• Clinical Endoscopy
• /
• v.57 no.1
• /
• pp.1-10
• /
• 2024

Barrett's esophagus (BE) is the precursor to esophageal adenocarcinoma (EAC), and is caused by chronic gastroesophageal reflux. BE can progress over time from metaplasia to dysplasia, and eventually to EAC. EAC is associated with a poor prognosis, often due to advanced disease at the time of diagnosis. However, if BE is diagnosed early, pharmacologic and endoscopic treatments can prevent progression to EAC. The current standard of care for BE surveillance utilizes the Seattle protocol. Unfortunately, a sizable proportion of early EAC and BE-related high-grade dysplasia (HGD) are missed due to poor adherence to the Seattle protocol and sampling errors. New modalities using artificial intelligence (AI) have been proposed to improve the detection of early EAC and BE-related HGD. This review will focus on AI technology and its application to various endoscopic modalities such as high-definition white light endoscopy, narrow-band imaging, and volumetric laser endomicroscopy.

• Journal of Engineering Education Research
• /
• v.14 no.2
• /
• pp.68-75
• /
• 2011

The purpose of this research is to search for directions in engineering education development in a knowledge-based society in terms of 'engineering ethics educatio'. Engineering ethics education, having been recognized as an inter-disciplinary research field between engineering and philosophy, is a field that has been a major issue in countries that execute engineering education accreditation. And engineering ethics education has been a peculiar research field focused on EAC(Ethics across the Curriculum). Therefore, this study has deduced several results by critically reviewing the extant EAC-related literatures. First, accomplishments by various researchers that may well quoted as the leader of engineering ethics study and education or the educational achievements of Kanazawa Institute of Technology in Japan are considerably substantial. However, the EAC discussions thus far still raise numerous barriers and unsolved issues. Second, the discussion of EAC thus far comprehends limitations such as a shortage of the recognition of inter-disciplinary study in the field of education and insufficient participation by education majors. Third, the engineering and philosophy field experts who have been leading EAC discussions have been pursuing integrated education courses either consciously or unconsciously. Fourth, EAC discussions may expand by again illuminating the intent of integrated education courses in terms of 'education and the study of education', and this new facet can be summed up with a new term, EAL, which stands for 'Ethics across the Living.'

• Applied Biological Chemistry
• /
• v.51 no.4
• /
• pp.294-298
• /
• 2008

Effects of endosulfan (EN), an insecticide, and bleomycin (BL), an antibiotic, on the body weight in the normal mice, and the in vivo cell growth, tumor weight, and hematological parameters of the Ehrlich ascites carcinoma (EAC) cell-bearing Swiss albino mice Mus musculus were evaluated. EN and BL were respectively administered orally and intraperitoneally to the experimental mice; the control group consisted of EAC cell-bearing untreated mice only. EN reduced the body weight in normal mice, whereas BL resulted in a steady body weight compared to the control. EN increased the EAC cell count significantly by reducing the growth of normal viable cells. In contrast, BL reduced the cell count by increasing the proportion of viable cells in the body. The tumor weights induced by EN were significantly higher than those of the EAC control and the BL-treated animals. In comparisons with the control and the BL mice, hematological parameters such as hemoglobin (%) and the number of RBC and lymphocytes were lowered, while counts of WBC, neutrophils, and monocytes were elevated after EN treatments. These results show that BL is capable of reducing the EN-induced neoplastic and haematological alterations in the mice under laboratory conditions.

• Archives of Craniofacial Surgery
• /
• v.24 no.4
• /
• pp.198-201
• /
• 2023

Maintaining the patency of the external auditory canal (EAC) during reconstruction is important because of its physiological role in hearing and immunological protective functions. The curved shape of the EAC presents a challenge when performing a skin graft. One of the key points for a successful skin graft is to ensure compression on the wound bed, and many novel methods, including prefabricated ear molds, have been reported for this purpose. In this study, we present a case of a skin graft performed to reconstruct a skin defect following excision of actinic keratosis in the EAC, using the cover of an ear thermometer probe as a mold for the graft to match the curvature of the EAC. This is an economical and practical method for secure compression dressing of a skin graft in the EAC.

• Journal of the Korea Concrete Institute
• /
• v.15 no.2
• /
• pp.352-359
• /
• 2003

Portland cement concrete (PCC) pavements are more durable and have superior surface friction compared to most dense-graded asphalt. However, data collected to date generally show PCC pavements to create more noise than asphaltic surfaces. Recent research has shown that some of the new concrete pavement textures are worthy of further examination. One of these, exposed aggregate surfaces, appear to provide better noise quality characteristics as well as good frictional characteristics and durability. In this paper, we considered the relationship between noise level and various textures of exposed aggregate concrete (EAC) pavement by tire impact noise measurement. As the results of that, it was suggested that optimum surface texture and manufacturing condition of EAC in order to reduce tire and pavement interaction noise. Conclusively, we would like to recommend optimum condition of EAC pavement at the respects of materials and treatment. Furthermore, Frequency spectrum as well as A-weighted noise level was also evaluated to analyze properties of noise between PCC and EAC.

