• Science of Emotion and Sensibility
• /
• v.11 no.4
• /
• pp.565-574
• /
• 2008

Functions of human brain including sensibility and emotion may be affected by drugs mediated by the blood-brain barrier (BBB). The present study was performed to evaluate whether injection route, volume and concentration of mannitol could alter the degree of disruption of the BBB. Under urethane anesthesia, female Sprague-Dawley rats were infused with 20% mannitol into the right internal carotid artery (ICA). In the other group, intravenous injection of mannitol through the femoral vein was performed. Evans blue(EB) dye was used as a marker of BBB disruption. When mannitol was injected via the ICA, the content of EB dye in the ipsilateral hemisphere was markedly increased. However, the content of EB in the brain was not increased when mannitol was injected via the femoral vein, even though the volume or concentration of mannitol was increased. These results suggest that the BBB was disrupted only through ICA injection route and this may provide a useful strategy for transient opening of the BBB to control the functions of human brain.

• Journal of the Korean earth science society
• /
• v.22 no.2
• /
• pp.130-137
• /
• 2001

A total of 58 species of radiolarians belonging to 41 genera were identified in 44 samples from core A9-EB2 of the Bransfield Basin in the Antarctic. The radiolarian assemblages from A9-EB2 are generally very low in abundance.The dominant species are Antarctissa denticulata, A. longa, A. strelkovi, Lithomelissa setosa, Lifhomitra lineata, Peridium longispinum and Phormacantha hystrix, constituting 75% of the total assemblage. Genera Challenge개n and Protocystis belonging to family Challeneriidae, found in core A9-EB2 have been recorded in the Quaternary sediments. Therefore, the geologic age of core A9-EB2 in Bransfield Basin is regarded to be Quternary (Pleistocene-Holocene). Typical circumpolar taxa such as Antarctissa strelkovi, A. denticulata, Cycladophora davisiana and Larcopyle buetschlii are representing the influence of waters from Bellingshausen Sea and Antarctic Circumpolar Current. Plectacantha oikiskos and Phomacantha hystrix are considered as a coastal indicator. Also, low amounts of Lithomelissa setosa are related to pelagic condition and entrance of cold waters from the Western Weddell Sea into Bransfield Basin. Therefore, the core sediments in Bransfield Basin were deposited under the coastal condition mainly influenced by the waters from Bellingshausen Sea and Antarctic Circumpolar Current. but also by the water from the Western Weddell Sea of the open-water condition.

• Bulletin of the Korean Chemical Society
• /
• v.31 no.1
• /
• pp.52-58
• /
• 2010

Human histamine H1 receptor (HHR1) is a G protein-coupled receptor and a primary target for antiallergic therapy. Here, the ligand-based three-dimensional pharmacophore models were built from a set of known HHR1 inverse agonists using HypoGen module of CATALYST software. All ten generated pharmacophore models consist of five essential features: hydrogen bond acceptor, ring aromatic, positive ionizable and two hydrophobic functions. Best model had a correlation coefficient of 0.854 for training set compounds and it was validated with an external test set with a high correlation value of 0.925. Using this model Maybridge database containing 60,000 compounds was screened for potential leads. A rigorous screening for drug-like compounds unveiled RH01692 and SPB00834, two novel molecules for HHR1 with good CATALYST fit and estimated activity values. The new lead molecules were docked into the active site of constructed HHR1 homology model based on recently crystallized squid rhodopsin as template. Both the hit compounds were found to have critical interactions with Glu177, Phe432 and other important amino acids. The interpretations of this study may effectively be deployed in designing of novel HHR1 inverse agonists.

