• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.15 no.2
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• pp.109-116
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• 2022

In this paper, we propose a band rejection filter (BRF) with a state variable filter (SVF) structure to effectively remove the influence of 60 Hz line frequency noise introduced into the sensor system. The conventional BRF of the SVF structure uses an additional operational amplifier (OPAMP) to add a low pass filter (LPF) output and a high pass filter (HPF) output or an input signal and a band pass filter. Therefore, the notch frequency and the notch depth that determine the signal attenuation of the BRF greatly depend on the tolerance of the resistors used to obtain the sum or difference of the signals. On the other hand, in the proposed BRF, since the BRF output is formed naturally within the SVF structure, there is no need for a combination between each port. The notch frequency of the proposed BRF is 59.99 Hz, and it can be confirmed that it is not affected at all by the tolerance of the resistor through the Monte Carlo simulation results. The notch depth also has an average of -42.54dB and a standard deviation of 0.63dB, confirming that normal operation as a BRF is possible. Also, with the proposed BRF, noise filtering was applied to the electrocardiogram (ECG) signal that interfered with 60 Hz noise, and it was confirmed that the 60 Hz noise was appropriately suppressed.

• Journal of Ginseng Research
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• v.47 no.1
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• pp.106-116
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• 2023

Background: Pirarubicin (THP) is an anthracycline antibiotic used to treat various malignancies in humans. The clinical usefulness of THP is unfortunately limited by its dose-related cardiotoxicity. Ginsenoside F1 (GF1) is a metabolite formed when the ginsenosides Re and Rg1 are hydrolyzed. However, the protective effects and underlying mechanisms of GF1 on THP-induced cardiotoxicity remain unclear. Methods: We investigated the anti-apoptotic and anti-oxidative stress effects of GF1 on an in vitro model, using H9c2 cells stimulated by THP, plus trigonelline or AKT inhibitor imidazoquinoxaline (IMQ), as well as an in vivo model using THP-induced cardiotoxicity in rats. Using an enzyme-linked immunosorbent test, the levels of malondialdehyde (MDA), brain natriuretic peptide (BNP), creatine kinase (CK-MB), cardiac troponin (c-TnT), lactate dehydrogenase (LDH), superoxide dismutase (SOD) and glutathione (GSH) were determined. Nuclear factor (erythroid-derived2)-like 2 (Nrf2) and the expression of Nrf2 target genes, including heme oxygenase-1 (HO-1), glutathione-S-transferase (Gst), glutamate-cysteine ligase modifier subunit (GCLM), and expression levels of AKT/Bcl-2 signaling pathway proteins were detected using Western blot analysis. Results: THP-induced myocardial histopathological damage, electrocardiogram (ECG) abnormalities, and cardiac dysfunction were reduced in vivo by GF1. GF1 also decreased MDA, BNP, CK-MB, c-TnT, and LDH levels in the serum, while raising SOD and GSH levels. GF1 boosted Nrf2 nuclear translocation and Nrf2 target gene expression, including HO-1, Gst, and GCLM. Furthermore, GF1 regulated apoptosis by activating AKT/Bcl-2 signaling pathways. Employing Nrf2 inhibitor trigonelline and AKT inhibitor IMQ revealed that GF1 lacked antioxidant and anti-apoptotic effects. Conclusion: In conclusion, GF1 was found to alleviate THP-induced cardiotoxicity via modulating Nrf2 and AKT/Bcl-2 signaling pathways, ultimately alleviating myocardial oxidative stress and apoptosis.

• Journal of the Institute of Convergence Signal Processing
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• v.23 no.2
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• pp.76-83
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• 2022

With the recent development of IT technology, research and interest in various biosignal measuring devices is increasing. As an aging society is in full swing, research on the elderly population using IT-related technologies is continuously developing. This study is about the development of life pattern detection and fall detection algorithm, which is one of the medical service areas for the elderly, who are rapidly developing as they enter a super-aged society. This study consisted of a system using a 3-axis accelerometer and an electrocardiogram sensor, collected data, and then analyzed the data. It was confirmed that behavioral patterns could be classified from the actual research results. In order to evaluate the usefulness of the human activity monitoring system implemented in this study, experiments were performed under various conditions, such as changes in posture and walking speed, and signal magnitude range and signal vector magnitude parameters reflecting the acceleration of gravity of the human body and the degree of human activity. was extracted. And the possibility of discrimination according to the condition of the subject was examined by these parameter values.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.38 no.3
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• pp.217-225
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• 2002

