• Korean Circulation Journal
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• 제53권6호
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• pp.406-417
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• 2023

Background and Objectives: Pathophysiological changes of right ventricle (RV) after repair of tetralogy of Fallot (TOF) are coupled with a highly compliant low-pressure pulmonary artery (PA) system. This study aimed to determine whether pulmonary vascular function was associated with RV parameters and exercise capacity, and its impact on RV remodeling after pulmonary valve replacement. Methods: In a total of 48 patients over 18 years of age with repaired TOF, pulmonary arterial elastance (Ea), RV volume data, and RV-PA coupling ratio were calculated and analyzed in relation to exercise capacity. Results: Patients with a low Ea showed a more severe pulmonary regurgitation volume index, greater RV end-diastolic volume index, and greater effective RV stroke volume (p=0.039, p=0.013, and p=0.011, respectively). Patients with a high Ea had lower exercise capacity than those with a low Ea (peak oxygen consumption [peak VO₂] rate: 25.8±7.7 vs. 34.3±5.5 mL/kg/min, respectively, p=0.003), while peak VO₂ was inversely correlated with Ea and mean PA pressure (p=0.004 and p=0.004, respectively). In the univariate analysis, a higher preoperative RV end-diastolic volume index and RV end-systolic volume index, left ventricular end-systolic volume index, and higher RV-PA coupling ratio were risk factors for suboptimal outcomes. Preoperative RV volume and RV-PA coupling ratio reflecting the adaptive PA system response are important factors in optimal postoperative results. Conclusions: We found that PA vascular dysfunction, presenting as elevated Ea in TOF, may contribute to exercise intolerance. However, Ea was inversely correlated with pulmonary regurgitation (PR) severity, which may prevent PR, RV dilatation, and left ventricular dilatation in the absence of significant pulmonary stenosis.

• 한국환경생태학회지
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• 제32권5호
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• pp.486-496
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• 2018

본 연구는 지형구조 차이에 따른 이온지수를 파악하고자 월악산국립공원 내 일본잎갈나무림을 연구대상지로 선정하였다. 측정지점은 월악산국립공원 내 일본잎갈나무가 우점하고 있는 동일한 생태적 구조로 조성된 능선(Ridge)과 계곡(Vally)의 위치에서 기상과 이온을 고정 측정하였다. 기상 측정 결과 기온은 능선부에서 평균 $28.22^{\circ}C$, 최고 $29.9^{\circ}C$, 최저 $26.4^{\circ}C$였으며, 계곡부에서 평균 $27.08^{\circ}C$, 최고 $27.8^{\circ}C$, 최저 $25.5^{\circ}C$로 분석되었다. 상대습도의 경우 능선부에서 평균 67.02%, 최고 75.25%, 최저 61.95%였으며, 계곡부에서 평균 69.74%, 최고 76.8%, 최저 63.75%로 분석되었다. 이온측정 결과 능선부에서는 양이온 발생량 평균 $698.40{\pm}59.80ea/cm^3$, 최대 $885.88ea/cm^3$, 최소 $597.88ea/cm^3$이었으며, 음이온 발생량 평균 $736.07{\pm}83.89ea/cm^3$, 최대 $934.53ea/cm^3$, 최소 $599.32ea/cm^3$이었다. 이를 이온지수로 산출한 결과 1.06으로 분석되었다. 계곡부에서는 양이온 발생량 평균 $1,732.49{\pm}354.08ea/cm^3$, 최대 $2,652.10ea/cm^3$, 최소 $1,110.92ea/cm^3$이였으며, 음이온 발생량 평균 $1,990.47{\pm}433.57ea/cm^3$, 최대 $3,126.75ea/cm^3$, 최소 $1,352.17ea/cm^3$이었다. 이를 이온지수로 산출한 결과 1.16으로 분석되었다. 이 연구의 결과는 국립공원 내 기후적 측면의 건강관리 기초자료로 제공하고자 하였다.