• Food Science and Preservation
• /
• v.23 no.1
• /
• pp.139-143
• /
• 2016

This study investigated the effect of electron beam (EB) treatment on the microbial reduction of dried laver (Porphyra tenera) and identified EB-resistant bacteria from the treated dried laver. After EB treatments of 4 kGy and 7 kGy, the numbers of total bacteria and EB-resistant bacteria were measured using tryptic soy agar and mannitol salt agar, respectively. The morphological and biochemical characteristics of each isolated EB-resistant bacteria were investigated and these bacteria were identified. Compared to the control ($1.5{\pm}0.2){\times}10^6CFU/g$, the total bacterial number was significantly decreased to ($5.4{\pm}0.5){\times}10^4CFU/g$ and ($1.1{\pm}0.6){\times}10^4CFU/g$ after EB treatments of 4 kGy and 7 kGy, respectively. With a higher EB dosage, the number of red colonies was almost same, whereas the number of yellow colonies was significantly decreased to ($3.3{\pm}1.2){\times}10^3CFU/g$ and 0 CFU/g for 4 kGy and 7 kGy, respectively. All red and yellow colonies were gram-positive cocci, catalase-positive, and resistant to 3% and 5% NaCl media. From the 16S rDNA sequence analysis, yellow and red colonies were identified as either Micrococcus flavus or M. luteus, with 99% similarity for the yellow colonies, and Deinococcus proteolyticus and D. piscis, with 99% and 97% similarity for the red colonies, respectively.

• Bulletin of the Korean Chemical Society
• /
• v.30 no.5
• /
• pp.1152-1156
• /
• 2009

Silent information regulator 2 (Sir2) or sirtuins are NAD(+)-dependent deacetylases, which hydrolyze the acetyllysine residues. In mammals, sirtuins are classified into seven different classes (SIRT1-7). SIRT1 was reported to be involved in age related disorders like obesity, metabolic syndrome, type II diabetes mellitus and Parkinson’s disease. Activation of SIRT1 is one of the promising approaches to treat these age related diseases. In this study, we have used HipHop module of CATALYST to identify a series of pharmacophore models to screen SIRT1 enhancing molecules. Three molecules from Sirtris Pharmaceuticals were selected as training set and 607 sirtuin activator molecules were used as test set. Five different hypotheses were developed and then validated using the training set and the test set. The results showed that the best pharmacophore model has four features, ring aromatic, positive ionization and two hydrogen-bond acceptors. The best hypothesis from our study, Hypo2, screened high number of active molecules from the test set. Thus, we suggest that this four feature pharmacophore model could be helpful to screen novel SIRT1 activator molecules. Hypo2-virtual screening against Maybridge database reveals seven molecules, which contains all the critical features. Moreover, two new scaffolds were identified from this study. These scaffolds may be a potent lead for the SIRT1 activation.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.20 no.3
• /
• pp.248-256
• /
• 2009

EB(Eigen-Beamforming) has widely been applied to MIMO(Multiple-Input Multiple-Output) systems to form beams which maximize the effective signal-to-interference plus noise ratio(SINR) of the receiver using the singular value decomposition(SVD) of the MIMO channel. However, the signal detection performance for the mobile station near the cell boundary is severely degraded and the transmission efficiency decreases due to the influence of the interference signal from the adjacent cells. In this paper, we propose an adaptive interference mitigation method for the EB transmission, and evaluate the reception performance. In particular, a reception strategy which adaptively utilizes optimal combining(OC) and minimum mean-squared error for Intercell spatial demultiplexing(MMSE-lSD) is proposed, and the reception performance is investigated in terms of the effective SINR and system capacity. For the average system capacity, the proposed adaptive reception demonstrates the performance enhancement compared to the conventional EB reception using the receiver beamforming vector, and up to 2 bps/Hz performance gain is achieved for mobile station located at the cell edge.