The authors examined the response of electrocardiogram(ECG) of Nile tilapia, Oreochromis niloticus [Linnaeus] to light stimuli. The experiments were performed in such a way that three levels of light stimuli(10, 100 and 400 lu$\chi$) were given to fishes with an electrode inserted into their bodies and then their ECGs were recorded continuously for 60 minutes in 16~18$^{\circ}C$. The results which are divided into by day and by night and then analyzed by fishes' conditions are as follows; 1. Nile tilapias reached a stable condition 3 minutes after anesthesia. In stable condition, the heart rate average was 47.6beat/min by day and 45.1beat/min by night. And the action potential average was 1.0.4$mutextrm{V}$ by day and 1.24$mutextrm{V}$ by night. 2. The heart rate average by three levels of light stimuli was, \circled1 In stimulus condition, in case of 10 lu$\chi$ 39.7beat/min by day and 38.2beat/min by night, in case of 100 lu $\chi$8.7beat/min by day and 36.9beat/min by night, and in case of 40.0. lux 36.8 beat/min by day and 35.8beat/min by night. \circled2 In recovery condition, in case of 10 lu$\chi$ 47.1beat/min by day and 46.0beat/min by night, in case of 100 lu$\chi$ 47.2beat/min by day and 45.6 beat/min by night, and in case of 400 lu$\chi$ 48.1beat/min by day and 46.6beat/min by night. 3. The action potential average by three levels of light stimuli was, \circled1 In stimulus condition, in case of 10 lu$\chi$ 1.22$mutextrm{V}$ by day and 0.71$mutextrm{V}$ by night, in case of 100 lu$\chi$ 0..63$mutextrm{V}$ by day and 0.90$mutextrm{V}$ by night, and in case of 400 lu$\chi$ 1.39$mutextrm{V}$ by day and 1.63$mutextrm{V}$ by night \circled2 In recovery condition, in case of 10 lu$\chi$ 1.26$mutextrm{V}$ by day and 1.59$mutextrm{V}$ by night, in case of 100 lu$\chi$ 2.63$mutextrm{V}$ by day and 3.65$mutextrm{V}$ by night, and in case of 400. lu$\chi$ 2.52$mutextrm{V}$ by day and 3.67$mutextrm{V}$ by night.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.37 no.2
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• pp.124-132
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• 2001

The authors examined the response of electrocardiogram (ECG) of Mirror carp, Cyprinus carpio [Linnaeus] to light stimuli. The experiments were performed in such a way that three levels of light stimuli (10, 100, and 400 lux) were given to fishes with an electrode inserted into their bodies and then their ECGs were recorded continuously for 60 minutes. The results which are divided into by day and by night and then analyzed by fishes conditions are as follows : 1. Mirror carps reached a stable condition 5 minutes after anesthesia. In this condition, the average heart rate was 64.9 beat/min by day and 65.3 beat/min by night. And the average action potential was 36.9 nV by day and 32.9 nV by night. 2. The average heart rate by three levels of light stimuli was, 1) In a stimulus condition, in case of 10 lux 68.7 beat/min by day and 46.0 beat/min by night, in case of 100 lux 53.4 beat/min by day and 44.1 beat/min by night, and in case of 400 lux 53.2 beat/min by day and 40.1 beat/min by night. 2) In a recovery condition, in case of 10 lux 67.9 beat/min by day and 57.2 beat/min by night, in case of 100 lux 68.8 beat/min by day and 61.0 beat/min by night, and in case of 400 lux 69.6 beat/min by day and 63.6 beat/min by night. 3. The average action potential by three levels of light stimuli was, 1) In a stimulus condition, in case of 10 lux 59.1 nV by day and 24.0 nV by night, in case of 100 lux 26.8 nV by day and 45.6 nV by night, and in case of 400 lux 71.7 nV by day and 14.4 nV by night. 2) In a recovery condition, in case of 10 lux 38.8 nV by day and 27.3 nV by night, in case of 100 lux 29.0 nV by day and 39.3 nV by night, and in case of 400 lux 66.4 nV by day and 21.4 nV by night.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.38 no.4
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• pp.284-288
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• 2002

