• Bulletin of the Korean Chemical Society
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• v.9 no.3
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• pp.149-152
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• 1988

A mixture of (Z,Z)-3,13-octadecadien-1-yl acetate(1) and its (E,Z)-isomer(2), the sex pheromone of the cherry tree borer, Synanthedon hector Butler was synthesized. (Z)-11-Octadecen-1-al(3) was prepared from 1,10-decandiol. The Wittig reaction the above aldehyde3 with carboethoxymethylenetriphenylphosphorane, or the Wadsworth-Emmons reaction of the above aldehyde3 with the anion of triethylphosphonoacetate gave ethyl (Z,Z)-2,13-octadecadienoate and its (E,Z)-isomer. Deconjugative protonation of ethyl (Z,Z)-2,13-octadecadienoate and its (E,Z)-isomer with potassium hexamethyldisilazide followed by aqueous ammonium chloride work-up afforded stereoselectiv디y ethyl (E,Z)-3,13-octadecadienoate and its (Z,Z)-isomer, respectively, of which stereoselectivity was adjusted to give the product in the required ratio. Exposure of the above deconjugated ester to excess lithium aluminium hydride resulted in formation of the penultimate (Z,Z)-3,13-octadecadien-1-ol and its (E,Z)-isomer. Acetylation of the desired alcohols afford the final products, (Z,Z)-3,13-octadecadien-1-yl acetate(1) and its (E,Z)-isomer(2).

• Journal of Korea Port Economic Association
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• v.18 no.2
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• pp.91-108
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• 2002

The World has been rapidly changing into either technological aspects or perception of those who has utilised to the corresponding informational impact. Whatever areas we have actually been involved in are strongly connected with this evolution of informational technology in one way or another. Logistics is not a exception as well as trade. Two main routes in distribution channel such as commercial and physical flow of goods, have been operating in terms of I-business. In order to activate E-trade with E-commerce, E-logistics should be utilised and emphasized in more efficient and effective manner of doing job as a facilitator. So, in this paper, it studied the role of E-logistics to make E-trade better work as well as to look into present situations in E-commerce. Then, it was identified that some facilities as 3PL or shipping company have to adopt information in their business process with a view of valued add service providers. This means those who have implemented E-Logistics activities, should be more competitive in the market, only when they provide the value-added total logistics services.

• International Journal of Internet, Broadcasting and Communication
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• v.15 no.1
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• pp.269-274
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• 2023

In this paper, we proposed a new UNet 3+ model for medical image segmentation. The proposed ensemble(E) UNet 3+ model consists of UNet 3+s of varying depths into one unified architecture. UNet 3+s of varying depths have same encoder, but have their own decoders. They can bridge semantic gap between encoder and decoder nodes of UNet 3+. Deep supervision was used for learning on a total of 8 nodes of the E-UNet 3+ to improve performance. The proposed E-UNet 3+ model shows better segmentation results than those of the UNet 3+. As a result of the simulation, the E-UNet 3+ model using deep supervision was the best with loss function values of 0.8904 and 0.8562 for training and validation data. For the test data, the UNet 3+ model using deep supervision was the best with a value of 0.7406. Qualitative comparison of the simulation results shows the results of the proposed model are better than those of existing UNet 3+.

• YAKHAK HOEJI
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• v.58 no.6
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• pp.371-377
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• 2014

A new series of 3-alkylthio-6-allylthio-4(or 5)-methylpyridazines (6a-e)-(7a-e) was synthesized from citraconic anhydride (1) for development of candidates possessing anticancer activity. The process involves the formation of pyridazine ring, dichlorination, monoallythiolation, and further another alkylthiolation. Compounds 6a-e, and 7a-e were prepared from 6-allylthio-3-chloro-4-methylpyridazine (4) or 6-allylthio-3-chloro-5-methylpyridazine (5) via nucleophilic substitution reaction with alkylthiol anion as nucleophile. Intermediates 4, and 5 could be converted to target pyridazines 6a-e, and 7a-e using 1~1.5 equivalent of alkylthiol at reflux temperature in methanol in the presence of sodium hydroxide. The structures of the synthetic compounds were characterized using NMR, IR, and GC-MS analyses.