• Korean Journal of Poultry Science
• /
• v.42 no.3
• /
• pp.215-221
• /
• 2015

Chicken breast meat samples were injected with marinade solution (salt, sugar, phosphate, monosodium glutamate, and nucleic acid) with or without 2% citrus peel extract (CPE), and then a subset were irradiated with a 1 or 2 kGy electron beam (EB) and/or subjected to high-pressure (HP) at 300 or 400 MPa. The initial total aerobic bacterial (TAB) count of the control sample was 4.57 log CFU/g and reached 7.17 log CFU/g after 3 days of storage at $4^{\circ}C$. The 2 kGy EB reduced the TAB count to 4.61 log CFU/g after 7 days. The 400 MPa HP treatment was also effective in reducing the TAB count, but the effect was slightly less than that noted with the 2 kGy EB. The CPE, in combination with the EB and HP, decreased the TAB count by 1.71 and 1.32 log CFU/g at the initial stage and further decreased the count during storage. The 2 kGy EB and the HP (300 and 400 MPa) increased the thiobarbituric acid-reactive substances value, whereas the CPE did not show an antioxidative effect. The EB and HP caused no difference in the sensory qualities. In contrast, the CPE decreased all sensory qualities tested. Sensory panelists commented that the samples with CPE were not in the "rejection" category but were "unfamiliar" for chicken breast meat. In conclusion, the EB was more effective than HP in improving the microbial quality of marinated chicken breast meat. The use of CPE in the marinade solution may synergistically increase the shelf life; however, it is necessary to develop an appropriate formulation to ensure that the sensory qualities are maintained.

• Journal of KIISE:Computing Practices and Letters
• /
• v.11 no.5
• /
• pp.436-450
• /
• 2005

Existing B2B, B2C computer systems and applications that executed business trans-actions were the client- server based architecture which consists of heterogeneous hardware and software including personal computers and mainframes. Due to the active boom of electronic business, integration and compatibility of exchanged data, applications and hardwares have emerged as hot issue. This paper designs and implements a message transport system and a document transformation system in order to solve the interoperability problem of integrated logistics system in e-Business when doing electronic business. Message transport system integrated ebMS 2.0 which is standard business message exchange format of ebXML, the international standard electronic commerce framework, and JMS of J2EE enable to ensure reliable messaging. The document transformation system could convert non-standard XML documents into standard XML documents and provide the web services after integrating message system. Using suggested business scenario and various test data, our message oriented system preyed to be interoperable and stable. We participated ebXML messaging interoperability test organized by ebXML Asia Committee ITG in oder to evaluate and certify the suitability for message system.

• Proceedings of the KIEE Conference
• /
• 2004.07c
• /
• pp.1775-1777
• /
• 2004

Taihan Electric Wire Co. developed accessories(PJ, EB-G, EB-A, EB-O) for 345kV XLPE $1C{\times}600mm^2$ cable as a small size conductor cable, after installed 345kV XLPE $1C{\times}600mm^2$ cable, PJ and EB-G on Youngseo${\sim}$Youngdeungpo project KEPCO planed in 2003. All of 345kV XLPE $1C{\times}600mm^2$ cable Accessories are finished the type tests successfully. Straight joint as a Prefabricated Joint(PJ) had shorter the days of assembling than those of TMJ used on the 154kV XLPE Cable. Particularly, the use of clean booth to prevent the dusts and the penetration of water also had made the quality of jointing improved.

• Korean Journal of Agricultural Science
• /
• v.39 no.3
• /
• pp.341-347
• /
• 2012

The objective of this study was to investigate the combined effect of electron beam irradiation (EB) and onion peel extracts and selected flavorings on microbiological and sensory quality of pork jerky. Total aerobic bacteria were detected in the range of $3.87{\pm}0.30{\sim}4.60{\pm}0.12$ log CFU/g in all samples. Addition of both onion peel extract and flavoring showed the decrease of total aerobic bacterial count in pork jerky. No viable cells were observed after EB at 4 kGy. Sensory evaluation indicated that the EB-treated pork jerky with 0.5% barbecue flavoring did not show any difference in overall acceptability compared with the control. Therefore, combined use of EB with onion peel extracts and barbecue flavoring may enhance the safety of pork jerky with proper sensory quality.