The authors examined the response of electrocardiogram (ECG) to Mirror carp, Cyprinus carpio of body length. The experiments were performed of three classes (10~15, 15~20 and 20~25cm) were given to fishes with an electrode inserted into their bodies and then their ECGs were recorded continuously for 30 minutes in 16-18$^{\circ}C$. The results which are divided into by day and by night and then analyzed by fishes' conditions are as follows; 1 In case of body length 10~15 cm, the average heart rate 43.4 beat/min by day and 45.9 beat/min by night, the average action potential 4.38 $mutextrm{V}$ by day and 3.64 $mutextrm{V}$ by night, in narcotism condition(0~9 min). the average heart rate 69.4 beat/min by day and 67.4 beat/min by night, the average action potential 3.82 $mutextrm{V}$ by day and 3.50 $mutextrm{V}$ by night, in stable condition(9~30 min). 2. In case of body length 15～20 cm, the average heart rate 42.2 beat/min by day and 45.4 beat/min by night, the average action potential 4.13 $mutextrm{V}$ by day and 3.95 $mutextrm{V}$ by night, in narcotism condition(0-5 min). the average heart rate 67.6 beat/min by day and 65.3 beat/min by night, the average action potential 4.58$mutextrm{V}$ by day and 4.61 $mutextrm{V}$ by night, in stable condition (5~30 min). 3. In case of body length 20～25 cm, the average heart rate 47.5 beat/min by day and 47.5 beat/min by night, the average action potential 4.81 $mutextrm{V}$ by day and 4.20 $mutextrm{V}$ by night, in narcotism condition(0-4 min). the average heart rate 67.5 bea/min by day and 64.8 beat/min by night, the average action potential 5.31 $mutextrm{V}$ by day and 4.90 $mutextrm{V}$ by night, in stable condition (4~30 min).

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.38 no.4
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• pp.278-283
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• 2002

The response of electrocardiogram(ECG) of Nile tilapia, Oreochromis niloticus [Linnaeus] was studied to the electric stimulus which was given to a certain part of body The experiments were performed in such a way that three levels of electric stimulus (20, 30, 40 Vp ； 10 msec) were given to fishes with electrode inserted into their bodies and then their ECGs were recorded continuously for 60 minutes in the water temperature of 16~18$^{\circ}C$ The results of the experiments were divided by day and night, and then were analyzed by experimental conditions as follows; 1. Nile tilapia reached a stable condition within 3 minutes after the electrode inserted into their bodies during anesthesia. In stable condition, the heart rates average was 45.8 beat/min during daytime and 45.0 beat/min at night. The action potentials average was 1.76 $mutextrm{V}$during daytime and 1.75 $mutextrm{V}$ at night. 2. The heart rates average by three levels of electric stimulus were \circled1 In the stimulus condition, the heart rates were 34.9 beat/min during daytime and 33.4 beat/min at night for the 20 Vp level, 36.8 bea/min during daytime and 36.0 beat/min at night for the 30 Vp level, and 38.0 beat/min during daytime and 36.4 beat/min at night for the 40Vp level. \circled2 In the recovery condition, the action potentials were 45.5 beat/min during daytime an 45.1 beat/min at night for the 20Vp level, 47.9 beat/min during daytime and 49.0 beat/min at night for the 30Vp level, and 51.4 beat/min during daytime and 50.7 beat/min at night for the 40Vp level 3. The action potentials average by three levels of electric stimulus were, \circled1 In the stimulus condition, action potentials were 2.54 $mutextrm{V}$ during daytime and 2.39 $mutextrm{V}$ at night for the 20 Vp level, 3.30 $mutextrm{V}$ during daytime and 2.30 $mutextrm{V}$ at night for the 30 Vp level and 6.05 $mutextrm{V}$ during daytime and 3.23 $mutextrm{V}$ at night for the 40 Vp level. \circled2 In the recovery condition, action potentials were 1.92 $mutextrm{V}$ during daytime and 1.95 $mutextrm{V}$ at night for the 20 Vp level and 2.78 $mutextrm{V}$ during daytime and 2.21 $mutextrm{V}$ at night for the 30Vp level and 3.6 0 $mutextrm{V}$ during daytime and 2.98 $mutextrm{V}$ at night for the 40 Vp level.