• Corrosion Science and Technology
• /
• v.15 no.4
• /
• pp.153-158
• /
• 2016

Light metal alloys of Mg, Ti, and Al undergo environmentally assisted cracking (EAC). Passive film breakdown and pitting are not only precursor events for stress corrosion, but can accelerate hydrogen evolution that is responsible for hydrogen embrittlement. This is clearly demonstrated in the case of Mg and Ti alloys. The so-called innocuous precipitates, which do not directly participate in either alloy strengthening or EAC can be effective precursors for initiating EAC. This aspect is highlighted using high strength aluminium alloys. Such behaviours lead to a paradigm shift in the design of alloys with resistance to EAC.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.5 no.3
• /
• pp.227-232
• /
• 2010

Submarine cable system has been affected by humankind activities like trawl and stow net which has been threatening submarine cable in Korea. This research presents the protection ways of submarine cable through the analyses of cable faults on EAC system for 8 years.

• Clinical and Experimental Otorhinolaryngology
• /
• v.11 no.4
• /
• pp.259-266
• /
• 2018

Objectives. Carcinomas of the external auditory canal (EAC) are rare, and management remains challenging. Previous studies seeking prognostic factors for EAC cancers included cancers other than carcinomas. In this study, we analyzed the treatment outcomes of, prognostic factors for, and survival rates associated with specifically squamous cell carcinoma (SCC) of the EAC. Methods. A retrospective review of 26 consecutive patients diagnosed with SCCs of the EAC in a 10-year period was performed in terms of clinical presentation, stage, choice of surgical procedure, and adjunct therapy. Overall survival (OS) and recurrence-free survival (RFS) were calculated and univariate analysis of prognostic factors was performed. Results. The median age of the 26 patients with SCCs of the EAC was 63 years (range, 40 to 72 years), and 16 males and 10 females were included. According to the modified University of Pittsburgh staging system, the T stages were T1 in 11, T2 in six, T3 in four, and T4 in five cases. The surgical procedures employed were wide excision in three cases, lateral temporal bone resection (LTBR) in 17, and extended LTBR in four, and subtotal temporal bone resection in two. Two patients underwent neoadjuvant chemotherapy, and two underwent adjuvant chemotherapy. One patient received preoperative radiation therapy, and eleven received postoperative radiation therapy. Of the possibly prognostic factors examined, advanced preoperative T stage and advanced overall stage were significant predictors of RFS, but not of OS. Conclusion. The advanced T stage and overall stage were associated with decreased survival after surgical treatment in patients with SCC of the EAC, highlighting the importance of clinical vigilance and early detection.

• Journal of the Korean Society of Radiology
• /
• v.11 no.6
• /
• pp.467-473
• /
• 2017

Using Digital Imaging and Communications in Medicine(DICOM) and a 3D medical imaging program, the characteristics of the external auditory canal(EAC) were compared. Using images of the ears of 63 different male and female subjects of varying age, this study measured and compared EAC transverse axis lengths, internal diameter circumferences, and upper and lower curvature angles. The findings of the study indicated differences in EAC shapes according not only to age and sex but also to the left and right of the same subject. A comparison between the sexes of the subjects (35 males and 28 females) indicated that, on average, the length of the EAC was 4.75mm longer in males. Based on the lower curvature angle, the interior side of the diameter circumference of the EAC was found to be reduced on average by 37.2% compared to the exterior side. Although the upper curvature angle was on average $25.7^{\circ}$ larger than the lower curvature angle, 4 subjects showed a larger lower curvature angle and large differences between the upper and lower curvature angles were observed in 8 subjects of the younger age group (4~14 years old). This indicated changes in EAC curvature shapes during growth. This study presents a method to raise safety and precision by comparing direct measurements taken through physical means and indirect measurements acquired from existing ear samples. This was possible due to technological developments in which 3D medical image representation technology creates images close to reality, and, through further development, this method is expected to be used for standardization research of EAC shapes.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.6
• /
• pp.2775-2780
• /
• 2012

In recent years there has been a substantial increase in the use of functional foods for disease control. Fruits and vegetables produce phytochemicals such as flavonoids and antioxidants which can lower oxidative stress and reduce the risk of chronic ailments like cancer. The aim of the present study was to investigate the antioxidant capacity and the possible protective effects of Amaranthus paniculatus leaves on the antioxidant defense system in Ehrlich's ascites carcinoma (EAC)-treated mice. Oral administration of the leaf extract at different doses caused a significant decrease in tumor volume, viable cell count and tumor weight and elevated the life span of EAC bearing mice. It also showed an improved antioxidant potential as evidenced by a significant increase in the cellular antioxidant defense system such as catalase, superoxide dismutase and reduced glutathione and also significantly reduced the levels of TBARS. The levels of RBC, hemoglobin and lymphocyte count were altered in EAC bearing mice and were reverted back to near normal levels after the treatment with the leaf extracts. Their adequate content of total phenolics and flavonoids, DPPH scavenging activity which further suggests that the extracts exert a significant protection against oxidative stress conditions.