• 한국환경과학회지
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• 제27권7호
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• pp.489-497
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• 2018

In this study, the ion index characteristics of small and medium urban land use types were investigated in the city of Chungju. The average temperature for each land use type was in the order: general commercial district ($29.59^{\circ}C$) > general residential district ($28.34^{\circ}C$) > productive green district ($28.31^{\circ}C$). The average relative humidity was in the order: productive green district (70.12%) > general residential district (69.93%) > general commercial district (66.48%). The average wind speed was in the order: productive green district (0.95 m/s) > general commercial district (0.87 m/s) > general residential district (0.54 m/s). Positive and negative ions were investigated to determine the ion index by land use type. The average amount of positive ion generated was in the order: general commercial district ($737ea/cm^3$) > general residential district ($492ea/cm^3$) > productive green district ($445ea/cm^3$). The average negative ion production decreased in the order: productive green district ($930ea/cm^3$) > general residential district ($754ea/cm^3$) > general commercial district ($744ea/cm^3$). The ion index calculated from measured data can be arranged in the order: productive green district (2.09) > general residential district (1.53) > general commercial district (1.01). These results confirm the state of positive and negative ion generation in each land use type. Further, the differences in the ion index by land use type were confirmed. However, a limitation of this study is that simple summer measurements were conducted, and seasonal characteristics were not considered. Therefore, any future investigation and research should consider seasonal variation characteristics.

• 약학회지
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• 제43권4호
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• pp.464-468
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• 1999

In order to find less toxic antiviral agents from basidiomycetes, EA, the water soluble substance, was isolated from the carpophores of Elfvingia applanata (Pers.) Karst. Anti-encephalomyocarditis (EMC) virus activity of EA was examined in Vero cells by plaque reduction assay in vitro. And the combined antiviral effects of EA with interferon (IFN) alpha and gamma were examined on the multiplication of EMC virus. EA exhibited a concentration-dependent reduction in the plaque formation of EMC virus with 50% effective concentration ($EC_{50}$) of 2.12 mg/ml. The results of combination assay were evaluated by the combination index (CI) that was analysed by the multiple drug effect analysis. The combination of EA with IFN alpha showed potent synergism with CI values of 0.40~0.60 for 50%, 70% and 90% effective levels, but that with IFN gamma showed antagonism with CI values of 2.16~2.83.

• 환경영향평가
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• 제32권2호
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• pp.146-156
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• 2023

관광단지 개발사업은 자연환경이 양호하고 경관이 우수한 지역을 대상으로 추진됨에 따라 주변 지역에 대한 환경부하를 지나치게 가중하는 점이 문제로 제시된 바 있다. 이에 본 연구에서는 2012년~2021년간 이루어진 국내 관광단지 개발사업의 환경영향평가 결과를 토대로 동 사업으로 야기되는 환경영향을 파악하였다. 특히 다양한 환경영향을 종합적·정량적으로 분석하고자 선행연구를 통해 마련된 EA-INDEX를 관광단지의 사업 특성에 적합하게 신규 도출하였으며, 이를 통해 관광단지 개발사업의 환경영향을 크게 자연환경 보전, 자원 보존, 생활환경 보호 부문으로 구분하여 각 세부 지표별로 살펴보았다. 그 결과 지난 10년간 국내 관광단지 개발사업은 친환경성이 증가하는 방향으로 추진·개발된 것으로 나타났으며, 특히 자연환경 보전 부문에서 그 증가 추세가 뚜렷함이 확인되었다. 반면 자원 보존 부문의 경우 친환경성이 감소하는 것으로 확인되었으므로 추후 신규 개발계획 수립 시 이를 제고할 수 있는 노력하는 것이 필요할 것으로 판단된다. 본 연구는 비교적 장기간에 걸친 관광단지 개발사업에 대한 환경적 영향을 파악하고, 특히 개발사업의 친환경성에 대해 각 세부 부문별 영향을 정량적으로 분석한 것에 의의가 있는 것으로 판단된다. 추후 개발사업과 관련한 정책 이벤트, 연관 사회적 이슈 등의 정보를 종합한 분석이 이뤄진다면, EA-INDEX를 활용한 개발사업의 경향 파악에 더욱 폭넓은 해설이 가능할 것으로 기대된다.

• Natural Product Sciences
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• 제5권2호
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• pp.107-111
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• 1999

To investigate less toxic antiviral agents from Basidiomycetes, EA, the water soluble substance, was isolated from the carpophores of Elfvingia applanata (pers.) Karst. Anti-varicella zoster virus (Oka strain; anti-VZV/Oka) activity of EA was examined in MRC-5 cells by plaque reduction assay in vitro. And the combined antiviral effects of EA with nucleoside anti-VZV agents, acyclovir and vidarabine, were examined on the multiplication of VZV/Oka. EA exhibited a concentration-dependent reduction in the plaque formation of VZV/Oka with a 50% effective concentration $(EC_{50})$ of $464.14\;{\mu}g/ml$. The results of combination assay were evaluated by the combination index (CI) that was calculated by the multiple drug effect analysis. The combination of EA with acyclovir showed more potent synergism with CI values of $0.18{\sim}0.62$ for $50{\sim}90%$ effective levels than that of EA with vidarabine with CI values of $0.67{\sim}1.04$.