• The Korean Journal of Physiology
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• v.18 no.1
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• pp.67-79
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• 1984

In an effort to elucidate the physiological characteristics in cardiopulmonary function, electromyogram(EMG), and blood chemistry in athletic high school students, an analysis of electrocardiogram(ECG) and EMG, pulmonary function test, venous blood gas analysis($Pvo_2$ and$Pvco_2$), and measurement of heart rate, blood pressure, respiratory rate, blood glucose and blood lactate were made for 16 to 19 year-old high school students who were divided into athletic (n=19) and non-athletic (n=20) group. The results obtained are summarized as follows. 1) ECG intervals in athletes were longer than in non-athletes, and the difference was significant in R-R, Q-T and T-P intervals. Resting heart rate in athletes was 56.3/min showing a bradycardia compared with 79.8/min in non-athletes. Amplitudes of R and T waves in lead $V_5$ were significantly higher than in non-athletes. 2) Pulmonary function parameters in athletes showed higher values than in non-athletes. Parameters which showed significant differences were FEV 0.5, PEF, FEF 25%, PIF and FEF $200{\sim}1.200\;ml. 3) Heart rate, blood pressure, and respiratory rate after exercise were significantly elevated from resting values. Heart rate and respiratory rate showed greater increase in non-athletes, while blood pressure showed greater increase in athletes. 4) $Pvo_2$ was lowered ana $Pvco_2$ was elevated after exercise, and there was no significant difference between two groups. 5) Blood glucose and lactate levels were elevated after exercise. The difference was significant in blood lactate, and was greater in non-athletes. 6) EMG amplitude was steadily increased with increasing load of exercise, and the increase was greater in athletes than in non-athletes.

• The Korean Journal of Nuclear Medicine
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• v.33 no.1
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• pp.40-48
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• 1999

Purpose: The sensitivity of ST-depression in the electrocardiogram during exercise is influenced by the level of efforts. However, unlike the prevalence of ST-depression on exercise ECG, the degree of exercise is reported to do not influence the diagnostic ability of myocardial perfusion scan. Furthermore, the relation between the prevalence of myocardial ischemia and effort is still controversial. We evaluated the effect of the degree of exercise on the ability of SPECT imaging to detect coronary artery stenosis. Materials and Methods: The patient population was comprised of 111 patients (73 men and 38 women, mean age 56 years) who underwent an exercise test in conjunction with Tc-99m MIBI and cardiac catheterization within 3 months apart each other. The degree of exercise was classified into four groups according to the percentage of maximal predicted heart rate. The sensitivity and specificity was compared between each group. Results: The overall diagnostic sensitivity was significantly higher with Tc-99m MIBI SPECT than exercise ECG. The specificity was not significantly different between two tests. Sensitivity and specificity of Tc-99m MIBI was not different between four groups. Sensitivity for individual coronary stenosis seemed to be lower in subjects who had premature termination of exercise due to early appearance of ST depression. Conclusion: These results suggest that the overall diagnostic sensitivity of Tc-99m MIBI myocardial perfusion SPECT is not significantly affected by the degree of exercise in stable patients undergoing symptom-limited treadmill exercise testing. Myocardial perfusion SPECT imaging should be added to routine exercise stress testing for the detection of coronary artery disease.

• Science of Emotion and Sensibility
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• v.8 no.1
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• pp.47-54
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• 2005

This study is aimed to inspect how the different sensitivities in Behavioral activation system(BAS) and behavioral inhibition system(BIS) modulate on the properties of physiological responses stimulated by positive or negative affective sound. We measured the electroencephalogram(EEG) and electrocardiogram (ECG) of 32 students, consisted of four groups depending on the BAS and BIS sensitivities, during listening to meditation music or noise. The EEG was recorded at Fpl and Fp2 sites and Power spectral density(PSD) of HRV was derived from the ECG, and the power of HRV was calculated for 3 major frequency ranges(low frequency[LF], medium frequency and high frequency[HF]). After listening to music or noise, subjects reported the affect induced by the sound. For EEG, the power in the alpha band at Fp2, especially in the alpha-2 band(9.0-11.0 Hz) increased during the subjects listening to music, while the power at Fpl increased during noise. During listening to meditation music, there is a tendency that the left-sided activation in prefrontal cortex(PFC) is positively correlated with the difference of BAS(Z)-BIS(Z). During listening to noise, there is a tendency that the right-sided activation in PFC is dominant in case any of the sensitivity of BAS or BIS is high. For HRV, we found that the index of MF/(LF+HF), during listening to music, was higher significantly in the individuals with a low BIS but high BAS than in the individuals with a low sensitivity both BIS and BAS individuals. With high BIS, regardless of the BAS sensitivity, the difference of this index values was not significant. From these results we suggest that the physiological responses of different individuals in BAS and BIS react differently under the same emotionally provocative challenge.