• International Journal of Knowledge Content Development & Technology
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• v.13 no.3
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• pp.75-93
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• 2023

A cross sectional survey method was used to determine the utilization of e-resources and their influence on the reading culture of 119 undergraduate students registered with the JD Amin library of Federal University Dutse. The data collected was analysed using both descriptive (frequency counts and means) and inferential statistics (regression analysis). The research found that databases (mean=4.00) and e-journal (mean=4.00) are available to the undergraduate students. It further found that e-resources are often utilized by the undergraduate student, with social media (mean=4.00), databases (mean=4.00) and e-journal (mean=4.00). the most commonly used e-resources. It was also found that erratic power supply (mean=3.91) and inability to seek, obtain and evaluate information (mean=3.67) are the prominent factors hindering the utilization of e-resources. The regression analysis rejected the null hypotheses of the study where it shows that the level of utilization of e-resources have positive statistical correlation (r=0.772) with the reading culture of undergraduate students. The study proposed a conceptual model for the sustainable reading culture of students by libraries providing of e-resources. The general conclusion of the research is that e-resources are necessary tools and are moderately available and adequately utilized for influencing reading culture. The study recommended that Internet facilities should be made available to undergraduate students to facilitate more utilization of e-resources.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.25 no.4
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• pp.283-292
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• 2022

Purpose: The prevalence of eosinophilic esophagitis (EoE) has been on the rise since it was first described in the 1990s. Several diseases and exogenous factors have been associated with EoE. Our aim was to investigate the epidemiology of EoE in cystic fibrosis (CF) patients. Methods: We identified individuals with CF from September 2014 to September 2019 within a database (IBM Explorys Solutions, Inc.). The prevalence of EoE in patients with CF was compared to the general population. Results: The database included 36,111,860 patients during the 5-year study period: 12,950 with CF (0.036%) and 28,090 with EoE (0.078%). EoE prevalence was higher in CF patients than the general population (46 in 10,000 vs. 7.8 in 10,000, p<0.001). Patients with CF and EoE were more likely to be male (50% vs. 33.5%, p<0.008), children (33.3% vs. 16.5%, p<0.001), and non-Hispanic (100% vs. 88.7%, p<0.001) than CF patients without EoE. CF with EoE patients were more likely to be children than EoE only (33.3% vs. 10.5%, p<0.001). Allergic conditions were generally more prevalent in CF with EoE than CF only (83.3% vs. 68.3%, p=0.01) and EoE only (83.3% vs. 69.3%, p=0.014). Conclusion: EoE is nearly 6-times more prevalent in CF patients. Those patients had higher incidence of other atopic conditions. EoE must be considered in the differential diagnosis of patients with CF presenting with dysphagia, refractory gastroesophageal reflux, vomiting, and other esophagus-related symptoms.

• Journal of Microbiology and Biotechnology
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• v.24 no.7
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• pp.969-978
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• 2014

The aprE2 gene with its prosequence from Bacillus subtilis CH3-5 was overexpressed in Escherichia coli BL21(DE3) by using plasmid pET26b(+). After IPTG induction, active and mature AprE2 was produced when cells were grown at $20^{\circ}C$, whereas inactive and insoluble enzyme was produced in a large amount when cells were grown at $37^{\circ}C$. The insoluble fraction was resuspended with 6 M guanidine-HCl and dialyzed against 2 M Tris-HCl (pH 7.0) or 0.5 M sodium acetate (pH 7.0) buffer. Then active AprE2 was regenerated and purified by a Ni-NTA column. Purified AprE2 from the soluble fraction had a specific activity of $1,069.4{\pm}42.4U/mg$ protein, higher than that from the renatured insoluble fraction. However, more active AprE2 was obtained by renaturation of the insoluble fraction. AprE2 was most stable at pH 7 and $40^{\circ}C$, respectively. The fibrinolytic activity of AprE2 was inhibited by PMSF, but not by EDTA and metal ions. AprE2 degraded $A{\alpha}$ and $B{\beta}$ chains of fibrinogen quickly, but not the ${\gamma}$-chain. AprE2 exhibited the highest specificity for N-succinyl-Ala-Ala-Pro-Phe-pNA. The $K_m$ and $k_{cat}/K_m$ of AprE2 was 0.56 mM and $3.10{\times}10^4S^{-1}M^{-1}$, respectively.

• Journal of Convergence for Information Technology
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• v.9 no.8
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• pp.274-281
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• 2019

This study examined the effects of GATA-3-dependent Th2 cells and IgE inhibition by using PM-E and PM-70M isolated from Sasao. It was analyzed that the 70 % methanol layer contained adsorbed chromatograms of the fraction of sodium hypochlorite that inhibited GATA-3 transcription factor activity. As a result, PM-70 %MFL fraction seems to have an antiallergic effect by inhibiting GATA-3 which regulates Th2 cytokine. PM-30A, PM-70A, and PM-30A layers by inhibiting IgE secretion in B cells by co-culturing the fractions with anti-CD40/rmIL-6 and TNF-${\alpha}$ mRNA and IgE were not different from control. However, expression of IL-6 and TNF-${\alpha}$ mRNA was $0.69{\pm}0.058$ (p<0.001) and $0.72{\pm}0.58$ (p<0.05), respectively. The amount of IgE secretion was $94.6{\pm}16.0$, which was significantly decreased by 45.6% (p<0.01) compared with the control group. This study suggests that the PM-70% MFL layer in the fraction of Sasao contains the components that inhibit the differentiation and activity of B cells.