• 약학회지
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• 제38권6호
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• pp.742-748
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• 1994

As part of our search for less toxic antimicrobial agents from natural resources, the carpophores of Elfvingia applanata$(P_{ers}.)K_{ARST}.$ was extracted with hot water. EA, the aqueous extract from the carpophores of E. applanata, was lyophilized and a dark brownish powder was obtained. Antimicrobial activity of EA was tested in vitro against Gram positive and Gram negative bacteria by serial broth dilution method, and the antimicrobial activity was expressed by minimal inhibitory concentration(MIC). Among fourteen species of bacteria tested, the antimicrobial activity of EA was the most potent against Proteus vulgaris showing MIC of 1.250 mg/ml. To investigate the effect of antimicrobial combinations of EA with four kinds of antibiotics(ampicillin, cefazolin, oxytetracycline and chloramphenicol), the fractional inhibitory concentration index(FICI) was determined by checkerboard assay for each strain. The antimicrobial combinations of EA with four kinds of antibiotics resulted in synergism in four instances, but no antagonism was observed. Four instances of synergism were observed when EA was combined with ampicillin against Micrococcus luteus, with cefazolin against Bacillus subtilis, with cefazolin against Micrococcus luteus and with oxytetracycline against Staphylococcus aureus.

• 생약학회지
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• 제30권1호
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• pp.25-33
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• 1999

In order to find less toxic antiviral agents from basidiomycetes, EA, the water soluble substance, was prepared from the carpophores of Elfvingia applanata (Pers.) Karst. EA was examined for antiviral activity against five strains of pathogenic viruses such as encephalomyocarditis virus (EMCV), vesicular stomatitis virus (VSV) Indiana and New Jersey strains, influenza A virus (Flu A), and varicella zoster virus (VZV) in vitro. Antiviral activity was evaluated by plaque reduction assay. Among five strains of viruses tested, EA exhibited the most potent antiviral activity against VSV Indiana strain with 50% effective concentration $(EC_{50})$ of 0.104 mg/ml in Vero cells, and its selectivity index (SI) was 36.5. EA was also examined for the virucidal activity, antiviral activity in preincubation on VSV Indiana strain in order to examine possible mode of antiviral activity. Preincubation of Vero cells with EA did not confer protection against VSV, however, prolonged exposure of cells to EA inhibited the replication of virus dose-dependently. In virucidal activity, the titer of infectious virus did not decrease significantly.

• Journal of Dairy Science and Biotechnology
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• 제36권2호
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• pp.121-124
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• 2018

Ellagic acid (EA) is a naturally occurring polyphenolic compound in vegetables, nuts, and fruits such as berries. EA has antioxidant, anticancer, anti-allergy, and anti-inflammatory activities. The objectives of this research were to investigate the physicochemical properties of nanoparticles before and after nano-encapsulation of EA in dairy protein and to develop a functional (anti-inflammatory) dairy protein-based beverage containing EA. A particle size analyzer was used to determine the physicochemical and morphological properties. High performance liquid chromatography was used to evaluate the entrapment efficiency of EA. The nanoparticles containing EA were 100 to 200 nm in diameter. The determined poly dispersity index value of 0.3 to 0.4 indicated that the nanoparticles were uniformly distributed with similar size. Zeta-potential values were also similar between the control groups. The entrapment efficiency of EA was nearly 90%. The results indicate the potential for development of nanoparticles containing EA beverage products with anti-inflammatory activity.

• 약학회지
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• 제43권4호
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• pp.469-473
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• 1999

EA, the water soluble substance, was prepared from the carpophores of Elfvingia applanata (Pers). Karst. Anti-influenza A virus (anti-Flu A) activity of EA was examined of Vero cells by plaque reduction assay in vitro. And the combined antiviral effects fo EA with interferon (IFN) alpha and gamma were examined on the multiplication of Flu A with 50% effective concentration ($EC_50$) of 1.50 mg/ml. The results of combination assay were evaluated by the combination index (CI) that was analysed by the multiple drug effect analysis. The combination of EA with IFN alpha on Flu A showed more potent synergism with CI values of 0.50~0.52 of 50%, 70%, 90% effective levels than that with IFN gamma with CI values of 0.82~0.99.