나타났다 (p < .001). 결론: MEDIC 영상은 불균질치가 현저히 낮으므로, 자기공명영상으로 연조직종양의 조직 성분을 평가하는데 지방억제 T2영상 보다 MEDIC 영상이 더 유용할 것으로 사료된다.

• 수산해양기술연구
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• 제37권2호
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• pp.85-94
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• 2001

1997년 10월 2일부터 10일 사이에 동해에서 계량어군탐지기를 이용하여 수집한 어탐기록과 CTD를 이용한 해양관측 결과 및 중층트롤에 의한 어획물의 생물학적 조성 등을 비교, 분석하여 어족생물의 일주기적인 유영행동특성을 검토, 고찰한 결과를 요약하면 다음과 같다. 1. 1997년 10월 3일에 북위 $36^\circ$04', 동경 $130^\circ$53'의 조사 해역의 경우, 수온약층은 수심 60~110m의 수층에 형성되었고, 혼합층과 수심 250m이 저층 수괴 사이의 온도차와 염분 차는 각각$21^\circ$, 0.6%이었다. 2. 조사대상해역에 있어서 1997년 10월 2일~3일에 대한 일주기적 연직회유행동을 고찰할 때, 주간에 수온약층 아래쪽 수심 250 m 전후에 분포하는 생물군의 평균상승속도는 시간대에 따라 약간의 차이는 있으나 0.51m/min이었고, 일출을 전후하여 100~ 125 m 수층에서 하향 이동하는 생물군의 평균하강 속도는 0.41 m/min이었다. 3. 조사대상해역에 있어서 어군의 체적산란강도는 표층, 중층, 저층의 순으로 높았고, 개체 생물의 반사강도는 저층, 중층, 표층의 순으로 높게 나타났다. 4. 중층트롤에 의한 시험조업의 결과, 초음파 산란층에 분포하는 어획 생물 중에서 살오징어가 점유하는 비율이 가장 높아 95.7%이었고, 그 평균 외투장과 평균체중은 각각 25.3 cm, 390.0g이었으며, 위 내용물은 살오징어, 갑각류, 치어류 등이었다.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2002년도 제7차 학술대회 초록집
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• pp.133-133
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• 2002

Purpose： The purpose of paper is to implement software to visualize brain fiber tract using a 24-bit color coding scheme and to test its feasibility. Materials and Methods： MR imaging was performed on GE 1.5 T Signa scanner. For diffusion tensor image, we used a single shot spin-echo EPI sequence with 7 non-colinear pulsed-field gradient directions： (x, y, z)：(1,1,0),(-1,1,0),(1,0,1),(-1,0,1),(0,1,1),(0,1,-1) and without diffusion gradient. B-factor was 500 sec/$\textrm{mm}^2$. Acquisition parameters are as follows： TUTE=10000ms/99ms, FOV=240mm, matrix=128${\times}$128, slice thickness/gap=6mm/0mm, total slice number=30. Subjects consisted of 10 normal young volunteers (age：21∼26 yrs, 5 men, 5 women). All DTI images were smoothed with Gaussian kernel with the FWHM of 2 pixels. Color coding schemes for visualization of directional information was as follows. HSV(Hue, Saturation, Value) color system is appropriate for assigning RGB(Red, Green, and Blue) value for every different directions because of its volumetric directional expression. Each of HSV are assigned due to (r,$\theta$,${\Phi}$) in spherical coordinate. HSV calculated by this way can be transformed into RGB color system by general HSV to RGB conversion formula. Symmetry schemes： It is natural to code the antipodal direction to be same color(antipodal symmetry). So even with no symmetry scheme, the antipodal symmetry must be included. With no symmetry scheme, we can assign every different colors for every different orientation.(H =${\Phi}$, S=2$\theta$/$\pi$, V=λw, where λw is anisotropy). But that may assign very discontinuous color even between adjacent yokels. On the other hand, Full symmetry or absolute value scheme includes symmetry for 180$^{\circ}$ rotation about xy-plane of color coordinate (rotational symmetry) and for both hemisphere (mirror symmetry). In absolute value scheme, each of RGB value can be expressed as follows. R=λw｜Vx｜, G=λw｜Vy｜, B=λw｜Vz｜, where (Vx, Vy, Vz) is eigenvector corresponding to the largest eigenvalue of diffusion tensor. With applying full symmetry or absolute value scheme, we can get more continuous color coding at the expense of coding same color for symmetric direction. For better visualization of fiber tract directions, Gamma and brightness correction had done. All of these implementations were done on the IDL 5.4 platform.