• Journal of Nutrition and Health
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• v.43 no.6
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• pp.628-637
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• 2010

To determine vitamin A and E intakes and their food sources, dietary intakes were collected by three consecutive 24-hour recalls from 192 adults living in Seoul and Gyeonggi Province, Korea. The mean vitamin A, retinol and ${\beta}$-carotene intakes were $1240.1{\pm}1101.1\;{\mu}g$ retinol equivalent/day ($693.3{\pm}563.2\;{\mu}g$ retinol activity equivalent/day), $182.6{\pm}149.5\;{\mu}g$/day and $5443.3{\pm}6365.5\;{\mu}g$/day, respectively. Only 9.4% of the subjects consumed less than the Korean Estimated Average Requirement for vitamin A. The mean vitamin E intake was $6.03{\pm}2.54\;mg$ ${\alpha}$-tocopherol equivalent/day. The ${\alpha}$-tocopherol and ${\gamma}$-tocopherol intakes were $4.83{\pm}2.03$ and $5.57{\pm}3.41\;mg$/day, respectively. Most of the subjects (93.8%) consumed less than the Korean Adequate Intake for vitamin E. The major food sources of vitamin A were sweet potato, carrot, red pepper powder, spinach, and citrus fruit, and the top 30 foods provided 91.5% of total Plant foods provided 81.0% and animalderived foods 10.5% of the vitamin A intake from the top 30 foods. The major food sources of vitamin E were soybean oil, red pepper powder, Ramyeon (cup noodles), spinach, and egg. The top 30 foods provided 78.0% of total vitamin E intake. Plant foods provided 61.3% and animal-derived foods 15.9% of the vitamin E intake from the top 30 foods. In conclusion, the vitamin A intake of the Korean adults in this study was ge-nerally adequate, but the vitamin E intake of many subjects was inadequate. Therefore, nutritional education may be of benefit to Korean adults to increase their vitamin E intake.

• Journal of Nutrition and Health
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• v.31 no.9
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• pp.1481-1497
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• 1998

The purpose of this study was to determine the relation between serum lipid profiles, apolipoprotein E phenotype, and dietary patterns in a cross-section of healthy individuals from Cheju-Do. Age, gender, anthropometric measurements, blood pressure, dietary consumption, drinking / smoking habits and menopausal status were surveyed. Total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, fasting blood glucose, and insulin levels were measured from overnight fasting blood. The study involved a total of 286 individuals(147 men and 139 women) between the ages of 20 and 60 years old. All of the subjects were recruited from a population of healthy individuals living in Cheju-Do. The results of the study are as follows : 1) Among the males, those in their 20's had the maximum food intake, while those in their 40's had the minimum food intake. For the females, food intake was the highest for those in their 30's. Energy and nutrient intakes were directly proportional to the amount of food intake. Men in their 30's were heavier than other men and women in their 40's were heavier than other women. The activity index for men in their 20's and 30's appeared to be lower than that of men above 40. The activity index of women in their 20's appeared to be lowest among all aged groups, and the index appeared to increase from the age of 30 onwards. 2) In terms of changes In serum constituents with age, men in their 40's appeared to have the highest levels of serum constituents such as lipids, glucose, and insulin. Men in their 50's showed the highest levels of serum LDL-cholesterol and glucose. Men in their 30's showed peak levels of serum triglycerides. On the other hand, women in their 50's appeared to have peak levels of serum total cholesterol, LDL-cholesterol, and triglycerides. There was no ch:ange with age in HDL-cholesterol and insulin levels for men and women. The percentage of the subjects had the following apo E phenotypes : E3/3, 91.3% ; E3/2, 5.4% ; E4/3, 2.5% ; E4/2, 0.7%. Lee's reserch with Korean female college students showed that the percentage of ApoE3/3, E3/2, E 4/2, E4/3, and E4/4 were 84.8%, 6.7%, 6.7%, 0.9%, 0.9%, respectively. The number of samples with ApoE mutation was so small that there was no statistical significance in the relation between apolipoprotein E phenotype and se겨m lipids. 3) To investigate the relati onship between weight and serum constituents, the subjects of this study were divided into three groups by BMI underweight, normal weight, and overweight. The serum constituents of men and women below the age 40 in the overweight groups belonged to the normal domain. On the other hand, serum cholesterol levels of both men and women above the age 40 in the overweight groups remained in the borderline-high region(above 200mg/dl), and the mean value of LDL-cholesterol(above 130mg/dl) and triglycerides of men were above normal. Fasting blood glucose levels also remained in the borderline-high region. Total cholesterol levels of women above the age 40 in the overweight group was in the borderline-high region. (Korean J Nutrition 31(9) : 1481-1497, 1998)