• Investigative Magnetic Resonance Imaging
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• 제7권2호
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• pp.108-115
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• 2003

목적 : MRI를 촬영하면서 동시에 측정한 뇌전도 신호에 가장 크게 영향을 미치는 것은 경사자계 유발 잡음이다. MRI와 동시에 측정한 뇌전도 신호에서 전류원 국지화를 수행할 때, 경사자계 유발 잡음이 미치는 영향을 분석하고자 한다. 대상 및 방법 : 사람의 머리와 유사하게 만든 뇌전도 팬텀과 MR compatible 뇌전도 측정시스템, 그리고 3.0 Tesla MRI 시스템을 실험에 사용하였다. 3.0 Tesla MRI 시스템 안에 전류원이 설치되어 있는 뇌전도 팬텀을 놓고, EPI 촬영을 하는 동안 뇌전도 신호를 측정하였다. 경사자계의 세기와 전류원의 위치를 조절하면서 뇌전도 신호 측정을 하였고, 측정된 뇌전도 신호에 대하여 전류원 국지화를 수행할 때 나타나는 국지화 오차를 평가하였다. 결과 : 경사자계 유발잡음에 의한 국지화 오차는 경사자계의 세기와 전류원의 위치에 따라 변화하는 것을 관찰하였다. 또한 경사자계 유발잡음이 Gaussian 잡음보다 전류원 국지화에 미치는 영향이 큰 것을 관찰하였으며, 경사자계 유발 잡음의 전력이 뇌전도 신호 전력의 $10\%$ 이하일 때는 전류원 국지화에 미치는 영향이 미미함을 관찰하였다. 결론 : 경사자계 유발 잡음 전력을 뇌전도 신호 전력의 $10\%$ 이하로 줄인다면 MRI를 하면서 동시에 측정한 뇌전도 신호로도 전류원 국지화를 할 수 있음을 알 수 있었다.

• Investigative Magnetic Resonance Imaging
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• 제20권2호
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• pp.81-87
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• 2016

Purpose: To analyze the feasibility of three-dimensional (3D) diffusion-weighted (DW) PSIF (reversed FISP [fast imaging with steady-state free precession]) sequence in order to evaluate peripheral nerves in the elbow. Materials and Methods: Ten normal, asymptomatic volunteers were enrolled (6 men, 4 women, mean age 27.9 years). The following sequences of magnetic resonance images (MRI) of the elbow were obtained using a 3.0-T machine: 3D DW PSIF, 3D T2 SPACE (sampling perfection with application optimized contrasts using different flip angle evolution) with SPAIR (spectral adiabatic inversion recovery) and 2D T2 TSE (turbo spin echo) with modified Dixon (m-Dixon) sequence. Two observers used a 5-point grading system to analyze the image quality of the ulnar, median, and radial nerves. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of each nerve were measured. We compared 3D DW PSIF images with other sequences using the Wilcoxon-signed rank test and Friedman test. Inter-observer agreement was measured using intraclass correlation coefficient (ICC) analysis. Results: The mean 5-point scores of radial, median, and ulnar nerves in 3D DW PSIF (3.9/4.2/4.5, respectively) were higher than those in 3D T2 SPACE SPAIR (1.9/2.8/2.8) and 2D T2 TSE m-Dixon (1.7/2.8/2.9) sequences (P < 0.05). The mean SNR in 3D DW PSIF was lower than 3D T2 SPACE SPAIR, but there was no difference between 3D DW PSIF and 2D T2 TSE m-Dixon in all of the three nerves. The mean CNR in 3D DW PSIF was lower than 3D T2 SPACE SPAIR and 2D T2 TSE m-Dixon in the median and ulnar nerves, but no difference among the three sequences in the radial nerve. Conclusion: The three-dimensional DW PSIF sequence may be feasible to evaluate the peripheral nerves around the elbow in MR imaging. However, further optimization of the image quality (SNR, CNR) is required.